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Causal inference in survival analysis using longitudinal observational data: Sequential trials and marginal structural models

纵向观察数据中的生存因果推断:序贯试验与边际结构模型

Longitudinal observational patient data can be used to investigate the causal effects of time-varying treatments on time-to-event outcomes. Several methods have been developed for controlling for the time-dependent confounding that typically occurs. The most commonly used is inverse probability weighted estimation of marginal structural models (MSM-IPTW). An alternative, the sequential trials approach, is increasingly popular, in particular in combination with the target…

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Robust decision-making under risk and ambiguity

风险与模糊性下的稳健决策

Economists often estimate economic models on data and use the point estimates as a stand-in for the truth when studying the model's implications for optimal decision-making. This practice ignores model ambiguity, exposes the decision problem to misspecification, and ultimately leads to post-decision disappointment. Using statistical decision theory, we develop a framework to explore, evaluate, and optimize robust decision rules that explicitly account for estimation…

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Beware the Gini Index! A New Inequality Measure

警惕基尼指数:一种新的不平等测度

The Gini index underestimates inequality for heavy-tailed distributions: for example, a Pareto distribution with exponent 1.5 (which has infinite variance) has the same Gini index as any exponential distribution (a mere 0.5). This is because the Gini index is relatively robust to extreme observations: while a statistic's robustness to extremes is desirable for data potentially distorted by outliers, it is misleading for heavy-tailed distributions, which inherently exhibit…

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Inference with Many Weak Instruments

大量弱工具变量下的统计推断

We develop a concept of weak identification in linear IV models in which the number of instruments can grow at the same rate or slower than the sample size. We propose a jackknifed version of the classical weak identification-robust Anderson-Rubin (AR) test statistic. Large-sample inference based on the jackknifed AR is valid under heteroscedasticity and weak identification. The feasible version of this statistic uses a novel variance estimator. The test has uniformly…

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Clarifying Selection Bias in Cluster Randomized Trials: Estimands and Estimation

厘清整群随机试验的选择偏差:目标参数与估计

In cluster randomized trials, patients are typically recruited after clusters are randomized, and the recruiters and patients may not be blinded to the assignment. This often leads to differential recruitment and consequently systematic differences in baseline characteristics of the recruited patients between intervention and control arms, inducing post-randomization selection bias. We rigorously define causal estimands in the presence of selection bias. We elucidate the…

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Volatility prediction comparison via robust volatility proxies: An empirical deviation perspective

用稳健波动率代理比较预测:经验偏差视角

Volatility forecasting is crucial to risk management and portfolio construction. One particular challenge of assessing volatility forecasts is how to construct a robust proxy for the unknown true volatility. In this work, we show that the empirical loss comparison between two volatility predictors hinges on the deviation of the volatility proxy from the true volatility. We then establish non-asymptotic deviation bounds for three robust volatility proxies, two of which are…

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Data Integration in Causal Inference

因果推断中的数据整合

Integrating data from multiple heterogeneous sources has become increasingly popular to achieve a large sample size and diverse study population. This paper reviews development in causal inference methods that combines multiple datasets collected by potentially different designs from potentially heterogeneous populations. We summarize recent advances on combining randomized clinical trial with external information from observational studies or historical controls, combining…

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Probabilistic Prediction for Binary Treatment Choice: with focus on personalized medicine

二元治疗选择中的概率预测:聚焦个体化医疗

This paper extends my research applying statistical decision theory to treatment choice with sample data, using maximum regret to evaluate the performance of treatment rules. The specific new contribution is to study as-if optimization using estimates of illness probabilities in clinical choice between surveillance and aggressive treatment. Beyond its specifics, the paper sends a broad message. Statisticians and computer scientists have addressed conditional prediction for…

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Inference on the maximal rank of time-varying covariance matrices using high-frequency data

利用高频数据推断时变协方差矩阵的最大秩

We study the rank of the instantaneous or spot covariance matrix $Σ_X(t)$ of a multidimensional continuous semi-martingale $X(t)$. Given high-frequency observations $X(i/n)$, $i=0,\ldots,n$, we test the null hypothesis $rank(Σ_X(t))\le r$ for all $t$ against local alternatives where the average $(r+1)$st eigenvalue is larger than some signal detection rate $v_n$. A major problem is that the inherent averaging in local covariance statistics produces a bias that distorts the…

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Causal Structural Learning Via Local Graphs

通过局部图学习因果结构

We consider the problem of learning causal structures in sparse high-dimensional settings that may be subject to the presence of (potentially many) unmeasured confounders, as well as selection bias. Based on the structure found in common families of large random networks and examining the representation of local structures in linear structural equation models (SEM), we propose a new local notion of sparsity for consistent structure learning in the presence of latent and…

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Regression-based estimation of heterogeneous treatment effects when extending inferences from a randomized trial to a target population

随机试验推断向目标人群扩展时的异质性处理效应回归估计

Methods for extending -- generalizing or transporting -- inferences from a randomized trial to a target population involve conditioning on a large set of covariates that is sufficient for rendering the randomized and non-randomized groups exchangeable. Yet, decision-makers are often interested in examining treatment effects in subgroups of the target population defined in terms of only a few discrete covariates. Here, we propose methods for estimating subgroup-specific…

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Causal Matrix Completion

因果矩阵补全

Matrix completion is the study of recovering an underlying matrix from a sparse subset of noisy observations. Traditionally, it is assumed that the entries of the matrix are "missing completely at random" (MCAR), i.e., each entry is revealed at random, independent of everything else, with uniform probability. This is likely unrealistic due to the presence of "latent confounders", i.e., unobserved factors that determine both the entries of the underlying matrix and the…

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Nonparametric Bounds on Treatment Effects with Imperfect Instruments

不完美工具变量下处理效应的非参数界

This paper extends the identification results in Nevo and Rosen (2012) to nonparametric models. We derive nonparametric bounds on the average treatment effect when an imperfect instrument is available. As in Nevo and Rosen (2012), we assume that the correlation between the imperfect instrument and the unobserved latent variables has the same sign as the correlation between the endogenous variable and the latent variables. We show that the monotone treatment selection and…

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Estimating subgroup effects in generalizability and transportability analyses

推广与迁移分析中的亚组效应估计

Methods for extending -- generalizing or transporting -- inferences from a randomized trial to a target population involve conditioning on a large set of covariates that is sufficient for rendering the randomized and non-randomized groups exchangeable. Yet, decision-makers are often interested in examining treatment effects in subgroups of the target population defined in terms of only a few discrete covariates. Here, we propose methods for estimating subgroup-specific…

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Evaluating the Robustness of Targeted Maximum Likelihood Estimators via Realistic Simulations in Nutrition Intervention Trials

通过营养干预试验的现实模拟评估目标最大似然估计的稳健性

Several recently developed methods have the potential to harness machine learning in the pursuit of target quantities inspired by causal inference, including inverse weighting, doubly robust estimating equations and substitution estimators like targeted maximum likelihood estimation. There are even more recent augmentations of these procedures that can increase robustness, by adding a layer of cross-validation (cross-validated targeted maximum likelihood estimation and…

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An Automated Approach to Causal Inference in Discrete Settings

离散情形下因果推断的自动化方法

When causal quantities cannot be point identified, researchers often pursue partial identification to quantify the range of possible values. However, the peculiarities of applied research conditions can make this analytically intractable. We present a general and automated approach to causal inference in discrete settings. We show causal questions with discrete data reduce to polynomial programming problems, and we present an algorithm to automatically bound causal effects…

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Conditional Cross-Design Synthesis Estimators for Generalizability in Medicaid

医疗补助人群推广分析中的条件跨设计综合估计量

While much of the causal inference literature has focused on addressing internal validity biases, both internal and external validity are necessary for unbiased estimates in a target population of interest. However, few generalizability approaches exist for estimating causal quantities in a target population when the target population is not well-represented by a randomized study but is reflected when additionally incorporating observational data. To generalize to a target…

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Nonparametric identification is not enough, but randomized controlled trials are

非参数识别还不够:随机对照试验的特殊作用

We argue that randomized controlled trials (RCTs) are special even among settings where average treatment effects are identified by a nonparametric unconfoundedness assumption. This claim follows from two results of Robins and Ritov (1997): (1) with at least one continuous covariate control, no estimator of the average treatment effect exists which is uniformly consistent without further assumptions, (2) knowledge of the propensity score yields a uniformly consistent…

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Quantile-based fuzzy C-means clustering of multivariate time series: Robust techniques

多变量时间序列的分位数模糊 C 均值聚类:稳健方法

Three robust methods for clustering multivariate time series from the point of view of generating processes are proposed. The procedures are robust versions of a fuzzy C-means model based on: (i) estimates of the quantile cross-spectral density and (ii) the classical principal component analysis. Robustness to the presence of outliers is achieved by using the so-called metric, noise and trimmed approaches. The metric approach incorporates in the objective function a distance…

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A Wavelet Method for Panel Models with Jump Discontinuities in the Parameters

参数存在跳跃不连续时的面板模型小波估计方法

While a substantial literature on structural break change point analysis exists for univariate time series, research on large panel data models has not been as extensive. In this paper, a novel method for estimating panel models with multiple structural changes is proposed. The breaks are allowed to occur at unknown points in time and may affect the multivariate slope parameters individually. Our method adapts Haar wavelets to the structure of the observed variables in order…

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Minimax Rates and Adaptivity in Combining Experimental and Observational Data

整合实验与观测数据的极小极大收敛率和自适应性

Randomized controlled trials (RCTs) are the gold standard for evaluating the causal effect of a treatment; however, they often have limited sample sizes and sometimes poor generalizability. On the other hand, non-randomized, observational data derived from large administrative databases have massive sample sizes and better generalizability, but they are prone to unmeasured confounding bias. It is thus of considerable interest to reconcile effect estimates obtained from…

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Simpson's Paradox: A Singularity of Statistical and Inductive Inference

辛普森悖论:统计推断与归纳推断的奇异现象

The occurrence of Simpson's paradox (SP) in $2\times 2$ contingency tables has been well studied. The present work comprehensively revisits this problem using a combination of philosophical reflections, causal considerations, and probability theory. The first contribution is to provide a schematic analysis of SP in $2\times 2$ contingency tables and present new results, detailed proofs of previous results and a unifying view of the important examples of SP that have been…

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Rejective Sampling, Rerandomization and Regression Adjustment in Survey Experiments

调查实验中的拒绝式抽样、再随机化与回归调整

Classical randomized experiments, equipped with randomization-based inference, provide assumption-free inference for treatment effects. They have been the gold standard for drawing causal inference and provide excellent internal validity. However, they have also been criticized for questionable external validity, in the sense that the conclusion may not generalize well to a larger population. The randomized survey experiment is a design tool that can help mitigate this…

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Bootstrap Inference for Hawkes and General Point Processes

Hawkes 及一般点过程的 Bootstrap 推断

Inference and testing in general point process models such as the Hawkes model is predominantly based on asymptotic approximations for likelihood-based estimators and tests. As an alternative, and to improve finite sample performance, this paper considers bootstrap-based inference for interval estimation and testing. Specifically, for a wide class of point process models we consider a novel bootstrap scheme labeled 'fixed intensity bootstrap' (FIB), where the conditional…

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