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IV regression with distribution-valued outcomes

分布值结局的工具变量回归

We develop IV Fréchet regression (IVFR), an instrumental-variable (IV) method for settings where the outcome is an entire distribution. Framing the problem as an IV regression in 2-Wasserstein space, IVFR extends global Fréchet regression to the case with endogenous covariates. IVFR projects IV-weighted quantile curves onto the space of valid distributions and then recovers the corresponding regression coefficient functions. The projection provably reduces the estimation…

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Heterogeneity-robust granular instruments

对异质性稳健的颗粒工具变量

Granular instrumental variables (GIV) has experienced sharp growth in empirical macro-finance. The methodology's rise showcases granularity's potential for identification across many economic environments, like the estimation of spillovers and demand systems. I propose a new estimator--called robust granular instrumental variables (RGIV)--that enables studying unit-level heterogeneity in spillovers. Unlike existing methods that assume heterogeneity is a function of…

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The Modified Egger Intercept Tests for Detecting Horizontal Pleiotropy in Two-Sample Summary-Data Mendelian Randomization

检测两样本汇总数据孟德尔随机化水平多效性的修正 Egger 截距检验

The Egger intercept (EI) test is a widely used tool to detect horizontal pleiotropy in two-sample summary-data Mendelian randomization. A significant EI test suggests that either the average pleiotropic effect differs from zero (i.e., directional pleiotropy) or the InSIDE (Instrument Strength Independent of Direct Effect) assumption is violated (i.e., correlated pleiotropy) or both. As such, the EI test provides an assessment of the validity of the instrumental variable…

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Automated, efficient and model-free inference for randomized clinical trials via data-driven covariate adjustment

通过数据驱动协变量调整实现随机临床试验的自动化高效无模型推断

In 2023, the U.S. Food and Drug Administration issued guidance for adjustment of covariates in randomized clinical trials, emphasizing its role in enhancing precision and power through prognostic baseline variables. Despite its potential, many trials underutilize this method partly due to challenges in pre-specifying optimal baseline covariates and their functional forms. We explore the potential of automated, data-adaptive methods-including stepwise regression, Lasso and…

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From nonstationarity to stationarity via $1/f$ noise: discrete Fourier transforms and sample mean asymptotics for testing

经由 1/f 噪声连接非平稳与平稳:离散傅里叶变换及样本均值检验渐近理论

We study the asymptotic behaviour of different statistics for time series exhibiting long memory and nonstationarity. For processes with memory parameter $d\in(-1/2,3/2)$, we derive the joint limiting distribution of discrete Fourier transforms at a fixed number of Fourier frequencies, with a unified normalization. The resulting limits are Gaussian with an explicit covariance structure. Particular attention is given to the boundary case $d=1/2$, also known as $1/f$ noise. We…

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Bayesian Latent Class Regression with Interpretable Binary Profiles

可解释二元剖面的贝叶斯潜在类别回归

High-dimensional categorical data arise in diverse scientific domains and are often accompanied by covariates. Latent class regression models are routinely used in such settings, reducing dimensionality by assuming conditional independence of the categorical variables given a single latent class that depends on covariates through a logistic regression model. However, such methods become unreliable as the dimensionality increases. To address this, we propose Bayesian latent…

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Regime-Based Portfolio Allocation Using Hidden Markov Models and Reinforcement Learning

结合隐马尔可夫模型与强化学习的状态依赖投资组合配置

This study develops a regime-aware portfolio allocation framework that integrates Markov switching models with Reinforcement Learning (RL) to dynamically allocate across equities (SPY), long-term Treasuries (TLT), and gold (GLD). Using daily ETF data from 2004-2025, we first characterize market behavior through a discrete Markov chain and then estimate a three-state Gaussian Hidden Markov Model (HMM) selected by the Bayesian Information Criterion (BIC). The estimated…

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Robust Moment-Based Estimation via Spectral Gradient Reweighting

基于谱梯度重加权的稳健矩估计

Moment-based estimation is a theoretically attractive approach to parametric inference, especially when likelihood-based estimation is unavailable, misspecified, or computationally inconvenient. However, the moment equations involve sample averages, which makes moment-based estimation sensitive to outliers. We propose the SGR-GMM algorithm, a robust generalized method of moments (GMM) procedure that uses a spectral gradient reweighting (SGR) primitive to soft-reweight the…

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Causally-interpretable meta-analysis using aggregate data

利用汇总数据开展具有因果解释的元分析

Evidence syntheses and meta-analyses are used to inform clinical practice guidelines and health economic evaluations. However, heterogeneity of treatment effects poses a significant challenge. Conventional meta-analysis addresses heterogeneity through random-effect assumptions, which are not supported by design and lead to estimates that may not apply to any real-world population. Causally-interpretable meta-analysis (CIMA) offers a rigorous framework for specification,…

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A Simple Measure of Robustness for External Validity under Covariate Shifts

协变量分布偏移下外部有效性的简明稳健性度量

This paper studies the robustness of estimated policy effects to changes in the distribution of covariates, a key determinant of the external validity of (quasi)-experimental results. I propose a novel robustness metric $δ^*$ which measures the smallest covariate shift needed to invalidate an empirical claim about the policy effect (e.g., $ATE > 0$). I estimate $δ^*$ via de-biased GMM, achieving a parametric rate of convergence while accommodating machine-learning estimators…

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Posterior Quantification of Borrowing from Multiple Historical Control Data in Bayesian Dynamic Borrowing Methods: A Scoping Review

贝叶斯动态借用方法中多历史对照信息借用的后验量化:范围综述

Bayesian dynamic borrowing methods incorporate historical control data into current clinical trial analyses while allowing the degree of borrowing to depend on the compatibility between historical and current data. Although many methods have been proposed, the degree of borrowing is often difficult to interpret, especially when multiple historical control sources are available. This scoping review focuses on posterior quantification of borrowing from multiple historical…

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Global Average Treatment Effects for Individualized Randomization Experiments with Aggregate Data

仅用聚合数据识别个体随机化实验的全局平均处理效应

Individualized randomized experiments are central to online platforms for optimizing personalized decisions in complex environments. In two-sided markets, however, standard treatment effect estimation is often invalid due to strong temporal and cross-unit interference, a challenge compounded when only aggregated data are available because of privacy or system constraints. To address these issues, we identify the Global Average Treatment Effect (GATE) using only group-level…

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Confounder Detection via Treatment Intent: A New Observational Study Design

通过处理意向发现混杂因素:一种新的观察研究设计

Understanding the effects of interventions is central to scientific progress, with randomized controlled trials (RCTs) regarded as the gold standard for causal inference in many applied fields. However, RCTs are costly, time-consuming, and often constrained by ethical or practical limitations, motivating the need for causal methods able to draw conclusions from observational data. While such data is collected at ever larger scale, making its use for causal inference is often…

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Pathwise guessing in categorical time series with unbounded alphabets

无界字母表分类时间序列中的路径猜测

The following learning problem arises naturally in various applications: Given a finite sample from a categorical or count time series, can we learn a function of the sample that (nearly) maximizes the probability of correctly guessing the values of a given portion of the data using the values from the remaining parts? Unlike classical approaches in statistical inference, our approach avoids explicitly estimating the conditional probabilities. We propose a non-parametric…

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Unobserved Heterogeneity in Threshold Regression Based on the Hitting Times of a Reflected Brownian Motion for Recurrent Hypoglycemia

基于反射布朗运动首达时间的复发性低血糖阈值回归与不可观测异质性

Analyses of recurrent hypoglycemia are critical for effective treatment management in diabetic patients. Typically, within-subject dependency in such analyses is captured through subject-level frailty. Recent research has modeled recurrent hypoglycemia using the first hitting times of a reflected Brownian motion. A close examination of this approach reveals that it does not adequately account for varying frailties among individuals, which indicate notable heterogeneity. To…

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Beyond Differences: Doubly Robust Meta-Learners for Ratio-Based Treatment Effects

超越差值:面向比率处理效应的双重稳健元学习器

When treatment effects are naturally expressed as ratios -- as in medicine, pricing, and marketing -- the ratio-based CATE $τ(x) = E[Y|W=1,X=x] / E[Y|W=0,X=x]$ is the appropriate estimand. Yet existing estimators either impose a log-linear parametric structure or apply generic regression without robustness guarantees for this functional. We introduce the Q-Learner, which decomposes $τ(x)$ into a product of two odds ratios, reducing ratio-CATE estimation for binary outcomes…

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Estimating Dynamic Marginal Policy Effects under Sequential Unconfoundedness

序贯无混杂条件下的动态边际政策效应估计

We develop methods for estimating how infinitesimal policy changes affect long-term outcomes in dynamic systems. We show that dynamic marginal policy effects (MPEs) can be identified via tractable reduced-form expressions, and can be estimated under a general sequential unconfoundedness assumption. We also propose a doubly robust estimator for dynamic MPEs. Our approach does not require observing full dynamic state information (as is typically assumed for off-policy…

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Causal Duration Analysis with Diff-in-Diff

基于双重差分的因果持续时间分析

In economic program evaluation, it is common to obtain panel data in which outcomes are indicators that an individual has reached an absorbing state. For example, they may indicate whether an individual has exited a period of unemployment, passed an exam, left a marriage, or had their parole revoked. The parallel trends assumption that underpins difference-in-differences generally fails in such settings. We suggest identifying conditions similar to those of…

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Estimation and Inference in Boundary Discontinuity Designs: Distance-Based Methods

边界不连续设计中的估计与推断:基于距离的方法

We study nonparametric distance-based (isotropic) local polynomial methods for estimating the boundary average treatment effect curve, a causal functional that captures treatment effect heterogeneity in boundary discontinuity designs. We establish identification, estimation, and inference results both pointwise and uniformly along the treatment assignment boundary. We show that the geometric regularity of the boundary, a one-dimensional manifold, plays a central role in…

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Preserving linear invariants in ensemble filtering methods

集合滤波方法中的线性不变量保持

Data assimilation combines dynamical models with observations to improve state estimates. Ensemble filters sequentially assimilate observations by updating a set of samples over time, alternating between a forecast and an analysis step. Accurate and robust predictions often require preserving critical invariants such as mass, stoichiometric balance of chemical species, and electrical charge. While modern numerical solvers maintain these invariants, existing…

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Transcripts and Algebraic Distances in Time Series: Stochastic Properties and Nonparametric Dependence Tests

时间序列中的序型转换与代数距离:随机性质及非参数依赖检验

The use of ordinal patterns (OPs) for analyzing the dependence structure of univariate and continuously distributed processes has gained popularity in recent years. This research goes one step further and considers the transcripts being computed from successive OPs in the time series. Transcripts constitute a kind of ``difference'' between successive OPs and thus naturally relate to two algebraic distances between OPs, the Cayley and Kendall edit distances. The original time…

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Double Local-to-Unity: Inference under Nearly Nonstationary Volatility

双重局部趋近单位根:近非平稳波动率下的推断

This article develops a moderate-deviation limit theory for autoregressive models with jointly persistent mean and volatility dynamics. The autoregressive coefficient is allowed to drift toward unity slower than the classical 1/n rate, while the volatility persistence parameter also converges to one at an even slower, logarithmic order, so that the conditional variance process is itself nearly nonstationary and its unconditional moments may diverge. This double localization…

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A Quasi Maximum Likelihood Estimation Method for Bergomi-Type Volatility Models

Bergomi 型波动率模型的拟极大似然估计方法

We propose a quasi maximum likelihood estimation method for Bergomi-type stochastic volatility models with parametrized kernels, focusing on the estimation of the kernel parameters from high-frequency time-series observations of option prices. We first show that the cumulative forward variance, which can be reconstructed from option prices, solves an infinite-dimensional stochastic differential equation driven by a one-dimensional Brownian motion under the Bergomi-type…

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Covariate-adjusted statistical dependence representation through partial copulas: bounds and new insights

通过偏 Copula 表示协变量调整后的统计依赖:界限与新认识

In this paper, we revisit the notion of partial copula, originally introduced to test conditional independence, highlighting its capability to represent the dependence between two random variables after removing their dependence with a covariate. Building upon results previously presented in the literature, we show that partial copulas can be seen as a nonlinear analogue of partial correlation. Then, we prove several results showing how dependence properties of the…

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