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Design-Based RCT Estimators and Central Limit Theorems for Baseline Subgroup and Related Analyses

基线子组及相关分析的设计型随机试验估计量与中心极限定理

There is a growing literature on design-based methods to estimate average treatment effects (ATEs) for randomized controlled trials (RCTs) for full sample analyses. This article extends these methods to estimate ATEs for discrete subgroups defined by pre-treatment variables, with an application to an RCT testing subgroup effects for a school voucher experiment in New York City. We consider ratio estimators for subgroup effects using regression methods, allowing for model…

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Testing Quantile Forecast Optimality

分位数预测最优性的检验

Quantile forecasts made across multiple horizons have become an important output of many financial institutions, central banks and international organisations. This paper proposes misspecification tests for such quantile forecasts that assess optimality over a set of multiple forecast horizons and/or quantiles. The tests build on multiple Mincer-Zarnowitz quantile regressions cast in a moment equality framework. Our main test is for the null hypothesis of autocalibration, a…

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On Extreme Value Asymptotics of Projected Sample Covariances in High Dimensions with Applications in Finance and Convolutional Networks

高维投影样本协方差的极值渐近理论及金融与卷积网络应用

Maximum-type statistics of certain functions of the sample covariance matrix of high-dimensional vector time series are studied to statistically confirm or reject the null hypothesis that a data set has been collected under normal conditions. The approach generalizes the case of the maximal deviation of the sample autocovariances function from its assumed values. Within a linear time series framework it is shown that Gumbel-type extreme value asymptotics holds true. As…

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Network Synthetic Interventions: A Causal Framework for Panel Data Under Network Interference

网络合成干预:网络干扰下的面板数据因果框架

We propose a generalization of the synthetic controls and synthetic interventions methodology to incorporate network interference. We consider the estimation of unit-specific potential outcomes from panel data in the presence of spillover across units and unobserved confounding. Key to our approach is a novel latent factor model that takes into account network interference and generalizes the factor models typically used in panel data settings. We propose an estimator,…

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G-formula for causal inference via multiple imputation

通过多重插补实现因果推断中的 G 公式

G-formula is a popular approach for estimating treatment or exposure effects from longitudinal data that are subject to time-varying confounding. G-formula estimation is typically performed by Monte-Carlo simulation, with non-parametric bootstrapping used for inference. We show that G-formula can be implemented by exploiting existing methods for multiple imputation (MI) for synthetic data. This involves using an existing modified version of Rubin's variance estimator. In…

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Statistical inference of high-dimensional vector autoregressive time series with non-i.i.d. innovations

非独立同分布创新下高维向量自回归时间序列的统计推断

Independent or i.i.d. innovations is an essential assumption in the literature for analyzing a vector time series. However, this assumption is either too restrictive for a real-life time series to satisfy or is hard to verify through a hypothesis test. This paper performs statistical inference on a sparse high-dimensional vector autoregressive time series, allowing its white noise innovations to be dependent, even non-stationary. To achieve this goal, it adopts a…

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Automatic Change-Point Detection in Time Series via Deep Learning

基于深度学习的时间序列自动变点检测

Detecting change-points in data is challenging because of the range of possible types of change and types of behaviour of data when there is no change. Statistically efficient methods for detecting a change will depend on both of these features, and it can be difficult for a practitioner to develop an appropriate detection method for their application of interest. We show how to automatically generate new offline detection methods based on training a neural network. Our…

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Positivity-free Policy Learning with Observational Data

无需正值性假设的观察数据政策学习

Policy learning utilizing observational data is pivotal across various domains, with the objective of learning the optimal treatment assignment policy while adhering to specific constraints such as fairness, budget, and simplicity. This study introduces a novel positivity-free (stochastic) policy learning framework designed to address the challenges posed by the impracticality of the positivity assumption in real-world scenarios. This framework leverages incremental…

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Ultra-high dimensional confounder selection algorithms comparison with application to radiomics data

超高维混杂变量选择算法比较及影像组学应用

Radiomics is an emerging area of medical imaging data analysis particularly for cancer. It involves the conversion of digital medical images into mineable ultra-high dimensional data. Machine learning algorithms are widely used in radiomics data analysis to develop powerful decision support model to improve precision in diagnosis, assessment of prognosis and prediction of therapy response. However, machine learning algorithms for causal inference have not been previously…

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Robust Minimum Distance Inference in Structural Models

结构模型中的稳健最小距离推断

This paper proposes minimum distance inference for a structural parameter of interest, which is robust to the lack of identification of other structural nuisance parameters. Some choices of the weighting matrix lead to asymptotic chi-squared distributions with degrees of freedom that can be consistently estimated from the data, even under partial identification. In any case, knowledge of the level of under-identification is not required. We study the power of our robust…

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A neutral comparison of statistical methods for time-to-event analyses under non-proportional hazards

非比例风险下生存分析统计方法的中立比较

While well-established methods for time-to-event data are available when the proportional hazards assumption holds, there is no consensus on the best inferential approach under non-proportional hazards (NPH). However, a wide range of parametric and non-parametric methods for testing and estimation in this scenario have been proposed. To provide recommendations on the statistical analysis of clinical trials where non proportional hazards are expected, we conducted a…

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Projecting infinite time series graphs to finite marginal graphs using number theory

用数论将无限时间序列图投影为有限边际图

In recent years, a growing number of method and application works have adapted and applied the causal-graphical-model framework to time series data. Many of these works employ time-resolved causal graphs that extend infinitely into the past and future and whose edges are repetitive in time, thereby reflecting the assumption of stationary causal relationships. However, most results and algorithms from the causal-graphical-model framework are not designed for infinite graphs.…

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On the mixed-model analysis of covariance in cluster-randomized trials

整群随机试验中的混合模型协方差分析

In the analyses of cluster-randomized trials, mixed-model analysis of covariance (ANCOVA) is a standard approach for covariate adjustment and handling within-cluster correlations. However, when the normality, linearity, or the random-intercept assumption is violated, the validity and efficiency of the mixed-model ANCOVA estimators for estimating the average treatment effect remain unclear. Under the potential outcomes framework, we prove that the mixed-model ANCOVA…

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Identification and Estimation in a Class of Potential Outcomes Models

一类潜在结果模型的识别与估计

This paper develops a class of potential outcomes models characterized by three main features: (i) Unobserved heterogeneity can be represented by a vector of potential outcomes and a type describing the manner in which an instrument determines the choice of treatment; (ii) The availability of an instrumental variable that is conditionally independent of unobserved heterogeneity; and (iii) The imposition of convex restrictions on the distribution of unobserved heterogeneity.…

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On changepoint detection in functional data using empirical energy distance

利用经验能量距离检测函数型数据的变点

We propose a novel family of test statistics to detect the presence of changepoints in a sequence of dependent, possibly multivariate, functional-valued observations. Our approach allows to test for a very general class of changepoints, including the "classical" case of changes in the mean, and even changes in the whole distribution. Our statistics are based on a generalisation of the empirical energy distance; we propose weighted functionals of the energy distance process,…

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Time-dependent mediators in survival analysis: Graphical representation of causal assumptions

生存分析中的时变中介:因果假设的图形表示

We study time-dependent mediators in survival analysis using a treatment separation approach due to Didelez [2019] and based on earlier work by Robins and Richardson [2011]. This approach avoids nested counterfactuals and crossworld assumptions which are otherwise common in mediation analysis. The causal model of treatment, mediators, covariates, confounders and outcome is represented by causal directed acyclic graphs (DAGs). However, the DAGs tend to be very complex when we…

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Robust inference with GhostKnockoffs in genome-wide association studies

全基因组关联研究中 GhostKnockoffs 的稳健推断

Genome-wide association studies (GWASs) have been extensively adopted to depict the underlying genetic architecture of complex diseases. Motivated by GWASs' limitations in identifying small effect loci to understand complex traits' polygenicity and fine-mapping putative causal variants from proxy ones, we propose a knockoff-based method which only requires summary statistics from GWASs and demonstrate its validity in the presence of relatedness. We show that GhostKnockoffs…

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Ultimate limit on learning non-Markovian behavior: Fisher information rate and excess information

学习非马尔可夫行为的极限:费舍尔信息率与超额信息

We address the fundamental limits of learning unknown parameters of any stochastic process from time-series data, and discover exact closed-form expressions for how optimal inference scales with observation length. Given a parametrized class of candidate models, the Fisher information of observed sequence probabilities lower-bounds the variance in model estimation from finite data. As sequence-length increases, the minimal variance scales as the square inverse of the length…

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Conformal Inference for Online Prediction with Arbitrary Distribution Shifts

任意分布漂移下在线预测的保形推断

We consider the problem of forming prediction sets in an online setting where the distribution generating the data is allowed to vary over time. Previous approaches to this problem suffer from over-weighting historical data and thus may fail to quickly react to the underlying dynamics. Here we correct this issue and develop a novel procedure with provably small regret over all local time intervals of a given width. We achieve this by modifying the adaptive conformal…

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Federated Adaptive Causal Estimation (FACE) of Target Treatment Effects

目标人群处理效应的联邦自适应因果估计(FACE)

Federated learning of causal estimands may greatly improve estimation efficiency by leveraging data from multiple study sites, but robustness to heterogeneity and model misspecifications is vital for ensuring validity. We develop a Federated Adaptive Causal Estimation (FACE) framework to incorporate heterogeneous data from multiple sites to provide treatment effect estimation and inference for a flexibly specified target population of interest. FACE accounts for site-level…

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Characterization of causal ancestral graphs for time series with latent confounders

含潜在混杂的时间序列因果祖先图刻画

In this paper, we introduce a novel class of graphical models for representing time lag specific causal relationships and independencies of multivariate time series with unobserved confounders. We completely characterize these graphs and show that they constitute proper subsets of the currently employed model classes. As we show, from the novel graphs one can thus draw stronger causal inferences -- without additional assumptions. We further introduce a graphical…

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Variational Inference for GARCH-family Models

GARCH 类模型的变分推断

The Bayesian estimation of GARCH-family models has been typically addressed through Monte Carlo sampling. Variational Inference is gaining popularity and attention as a robust approach for Bayesian inference in complex machine learning models; however, its adoption in econometrics and finance is limited. This paper discusses the extent to which Variational Inference constitutes a reliable and feasible alternative to Monte Carlo sampling for Bayesian inference in GARCH-like…

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Partially Specified Causal Simulations

部分指定的因果模拟

Simulation studies play a key role in the validation of causal inference methods. The simulation results are reliable only if the study is designed according to the promised operational conditions of the method-in-test. Still, many causal inference literature tend to design over-restricted or misspecified studies. In this paper, we elaborate on the problem of improper simulation design for causal methods and compile a list of desiderata for an effective simulation framework.…

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High Dimensional Generalised Penalised Least Squares

高维广义惩罚最小二乘

In this paper we develop inference for high dimensional linear models, with serially correlated errors. We examine Lasso under the assumption of strong mixing in the covariates and error process, allowing for fatter tails in their distribution. While the Lasso estimator performs poorly under such circumstances, we estimate via GLS Lasso the parameters of interest and extend the asymptotic properties of the Lasso under more general conditions. Our theoretical results indicate…

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