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How should parallel cluster randomized trials with a baseline period be analyzed? A survey of estimands and common estimators

带基线期的平行整群随机试验:估计目标与常用估计量

The parallel cluster randomized trial with baseline (PB-CRT) is a common variant of the standard parallel cluster randomized trial (P-CRT). We define two natural estimands in the context of PB-CRTs with informative cluster sizes, the participant-average treatment effect (pATE) and cluster-average treatment effect (cATE), to address participant and cluster-level hypotheses. In this work, we theoretically derive the convergence of the unweighted and inverse cluster-period size…

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Unsupervised Pairwise Causal Discovery on Heterogeneous Data using Mutual Information Measures

利用互信息度量对异质数据进行无监督成对因果发现

A fundamental task in science is to determine the underlying causal relations because it is the knowledge of this functional structure what leads to the correct interpretation of an effect given the apparent associations in the observed data. In this sense, Causal Discovery is a technique that tackles this challenge by analyzing the statistical properties of the constituent variables. In this work, we target the generalizability of the discovery method by following a…

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Semi-parametric local variable selection under misspecification

模型误设下的半参数局部变量选择

Local variable selection aims to test for the effect of covariates on an outcome within specific regions. We outline a challenge that arises in the presence of non-linear effects and model misspecification. Specifically, for common semi-parametric methods even slight model misspecification can result in a high false positive rate, in a manner that is highly sensitive to the chosen basis functions. We propose a methodology based on orthogonal cut splines that avoids false…

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Estimating heterogeneous treatment effects by W-MCM based on Robust reduced rank regression

基于稳健降秩回归的 W-MCM 异质性处理效应估计

Recently, from the personalized medicine perspective, there has been an increased demand to identify subgroups of subjects for whom treatment is effective. Consequently, the estimation of heterogeneous treatment effects (HTE) has been attracting attention. While various estimation methods have been developed for a single outcome, there are still limited approaches for estimating HTE for multiple outcomes. Accurately estimating HTE remains a challenge especially for datasets…

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Methodological Foundations of Modern Causal Inference in Social Science Research

社会科学现代因果推断的方法论基础

This paper serves as a literature review of methodology concerning the (modern) causal inference methods to address the causal estimand with observational/survey data that have been or will be used in social science research. Mainly, this paper is divided into two parts: inference from statistical estimand for the causal estimand, in which we reviewed the assumptions for causal identification and the methodological strategies addressing the problems if some of the…

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Identification and Estimation of Partial Effects in Nonlinear Semiparametric Panel Models

非线性半参数面板模型中偏效应的识别与估计

Average partial effects (APEs) are often not point identified in panel models with unrestricted unobserved individual heterogeneity, such as a binary response panel model with fixed effects and logistic errors as a special case. This lack of point identification occurs despite the identification of these models' common coefficients. We provide a unified framework to establish the point identification of various partial effects in a wide class of nonlinear semiparametric…

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A Local Modal Outer-Product-Gradient Estimator for Dimension Reduction

局部众数外积梯度降维估计量

Sufficient dimension reduction (SDR) is a valuable approach for handling high-dimensional data. Outer Product Gradient (OPG) is an popular approach. However, because of focusing the mean regression function, OPG may ignore some directions of central subspace (CS) when the distribution of errors is symmetric about zero. The mode of a distribution can provide an important summary of data. A Local Modal OPG (LMOPG) and its algorithm through mode regression are proposed to…

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Industrial-Grade Smart Troubleshooting through Causal Technical Language Processing: a Proof of Concept

通过因果技术语言处理实现工业智能故障排查:概念验证

This paper describes the development of a causal diagnosis approach for troubleshooting an industrial environment on the basis of the technical language expressed in Return on Experience records. The proposed method leverages the vectorized linguistic knowledge contained in the distributed representation of a Large Language Model, and the causal associations entailed by the embedded failure modes and mechanisms of the industrial assets. The paper presents the elementary but…

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Causal Effect Estimation after Propensity Score Trimming with Continuous Treatments

连续处理下倾向得分修剪后的因果效应估计

Propensity score trimming, which discards subjects with propensity scores below a threshold, is a common way to address positivity violations that complicate causal effect estimation. However, most works on trimming assume treatment is discrete and models for the outcome regression and propensity score are parametric. This work proposes nonparametric estimators for trimmed average causal effects in the case of continuous treatments based on efficient influence functions. For…

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Design-based inference for generalized network experiments with stochastic interventions

随机干预下广义网络实验的基于设计推断

A growing number of researchers are conducting randomized experiments to analyze causal relationships in network settings where units influence one another. A dominant methodology for analyzing these experiments is design-based, leveraging random treatment assignments as the basis for inference. In this paper, we generalize this design-based approach to accommodate complex experiments with a variety of causal estimands and different target populations. An important special…

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Causal Interventional Prediction System for Robust and Explainable Effect Forecasting

因果干预预测系统:稳健且可解释的效应预测

Although the widespread use of AI systems in today's world is growing, many current AI systems are found vulnerable due to hidden bias and missing information, especially in the most commonly used forecasting system. In this work, we explore the robustness and explainability of AI-based forecasting systems. We provide an in-depth analysis of the underlying causality involved in the effect prediction task and further establish a causal graph based on treatment, adjustment…

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Causal effect estimation under network interference with mean-field methods

利用平均场方法估计网络干扰下的因果效应

We study causal effect estimation from observational data under interference. The interference pattern is captured by an observed network. We adopt the chain graph framework of Tchetgen Tchetgen et. al. (2021), which allows (i) interaction among the outcomes of distinct study units connected along the graph and (ii) long range interference, whereby the outcome of an unit may depend on the treatments assigned to distant units connected along the interference network. For…

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Identification and Inference with Invalid Instruments

无效工具变量下的识别与推断

Instrumental variables (IVs) are widely used to study the causal effect of an exposure on an outcome in the presence of unmeasured confounding. IVs require an instrument, a variable that is (A1) associated with the exposure, (A2) has no direct effect on the outcome except through the exposure, and (A3) is not related to unmeasured confounders. Unfortunately, finding variables that satisfy conditions (A2) or (A3) can be challenging in practice. This paper reviews works where…

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Heterogeneous Grouping Structures in Panel Data

面板数据中的异质性分组结构

In this paper we examine the existence of heterogeneity within a group, in panels with latent grouping structure. The assumption of within group homogeneity is prevalent in this literature, implying that the formation of groups alleviates cross-sectional heterogeneity, regardless of the prior knowledge of groups. While the latter hypothesis makes inference powerful, it can be often restrictive. We allow for models with richer heterogeneity that can be found both in the…

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Multitask Learning and Bandits via Robust Statistics

稳健统计下的多任务学习与赌博机算法

Decision-makers often simultaneously face many related but heterogeneous learning problems. For instance, a large retailer may wish to learn product demand at different stores to solve pricing or inventory problems, making it desirable to learn jointly for stores serving similar customers; alternatively, a hospital network may wish to learn patient risk at different providers to allocate personalized interventions, making it desirable to learn jointly for hospitals serving…

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Using representation balancing to learn conditional-average dose responses from clustered data

利用表征平衡学习聚类数据中的条件平均剂量反应

Estimating a unit's responses to interventions with an associated dose, the "conditional average dose response" (CADR), is relevant in a variety of domains, from healthcare to business, economics, and beyond. Such a response typically needs to be estimated from observational data, which introduces several challenges. That is why the machine learning (ML) community has proposed several tailored CADR estimators. Yet, the proposal of most of these methods requires strong…

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Integration of Structural Equation Modeling and Bayesian Networks in the Context of Causal Inference: A Case Study on Personal Positive Youth Development

因果推断中的结构方程模型与贝叶斯网络整合:积极青少年发展案例

In this study, the combined use of structural equation modeling (SEM) and Bayesian network modeling (BNM) in causal inference analysis is revisited. The perspective highlights the debate between proponents of using BNM as either an exploratory phase or even as the sole phase in the definition of structural models, and those advocating for SEM as the superior alternative for exploratory analysis. The individual strengths and limitations of SEM and BNM are recognized, but this…

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Heterogeneous Treatment Effect Bounds under Sample Selection with an Application to the Effects of Social Media on Political Polarization

样本选择下异质性治疗效应的界:社交媒体与政治极化应用

We propose a method for estimation and inference for bounds for heterogeneous causal effect parameters in general sample selection models where the treatment can affect whether an outcome is observed and no exclusion restrictions are available. The method provides conditional effect bounds as functions of policy relevant pre-treatment variables. It allows for conducting valid statistical inference on the unidentified conditional effects. We use a flexible debiased/double…

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Causal estimands and identification of time-varying effects in non-stationary time series from N-of-1 mobile device data

单人移动设备非平稳时间序列中的时变因果效应:目标量与识别

Mobile technology (mobile phones and wearable devices) generates continuous data streams encompassing outcomes, exposures and covariates, presented as intensive longitudinal or multivariate time series data. The high frequency of measurements enables granular and dynamic evaluation of treatment effect, revealing their persistence and accumulation over time. Existing methods predominantly focus on the contemporaneous effect, temporal-average, or population-average effects,…

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Semiparametric Piecewise Accelerated Failure Time Model for the Analysis of Immune-Oncology Clinical Trials

用于肿瘤免疫治疗临床试验的半参数分段加速失效时间模型

Effectiveness of immune-oncology chemotherapies has been presented in recent clinical trials. The Kaplan-Meier estimates of the survival functions of the immune therapy and the control often suggested the presence of the lag-time until the immune therapy began to act. It implies the use of hazard ratio under the proportional hazards assumption would not be appealing, and many alternatives have been investigated such as the restricted mean survival time. In addition to such…

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Regularization and Model Selection for Ordinal-on-Ordinal Regression with Applications to Food Products' Testing and Survey Data

有序自变量对有序因变量回归的正则化与模型选择:在食品测试与调查数据中的应用

Ordinal data are quite common in applied statistics. Although some model selection and regularization techniques for categorical predictors and ordinal response models have been developed over the past few years, less work has been done concerning ordinal-on-ordinal regression. Motivated by a consumer test and a survey on the willingness to pay for luxury food products consisting of Likert-type items, we propose a strategy for smoothing and selecting ordinally scaled…

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Periodicity significance testing with null-signal templates: reassessment of PTF's SMBH binary candidates

利用无信号模板检验周期显著性:重新评估 PTF 超大质量黑洞双星候选

Periodograms are widely employed for identifying periodicity in time series data, yet they often struggle to accurately quantify the statistical significance of detected periodic signals when the data complexity precludes reliable simulations. We develop a data-driven approach to address this challenge by introducing a null-signal template (NST). The NST is created by carefully randomizing the period of each cycle in the periodogram template, rendering it non-periodic. It…

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Optimal Bias-Correction and Valid Inference in High-Dimensional Ridge Regression: A Closed-Form Solution

高维岭回归中的最优偏差修正与有效推断:闭式解

Ridge regression is an indispensable tool in big data analysis. Yet its inherent bias poses a significant and longstanding challenge, compromising both statistical efficiency and scalability across various applications. To tackle this critical issue, we introduce an iterative strategy to correct bias effectively when the dimension $p$ is less than the sample size $n$. For $p>n$, our method optimally mitigates the bias such that any remaining bias in the proposed de-biased…

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Effect Heterogeneity with Earth Observation in Randomized Controlled Trials: Exploring the Role of Data, Model, and Evaluation Metric Choice

随机对照试验中的地球观测与效应异质性:数据、模型及评价指标的选择

Many social and environmental phenomena are associated with macroscopic changes in the built environment, captured by satellite imagery on a global scale and with daily temporal resolution. While widely used for prediction, these images and especially image sequences remain underutilized for causal inference, especially in the context of randomized controlled trials (RCTs), where causal identification is established by design. In this paper, we develop and compare a set of…

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