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A unified spectral analysis of high-dimensional linear regression: debiasing and thresholding

高维线性回归的统一谱分析:去偏与阈值化

We use spectral analysis to establish a unified theory of debiasing, thresholding, and simultaneous inference for high-dimensional linear regression with ill-conditioned designs. The methods include Ridge regression, spectral cut-off, and iterative and dynamical regression procedures. A common debiasing procedure uses two applications of the original linear algorithm with fixed parameters. Spectral analysis shows that debiasing squares the residual, while implementations…

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Accuracy of Uniform Inference on Fine Grid Points

Uniform confidence bands are widely used in empirical analysis for uncertainty qualification of nonparametric inference of unknown functions. A variety of simple implementation methods, including multiplier bootstrap, have been proposed and theoretically justified. However, an implementation over a literally continuous index set is generally computationally infeasible, and practitioners therefore compute the critical value by evaluating the statistic on a finite evaluation…

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Debiased inference for proximal dose-response function

We study nonparametric inference for a continuous-treatment causal dose-response curve and its first derivative under unmeasured confounding, using treatment- and outcome-inducing proxies. We establish a proximal doubly robust pseudo-outcome whose conditional mean given treatment equals the dose-response curve whenever either bridge function is correctly specified. Their (smoothed) efficient influence function representations lead to cross-fitted local-polynomial estimators…

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Longitudinal causal inference under informative missingness using the self-censoring model

自删失模型下信息性缺失的纵向因果推断

Longitudinal observational data are often subject to informative missingness. For example, in healthcare research using electronic health records, covariates and outcomes are measured only when patients interact with the healthcare system. Whether these data are observed usually depends on the unobserved variable values themselves, introducing a common form of data missing not at random. We develop identification and estimation methods for the effects of longitudinal…

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Function on Scalar Regression with Complex Survey Designs

复杂调查设计下的函数型响应对标量协变量回归

Large health surveys increasingly collect high-dimensional functional data from wearable devices, and function on scalar regression (FoSR) is used to quantify the relationship between these functional outcomes and scalar covariates like age and sex. However, existing methods for FoSR fail to account for complex survey design. We introduce inferential methods for FoSR with complex survey designs. The approach combines fast univariate inference (FUI) developed for functional…

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Causal Lag Structure Discovery in Confounded Time Series via Orthogonalized Adaptive Estimation

通过正交化自适应估计发现存在混杂的时间序列因果滞后结构

Finding which variables cause which others in multivariate time series, and at what lags, is central to science and policy, yet existing methods force a choice between flexible confounder adjustment, data-driven lag selection, and inference that controls the false discovery rate (FDR). ORACLE-VARX does all three in one pipeline. First, double/debiased machine learning (DML) removes nonlinear confounder effects from the outcomes and the lagged series. Second, adaptive causal…

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Interpretable Discovery from Unstructured Data: A High-Dimensional Approach

We propose an automatic, general-purpose framework for making discoveries from unstructured data (e.g., text data from open-ended surveys of economic beliefs). The framework leverages recent methods from the literature on AI interpretability to transform unstructured datasets into high-dimensional, structured datasets of interpretable concept measurements; specifies concept-level parameters and null hypotheses based on this transformed dataset; tests these hypotheses using…

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Bayesian Univariate-Guided Sparse Regression for Ultra-High-Dimensional Data

面向超高维数据的贝叶斯单变量引导稀疏回归

Ultra-high-dimensional genomic studies require simultaneous identification of sparse signals, control of spurious discoveries, and computationally feasible inference when the number of predictors can reach hundreds of thousands or more. We propose Bayesian Univariate-Guided Sparse Regression (BUGS), a global--local shrinkage framework that incorporates marginal association information directly into the prior through continuous modulation of shrinkage. By embedding univariate…

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Uncertainty Quantification in Forecast Comparisons

预测比较中的不确定性量化

Skill scores, which measure the relative improvement of a forecasting method over a benchmark via consistent scoring functions and proper scoring rules, are a standard tool in forecast evaluation, yet their sampling uncertainty is rarely rigorously quantified. With modern forecasting applications being increasingly multivariate and involving evaluations across multiple horizons, variables, spatial locations, and forecasting methods, standard tools like the pairwise…

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Always-On Experimentation

持续在线实验:动态处理下的序贯检验与错误发现率控制

Generative AI has dramatically accelerated the rate at which new treatments---from novel pharmaceuticals to online marketing campaigns---can be conceived and deployed. As a result, modern experimentation platforms often run continuously, with treatments added as they are ready and removed when they underperform. We formalize this "Always-On" experimental setting, in which treatments can be dynamically generated, added to, and removed from a running experiment, and study the…

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Debiased and Simultaneous Inference for Heterogeneous Factorial Effect Modifiers via Residualized Walsh-Hadamard Scores

基于残差化 Walsh–Hadamard 得分的异质析因效应修饰因子去偏与同时推断

In factorial randomized experiments with $K$ binary treatment components, we study which baseline covariates modify component main effects and interactions. We define effect-modifier cells $(j,S)$, $j\in[p]$ and $\emptyset\neq S\subseteq[K]$, through the coefficients $θ^\ast_{jS}$ of population linear projections of conditional Walsh--Hadamard contrasts $τ_{S}$ onto standardized covariates. Using baseline-robust direct scores, we develop frequentist inference for all $p(2^K-1)$…

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Multiple testing of a function's monotonicity

函数单调性的多重检验

Instead of having a single "yes" or "no" result from a test of the global null hypothesis that a function is increasing, we propose a multiple testing procedure of the function's increasingness at several points. If the global null is rejected, then multiple testing provides more information about why. If the global null is not rejected, then multiple testing can provide stronger evidence in favor of increasingness, by rejecting null hypotheses that the function is…

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Simultaneous Inference for Proximal Causal Learning with Weak Proxies

弱代理变量下近端因果学习的同时推断

Proximal causal learning uses the treatment-inducing proxy and the outcome-inducing proxy through the outcome bridge and the treatment bridge to provide a way to address unobserved confounding in observational studies. This paper studies simultaneous inference for the marginal counterfactual distribution and quantile treatment effect under weak proxies. First, we propose a measure of weak-proxy strength and tightens the population-bias bound for the counterfactual CDF…

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Scalable Variable Selection under Predictor Dependence with Adaptive Virtual Dummies

预测变量相关下基于自适应虚拟变量的可扩展变量选择

Reliable high-dimensional variable selection requires scalable error-controlling methods. The Terminating-Random Experiments (T-Rex) selector estimates the false discovery rate (FDR) by aggregating early-terminated forward-selection paths in which predictors compete with synthetic dummies. We address two remaining challenges: i) predictor dependence can bias dummy-predictor competition; ii) computation is wasted on recomputing terms shared across experiments. Building on…

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Statistical Inference for Causal Discovery under Selection and Latent Variables via Single-Target Interventions

潜变量与选择偏差下基于单目标干预的因果发现推断

Causal discovery from observational and interventional data becomes challenging in the presence of latent confounding and selection bias, where causal structure is no longer adequately represented by directed acyclic graphs over observed variables. Existing model-free methods often rely on an exponential number of conditional independence tests and provide limited uncertainty quantification in high-dimensional settings. We develop a model-free and constraint-query optimal…

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Uniform Inference for Parameters Identified by Conditional Quantile Restrictions

条件分位数限制识别参数的一致推断

Many structural and dynamic economic models imply that key parameters are identified by conditional quantile restrictions. Building on the exponential-weighting approach of Bierens (1990) and recent advances in penalized maximum statistics for conditional moment restrictions (Chen et al., 2025), we develop a unified inference framework for such parameters. We propose an adaptive $\ell_1$-penalized supremum statistic that transforms the conditional restriction into a…

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Model-free and Distributionally Robust Feature Screening with False Discovery Control for High-Dimensional Heterogeneous Data

面向高维异质数据的无模型、分布稳健特征筛选与错误发现控制

In this paper, we propose a model-free feature screening framework tailored for high-dimensional and heterogeneous datasets, based on a novel distributionally robust dependence measure termed Copula Divergence. The proposed screening method, named CD-Screen, addresses critical limitations of existing feature screening methods, such as restrictive modeling assumptions and sensitivity to heterogeneous feature distributions. CD-Screen ranks features according to their Copula…

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Robust filtering and smoothing via perturbation methods

基于扰动方法的稳健滤波与平滑

Using a perturbation technique, we derive a new approximate filtering and smoothing methodology generalizing along different directions several existing approaches to robust filtering based on the score and the Hessian matrix of the observation density. The main advantages of the methodology can be summarized as follows: (i) it relaxes the critical assumption of a Gaussian conditional distribution for the latent states underlying such approaches; (ii) can be applied to a…

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Testing Conditional Stochastic Dominance via Copula Derivatives

利用 Copula 导数检验条件随机占优

Comparing two populations at the same physical covariate value requires more than conditional means or isolated target-point decisions: researchers may need evidence about an entire conditional-distribution ordering over a continuum, even when covariate margins differ. This paper makes that common-value comparison estimable under an explicit structure--flexibility tradeoff and turns the resulting surface into simultaneous evidence for first-order stochastic dominance.…

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Gain-function optimisation of graphical multiple testing procedures for confirmatory clinical trials

确证性临床试验中图形多重检验程序的收益函数优化

Graphical multiple testing procedures are a flexible and transparent way to control the family-wise error rate when a confirmatory trial pursues several label claims, but they leave open the question of which graph to use. In practice sponsors often fall back on fixed-sequence or Holm procedures that may poorly reflect what the trial is actually trying to achieve. We propose to instead choose the graph that maximises an explicit gain function, which states what each possible…

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A Heavily Right Strategy for Statistical Inference with Dependent Studies in Arbitrary Dimensions

任意维度下依赖研究推断的重右尾策略

We leverage recent advances in heavy-tail approximations for global hypothesis testing with dependent studies to construct approximate confidence regions without modeling or estimating their dependence structures. A non-rejection region is a confidence region but it may not be convex. Convexity is appealing because it ensures any one-dimensional linear projection of the region is a confidence interval, easy to compute and interpret. We show why convexity fails for nearly all…

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Iterative Exploration-Driven Sparse SDP Clustering via Thompson Sampling

通过汤普森采样实现探索驱动的迭代稀疏半定规划聚类

High-dimensional sparse clustering is a challenging combinatorial problem due to the tight coupling between cluster assignment and variable selection. We demonstrate that semidefinite programming (SDP) relaxation of K-means is robust to variable over-selection by establishing minimax separation bounds. Leveraging this robustness, we offer a twist on the recent trend of using exogenous randomness to evaluate feature importance and control false discovery by partially shifting…

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Nonparametric Regression with Measurement Error in Banach Spaces

Banach 空间中含测量误差的非参数回归

We consider nonparametric regression with a Banach-space-valued predictor where the covariate takes values in a general separable Banach space. Our primary objective is to develop a unified framework for estimating the regression operator without relying on an inner-product structure, thereby extending classical and functional nonparametric regression beyond Euclidean and Hilbert spaces in the presence of measurement error. We establish the fundamental properties of the…

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From Good Starts to Optimal Inference: Generalized Latent Factor Models with Missingness and Implicit Regularization

缺失数据下广义潜因子模型的初始化、隐式正则化与推断

Generalized latent factor models provide a flexible framework for analyzing high-dimensional non-Gaussian data, but principled estimation and uncertainty quantification under missingness remain substantially less developed. We develop a theory that connects a computationally tractable nonconvex procedure directly to statistical inference for nonlinear latent factor models with exponential-family links and partially observed entries. Our procedure combines a link-aware…

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