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A flexible approach for causal inference with multiple treatments and clustered survival outcomes

多重处理与聚类生存结局的灵活因果推断方法

When drawing causal inferences about the effects of multiple treatments on clustered survival outcomes using observational data, we need to address implications of the multilevel data structure, multiple treatments, censoring and unmeasured confounding for causal analyses. Few off-the-shelf causal inference tools are available to simultaneously tackle these issues. We develop a flexible random-intercept accelerated failure time model, in which we use Bayesian additive…

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Auction Throttling and Causal Inference of Online Advertising Effects

广告竞价节流与在线广告效果的因果推断

Causally identifying the effect of digital advertising is challenging, because experimentation is expensive, and observational data lacks random variation. This paper identifies a pervasive source of naturally occurring, quasi-experimental variation in user-level ad-exposure in digital advertising campaigns. It shows how this variation can be utilized by ad-publishers to identify the causal effect of advertising campaigns. The variation pertains to auction throttling, a…

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An RKHS approach for pivotal inference in functional linear regression

函数型线性回归中枢轴推断的再生核希尔伯特空间方法

We develop methodology for testing hypotheses regarding the slope function in functional linear regression for time series via a reproducing kernel Hilbert space approach. In contrast to most of the literature, which considers tests for the exact nullity of the slope function, we are interested in the null hypothesis that the slope function vanishes only approximately, where deviations are measured with respect to the $L^2$-norm. An asymptotically pivotal test is proposed,…

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Partial Sum Processes of Residual-Based and Wald-type Break-Point Statistics in Time Series Regression Models

时间序列回归中残差型与 Wald 型断点统计量的部分和过程

We revisit classical asymptotics when testing for a structural break in linear regression models by obtaining the limit theory of residual-based and Wald-type processes. First, we establish the Brownian bridge limiting distribution of these test statistics. Second, we study the asymptotic behaviour of the partial-sum processes in nonstationary (linear) time series regression models. Although, the particular comparisons of these two different modelling environments is done…

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Benign-Overfitting in Conditional Average Treatment Effect Prediction with Linear Regression

线性回归预测条件平均处理效应中的良性过拟合

We study the benign overfitting theory in the prediction of the conditional average treatment effect (CATE), with linear regression models. As the development of machine learning for causal inference, a wide range of large-scale models for causality are gaining attention. One problem is that suspicions have been raised that the large-scale models are prone to overfitting to observations with sample selection, hence the large models may not be suitable for causal prediction.…

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POT-flavored estimator of Pickands dependence function

融合超阈值思路的 Pickands 依赖函数估计量

This work proposes an estimator with both Peak-Over-Threshold and Block-Maxima flavors, uses it to estimate the Pickands dependence function of bivariate time series, and illustrates how it brings down the asymptotic bias and the overall mean squared error.

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Intervention treatment distributions that depend on the observed treatment process and model double robustness in causal survival analysis

依赖观测处理过程的干预分布与因果生存分析中的模型双重稳健性

The generalized g-formula can be used to estimate the probability of survival under a sustained treatment strategy. When treatment strategies are deterministic, estimators derived from the so-called efficient influence function (EIF) for the g-formula will be doubly robust to model misspecification. In recent years, several practical applications have motivated estimation of the g-formula under non-deterministic treatment strategies where treatment assignment at each time…

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Approximate Bayesian inference and forecasting in huge-dimensional multi-country VARs

超高维多国 VAR 的近似贝叶斯推断与预测

Panel Vector Autoregressions (PVARs) are a popular tool for analyzing multi-country datasets. However, the number of estimated parameters can be enormous, leading to computational and statistical issues. In this paper, we develop fast Bayesian methods for estimating PVARs using integrated rotated Gaussian approximations. We exploit the fact that domestic information is often more important than international information and group the coefficients accordingly. Fast…

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The Lifecycle of a Statistical Model: Model Failure Detection, Identification, and Refitting

统计模型的生命周期:失效检测、定位与重新拟合

The statistical machine learning community has demonstrated considerable resourcefulness over the years in developing highly expressive tools for estimation, prediction, and inference. The bedrock assumptions underlying these developments are that the data comes from a fixed population and displays little heterogeneity. But reality is significantly more complex: statistical models now routinely fail when released into real-world systems and scientific applications, where…

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Validity of tests for time-to-event endpoints in studies with the Pocock and Simon covariate-adaptive randomization

Pocock–Simon 协变量自适应随机化下生存终点检验的有效性

In the presence of prognostic covariates, inference about the treatment effect with time-to-event endpoints is mostly conducted via the stratified log-rank test or the score test based on the Cox proportional hazards model. In their ground-breaking work Ye and Shao (2020) have demonstrated theoretically that when the model is misspecified, the robust score test (Wei and Lin, 1989) as well as the unstratified log-rank test are conservative in trials with stratified…

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Causal inference from treatment-control studies having an additional factor with unknown assignment mechanism

附加因素分配机制未知时的处理与对照研究因果推断

Consider a situation with two treatments, the first of which is randomized but the second is not, and the multifactor version of this. Interest is in treatment effects, defined using standard factorial notation. We define estimators for the treatment effects and explore their properties when there is information about the nonrandomized treatment assignment and when there is no information on the assignment of the nonrandomized treatment. We show when and how hidden…

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Estimands and their Estimators for Clinical Trials Impacted by the COVID-19 Pandemic: A Report from the NISS Ingram Olkin Forum Series on Unplanned Clinical Trial Disruptions

受新冠疫情影响的临床试验:目标估计量及其估计方法

The COVID-19 pandemic continues to affect the conduct of clinical trials globally. Complications may arise from pandemic-related operational challenges such as site closures, travel limitations and interruptions to the supply chain for the investigational product, or from health-related challenges such as COVID-19 infections. Some of these complications lead to unforeseen intercurrent events in the sense that they affect either the interpretation or the existence of the…

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Sensitivity Analysis in the Generalization of Experimental Results

实验结果推广中的敏感性分析

Randomized controlled trials (RCT's) allow researchers to estimate causal effects in an experimental sample with minimal identifying assumptions. However, to generalize or transport a causal effect from an RCT to a target population, researchers must adjust for a set of treatment effect moderators. In practice, it is impossible to know whether the set of moderators has been properly accounted for. In the following paper, I propose a three parameter sensitivity analysis for…

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Heterogeneous Overdispersed Count Data Regressions via Double Penalized Estimations

异质过度离散计数回归的双重惩罚估计

This paper studies the non-asymptotic merits of the double $\ell_1$-regularized for heterogeneous overdispersed count data via negative binomial regressions. Under the restricted eigenvalue conditions, we prove the oracle inequalities for Lasso estimators of two partial regression coefficients for the first time, using concentration inequalities of empirical processes. Furthermore, derived from the oracle inequalities, the consistency and convergence rate for the estimators…

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Predicting Default Probabilities for Stress Tests: A Comparison of Models

压力测试中的违约概率预测:模型比较

Since the Great Financial Crisis (GFC), the use of stress tests as a tool for assessing the resilience of financial institutions to adverse financial and economic developments has increased significantly. One key part in such exercises is the translation of macroeconomic variables into default probabilities for credit risk by using macrofinancial linkage models. A key requirement for such models is that they should be able to properly detect signals from a wide array of…

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Evaluation Methods and Measures for Causal Learning Algorithms

因果学习算法的评价方法与指标

The convenient access to copious multi-faceted data has encouraged machine learning researchers to reconsider correlation-based learning and embrace the opportunity of causality-based learning, i.e., causal machine learning (causal learning). Recent years have therefore witnessed great effort in developing causal learning algorithms aiming to help AI achieve human-level intelligence. Due to the lack-of ground-truth data, one of the biggest challenges in current causal…

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Causal Inference Using Tractable Circuits

利用可处理电路进行因果推断

The aim of this paper is to discuss a recent result which shows that probabilistic inference in the presence of (unknown) causal mechanisms can be tractable for models that have traditionally been viewed as intractable. This result was reported recently to facilitate model-based supervised learning but it can be interpreted in a causality context as follows. One can compile a non-parametric causal graph into an arithmetic circuit that supports inference in time linear in the…

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Backtesting Systemic Risk Forecasts using Multi-Objective Elicitability

利用多目标可诱导性回测系统性风险预测

Systemic risk measures such as CoVaR, CoES and MES are widely-used in finance, macroeconomics and by regulatory bodies. Despite their importance, we show that they fail to be elicitable and identifiable. This renders forecast comparison and validation, commonly summarised as `backtesting', impossible. The novel notion of \emph{multi-objective elicitability} solves this problem. Specifically, we propose Diebold--Mariano type tests utilising two-dimensional scores equipped…

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Tests for Group-Specific Heterogeneity in High-Dimensional Factor Models

高维因子模型中群组特异异质性的检验

Standard high-dimensional factor models assume that the comovements in a large set of variables could be modeled using a small number of latent factors that affect all variables. In many relevant applications in economics and finance, heterogenous comovements specific to some known groups of variables naturally arise, and reflect distinct cyclical movements within those groups. This paper develops two new statistical tests that can be used to investigate whether there is…

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Adaptive information-based methods for determining the co-integration rank in heteroskedastic VAR models

异方差 VAR 模型中确定协整秩的自适应信息准则方法

Standard methods, such as sequential procedures based on Johansen's (pseudo-)likelihood ratio (PLR) test, for determining the co-integration rank of a vector autoregressive (VAR) system of variables integrated of order one can be significantly affected, even asymptotically, by unconditional heteroskedasticity (non-stationary volatility) in the data. Known solutions to this problem include wild bootstrap implementations of the PLR test or the use of an information criterion,…

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Statistical inference in factor analysis for diffusion processes from discrete observations

基于离散观测的扩散过程因子分析统计推断

We consider statistical inference in factor analysis for ergodic and non-ergodic diffusion processes from discrete observations. Factor model based on high frequency time series data has been mainly discussed in the field of high dimensional covariance matrix estimation. In this field, the method based on principal component analysis has been mainly used. However, this method is effective only for high dimensional model. On the other hand, there is a method based on the…

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Incorporating baseline covariates to validate surrogate endpoints with a constant biomarker under control arm

纳入基线协变量验证对照组生物标志物恒定的替代终点

A surrogate endpoint S in a clinical trial is an outcome that may be measured earlier or more easily than the true outcome of interest T. In this work, we extend causal inference approaches to validate such a surrogate using potential outcomes. The causal association paradigm assesses the relationship of the treatment effect on the surrogate with the treatment effect on the true endpoint. Using the principal surrogacy criteria, we utilize the joint conditional distribution…

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Ergodic descriptors of nonergodic stochastic processes

非遍历随机过程的遍历性描述指标

The stochastic processes underlying the growth and stability of biological and psychological systems reveal themselves when far from equilibrium. Far from equilibrium, nonergodicity reigns. Nonergodicity implies that the average outcome for a group/ensemble (i.e., of representative organisms/minds) is not necessarily a reliable estimate of the average outcome for an individual over time. However, the scientific interest in causal inference suggests that we somehow aim at…

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Efficient Volatility Estimation for Lévy Processes with Jumps of Unbounded Variation

具有无界变差跳跃的 Lévy 过程的有效波动率估计

Statistical inference for stochastic processes based on high-frequency observations has been an active research area for more than a decade. One of the most well-known and widely studied problems is that of estimation of the quadratic variation of the continuous component of an Itô semimartingale with jumps. Several rate- and variance-efficient estimators have been proposed in the literature when the jump component is of bounded variation. However, to date, very few methods…

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