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Structurally Aware Robust Model Selection for Mixtures

考虑结构信息的稳健混合模型选择

Mixture models are often used to identify meaningful subpopulations (i.e., clusters) in observed data such that the subpopulations have a real-world interpretation (e.g., as cell types). However, when used for subpopulation discovery, mixture model inference is usually ill-defined a priori because the assumed observation model is only an approximation to the true data-generating process. Thus, as the number of observations increases, rather than obtaining better inferences,…

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Substitute adjustment via recovery of latent variables

通过恢复潜变量进行替代变量调整

The deconfounder was proposed as a method for estimating causal parameters in a context with multiple causes and unobserved confounding. It is based on recovery of a latent variable from the observed causes. We disentangle the causal interpretation from the statistical estimation problem and show that the deconfounder in general estimates adjusted regression target parameters. It does so by outcome regression adjusted for the recovered latent variable termed the substitute.…

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CAREER: A Foundation Model for Labor Sequence Data

CAREER:劳动就业序列数据的基础模型

Labor economists regularly analyze employment data by fitting predictive models to small, carefully constructed longitudinal survey datasets. Although machine learning methods offer promise for such problems, these survey datasets are too small to take advantage of them. In recent years large datasets of online resumes have also become available, providing data about the career trajectories of millions of individuals. However, standard econometric models cannot take…

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DIGIC: Domain Generalizable Imitation Learning by Causal Discovery

DIGIC:通过因果发现实现跨域泛化的模仿学习

Causality has been combined with machine learning to produce robust representations for domain generalization. Most existing methods of this type require massive data from multiple domains to identify causal features by cross-domain variations, which can be expensive or even infeasible and may lead to misidentification in some cases. In this work, we make a different attempt by leveraging the demonstration data distribution to discover the causal features for a domain…

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Prognostic Covariate Adjustment for Logistic Regression in Randomized Controlled Trials

随机对照试验中 Logistic 回归的预后协变量调整

Randomized controlled trials (RCTs) with binary primary endpoints introduce novel challenges for inferring the causal effects of treatments. The most significant challenge is non-collapsibility, in which the conditional odds ratio estimand under covariate adjustment differs from the unconditional estimand in the logistic regression analysis of RCT data. This issue gives rise to apparent paradoxes, such as the variance of the estimator for the conditional odds ratio from a…

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Abadie's Kappa and Weighting Estimators of the Local Average Treatment Effect

Abadie 的 Kappa 与局部平均处理效应加权估计量

Recent research has demonstrated the importance of flexibly controlling for covariates in instrumental variables estimation. In this paper we study the finite sample and asymptotic properties of various weighting estimators of the local average treatment effect (LATE), motivated by Abadie's (2003) kappa theorem and offering the requisite flexibility relative to standard practice. We argue that two of the estimators under consideration, which are weight normalized, are…

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Bayesian Prognostic Covariate Adjustment With Additive Mixture Priors

采用加性混合先验的贝叶斯预后协变量调整

Effective and rapid decision-making from randomized controlled trials (RCTs) requires unbiased and precise treatment effect inferences. Two strategies to address this requirement are to adjust for covariates that are highly correlated with the outcome, and to leverage historical control information via Bayes' theorem. We propose a new Bayesian prognostic covariate adjustment methodology, referred to as Bayesian PROCOVA, that combines these two strategies. Covariate…

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Inference for Heteroskedastic PCA with Missing Data

缺失数据下异方差主成分分析的统计推断

This paper studies how to construct confidence regions for principal component analysis (PCA) in high dimension, a problem that has been vastly under-explored. While computing measures of uncertainty for nonlinear/nonconvex estimators is in general difficult in high dimension, the challenge is further compounded by the prevalent presence of missing data and heteroskedastic noise. We propose a novel approach to performing valid inference on the principal subspace under a…

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Difference-based covariance matrix estimate in time series nonparametric regression with applications to specification tests

时间序列非参数回归中基于差分的协方差矩阵估计及其设定检验应用

Long-run covariance matrix estimation is the building block of time series inference. The corresponding difference-based estimator, which avoids detrending, has attracted considerable interest due to its robustness to both smooth and abrupt structural breaks and its competitive finite sample performance. However, existing methods mainly focus on estimators for the univariate process while their direct and multivariate extensions for most linear models are asymptotically…

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Advancing Counterfactual Inference through Nonlinear Quantile Regression

通过非线性分位数回归推进反事实推断

The capacity to address counterfactual "what if" inquiries is crucial for understanding and making use of causal influences. Traditional counterfactual inference, under Pearls' counterfactual framework, typically depends on having access to or estimating a structural causal model. Yet, in practice, this causal model is often unknown and might be challenging to identify. Hence, this paper aims to perform reliable counterfactual inference based solely on observational data and…

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An Online Bootstrap for Time Series

时间序列的在线自助法

Resampling methods such as the bootstrap have proven invaluable in the field of machine learning. However, the applicability of traditional bootstrap methods is limited when dealing with large streams of dependent data, such as time series or spatially correlated observations. In this paper, we propose a novel bootstrap method that is designed to account for data dependencies and can be executed online, making it particularly suitable for real-time applications. This method…

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Doubly Robust Identification of Causal Effects of a Continuous Treatment using Discrete Instruments

利用离散工具变量双重稳健识别连续处理的因果效应

Many empirical applications estimate causal effects of a continuous endogenous variable (treatment) using a binary instrument. Estimation is typically done through linear 2SLS. This approach requires a mean treatment change and causal interpretation requires the LATE-type monotonicity in the first stage. An alternative approach is to explore distributional changes in the treatment, where the first-stage restriction is treatment rank similarity. We propose causal estimands…

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Robust Evaluation of Longitudinal Surrogate Markers with Censored Data

删失数据下纵向替代标志物的稳健评估

The development of statistical methods to evaluate surrogate markers is an active area of research. In many clinical settings, the surrogate marker is not simply a single measurement but is instead a longitudinal trajectory of measurements over time, e.g., fasting plasma glucose measured every 6 months for 3 years. In general, available methods developed for the single-surrogate setting cannot accommodate a longitudinal surrogate marker. Furthermore, many of the methods have…

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Nonparametric assessment of regimen response curve estimators

治疗方案响应曲线估计量的非参数评估

Marginal structural models have been widely used in causal inference to estimate mean outcomes under either a static or a prespecified set of treatment decision rules. This approach requires imposing a working model for the mean outcome given a sequence of treatments and possibly baseline covariates. In this paper, we introduce a dynamic marginal structural model that can be used to estimate an optimal decision rule within a class of parametric rules. Specifically, we will…

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Fast Algorithms for Quantile Regression with Selection

含样本选择的分位数回归快速算法

This paper addresses computational challenges in estimating Quantile Regression with Selection (QRS). The estimation of the parameters that model self-selection requires the estimation of the entire quantile process several times. Moreover, closed-form expressions of the asymptotic variance are too cumbersome, making the bootstrap more convenient to perform inference. Taking advantage of recent advancements in the estimation of quantile regression, along with some specific…

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Estimation with Pairwise Observations

基于成对观测的估计

The paper introduces a new estimation method for the standard linear regression model. The procedure is not driven by the optimisation of any objective function rather, it is a simple weighted average of slopes from observation pairs. The paper shows that such estimator is consistent for carefully selected weights. Other properties, such as asymptotic distributions, have also been derived to facilitate valid statistical inference. Unlike traditional methods, such as Least…

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The Role of Contextual Information in Best Arm Identification

情境信息在最优臂识别中的作用

We study the best-arm identification problem with fixed confidence when contextual (covariate) information is available in stochastic bandits. Although we can use contextual information in each round, we are interested in the marginalized mean reward over the contextual distribution. Our goal is to identify the best arm with a minimal number of samplings under a given value of the error rate. We show the instance-specific sample complexity lower bounds for the problem. Then,…

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Estimating Stochastic Block Models in the Presence of Covariates

含协变量的随机块模型估计

In the standard stochastic block model for networks, the probability of a connection between two nodes, often referred to as the edge probability, depends on the unobserved communities each of these nodes belongs to. We consider a flexible framework in which each edge probability, together with the probability of community assignment, are also impacted by observed covariates. We propose a computationally tractable two-step procedure to estimate the conditional edge…

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The role of randomization inference in unraveling individual treatment effects in early phase vaccine trials

早期疫苗试验中个体处理效应的随机化推断

Randomization inference is a powerful tool in early phase vaccine trials when estimating the causal effect of a regimen against a placebo or another regimen. Randomization-based inference often focuses on testing either Fisher's sharp null hypothesis of no treatment effect for any participant or Neyman's weak null hypothesis of no sample average treatment effect. Many recent efforts have explored conducting exact randomization-based inference for other summaries of the…

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Simulation-based transition density approximation for the inference of SDE models

基于模拟的转移密度近似与随机微分方程模型推断

Stochastic Differential Equations (SDEs) serve as a powerful modeling tool in various scientific domains, including systems science, engineering, and ecological science. While the specific form of SDEs is typically known for a given problem, certain model parameters remain unknown. Efficiently inferring these unknown parameters based on observations of the state in discrete time series represents a vital practical subject. The challenge arises in nonlinear SDEs, where…

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Impact of Physical Activity on Quality of Life During Pregnancy: A Causal ML Approach

孕期身体活动对生活质量的影响:因果机器学习方法

The concept of Quality of Life (QoL) refers to a holistic measurement of an individual's well-being, incorporating psychological and social aspects. Pregnant women, especially those with obesity and stress, often experience lower QoL. Physical activity (PA) has shown the potential to enhance the QoL. However, pregnant women who are overweight and obese rarely meet the recommended level of PA. Studies have investigated the relationship between PA and QoL during pregnancy…

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GENIUS-MAWII: For Robust Mendelian Randomization with Many Weak Invalid Instruments

GENIUS-MAWII:应对大量弱且无效工具变量的稳健孟德尔随机化

Mendelian randomization (MR) has become a popular approach to study causal effects by using genetic variants as instrumental variables. We propose a new MR method, GENIUS-MAWII, which simultaneously addresses the two salient phenomena that adversely affect MR analyses: many weak instruments and widespread horizontal pleiotropy. Similar to MR GENIUS (Tchetgen Tchetgen et al., 2021), we achieve identification of the treatment effect by leveraging heteroscedasticity of the…

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Benchmarking Observational Studies with Experimental Data under Right-Censoring

右删失下利用实验数据检验观察性研究

Drawing causal inferences from observational studies (OS) requires unverifiable validity assumptions; however, one can falsify those assumptions by benchmarking the OS with experimental data from a randomized controlled trial (RCT). A major limitation of existing procedures is not accounting for censoring, despite the abundance of RCTs and OSes that report right-censored time-to-event outcomes. We consider two cases where censoring time (1) is independent of time-to-event…

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A Bayesian Dirichlet Auto-Regressive Moving Average Model for Forecasting Lead Times

用于收入确认提前期预测的贝叶斯 Dirichlet 自回归移动平均模型

Lead time data is compositional data found frequently in the hospitality industry. Hospitality businesses earn fees each day, however these fees cannot be recognized until later. For business purposes, it is important to understand and forecast the distribution of future fees for the allocation of resources, for business planning, and for staffing. Motivated by 5 years of daily fees data, we propose a new class of Bayesian time series models, a Bayesian Dirichlet…

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