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A Causal Machine Learning Framework for Treatment Personalization in Clinical Trials: Application to Ulcerative Colitis

临床试验治疗个性化的因果机器学习框架:溃疡性结肠炎应用

Randomized controlled trials estimate average treatment effects, but treatment response heterogeneity motivates personalized approaches. A critical question is whether statistically detectable heterogeneity translates into improved treatment decisions -- these are distinct questions that can yield contradictory answers. We present a modular causal machine learning framework that evaluates each question separately: permutation importance identifies which features predict…

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Sparsified-Learning for High-Dimensional Heavy-Tailed Locally Stationary Time Series, Concentration and Oracle Inequalities

高维重尾局部平稳时间序列的稀疏学习:集中与预言不等式

Sparse learning is ubiquitous in many machine learning tasks. It aims to regularize the goodness-of-fit objective by adding a penalty term to encode structural constraints on the model parameters. In this paper, we develop a flexible sparse learning framework tailored to high-dimensional heavy-tailed locally stationary time series (LSTS). The data-generating mechanism incorporates a regression function that changes smoothly over time and is observed under noise belonging to…

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Beating the Winner's Curse via Inference-Aware Policy Optimization

通过考虑推断的政策优化缓解赢家诅咒

There has been a surge of recent interest in automatically learning policies to target treatment decisions based on rich individual covariates. In addition, practitioners want confidence that the learned policy has better performance than the incumbent policy according to downstream policy evaluation. However, due to the winner's curse -- an issue where the policy optimization procedure exploits prediction errors rather than finding actual improvements -- predicted…

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Identification and Debiased Learning of Causal Effects with General Instrumental Variables

一般工具变量下因果效应的识别与去偏学习

Instrumental variable methods are fundamental to causal inference when treatment assignment is confounded by unobserved variables. In this article, we develop a general nonparametric causal framework for identification and learning with multi-categorical or continuous instrumental variables. Specifically, the mean potential outcomes and the average treatment effect can be identified via a regular weighting function derived from the proposed framework. Leveraging…

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On the Computational Efficiency of Bayesian Additive Regression Trees: An Asymptotic Analysis

贝叶斯加性回归树的计算效率:渐近分析

Bayesian Additive Regression Trees (BART) is a popular Bayesian non-parametric regression model that is commonly used in causal inference and beyond. Its strong predictive performance is supported by well-developed estimation theory, comprising guarantees that its posterior distribution concentrates around the true regression function at optimal rates under various data generative settings and for appropriate prior choices. However, the computational properties of the…

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Inference for Heterogeneous Treatment Effects with Efficient Instruments and Machine Learning

利用有效工具变量与机器学习推断异质处理效应

We introduce a new instrumental variable (IV) estimator for heterogeneous treatment effects in the presence of endogeneity. Our estimator is based on double/debiased machine learning (DML) and uses efficient machine learning instruments (MLIV) and kernel smoothing. We prove consistency and asymptotic normality of our estimator and also construct confidence sets that are more robust towards weak IV. Along the way, we also provide an accessible discussion of the corresponding…

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Personalized Policy Learning through Discrete Experimentation: Theory and Empirical Evidence

通过离散实验学习个性化连续策略:理论与实证证据

Randomized Controlled Trials (RCTs), or A/B testing, have become the gold standard for optimizing various operational policies on online platforms. However, RCTs on these platforms typically cover a limited number of discrete treatment levels, while the platforms increasingly face complex operational challenges involving optimizing continuous variables, such as pricing and incentive programs. The current industry practice involves discretizing these continuous decision…

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Global Testing in Multivariate Regression Discontinuity Designs

多维断点回归设计中的全局检验

Regression discontinuity (RD) designs with multiple running variables arise in a growing number of empirical applications, including geographic boundaries and multi-score assignment rules. Although recent methodological work has extended estimation and inference tools to multivariate settings, far less attention has been devoted to developing global testing methods that formally assess whether a discontinuity exists anywhere along a multivariate treatment boundary. Existing…

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Causal inference for calibrated scaling interventions on time-to-event processes

事件时间过程中校准缩放干预的因果推断

This work develops a flexible inferential framework for nonparametric causal inference in time-to-event settings, based on stochastic interventions defined through multiplicative scaling of the intensity governing an intermediate event process. These interventions induce a family of estimands indexed by a scalar parameter α, representing effects of modifying event rates while preserving the temporal and covariate-dependent structure of the observed data generating mechanism.…

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Neural Entropic Optimal Transport and Gromov-Wasserstein Alignment

神经熵正则最优传输与 Gromov-Wasserstein 对齐

Optimal transport (OT) and Gromov-Wasserstein (GW) alignment are powerful frameworks for geometrically driven matching of probability distributions, yet their large-scale usage is hampered by high statistical and computational costs. Entropic regularization has emerged as a promising solution, allowing parametric convergence rates via the plug-in estimator, which can be computed using the Sinkhorn algorithm (or its iterations in the GW case). However, Sinkhorn's $O(n^2)$ time…

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Nonparametric Inference with an Instrumental Variable under a Separable Binary Treatment Choice Model

可分二元治疗选择模型下的工具变量非参数推断

Instrumental variable (IV) methods are widely used to infer treatment effects in the presence of unmeasured confounding. In this paper, we study nonparametric inference with an IV under a separable binary treatment choice model, which posits that the odds of the probability of taking the treatment, conditional on the instrument and the treatment-free potential outcome, factor into separable components for each variable. While nonparametric identification of smooth…

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Causal Inference for Preprocessed Outcomes with an Application to Functional Connectivity

预处理结局的因果推断及其在功能连接中的应用

In biomedical research, repeated measurements within each subject are often processed to remove artifacts and unwanted sources of variation. The resulting data are used to construct derived outcomes that act as proxies for scientific outcomes that are not directly observable. Although intra-subject processing is widely used, its impact on inter-subject statistical inference has not been systematically studied, and a principled framework for causal analysis in this setting is…

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Neural Network Machine Regression (NNMR): A Deep Learning Framework for Uncovering High-order Synergistic Effects

神经网络机器回归:揭示高阶协同效应的深度学习框架

We propose a new neural network framework, termed Neural Network Machine Regression (NNMR), which integrates trainable input gating and adaptive depth regularization to jointly perform feature selection and function estimation in an end-to-end manner. By penalizing both gating parameters and redundant layers, NNMR yields sparse and interpretable architectures while capturing complex nonlinear relationships driven by high-order synergistic effects. We further develop a…

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Forecasting Oil Consumption: The Statistical Review of World Energy Meets Machine Learning

预测石油消费:世界能源统计与机器学习的结合

This paper studies whether a small set of dominant countries can account for most of the dynamics of regional oil demand and improve forecasting performance. We focus on dominant drivers within the OECD and a broad GVAR sample covering over 90\% of world GDP. Our approach identifies dominant drivers from a high-dimensional concentration matrix estimated row by row using two complementary variable-selection methods, LASSO and the one-covariate-at-a-time multiple testing…

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Optimal Hold-Out Size in Cross-Validation

交叉验证中的最优留出规模

Cross-validation (CV) is routinely used across the sciences to select models and tune parameters, and the resulting choices are often interpreted as substantive scientific conclusions (e.g., which variables, mechanisms, or risk factors are ``supported by the data''). A key part of the CV procedure -- the hold-out size, or equivalently the fold count $K$ -- is typically set by convention (e.g., 80/20, $K=5$) rather than by a principled criterion. Central to the issue is the…

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Graph Attention Network for Node Regression on Random Geometric Graphs with Erdős--Rényi contamination

随机几何图上的图注意力网络节点回归:含Erdős–Rényi污染

Graph attention networks (GATs) are widely used and often appear robust to noise in node covariates and edges, yet rigorous statistical guarantees demonstrating a provable advantage of GATs over non-attention graph neural networks~(GNNs) are scarce. We partially address this gap for node regression with graph-based errors-in-variables models under simultaneous covariate and edge corruption: responses are generated from latent node-level covariates, but only noise-perturbed…

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ScoreMatchingRiesz: Score Matching for Debiased Machine Learning and Policy Path Estimation

ScoreMatchingRiesz:用于去偏机器学习与政策路径估计的得分匹配

We propose ScoreMatchingRiesz, a family of Riesz representer estimators based on score matching. The Riesz representer is a key nuisance component in debiased machine learning, enabling $\sqrt{n}$-consistent and asymptotically efficient estimation of causal and structural targets via Neyman-orthogonal scores. We formulate Riesz representer estimation as a score estimation problem. This perspective stabilizes representer estimation by allowing us to leverage denoising score…

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Online Detection of Changes in Moment-Based Projections: When to Retrain Deep Learners or Update Portfolios?

基于矩的投影变化在线检测:何时重训深度学习模型或调整组合

Training deep learning neural networks often requires massive amounts of computational ressources. We propose to sequentially monitor network predictions to trigger retraining only if the predictions are no longer valid. This can reduce drastically computational costs and opens a door to green deep learning. Our approach is based on the relationship to projected second moments monitoring, a problem also arising in other areas such as computational finance. Various open-end…

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United in Currency, Divided in Growth: Dynamic Effects of Euro Adoption

货币统一、增长分化:采用欧元的动态效应

Does euro adoption affect long-run economic growth? Existing evidence is mixed, reflecting limited treated countries, long horizons that challenge inference, and heterogeneity across member states. We estimate causal dynamic and heterogeneous treatment effects using Causal Forests with Fixed Effects (CFFE), a machine-learning approach that combines causal forests with two-way fixed effects. Under a conditional parallel-trends assumption, we find that euro adoption reduced…

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Revisiting Incremental Stochastic Majorization-Minimization Algorithms with Applications to Mixture of Experts

重新审视增量随机主化最小化算法及其在专家混合模型中的应用

Processing high-volume, streaming data is increasingly common in modern statistics and machine learning, where batch-mode algorithms are often impractical because they require repeated passes over the full dataset. This has motivated incremental stochastic estimation methods, including the incremental stochastic Expectation-Maximization (EM) algorithm formulated via stochastic approximation. In this work, we revisit and analyze an incremental stochastic variant of the…

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Normalized Fractional Order Entropy-Based Decision-Making Models under Risk

风险下的归一化分数阶熵决策模型

Constructing efficient portfolios requires balancing expected returns with risk through optimal stock selection, while accounting for investor preferences. In a recent work by Paul and Kundu (2026), the fractional-order entropy due to Ubriaco was introduced as an uncertainty measure to capture varying investor attitudes toward risk. Building on this foundation, we introduce a novel normalized fractional order entropy aligned with investors' risk preferences that combines…

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Incremental effects for continuous exposures

连续暴露的增量效应

Causal inference problems often involve continuous treatments, such as dose, duration, or frequency. However, identifying and estimating standard dose-response estimands requires that everyone has some chance of receiving any level of the exposure (i.e., positivity). To avoid this assumption, we consider stochastic interventions based on exponentially tilting the treatment distribution by some parameter $δ$ (an incremental effect); this increases or decreases the likelihood…

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Towards Interpretable Deep Generative Models via Causal Representation Learning

通过因果表征学习构建可解释的深度生成模型

Recent developments in generative artificial intelligence (AI) rely on machine learning techniques such as deep learning and generative modeling to achieve state-of-the-art performance across wide-ranging domains. These methods' surprising performance is due in part to their ability to learn implicit "representations" of complex, multi-modal data. Unfortunately, deep neural networks are notoriously black boxes that obscure these representations, making them difficult to…

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Event history analysis with time-dependent covariates via landmarking supermodels and boosted trees

基于地标超级模型与提升树的时间依赖协变量事件史分析

We propose a nonparametric method for dynamic prediction in event history analysis with high-dimensional, time-dependent covariates. The approach estimates future conditional hazards by combining landmarking supermodels with gradient boosted trees. Unlike joint modeling or Cox landmarking models, the proposed estimator flexibly captures interactions and nonlinear effects without imposing restrictive parametric assumptions or requiring the covariate process to be Markovian.…

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