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Estimating equations for causal survival analysis with pooled logistic regression

使用合并逻辑回归的因果生存分析估计方程

Background: Pooled logistic regression models are commonly applied in survival analysis. However, the standard implementation can be computationally demanding, which is further exacerbated when using the nonparametric bootstrap for inference. To ease these computational burdens, investigators often coarsen time intervals or assume a parametric functional form for time. These approaches impose restrictive assumptions, which may not always have a well-motivated substantive…

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Estimating quantile treatments without strict overlap

缺乏严格重叠时的分位数处理效应估计

We consider the problem of estimating quantile treatment effects without assuming strict overlap, i.e., we do not assume that the propensity score is bounded away from zero. More specifically, we consider an inverse probability weighting (IPW) approach for estimating quantiles in the potential outcomes framework and pay special attention to scenarios where the propensity scores can tend to zero as a regularly varying function. Our approach effectively considers a…

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Combining covariate adjustment with information from secondary endpoints to improve precision in randomized trials

结合协变量调整与次要终点信息提高随机试验精度

Background/Aims: Adjustment for prognostic baseline covariates can improve precision in randomized trials. Previous work has shown that jointly modeling primary and secondary endpoints can yield additional precision by borrowing information across endpoints. We investigated whether these approaches can be combined to achieve efficiency gains beyond those obtained through covariate adjustment alone. Methods: We extended a previously proposed one-factor structural equation…

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Analyzing Within-Subject Experiments: Identification, Testing, and Sensitivity

受试者内实验的分析:识别、检验与敏感性

Recent work encourages political scientists to move from post-only toward within-subject designs for improved precision from repeated measurements. We formalize a potential-outcomes framework for two-period within-subject designs that allows for unequal allocation and heterogeneous treatment and carryover effects. We characterize the pooled estimator and evaluate the carryover test used to justify pooling. We find: first, pooling identifies the average treatment effect only…

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DIRECT: Decomposing Audience Preference and Creative Effect in Visual Content Analytics

DIRECT:分解视觉内容分析中的受众偏好与创作效应

Which visual choices make a post perform better? A growing literature answers this question with pooled coefficients estimated across many creators, which platforms translate into creative recommendations. We show that these coefficients blend two distinct patterns that can point in opposite directions for the same attribute. The first, audience preference, arises because creators who favor a style attract differently composed audiences, so their posts perform differently…

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A Unified Adaptive Enrichment Design for Power Enhancement

提高检验功效的统一自适应富集设计

Randomized controlled trials (RCTs) are the gold standard for evaluating treatment effects, but fixed eligibility criteria and enrollment decisions can be inefficient, especially when treatment effects vary across patient subpopulations. Adaptive enrichment trials update enrollment using interim data to improve efficiency. Enrichment methods are developed for two settings: prespecified subgroups, and continuous covariates where enrollment is guided by a learned cutoff. Many…

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Inference for High-Dimensional Network Data

高维网络数据的统计推断

We develop a novel method of inference for network-dependent high-dimensional random vectors. Dependence is characterized via a functional dependence measure based on graph distance, allowing the approximation theory to capture the interaction between the decay of dependence and the growth of network neighborhoods. We establish Gaussian approximation results for the maximum norm under finite-moment and sub-Weibull conditions, providing explicit conditions under which the…

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Wavelet-Based Bayesian Hierarchical Modeling with Regularized Horseshoe Priors for Spatially Correlated Functional Data

空间相关函数数据的小波贝叶斯层级模型与正则化马蹄先验

Environmental monitoring networks increasingly record pollutant levels as curves observed over time at fixed stations. Yet, exposure and risk assessment often require predicting these curves, with their uncertainty, at unmonitored locations. Conventional smooth-basis methods for such spatially correlated functional data, including spline-based kriging, tend to over-smooth acute, high-frequency episodes such as pollution peaks. We propose a parsimonious wavelet-based Bayesian…

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Power and Sample Size Calculations for Hybrid Controlled Trials

混合对照试验的功效与样本量计算

Hybrid controlled trials (HCTs) augment randomized controls with external controls (ECs) to address practical challenges in randomized controlled trials (RCTs) and improve statistical power in settings such as rare diseases, oncology, and pediatrics. However, prospective sample-size determination is challenging because the required RCT sample size depends on the comparability of ECs with RCT controls, which are unavailable at the planning stage. We propose a 5+3 design for…

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Marginal Structural Models for Electricity Demand under Treatment-Confounder Feedback: A Continuous-Treatment Outcome-Adaptive and Fused LASSO Approach

处理—混杂反馈下电力需求的边际结构模型与连续处理自适应 LASSO

Temperature is the most important meteorological driver of electricity demand, but its causal effect has not been estimated under the time-varying confounding that characterizes weather processes. Current temperature is associated with weather conditions, including precipitation, snow cover, and cloud cover, that also influence electricity demand, and past temperature shapes future weather, producing treatment-confounder feedback under which standard regression adjustment is…

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Finely Stratified Rerandomization Designs

精细分层再随机化设计

Finely stratified randomization makes unadjusted treatment effect estimation efficient when matches are tight. However, match quality deteriorates rapidly as covariate dimension increases, attenuating the gains from stratification. Motivated by this problem, we study designs that finely stratify on a few important covariates, then rerandomize within matched groups to balance the remainder. We derive the asymptotic distribution for GMM estimators of general causal parameters…

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FLEX-CP-DT: A Flexible Conditional Power Framework for Interim Futility Analysis in Clinical Trials with Count Endpoints and Temporal Trends

FLEX-CP-DT:计数终点与时间趋势下的期中无效性分析

Many large-scale phase III trials with recurrent event endpoints include a pre-planned interim analysis to evaluate early futility. Conditional power (CP), which quantifies the probability of achieving statistical significance at the final analysis given the interim data, is a commonly used tool to support such decisions. The standard negative binomial model with an offset term, widely adopted for analyzing recurrent events, implicitly assumes that event rates and treatment…

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PLRD: Partially Linear Regression Discontinuity Inference

PLRD:部分线性断点回归推断

Regression discontinuity designs have become one of the most popular research designs in empirical economics. We argue, however, that the widely used approaches to building confidence intervals in regression discontinuity designs often exhibit suboptimal behavior in practice. We propose a new estimator, the partially linear regression discontinuity (PLRD) estimator that, in set of a simulation studies carefully calibrated to twelve high-profile applications of regression…

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Limit Theory for U-Statistics under Clustered and Weakly Dependent Data

聚类与弱依赖数据下 U 统计量的极限理论

This paper develops asymptotic theory and feasible inference for unbounded-kernel order-k U-statistics under clustered sampling and weakly dependent time-series. The analysis first builds the complete order-2 pipeline, moving from clustered data to exact $m$-dependence and then to near-epoch dependence. The same logic is subsequently extended to general order k greater or equal to 2. Under clustered sampling, the theory allows arbitrary within-cluster dependence and growing,…

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Random Invariance Testing on Quadratic Form Statistics with Application to Autocorrelation

二次型统计量的随机不变性检验及自相关应用

Randomization testing with permutations is a very common nonparametric approach to hypothesis testing. However, randomization testing can be done with other group transformations including random rotations. In this work, we consider the problem of invariance in quadratic form statistics under a unified framework with closed form p-values. In particular, we propose a nonparametric variant of the classic Durbin-Watson test for testing for autocorrelation in time series data at…

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Proximal Causal Inference for Hidden Outcomes

隐藏结果的近端因果推断

Methods that rely on proxies, without imposing strong parametric structure, are increasingly used to deal with unobserved variables in causal inference. One influential line of this work reconstructs latent distributions used to identify the target functional by exploiting eigenvalue eigenvector structure. Within this framework, we first establish identification of the full data law in the presence of hidden outcomes, and then develop influence function based estimators for…

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Estimating Treatment Effects Under Bounded Heterogeneity

有界异质性下的处理效应估计

Specifications that impose constant treatment effects are common and can be biased under heterogeneity, whereas fully flexible alternatives can be imprecise or infeasible. Under a bound on the target-weighted variance of treatment effects, this paper proposes a generalized ridge estimator, $\texttt{regulaTE}$, that yields heterogeneity-aware confidence intervals (CIs). The ridge penalty is chosen to minimize the heterogeneity-aware CI length in a homoskedastic Gaussian…

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Nonparametric Bayesian Inference for Partially Identified Discrete Response Models

部分识别离散响应模型的非参数贝叶斯推断

This paper proposes a nonparametric Bayesian inference framework for partially identified discrete response models. The key observation is that these models map a reduced-form conditional choice probability to an identified set. Consequently, nonparametric Bayesian inference for the conditional probability mass function leads to Bayesian inference for the identified set. The inference framework nests conditional moment inequalities and linear systems with unknown…

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Frequency Domain Bootstrap for Functional Time Series

函数型时间序列的频域自助法

A frequency domain bootstrap procedure for functional time series is proposed and applied to the class of spectral mean operators. The procedure works by first generating independent pseudo periodogram operators across the positive Fourier frequencies using an estimator of the spectral density operator involved. Functional replicates of the spectral mean operators of interest are then generated. Through an additive, projection-based decomposition of the bootstrapped spectral…

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Endogenous Selection and Spillovers: Bayesian Inference for Policy-Relevant Causal Effects

内生选择与溢出:政策相关因果效应的贝叶斯推断

This paper develops a new econometric framework to identify and estimate policy-relevant causal effects in contexts with endogenous selection into treatment and spillovers within single large networks or spatial settings. Conventional causal inference methods relying on either unconfoundedness or no-interference assumptions are generally inadequate in these scenarios. We introduce a Spillover Roy model that jointly models endogenous treatment selection and potential outcomes…

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Goodness-of-Fit Tests for Linear Non-Gaussian Structural Equation Models

线性非高斯结构方程模型的拟合优度检验

The field of causal discovery develops model selection methods to infer cause-effect relations among a set of random variables. For this purpose, different modelling assumptions have been proposed to render cause-effect relations identifiable. One prominent assumption is that the joint distribution of the observed variables follows a linear non-Gaussian structural equation model. In this paper, we develop novel goodness-of-fit tests that assess the validity of this…

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Robust Nonparametric Testing for Structural Changes in Multivariate Volatility via Multiple Quantiles

利用多分位数稳健检验多变量波动率的结构变化

We propose an omnibus nonparametric test for structural changes in the multivariate volatility matrix. The test aggregates bounded generalized quantile scores over a range of quantile levels and has a weighted leave-$q$-out $U$-statistic representation. Deleting nearby index pairs renders the centering effect induced by serial dependence asymptotically negligible. All quantities required for implementation, including the variance estimator used for standardization, are…

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SAUSS: Stochastic Approximation with Unbiased Simulated Scores for Limited Dependent Variable Models

SAUSS:有限因变量模型的无偏模拟得分随机逼近

Multinomial choice models allow flexible substitution patterns but become computationally demanding with many alternatives or observations. With a fixed per-observation simulation budget, simulated maximum likelihood introduces simulation bias, while each optimization step requires a full-sample likelihood evaluation. We propose Stochastic Approximation with Unbiased Simulated Scores (SAUSS), an averaged stochastic approximation based on conditionally unbiased mini-batch…

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Simple Covariate Adjustment for Many Estimands Using Stable Balancing Weights

利用稳定平衡权重对多种目标参数进行简便协变量调整

Covariate adjustment can improve precision in estimating treatment effects in clinical trials, and regulatory guidance increasingly encourages its implementation. Despite its benefits, covariate adjustment can require advanced statistical techniques or tailored approaches for different estimands, which can deter its use in practice. To address this issue, we introduce a simplified approach to covariate adjustment using stable balancing weights that applies directly across…

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