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结局延迟随机临床试验期中监测的组序贯方法AI 解读

The primary analysis in two-arm clinical trials usually involves inference on a scalar treatment effect parameter; e.g., depending on the outcome, the difference of treatment-specific means, risk difference, risk ratio, or odds ratio. Most clinical trials are monitored for the possibility of early stopping. Because ordinarily the outcome on any given subject can be ascertained only after some time lag, at the time of an interim analysis, among the subjects already enrolled,…

平均因果效应熵平衡估计量的大样本性质AI 解读

Weighting methods are used in observational studies to adjust for covariate imbalances between treatment and control groups. Entropy balancing (EB) is an alternative to inverse probability weighting with an estimated propensity score. The EB weights are constructed to satisfy balance constraints and optimized towards stability. We describe large sample properties of EB estimators of the average causal treatment effect, based on the Kullback-Leibler and quadratic Rényi…

因果推断稀疏方法的信息准则AI 解读

For propensity score analysis and sparse estimation, we develop an information criterion for determining the regularization parameters needed in variable selection. First, for Gaussian distribution-based causal inference models, we extend Stein's unbiased risk estimation theory, which leads to a generalized Cp criterion that has almost no weakness in conventional sparse estimation, and derive an inverse-probability-weighted sparse estimation version of the criterion without…

Intact-VAE：未观测混杂下的处理效应估计AI 解读

NOTE: This preprint has a flawed theoretical formulation. Please avoid it and refer to the ICLR22 publication https://openreview.net/forum?id=q7n2RngwOM. Also, arXiv:2109.15062 contains some new ideas on unobserved Confounding. As an important problem of causal inference, we discuss the identification and estimation of treatment effects under unobserved confounding. Representing the confounder as a latent variable, we propose Intact-VAE, a new variant of variational…

适用于非参数收敛速率的置换检验AI 解读

Classical two-sample permutation tests for equality of distributions have exact size in finite samples, but they fail to control size for testing equality of parameters that summarize each distribution. This paper proposes permutation tests for equality of parameters that are estimated at root-$n$ or slower rates. Our general framework applies to both parametric and nonparametric models, with two samples or one sample split into two subsamples. Our tests have correct size…

异方差时间序列极值的统计方法AI 解读

Einmahl, de Haan and Zhou (2016, Journal of the Royal Statistical Society: Series B, 78(1), 31-51) recently introduced a stochastic model that allows for heteroscedasticity of extremes. The model is extended to the situation where the observations are serially dependent, which is crucial for many practical applications. We prove a local limit theorem for a kernel estimator for the scedasis function, and a functional limit theorem for an estimator for the integrated scedasis…

利用条件独立性预先指定结构，优化数据收集与研究透明度AI 解读

Data collection and research methodology represents a critical part of the research pipeline. On the one hand, it is important that we collect data in a way that maximises the validity of what we are measuring, which may involve the use of long scales with many items. On the other hand, collecting a large number of items across multiple scales results in participant fatigue, and expensive and time consuming data collection. It is therefore important that we use the available…

不依从随机实验中二元结局的模型辅助依从者平均处理效应估计AI 解读

In randomized experiments, the actual treatments received by some experimental units may differ from their treatment assignments. This non-compliance issue often occurs in clinical trials, social experiments, and the applications of randomized experiments in many other fields. Under certain assumptions, the average treatment effect for the compliers is identifiable and equal to the ratio of the intention-to-treat effects of the potential outcomes to that of the potential…

因果推断中平均处理效应的抗异常值估计AI 解读

The inverse probability (IPW) and doubly robust (DR) estimators are often used to estimate the average causal effect (ATE), but are vulnerable to outliers. The IPW/DR median can be used for outlier-resistant estimation of the ATE, but the outlier resistance of the median is limited and it is not resistant enough for heavy contamination. We propose extensions of the IPW/DR estimators with density power weighting, which can eliminate the influence of outliers almost…

非线性固定效应面板模型的间接推断AI 解读

Fixed effect estimators of nonlinear panel data models suffer from the incidental parameter problem. This leads to two undesirable consequences in applied research: (1) point estimates are subject to large biases, and (2) confidence intervals have incorrect coverages. This paper proposes a simulation-based method for bias reduction. The method simulates data using the model with estimated individual effects, and finds values of parameters by equating fixed effect estimates…

使用稳健已实现积分贝塔估计量的动态已实现贝塔模型AI 解读

This paper introduces a unified parametric modeling approach for time-varying market betas that can accommodate continuous-time diffusion and discrete-time series models based on a continuous-time series regression model to better capture the dynamic evolution of market betas. We call this the dynamic realized beta (DR Beta). We first develop a non-parametric realized integrated beta estimator using high-frequency financial data contaminated by microstructure noises, which…

面向收缩估计的实验设计AI 解读

We consider how increasingly available observational data can be used to improve the design of randomized controlled trials (RCTs). We seek to design a prospective RCT, with the intent of using an Empirical Bayes estimator to shrink the causal estimates from our trial toward causal estimates obtained from an observational study. We ask: how might we design the experiment to better complement the observational study in this setting? We propose using an estimator that shrinks…

含缺失数据的多条多元时间序列无限隐马尔可夫模型AI 解读

Exposure to air pollution is associated with increased morbidity and mortality. Recent technological advancements permit the collection of time-resolved personal exposure data. Such data are often incomplete with missing observations and exposures below the limit of detection, which limit their use in health effects studies. In this paper we develop an infinite hidden Markov model for multiple asynchronous multivariate time series with missing data. Our model is designed to…

ARDL 模型中的 bootstrap 协整检验AI 解读

The paper proposes a new bootstrap approach to the Pesaran, Shin and Smith's bound tests in a conditional equilibrium correction model with the aim to overcome some typical drawbacks of the latter, such as inconclusive inference and distortion in size. The bootstrap tests are worked out under several data generating processes, including degenerate cases. Monte Carlo simulations confirm the better performance of the bootstrap tests with respect to bound ones and to the…

非嵌套设计中将试验证据推广至目标人群：艾滋病临床试验应用AI 解读

Comparative effectiveness evidence from randomized trials may not be directly generalizable to a target population of substantive interest when, as in most cases, trial participants are not randomly sampled from the target population. Motivated by the need to generalize evidence from two trials conducted in the AIDS Clinical Trials Group (ACTG), we consider weighting, regression and doubly robust estimators to estimate the causal effects of HIV interventions in a specified…

分布式锚回归AI 解读

Prediction models often fail if train and test data do not stem from the same distribution. Out-of-distribution (OOD) generalization to unseen, perturbed test data is a desirable but difficult-to-achieve property for prediction models and in general requires strong assumptions on the data generating process (DGP). In a causally inspired perspective on OOD generalization, the test data arise from a specific class of interventions on exogenous random variables of the DGP,…

条件因子模型的稳健估计AI 解读

This paper develops estimation and inference methods for conditional quantile factor models. We first introduce a simple sieve estimation, and establish asymptotic properties of the estimators under large $N$. We then provide a bootstrap procedure for estimating the distributions of the estimators. We also provide two consistent estimators for the number of factors. The methods allow us not only to estimate conditional factor structures of distributions of asset returns…

利用小波与差分建模时间序列的时变一阶和二阶结构AI 解读

Most time series observed in practice exhibit time-varying trend (first-order) and autocovariance (second-order) behaviour. Differencing is a commonly-used technique to remove the trend in such series, in order to estimate the time-varying second-order structure (of the differenced series). However, often we require inference on the second-order behaviour of the original series, for example, when performing trend estimation. In this article, we propose a method, using…

协整回归推断中的自助法辅助自标准化方法AI 解读

Traditional inference in cointegrating regressions requires tuning parameter choices to estimate a long-run variance parameter. Even in case these choices are "optimal", the tests are severely size distorted. We propose a novel self-normalization approach, which leads to a nuisance parameter free limiting distribution without estimating the long-run variance parameter directly. This makes our self-normalized test tuning parameter free and considerably less prone to size…

面向数据科学家的预测评估：常见陷阱与最佳实践AI 解读

Machine Learning (ML) and Deep Learning (DL) methods are increasingly replacing traditional methods in many domains involved with important decision making activities. DL techniques tailor-made for specific tasks such as image recognition, signal processing, or speech analysis are being introduced at a fast pace with many improvements. However, for the domain of forecasting, the current state in the ML community is perhaps where other domains such as Natural Language…

分布式数据共享管理下的协作因果推断AI 解读

Data sharing barriers are paramount challenges arising from multicenter clinical trials where multiple data sources are stored in a distributed fashion at different local study sites. Merging such data sources into a common data storage for a centralized statistical analysis requires a data use agreement, which is often time-consuming. Data merging may become more burdensome when causal inference is of primary interest because propensity score modeling involves combining…

带变量选择的贝叶斯非齐次隐马尔可夫模型：癫痫发作风险周期的驱动因素AI 解读

A major issue in the clinical management of epilepsy is the unpredictability of seizures. Yet, traditional approaches to seizure forecasting and risk assessment in epilepsy rely heavily on raw seizure frequencies, which are a stochastic measurement of seizure risk. We consider a Bayesian non-homogeneous hidden Markov model for unsupervised clustering of zero-inflated seizure count data. The proposed model allows for a probabilistic estimate of the sequence of seizure risk…

用于不规则观测离散时间序列的新型一阶自回归移动平均模型AI 解读

A novel first-order autoregressive moving average model for analyzing discrete-time series observed at irregularly spaced times is introduced. Under Gaussianity, it is established that the model is strictly stationary and ergodic. In the general case, it is shown that the model is weakly stationary. The lowest dimension of the state-space representation is given along with the one-step linear predictors and their mean squared errors. The maximum likelihood estimation…

基于 SURE 的稳健信号维度估计AI 解读

The estimation of signal dimension under heavy-tailed latent factor models is studied. As a primary contribution, robust extensions of an earlier estimator based on Gaussian Stein's unbiased risk estimation are proposed. These novel extensions are based on the framework of elliptical distributions and robust scatter matrices. Extensive simulation studies are conducted in order to compare the novel methods with several well-known competitors in both estimation accuracy and…