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A new method for clustered survival data]{A new method for clustered survival data: Estimation of treatment effect heterogeneity and variable selection

集群生存数据的新方法:处理效应异质性估计与变量选择

We recently developed a new method riAFT-BART to draw causal inferences about population treatment effect on patient survival from clustered and censored survival data while accounting for the multilevel data structure. The practical utility of this method goes beyond the estimation of population average treatment effect. In this work, we exposit how riAFT-BART can be used to solve two important statistical questions with clustered survival data: estimating the treatment…

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A Guide to Impact Evaluation under Sample Selection and Missing Data: Teacher's Aides and Adolescent Mental Health

样本选择与缺失数据下的影响评估:教师助理与青少年心理健康

This paper is concerned with identification, estimation, and specification testing in causal evaluation problems when data is selective and/or missing. We leverage recent advances in the literature on graphical methods to provide a unifying framework for guiding empirical practice. The approach integrates and connects to prominent identification and testing strategies in the literature on missing data, causal machine learning, panel data analysis, and more. We demonstrate…

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Counterfactual Inference for Consumer Choice Across Many Product Categories

跨多产品类别消费者选择的反事实推断

This paper proposes a method for estimating consumer preferences among discrete choices, where the consumer chooses at most one product in a category, but selects from multiple categories in parallel. The consumer's utility is additive in the different categories. Her preferences about product attributes as well as her price sensitivity vary across products and are in general correlated across products. We build on techniques from the machine learning literature on…

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Estimating the causal effects of multiple intermittent treatments with application to COVID-19

多种间歇性治疗的因果效应估计及其新冠应用

To draw real-world evidence about the comparative effectiveness of multiple time-varying treatments on patient survival, we develop a joint marginal structural survival model and a novel weighting strategy to account for time-varying confounding and censoring. Our methods formulate complex longitudinal treatments with multiple start/stop switches as the recurrent events with discontinuous intervals of treatment eligibility. We derive the weights in continuous time to handle…

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Interpretable (not just posthoc-explainable) heterogeneous survivor bias-corrected treatment effects for assignment of postdischarge interventions to prevent readmissions

校正幸存者偏差的可解释异质性治疗效应:出院后干预与再入院预防

We used survival analysis to quantify the impact of postdischarge evaluation and management (E/M) services in preventing hospital readmission or death. Our approach avoids a specific pitfall of applying machine learning to this problem, which is an inflated estimate of the effect of interventions, due to survivors bias -- where the magnitude of inflation may be conditional on heterogeneous confounders in the population. This bias arises simply because in order to receive an…

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Amortized neural networks for agent-based model forecasting

用于基于主体模型预测的摊销神经网络

In this paper, we propose a new procedure for unconditional and conditional forecasting in agent-based models. The proposed algorithm is based on the application of amortized neural networks and consists of two steps. The first step simulates artificial datasets from the model. In the second step, a neural network is trained to predict the future values of the variables using the history of observations. The main advantage of the proposed algorithm is its speed. This is due…

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Effect or Treatment Heterogeneity? Policy Evaluation with Aggregated and Disaggregated Treatments

效应异质性还是处理异质性?聚合与细分处理的政策评估

Binary treatments are often ex-post aggregates of multiple treatments or can be disaggregated into multiple treatment versions. Thus, effects can be heterogeneous due to either effect or treatment heterogeneity. We propose a decomposition method that uncovers masked heterogeneity, avoids spurious discoveries, and evaluates treatment assignment quality. The estimation and inference procedure based on double/debiased machine learning allows for high-dimensional confounding,…

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Causation versus Prediction: Comparing Causal Discovery and Inference with Artificial Neural Networks in Travel Mode Choice Modeling

因果与预测:出行方式选择中的因果方法与人工神经网络比较

This study compares the performance of a causal and a predictive model in modeling travel mode choice in three neighborhoods in Chicago. A causal discovery algorithm and a causal inference technique were used to extract the causal relationships in the mode choice decision making process and to estimate the quantitative causal effects between the variables both directly from observational data. The model results reveal that trip distance and vehicle ownership are the direct…

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Causal Lifting and Link Prediction

因果提升与链接预测

Existing causal models for link prediction assume an underlying set of inherent node factors -- an innate characteristic defined at the node's birth -- that governs the causal evolution of links in the graph. In some causal tasks, however, link formation is path-dependent: The outcome of link interventions depends on existing links. Unfortunately, these existing causal methods are not designed for path-dependent link formation, as the cascading functional dependencies…

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Minimax Optimal Kernel Operator Learning via Multilevel Training

通过多层训练实现极小极大最优核算子学习

Learning mappings between infinite-dimensional function spaces has achieved empirical success in many disciplines of machine learning, including generative modeling, functional data analysis, causal inference, and multi-agent reinforcement learning. In this paper, we study the statistical limit of learning a Hilbert-Schmidt operator between two infinite-dimensional Sobolev reproducing kernel Hilbert spaces. We establish the information-theoretic lower bound in terms of the…

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Feature Selection for Personalized Policy Analysis

个性化政策分析中的特征选择

In this paper, we propose Forest-PLS, a feature selection method for analyzing policy effect heterogeneity in a more flexible and comprehensive manner than is typically available with conventional methods. In particular, our method is able to capture policy effect heterogeneity both within and across subgroups of the population defined by observable characteristics. To achieve this, we employ partial least squares to identify target components of the population and causal…

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Flexible machine learning estimation of conditional average treatment effects: a blessing and a curse

灵活机器学习估计条件平均处理效应:优势与隐患

Causal inference from observational data requires untestable identification assumptions. If these assumptions apply, machine learning (ML) methods can be used to study complex forms of causal effect heterogeneity. Recently, several ML methods were developed to estimate the conditional average treatment effect (CATE). If the features at hand cannot explain all heterogeneity, the individual treatment effects (ITEs) can seriously deviate from the CATE. In this work, we…

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Multiply Robust Estimator Circumvents Hyperparameter Tuning of Neural Network Models in Causal Inference

以多重稳健估计整合因果推断中的神经网络调参模型

Estimation of the Average Treatment Effect (ATE) is often carried out in 2 steps, wherein the first step, the treatment and outcome are modeled, and in the second step the predictions are inserted into the ATE estimator. In the first steps, numerous models can be fit to the treatment and outcome, including using machine learning algorithms. However, it is a difficult task to choose among the hyperparameter sets which will result in the best causal effect estimation and…

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Model-robust and efficient covariate adjustment for cluster-randomized experiments

整群随机实验中模型稳健且高效的协变量调整

Cluster-randomized experiments are increasingly used to evaluate interventions in routine practice conditions, and researchers often adopt model-based methods with covariate adjustment in the statistical analyses. However, the validity of model-based covariate adjustment is unclear when the working models are misspecified, leading to ambiguity of estimands and risk of bias. In this article, we first adapt two conventional model-based methods, generalized estimating equations…

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Comparative Analysis of Machine Learning, Hybrid, and Deep Learning Forecasting Models Evidence from European Financial Markets and Bitcoins

欧洲金融市场与比特币预测:机器学习、混合及深度学习模型比较

This study analyzes the transmission of market uncertainty on key European financial markets and the cryptocurrency market over an extended period, encompassing the pre, during, and post-pandemic periods. Daily financial market indices and price observations are used to assess the forecasting models. We compare statistical, machine learning, and deep learning forecasting models to evaluate the financial markets, such as the ARIMA, hybrid ETS-ANN, and kNN predictive models.…

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Doubly robust machine learning for an instrumental variable study of surgical care for cholecystitis

胆囊炎手术治疗工具变量研究中的双重稳健机器学习

Comparative effectiveness research frequently employs the instrumental variable design since randomized trials can be infeasible for many reasons. In this study, we investigate and compare treatments for emergency cholecystitis -- inflammation of the gallbladder. A standard treatment for cholecystitis is surgical removal of the gallbladder, while alternative non-surgical treatments include managed care and pharmaceutical options. As randomized trials are judged to violate…

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Expert Aggregation for Financial Forecasting

金融预测中的专家聚合

Machine learning algorithms dedicated to financial time series forecasting have gained a lot of interest. But choosing between several algorithms can be challenging, as their estimation accuracy may be unstable over time. Online aggregation of experts combine the forecasts of a finite set of models in a single approach without making any assumption about the models. In this paper, a Bernstein Online Aggregation (BOA) procedure is applied to the construction of long-short…

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Panel Data Nowcasting: The Case of Price-Earnings Ratios

面板数据即时预测:以市盈率为例

The paper uses structured machine learning regressions for nowcasting with panel data consisting of series sampled at different frequencies. Motivated by the problem of predicting corporate earnings for a large cross-section of firms with macroeconomic, financial, and news time series sampled at different frequencies, we focus on the sparse-group LASSO regularization which can take advantage of the mixed frequency time series panel data structures. Our empirical results show…

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Unveiling Causal Mediation Pathways in High-Dimensional Mixed Exposures: A Data-Adaptive Target Parameter Strategy

高维混合暴露的因果中介路径识别:数据自适应目标参数策略

Mediation analysis in causal inference typically concentrates on one binary exposure, using deterministic interventions to split the average treatment effect into direct and indirect effects through a single mediator. Yet, real-world exposure scenarios often involve multiple continuous exposures impacting health outcomes through varied mediation pathways, which remain unknown a priori. Addressing this complexity, we introduce NOVAPathways, a methodological framework that…

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Identification of Causal Relationship between Amyloid-beta Accumulation and Alzheimer's Disease Progression via Counterfactual Inference

通过反事实推断识别淀粉样蛋白积累与阿尔茨海默病进展的因果关系

Alzheimer's disease (AD) is a neurodegenerative disorder that is beginning with amyloidosis, followed by neuronal loss and deterioration in structure, function, and cognition. The accumulation of amyloid-beta in the brain, measured through 18F-florbetapir (AV45) positron emission tomography (PET) imaging, has been widely used for early diagnosis of AD. However, the relationship between amyloid-beta accumulation and AD pathophysiology remains unclear, and causal inference…

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Neural Algorithmic Reasoning with Causal Regularisation

带因果正则化的神经算法推理

Recent work on neural algorithmic reasoning has investigated the reasoning capabilities of neural networks, effectively demonstrating they can learn to execute classical algorithms on unseen data coming from the train distribution. However, the performance of existing neural reasoners significantly degrades on out-of-distribution (OOD) test data, where inputs have larger sizes. In this work, we make an important observation: there are many different inputs for which an…

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Doubly Robust Estimation of Direct and Indirect Quantile Treatment Effects with Machine Learning

结合机器学习的直接与间接分位数处理效应双重稳健估计

We suggest double/debiased machine learning estimators of direct and indirect quantile treatment effects under a selection-on-observables assumption. This permits disentangling the causal effect of a binary treatment at a specific outcome rank into an indirect component that operates through an intermediate variable called mediator and an (unmediated) direct impact. The proposed method is based on the efficient score functions of the cumulative distribution functions of…

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Near Optimal Heteroscedastic Regression with Symbiotic Learning

通过协同学习实现近最优异方差回归

We consider the problem of heteroscedastic linear regression, where, given $n$ samples $(\mathbf{x}_i, y_i)$ from $y_i = \langle \mathbf{w}^{*}, \mathbf{x}_i \rangle + ε_i \cdot \langle \mathbf{f}^{*}, \mathbf{x}_i \rangle$ with $\mathbf{x}_i \sim N(0,\mathbf{I})$, $ε_i \sim N(0,1)$, we aim to estimate $\mathbf{w}^{*}$. Beyond classical applications of such models in statistics, econometrics, time series analysis etc., it is also particularly relevant in machine learning…

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Necessary and sufficient graphical conditions for optimal adjustment sets in causal graphical models with hidden variables

含隐藏变量因果图中最优调整集的充要图条件

The problem of selecting optimal backdoor adjustment sets to estimate causal effects in graphical models with hidden and conditioned variables is addressed. Previous work has defined optimality as achieving the smallest asymptotic estimation variance and derived an optimal set for the case without hidden variables. For the case with hidden variables there can be settings where no optimal set exists and currently only a sufficient graphical optimality criterion of limited…

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