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Nonparametric tests of treatment effect homogeneity for policy-makers

面向政策制定者的处理效应同质性非参数检验

Recent work has focused on nonparametric estimation of conditional treatment effects, but inference has remained relatively unexplored. We propose a class of nonparametric tests for both quantitative and qualitative treatment effect heterogeneity. The tests can incorporate a variety of structured assumptions on the conditional average treatment effect, allow for both continuous and discrete covariates, and do not require sample splitting to obtain a tractable asymptotic null…

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The Generalised Kernel Covariance Measure

广义核协方差度量

We consider the problem of conditional independence (CI) testing and adopt a kernel-based approach. Kernel-based CI tests embed variables in reproducing kernel Hilbert spaces, regress their embeddings on the conditioning variables, and test the resulting residuals for marginal independence. This approach yields tests that are sensitive to a broad range of conditional dependencies. Existing methods, however, rely heavily on kernel ridge regression, which is computationally…

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Nonparametric Regression Discontinuity Designs with Survival Outcomes

生存结局的非参数断点回归设计

Quasi-experimental evaluations are central for generating real-world causal evidence and complementing insights from randomized trials. The regression discontinuity design (RDD) is a quasi-experimental design that can be used to estimate the causal effect of treatments that are assigned based on a running variable crossing a threshold. Such threshold-based rules are ubiquitous in healthcare, where predictive and prognostic biomarkers frequently guide treatment decisions.…

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Estimating treatment effects with competing intercurrent events in randomized controlled trials

随机对照试验中存在竞争性伴发事件的处理效应估计

The analysis of randomized controlled trials is often complicated by intercurrent events (IEs) -- events that occur after treatment initiation and affect either the interpretation or existence of outcome measurements. Examples include treatment discontinuation or the use of additional medications. In two recent clinical trials for systemic lupus erythematosus with complications of IEs, we classify the IEs into two broad categories: effect-informative (e.g., treatment…

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Identification and Inference in Nonlinear Dynamic Network Models

非线性动态网络模型的识别与推断

We study identification and inference in nonlinear dynamic systems defined on unknown interaction networks. The system evolves through an unobserved dependence matrix governing cross-sectional shock propagation via a nonlinear operator. We show that the network structure is not generically identified, and that identification requires sufficient spectral heterogeneity. In particular, identification arises when the network induces non-exchangeable covariance patterns through…

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Frequency-Domain Analysis of Time Series with Network-Structured Dependence: Application to Global Bank Connectedness

网络依赖时间序列的频域分析:全球银行关联应用

Financial spillovers in interconnected systems, such as global banking networks, require tools that capture temporal and frequency dynamics, while incorporating the underlying network topology. While current network time series models are developed in the time-domain, frequency-domain approaches, which reveal how cross-nodal dependencies vary across different cycles, remain under-explored. This paper develops a spectral analysis framework that accommodates flexible forms of…

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Penalized GMM Framework for Inference on Functionals of Nonparametric Instrumental Variable Estimators

非参数工具变量估计泛函推断的惩罚 GMM 框架

This paper develops a penalized GMM (PGMM) framework for automatic debiased inference on functionals of nonparametric instrumental variable estimators. We derive convergence rates for the PGMM estimator and provide conditions for root-n consistency and asymptotic normality of debiased functional estimates, covering both linear and nonlinear functionals. Monte Carlo experiments on average derivative show that the PGMM-based debiased estimator performs on par with the…

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Causal K-Means Clustering

因果 K 均值聚类

Causal effects are often characterized with population summaries. These might provide an incomplete picture when there are heterogeneous treatment effects across subgroups. Since the subgroup structure is typically unknown, it is more challenging to identify and evaluate subgroup effects than population effects. We propose a new solution to this problem: \emph{Causal k-Means Clustering}, which leverages the k-means clustering algorithm to uncover the unknown subgroup…

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Causal-ICM: A Data Fusion Framework For Heterogeneous Treatment Effect Estimation With Multi-Task Gaussian Processes

Causal-ICM:用多任务高斯过程融合数据估计异质处理效应

Bridging the gap between internal and external validity is crucial for heterogeneous treatment effect estimation. Randomised controlled trials (RCTs), favoured for their internal validity due to randomisation, often encounter challenges in generalising findings due to strict eligibility criteria. Observational studies, on the other hand, may provide stronger external validity through larger and more representative samples but can suffer from compromised internal validity due…

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Causal-DRF: Conditional Kernel Treatment Effect Estimation using Distributional Random Forest

Causal-DRF:基于分布随机森林的条件核处理效应估计

The conditional average treatment effect (CATE) is a commonly targeted statistical parameter for measuring the effect of a treatment conditional on covariates. However, the CATE will fail to capture effects of treatments beyond differences in conditional expectations. Inspired by causal forests for CATE estimation, we develop a forest-based method to estimate the conditional kernel treatment effect (CKTE), based on the recently introduced Distributional Random Forest (DRF)…

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Nonparametric estimation of the total treatment effect with multiple outcomes in the presence of terminal events

终末事件存在时多结局总处理效应的非参数估计

As standards of care advance, patients are living longer and once-fatal diseases are becoming manageable. Clinical trials increasingly focus on reducing disease burden, which can be quantified by the timing and occurrence of multiple non-fatal clinical events. Most existing methods for the analysis of multiple event-time data require stringent modeling assumptions that can be difficult to verify empirically, leading to treatment efficacy estimates that forego…

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Identifying and Estimating Causal Direct Effects Under Unmeasured Confounding

未测量混杂下因果直接效应的识别与估计

Causal mediation analysis provides techniques for defining and estimating effects that may be endowed with mechanistic interpretations. With many scientific investigations seeking to address mechanistic questions, causal direct and indirect effects have garnered much attention. The natural direct and indirect effects, the most widely used among such causal mediation estimands, are limited in their practical utility due to stringent identification requirements. Accordingly,…

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Adaptive Nonparametric Perturbations of Parametric Models with Generalized Bayes

通过广义贝叶斯对参数模型进行自适应非参数扰动

Parametric Bayesian modeling offers a powerful and flexible toolbox for machine learning. Yet the model, however detailed, may still be wrong, and this can make inferences untrustworthy. In this paper we introduce a new class of semiparametric corrections for parametric Bayesian models, when the target of inference is a functional of the true data distribution. Our starting point is a fully Bayesian modeling approach, which explicitly accounts for the possibility that the…

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Bayesian Multi-Group Functional Factor Models with Parameter-Expanded Cumulative Shrinkage Priors

采用参数扩展累积收缩先验的贝叶斯多组函数型因子模型

Functional data consist of trajectories observed over a continuous domain, such as time, space, or wavelength. Here we consider curves observed on different groups of subjects and propose a Bayesian multi-group functional factor analysis framework that jointly models the data via an explicit decomposition into group-specific mean functions and latent components that capture both common and distinct latent structures across the groups. We represent these functional components…

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Regularizing Extrapolation in Causal Inference

因果推断中的外推正则化

Many common estimators in machine learning and causal inference are linear smoothers, where the prediction is a weighted average of the training outcomes. Some estimators, such as ordinary least squares and kernel ridge regression, allow for arbitrarily negative weights, which improve feature imbalance but often at the cost of increased dependence on parametric modeling assumptions and higher variance. By contrast, estimators like importance weighting and random forests…

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A generalized tetrad constraint for testing conditional independence given a latent variable

检验给定潜变量条件独立性的广义四元约束

The tetrad constraint is widely used to test whether four observed variables are conditionally independent given a latent variable, based on the fact that if four observed variables following a linear model are mutually independent after conditioning on an unobserved variable, then products of covariances of any two different pairs of these four variables are equal. It is an important tool for discovering a latent common cause or distinguishing between alternative linear…

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Constructive Instrumental Variable Identification and Inference with Many Weak Interaction Moments

利用大量弱交互矩的构造性工具变量识别与推断

Instrumental variable methods are widely used for causal inference, but identification becomes especially challenging when instruments are weak and potentially invalid. These challenges are particularly pronounced in Mendelian randomization, where genetic variants serve as instruments and violations of exclusion restriction or independence assumptions are common. We propose MAGIC, a constructive and assumption-lean framework that achieves identification even when all…

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A Unified Framework for Nonlinear Mediation Analysis of Random Objects

随机对象非线性中介分析的统一框架

Mediation analysis for complex, non-Euclidean data, such as probability distributions, compositions, images, and networks, presents significant methodological challenges due to the inherent nonlinearity and geometric constraints of such spaces. Existing approaches are often restricted to Euclidean settings or specific data types. We propose Random Object Mediation Analysis (ROMA), a unified framework that simultaneously accommodates object-valued exposures, mediators, and…

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Inference on Optimal Policy Values and Other Irregular Functionals via Softmax Smoothing

通过 Softmax 平滑推断最优政策价值及其他非正则泛函

Constructing confidence intervals for the value of an (unknown) optimal treatment policy is a fundamental problem in causal inference. Insight into the optimal policy value can guide the development of reward-maximizing, individualized treatment regimes. However, because the functional that defines the optimal value is non-differentiable, standard semi-parametric approaches for performing inference fail to be directly applicable. Many existing works circumvent…

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Identifying the desert decision rule to assess and achieve fairness

识别应得决策规则以评估与实现公平

We study fairness in decision-making when the data may encode systematic bias. Existing approaches typically impose fairness constraints while predicting the observed decision, which may itself be unfair. We propose a novel framework for characterising and addressing fairness issues by introducing the notion of desert decision, a latent variable representing the decision an individual rightfully deserves based on their actions, efforts, or abilities. This formulation shifts…

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Gimbal Regression: Orientation-Adaptive Local Linear Regression under Spatial Heterogeneity

Gimbal 回归:空间异质性下方向自适应的局部线性回归

Local regression is widely used to explore spatial heterogeneity, but anisotropic or effectively low-dimensional neighborhoods can produce ill-conditioned local solves, causing coefficient variation driven by numerical artifacts rather than substantive structure. Such instability is often hidden when estimation relies on implicit tuning or optimization without exposing local diagnostics. This paper proposes Gimbal Regression (GR), a deterministic, geometry-aware local…

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Optimal Demixing of Nonparametric Densities

非参数密度的最优解混

Motivated by applications in statistics and machine learning, we consider a problem of unmixing convex combinations of nonparametric densities. Suppose we observe $n$ groups of samples, where the $i$th group consists of $N_i$ independent samples from a $d$-variate density $f_i(x)=\sum_{k=1}^K π_i(k)g_k(x)$. Here, each $g_k(x)$ is a nonparametric density, and each $π_i$ is a $K$-dimensional mixed membership vector. We aim to estimate $g_1(x), \ldots,g_K(x)$. This problem…

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A Nonparametric Framework for Universal Difference-in-Differences

通用双重差分的非参数框架

Difference-in-differences (DiD) is a popular approach to evaluate treatment effects in settings where both pre- and post-treatment measurements of the outcome are available. Despite its popularity, existing methods face important limitations. Specifically, they either: (i) only apply to continuous outcomes and the average treatment effect on the treated; (ii) are sensitive to the transformation of the outcome; (iii) rely on a no unmeasured confounding assumption given…

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A framework for joint assessment of a terminal event and a score existing only in the absence of the terminal event

终末事件与仅在事件未发生时存在的评分之联合评估框架

Analysis of data from randomized controlled trials in vulnerable populations requires special attention when assessing treatment effect by a score measuring, e.g., disease stage or activity together with onset of prevalent terminal events. In reality, it is impossible to disentangle a disease score from the terminal event, since the score is not clinically meaningful after this event. In this work, we propose to assess treatment interventions simultaneously on the terminal…

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