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早产儿观察研究中连续工具变量的增强：匹配、部分识别界与推断AI 解读

Regionalization of intensive care for premature babies refers to a triage system of mothers with high-risk pregnancies to hospitals of varied capabilities based on risks faced by infants. Due to the limited capacity of high-level hospitals, which are equipped with advanced expertise to provide critical care, understanding the effect of delivering premature babies at such hospitals on infant mortality for different subgroups of high-risk mothers could facilitate the design of…

利用因果图识别自相关时间序列中的弹性AI 解读

The price elasticity of demand can be estimated from observational data using instrumental variables (IV). However, naive IV estimators may be inconsistent in settings with autocorrelated time series. We argue that causal time graphs can simplify IV identification and help select consistent estimators. To do so, we propose to first model the equilibrium condition by an unobserved confounder, deriving a directed acyclic graph (DAG) while maintaining the assumption of a…

以噪声对抗噪声：大量候选工具变量下的因果推断AI 解读

Instrumental variable methods provide useful tools for inferring causal effects in the presence of unmeasured confounding. To apply these methods with large-scale data sets, a major challenge is to find valid instruments from a possibly large candidate set. In practice, most of the candidate instruments are often not relevant for studying a particular exposure of interest. Moreover, not all relevant candidate instruments are valid as they may directly influence the outcome…

利用相关工具变量集合预测具有多效性调控作用的 GWAS 位点因果基因AI 解读

Multivariate Mendelian randomization (MVMR) is a statistical technique that uses sets of genetic instruments to estimate the direct causal effects of multiple exposures on an outcome of interest. At genomic loci with pleiotropic gene regulatory effects, that is, loci where the same genetic variants are associated to multiple nearby genes, MVMR can potentially be used to predict candidate causal genes. However, consensus in the field dictates that the genetic instruments in…

跨研究工具变量估计的非参数复现AI 解读

Replicating causal estimates across different cohorts is crucial for increasing the integrity of epidemiological studies. However, strong assumptions regarding unmeasured confounding and effect modification often hinder this goal. By employing an instrumental variable (IV) approach and targeting the local average treatment effect (LATE), these assumptions can be relaxed to some degree; however, little work has addressed the replicability of IV estimates. In this paper, we…

大量弱工具变量下的第一阶段 F 检验AI 解读

A widely adopted approach for detecting weak instruments is to use the first-stage $F$ statistic. While this method was developed with a fixed number of instruments, its performance with many instruments remains insufficiently explored. We show that the first-stage $F$ test exhibits distorted sizes for detecting many weak instruments, regardless of the choice of pretested estimators or Wald tests. These distortions occur due to the inadequate approximation using classical…

空间自回归模型的迁移学习及美国总统选举预测应用AI 解读

It is important to incorporate spatial geographic information into U.S. presidential election analysis, especially for swing states. The state-level analysis also faces significant challenges of limited spatial data availability. To address the challenges of spatial dependence and small sample sizes in predicting U.S. presidential election results using spatially dependent data, we propose a novel transfer learning framework within the SAR model, called as tranSAR. Classical…

内生性下的极端分位数处理效应：评估最弱势群体的政策效果AI 解读

We introduce a novel method for estimating and conducting inference about extreme quantile treatment effects (QTEs) in the presence of endogeneity. Our approach is applicable to a broad range of empirical research designs, including instrumental variables design and regression discontinuity design, among others. By leveraging regular variation and subsampling, the method ensures robust performance even in extreme tails, where data may be sparse or entirely absent. Simulation…

异方差与异常值下过度识别线性模型的估计AI 解读

A large degree of overidentification causes severe bias in TSLS. A conventional heuristic rule used to motivate new estimators in this context is approximate bias. This paper formalizes the definition of approximate bias and expands the applicability of approximate bias to various classes of estimators that bridge OLS, TSLS, and Jackknife IV estimators (JIVEs). By evaluating their approximate biases, I propose new approximately unbiased estimators, including UOJIVE1 and…

少数大聚类与弱识别下工具变量分位数回归的梯度野生自助法AI 解读

We study the gradient wild bootstrap-based inference for instrumental variable quantile regressions in the framework of a small number of large clusters in which the number of clusters is viewed as fixed, and the number of observations for each cluster diverges to infinity. For the Wald inference, we show that our wild bootstrap Wald test, with or without studentization using the cluster-robust covariance estimator (CRVE), controls size asymptotically up to a small error as…

利用工具变量处理不可忽略缺失的双重稳健估计AI 解读

Suppose we are interested in the mean of an outcome that is subject to nonignorable nonresponse. This paper develops new semiparametric estimation methods with instrumental variables which affect nonresponse, but not the outcome. The proposed estimators remain consistent and asymptotically normal even under partial model misspecifications for two variation independent nuisance components. We evaluate the performance of the proposed estimators via a simulation study, and…

使用工具变量估计需治疗人数、需暴露人数与暴露影响人数AI 解读

The Number needed to treat (NNT) is an efficacy index defined as the average number of patients needed to treat to attain one additional treatment benefit. In observational studies, specifically in epidemiology, the adequacy of the populationwise NNT is questionable since the exposed group characteristics may substantially differ from the unexposed. To address this issue, groupwise efficacy indices were defined: the Exposure Impact Number (EIN) for the exposed group and the…

因果图辅助的动脉瘤性蛛网膜下腔出血观察研究因果发现AI 解读

Causal inference methods for observational data are increasingly recognized as a valuable complement to randomized clinical trials (RCTs). They can, under strong assumptions, emulate RCTs or help refine their focus. Our approach to causal inference uses causal directed acyclic graphs (DAGs). We are motivated by a concern that many observational studies in medicine begin without a clear definition of their objectives, without awareness of the scientific potential, and without…

分布因果效应的工具变量估计AI 解读

Estimating the causal effect of a treatment on the entire response distribution is an important yet challenging task. For instance, one might be interested in how a pension plan affects not only the average savings among all individuals but also how it affects the entire savings distribution. While sufficiently large randomized studies can be used to estimate such distributional causal effects, they are often either not feasible in practice or involve non-compliance. A…

从大量弱效应实验中学习处理效应的协方差AI 解读

When primary objectives are insensitive or delayed, experimenters may instead focus on proxy metrics derived from secondary outcomes. For example, technology companies often infer the long-term impacts of product interventions from their effects on short-term user engagement signals. We consider the meta-analysis of many historical experiments to learn the covariance of treatment effects on these outcomes, which can support the construction of such proxies. Even when…

无效工具变量下的识别与推断AI 解读

Instrumental variables (IVs) are widely used to study the causal effect of an exposure on an outcome in the presence of unmeasured confounding. IVs require an instrument, a variable that is (A1) associated with the exposure, (A2) has no direct effect on the outcome except through the exposure, and (A3) is not related to unmeasured confounders. Unfortunately, finding variables that satisfy conditions (A2) or (A3) can be challenging in practice. This paper reviews works where…

线性工具变量回归中的稳健置换检验AI 解读

This paper develops permutation versions of identification-robust tests in linear instrumental variables (IV) regression. Unlike the existing randomization and rank-based tests in which independence between the instruments and the error terms is assumed, the permutation Anderson- Rubin (AR), Lagrange Multiplier (LM) and Conditional Likelihood Ratio (CLR) tests are asymptotically similar and robust to conditional heteroskedasticity under standard exclusion restriction i.e.…

利用工具变量时间序列识别因果效应：辅助变量与历史依赖调整AI 解读

Instrumental variable (IV) regression relies on instruments to infer causal effects from observational data with unobserved confounding. We consider IV regression in time series models, such as vector auto-regressive (VAR) processes. Direct applications of i.i.d. techniques are generally inconsistent as they do not correctly adjust for dependencies in the past. In this paper, we outline the difficulties that arise due to time structure and propose methodology for…

利用凝聚型层次聚类选择有效工具变量AI 解读

We propose a procedure which combines hierarchical clustering with a test of overidentifying restrictions for selecting valid instrumental variables (IV) from a large set of IVs. Some of these IVs may be invalid in that they fail the exclusion restriction. We show that if the largest group of IVs is valid, our method achieves oracle properties. Unlike existing techniques, our work deals with multiple endogenous regressors. Simulation results suggest an advantageous…

前向正交离差 GMM 与大样本偏差的消除AI 解读

It is well known that generalized method of moments (GMM) estimators of dynamic panel data regressions can have significant bias when the number of time periods ($T$) is not small compared to the number of cross-sectional units ($n$). The bias is attributed to the use of many instrumental variables. This paper shows that if the maximum number of instrumental variables used in a period increases with $T$ at a rate slower than $T^{1/2}$, then GMM estimators that exploit the…

利用可能无效的工具变量发现双向因果关系并进行推断AI 解读

Learning causal relationships between pairs of complex traits from observational studies is of great interest across various scientific domains. However, most existing methods assume the absence of unmeasured confounding and restrict causal relationships between two traits to be uni-directional, which may be violated in real-world systems. In this paper, we address the challenge of causal discovery and effect inference for two traits while accounting for unmeasured…

存在部分无效工具变量时双向孟德尔随机化的识别与估计AI 解读

We consider the challenging problem of estimating causal effects from purely observational data in the bi-directional Mendelian randomization (MR), where some invalid instruments, as well as unmeasured confounding, usually exist. To address this problem, most existing methods attempt to find proper valid instrumental variables (IVs) for the target causal effect by expert knowledge or by assuming that the causal model is a one-directional MR model. As such, in this paper, we…

使用时变工具变量的两阶段最小二乘：二型糖尿病治疗强化评估AI 解读

As longitudinal data becomes more available in many settings, policy makers are increasingly interested in the effect of time-varying treatments (e.g. sustained treatment strategies). In settings such as this, the preferred analysis techniques are the g-methods, however these require the untestable assumption of no unmeasured confounding. Instrumental variable analyses can minimise bias through unmeasured confounding. Of these methods, the Two Stage Least Squares technique…

纵向重复测量数据中针对假设性目标量的工具变量方法：STEP 1 试验应用AI 解读

The STEP 1 randomized trial evaluated the effect of taking semaglutide vs placebo on body weight over a 68 week duration. As with any study evaluating an intervention delivered over a sustained period, non-adherence was observed. This was addressed in the original trial analysis within the Estimand Framework by viewing non-adherence as an intercurrent event. The primary analysis applied a treatment policy strategy which viewed it as an aspect of the treatment regimen, and…