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WEIRDO：以弱残差正则化估计 Doob h 变换的扩散引导AI 解读

We study the problem of estimating the guidance that steers the distribution learned by a diffusion generative model toward a tilted target $q_0 \propto w\,p_0$ at inference time. Relying on the stochastic optimal control approach, we observe that the exact drift correction is the gradient of the logarithm of Doob's $h$-function, and we study the problem of estimating it from a sample. In the present paper, we assume that the score of the pretrained model is available, that…

最优配置与曲面下体积AI 解读

This paper develops a framework for estimation and inference on the volumes of sets that are projections of critical function sets, focusing particularly on the convex body beneath the optimal receiver operating characteristic (ROC) surface. Specifically, we propose a volume calculation method that first uses an Aumann expectation representation and then applies Minkowski mixed volumes. Using this framework, we show that the population volume under the ROC surface (VUS) is…

贝叶斯神经网络辅助多处理混合治愈生存模型：儿科肿瘤应用AI 解读

Estimating covariate-conditional treatment effects in multi-arm oncology studies is complicated when treatment arms have common distributional features and a non-negligible fraction of patients achieve long-term remission. We propose a joint mixture cure model with covariate-dependent mixtures of log-normal kernels with treatment-specific inclusions. Both linear and neural-network-assisted non-linear covariate links are proposed. Specifically, the susceptible survival…

正则非光滑模型的归一化最大似然：测度论基础与几何采样AI 解读

The Normalized Maximum Likelihood (NML) codelength, or stochastic complexity, represents a principled criterion for universal coding. While recent coarea-based formulations provided a calculation method for smooth models, this framework collapses for the non-smooth estimators ubiquitous in modern machine learning (e.g., Lasso, Sparse SVMs). In this work, we provide a rigorous framework for computing the NML for regular path-differentiable Lipschitz (PDL) estimators. By…

持续在线实验：动态处理下的序贯检验与错误发现率控制AI 解读

Generative AI has dramatically accelerated the rate at which new treatments---from novel pharmaceuticals to online marketing campaigns---can be conceived and deployed. As a result, modern experimentation platforms often run continuously, with treatments added as they are ready and removed when they underperform. We formalize this "Always-On" experimental setting, in which treatments can be dynamically generated, added to, and removed from a running experiment, and study the…

插补就够了：平均处理效应估计的双稳健、半参数有效性与自动协变量平衡AI 解读

Imputation-based causal estimation is typically viewed as relying exclusively on an outcome model, in contrast to augmented inverse-probability weighting, whose consistency is protected by fitting two nuisance models. This paper argues that this view can be misleading by highlighting a hidden dual weighting structure in least-squares sieve regression imputation. Although only outcome regressions are explicitly fitted, the resulting imputation estimator admits an exact…

时变协变量下交错双重差分处理效应的双重稳健估计AI 解读

With staggered adoption, difference-in-differences (DiD) analyses define the average treatment effect on the treated (ATT) at the group-period level and aggregate it into groupwise, periodwise, dynamic, and overall effects. We study a period-by-period version of conditional parallel trends, with covariates unaffected by treatment while allowing covariates to shift the trends in untreated potential outcomes. We propose an augmented inverse probability weighting (AIPW)…

数据驱动亚组发现后标准试验估计量的推断AI 解读

Data-driven subgroup identification is increasingly used in clinical trials, yet the effect reported for a discovered subgroup is typically the standard analysis: a Cox or generalized-linear-model treatment coefficient fitted within that subgroup. Selection by an effect-driven rule --- rewarding large estimated effects subject to screening and size criteria --- inflates the reported coefficient: a winner's curse invalidating naive intervals whether or not the identifier's…

通过交叉代理平衡的近似因果推断AI 解读

Proximal causal inference identifies causal effects in the presence of unmeasured confounding by drawing on two sets of proxy variables. Identification typically utilizes bridge functions, defined as solutions to integral equations. However, the mechanism by which fitted bridge functions correct for confounding bias remains opaque, offering little to interpret, inspect or stress-test. We show that the defining equation of a treatment bridge function is already a balance…

时间序列基础模型的潜在推理时引导AI 解读

Time Series Foundation Models (TSFMs) currently provide state-of-the-art results in forecasting tasks. They are available out-of-the-box and rely on in-context learning to make their predictions, which makes the quality of their performance highly sensitive to the user-selected lookback, covariates, horizon and training data distributions. In practise, the quality of the forecasts are variable but complementary, which highlights the need for a principled ensembling approach,…

最小设定扰动：以距证伪的距离衡量因果推断稳健性AI 解读

Empirical causal claims depend on many analyst decisions, from selecting covariates to choosing estimators. Existing robustness tools summarize how results vary across these choices, but, to the best of our knowledge, do not answer: \textbf{How many analyst decisions must change to reach a specification, which is a set of choices, whose confidence interval (CI) contains zero?} We introduce \emph{Minimum Specification Perturbation (MSP)}, the smallest number of changes. MSP…

高维椭圆因子模型中主特征值与特征向量的两样本检验AI 解读

Changes in principal eigenvalues and eigendirections provide complementary diagnostics of structural instability in factor models, but covariance-based inference can be unreliable under heavy tails. We develop two-sample tests for equality of these features of trace-normalized shape matrices under high-dimensional elliptical factor models. Our approach combines Tyler's identity with orthogonalization and cross-fitting to accommodate general location and precision pilots. We…

大面板中的颗粒工具变量：强、近弱与弱工具下的识别和推断AI 解读

I develop asymptotic theory for Granular Instrumental Variables (GIV) in large panels with both $N$ and $T$ growing. The granular instrument is constructed from individual shocks that must be estimated from the panel. I show that this estimation has a first-order effect on the asymptotic variance of the GIV estimator. Existing methods do not account for this effect, leading to incorrect standard errors and invalid inference. I derive corrected standard errors that deliver…

何时能够进行奈曼正交推断？存在性与信息相关性AI 解读

Neyman-orthogonal moments underpin debiased and double machine learning, yet their existence and informativeness are typically presumed. We ask three questions: when do nontrivial orthogonal moments exist, which target directions contain first-order information, and does a proposed moment detect all such directions? Restricted local overidentification characterizes existence under attainability. Effective Fisher information determines relevance; its rank counts informative…

随时间刻画幸存者主层：识别、有效估计与敏感性分析AI 解读

Longitudinal studies with functional outcomes subject to truncation-by-death frequently report time-indexed survivor average causal effect estimates, defined among individuals who would survive regardless of treatment assignment. Because the survivor stratum can change over time, the resulting effect estimates may pertain to populations with different characteristics. We propose accompanying survivor average causal effect estimates with measures of covariate divergence…

SPARK：基于残差投影的通用拟合优度评估AI 解读

Goodness-of-fit testing is a basic tool for assessing whether a fitted procedure has captured the systematic information contained in the covariates. While traditional theory has largely focused on parametric regression models, modern data analysis increasingly relies on flexible black-box learners, whose predictive success alone is insufficient to assess model accuracy. In this paper, we propose SPARK, a general framework for goodness-of-fit testing that applies to…

小样本多协变量随机对照试验中的G计算AI 解读

In contemporary randomized controlled trials (RCTs), the number of patients is often small relative to the number of baseline covariates collected. In such settings, maximum likelihood estimators of conditional treatment effects in generalized linear models, along with their standard errors, may exhibit substantial bias. This study examines whether similar bias arises in G-computation estimators of marginal treatment effects, which are known for their robustness to model…

多控制变量下工资不平等界的去偏推断AI 解读

We study estimation and inference for a partially identified parameter whose identified set depends on a first-stage nuisance parameter that must itself be estimated. Combining the criterion-function approach with the theory of Neyman-orthogonal moments that underlies double/debiased machine learning, we propose a two-step procedure: the point-identified nuisance is estimated by flexible machine-learning methods, and the set-identified target is recovered as a level set of a…

不可观测异质性的去偏机器学习：高维面板与测量误差模型AI 解读

Developing robust inference for models with nonparametric Unobserved Heterogeneity (UH) is both important and challenging. We propose novel Debiased Machine Learning (DML) procedures for valid inference on functionals of UH, allowing for partial identification of multivariate target and high-dimensional nuisance parameters. Our main contribution is a full characterization of all relevant Neyman-orthogonal moments in models with nonparametric UH, where relevance means…

基于残差化 Walsh–Hadamard 得分的异质析因效应修饰因子去偏与同时推断AI 解读

In factorial randomized experiments with $K$ binary treatment components, we study which baseline covariates modify component main effects and interactions. We define effect-modifier cells $(j,S)$, $j\in[p]$ and $\emptyset\neq S\subseteq[K]$, through the coefficients $θ^\ast_{jS}$ of population linear projections of conditional Walsh--Hadamard contrasts $τ_{S}$ onto standardized covariates. Using baseline-robust direct scores, we develop frequentist inference for all $p(2^K-1)$…

全正编码下的 INSIDE 假设：解释与部分经验评估AI 解读

Mendelian randomisation (MR) implemented through instrumental variable (IV) analysis is a popular strategy for strengthening causal inference in observational studies. A key assumption for several MR estimators, including MR-Egger regression, is the INstrument Strength Independent of Direct Effect (INSIDE) assumption. However, there is no established empirical test for assessing the plausibility of this assumption. Moreover, INSIDE depends on how genetic variants are coded…

识别临床AI预测多重性中亚组脆弱性的统计框架AI 解读

AI models trained on the same data can disagree about patient risk, with disagreement potentially concentrated in clinically important subgroups. We propose V(S), a statistically grounded vulnerability index combining an observable lower-bound witness of model disagreement with clinical severity, and develop inference and multiplicity-adjustment procedures for auditing prespecified subgroups. We applied the framework to two large critical-care cohorts, MIMIC-IV (n = 65,078)…

BRP-GABLE：适用于多种结果类型的可解释规则预测框架AI 解读

Interpretable prediction models are important in biomedical research, where predictive accuracy must often be balanced against the ability to examine predictor-outcome relationships. Automatic Binary Logistic Estimation (ABLE) provides interpretable rule-based representations by constructing additive models using threshold rules. However, the original method is restricted to binary outcomes, and its greedy forward construction follows a search path, making candidate rules…

删失持续时间模型中的未观测异质性检验：EM方法AI 解读

Ignoring unobserved heterogeneity in duration models biases parameter estimates and invalidates inference, but testing for it is non-regular: the null hypothesis lies on the boundary of the parameter space and some parameters are unidentified under the null. These features render standard asymptotic theory inapplicable. This paper develops an EM test for unobserved heterogeneity in censored Weibull duration models, building on the EM approach of Li, Chen, and Marriott…