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Rank-transformed subsampling: inference for multiple data splitting and exchangeable p-values

秩变换子抽样:多重数据划分与可交换 p 值的推断

Many testing problems are readily amenable to randomised tests such as those employing data splitting. However despite their usefulness in principle, randomised tests have obvious drawbacks. Firstly, two analyses of the same dataset may lead to different results. Secondly, the test typically loses power because it does not fully utilise the entire sample. As a remedy to these drawbacks, we study how to combine the test statistics or p-values resulting from multiple random…

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A Principal Square Response Forward Regression Method for Dimension Reduction

主平方响应前向回归的降维方法

Dimension reduction techniques, such as Sufficient Dimension Reduction (SDR), are indispensable for analyzing high-dimensional datasets. This paper introduces a novel SDR method named Principal Square Response Forward Regression (PSRFR) for estimating the central subspace of the response variable Y, given the vector of predictor variables $\bm{X}$. We provide a computational algorithm for implementing PSRFR and establish its consistency and asymptotic properties. Monte Carlo…

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Double Machine Learning at Scale to Predict Causal Impact of Customer Actions

大规模双重机器学习:预测客户行为的因果影响

Causal Impact (CI) of customer actions are broadly used across the industry to inform both short- and long-term investment decisions of various types. In this paper, we apply the double machine learning (DML) methodology to estimate the CI values across 100s of customer actions of business interest and 100s of millions of customers. We operationalize DML through a causal ML library based on Spark with a flexible, JSON-driven model configuration approach to estimate CI at…

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Simulation-calibration testing for inference in Lasso regressions

Lasso 回归推断的模拟校准检验

We propose a test of the significance of a variable appearing on the Lasso path and use it in a procedure for selecting one of the models of the Lasso path, controlling the Family-Wise Error Rate. Our null hypothesis depends on a set A of already selected variables and states that it contains all the active variables. We focus on the regularization parameter value from which a first variable outside A is selected. As the test statistic, we use this quantity's conditional…

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Estimand-based Inference in Presence of Long-Term Survivors

存在长期存活者时基于目标量的推断

In this article, we develop nonparametric inference methods for comparing survival data across two samples, which are beneficial for clinical trials of novel cancer therapies where long-term survival is a critical outcome. These therapies, including immunotherapies or other advanced treatments, aim to establish durable effects. They often exhibit distinct survival patterns such as crossing or delayed separation and potentially leveling-off at the tails of survival curves,…

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A sparse PAC-Bayesian approach for high-dimensional quantile prediction

高维分位数预测的稀疏 PAC-Bayes 方法

Quantile regression, a robust method for estimating conditional quantiles, has advanced significantly in fields such as econometrics, statistics, and machine learning. In high-dimensional settings, where the number of covariates exceeds sample size, penalized methods like lasso have been developed to address sparsity challenges. Bayesian methods, initially connected to quantile regression via the asymmetric Laplace likelihood, have also evolved, though issues with posterior…

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Inference for linear functionals of high-dimensional longitudinal proteomics data using generalized estimating equations

高维纵向蛋白质组数据中广义估计方程线性泛函的推断

Regression analysis of correlated data, where multiple correlated responses are recorded on the same unit, is ubiquitous in many scientific areas. With the advent of new technologies, in particular high-throughput omics profiling assays, such correlated data increasingly consist of large number of variables compared with the available sample size. Motivated by recent longitudinal proteomics studies of COVID-19, we propose a novel inference procedure for linear functionals of…

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Uplift Modeling Under Limited Supervision

有限监督下的增益建模

Estimating causal effects in e-commerce tends to involve costly treatment assignments which can be impractical in large-scale settings. Leveraging machine learning to predict such treatment effects without actual intervention is a standard practice to diminish the risk. However, existing methods for treatment effect prediction tend to rely on training sets of substantial size, which are built from real experiments and are thus inherently risky to create. In this work we…

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Bayesian nonparametric mixtures of categorical directed graphs for heterogeneous causal inference

用于异质性因果推断的分类变量有向图贝叶斯非参数混合模型

Quantifying causal effects of exposures on outcomes, such as a treatment and a disease respectively, is a crucial issue in medical science for the administration of effective therapies. Importantly, any related causal analysis should account for all those variables, e.g. clinical features, that can act as risk factors involved in the occurrence of a disease. In addition, the selection of targeted strategies for therapy administration requires to quantify such treatment…

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The power of visualizing distributional differences: Formal graphical $n$-sample tests

可视化分布差异:形式化的多样本图形检验

Classical tests are available for the two-sample test of correspondence of distribution functions. From these, the Kolmogorov-Smirnov test provides also the graphical interpretation of the test results, in different forms. Here, we propose modifications of the Kolmogorov-Smirnov test with higher power. The proposed tests are based on the so-called global envelope test which allows for graphical interpretation, similarly as the Kolmogorov-Smirnov test. The tests are based on…

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Long-term Causal Inference Under Persistent Confounding via Data Combination

持续混杂下通过数据结合开展长期因果推断

We study the identification and estimation of long-term treatment effects when both experimental and observational data are available. Since the long-term outcome is observed only after a long delay, it is not measured in the experimental data, but only recorded in the observational data. However, both types of data include observations of some short-term outcomes. In this paper, we uniquely tackle the challenge of persistent unmeasured confounders, i.e., some unmeasured…

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Comparing Propensity Score-Based Methods in Estimating the Treatment Effects: A Simulation Study

倾向得分处理效应估计方法的模拟比较

In observational studies, the recorded treatment assignment is not purely random, but it is influenced by external factors such as patient characteristics, reimbursement policies, and existing guidelines. Therefore, the treatment effect can be estimated only after accounting for confounding factors. Propensity score (PS) methods are a family of methods that is widely used for this purpose. Although they are all based on the estimation of the a posteriori probability of…

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Invariant Causal Prediction with Local Models

使用局部模型的不变因果预测

We consider the task of identifying the causal parents of a target variable among a set of candidates from observational data. Our main assumption is that the candidate variables are observed in different environments which may, under certain assumptions, be regarded as interventions on the observed system. We assume a linear relationship between target and candidates, which can be different in each environment with the only restriction that the causal structure is invariant…

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Estimation and inference of average treatment effects under heterogeneous additive treatment effect model

异质加性处理效应模型下平均处理效应的估计与推断

Randomized experiments are the gold standard for estimating treatment effects, yet network interference challenges the validity of traditional estimators by violating the stable unit treatment value assumption and introducing bias. While cluster randomized experiments mitigate this bias, they encounter limitations in handling network complexity and fail to distinguish between direct and indirect effects. To address these challenges, we develop a design-based asymptotic…

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An Oracle Gradient Regularized Newton Method for Quadratic Measurements Regression

二次测量回归的Oracle梯度正则化牛顿法

Recovering an unknown signal from quadratic measurements has gained popularity due to its wide range of applications, including phase retrieval, fusion frame phase retrieval, and positive operator-valued measures. In this paper, we employ a least squares approach to reconstruct the signal and establish its non-asymptotic statistical properties. Our analysis shows that the estimator perfectly recovers the true signal in the noiseless case, while the error between the…

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Finite Sample Valid Inference via Calibrated Bootstrap

校准自助法实现有限样本有效推断

While widely used as a general method for uncertainty quantification, the bootstrap method encounters difficulties that raise concerns about its validity in practical applications. This paper introduces a new resampling-based method, termed $\textit{calibrated bootstrap}$, designed to generate finite sample-valid parametric inference from a sample of size $n$. The central idea is to calibrate an $m$-out-of-$n$ resampling scheme, where the calibration parameter $m$ is…

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Effect Aliasing in Observational Studies

观察性研究中的效应混叠

In experimental design, aliasing of effects occurs in fractional factorial experiments, where certain low order factorial effects are indistinguishable from certain high order interactions: low order contrasts may be orthogonal to one another, while their higher order interactions are aliased and not identified. In observational studies, aliasing occurs when certain combinations of covariates -- e.g., time period and various eligibility criteria for treatment -- perfectly…

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Replica Analysis for Ensemble Techniques in Variable Selection

变量选择中集成技术的复制分析

Variable selection is a problem of statistics that aims to find the subset of the $N$-dimensional possible explanatory variables that are truly related to the generation process of the response variable. In high-dimensional setups, where the input dimension $N$ is comparable to the data size $M$, it is difficult to use classic methods based on $p$-values. Therefore, methods based on the ensemble learning are often used. In this review article, we introduce how the…

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Scalable Variational Causal Discovery Unconstrained by Acyclicity

无需显式无环约束的可扩展变分因果发现

Bayesian causal discovery offers the power to quantify epistemic uncertainties among a broad range of structurally diverse causal theories potentially explaining the data, represented in forms of directed acyclic graphs (DAGs). However, existing methods struggle with efficient DAG sampling due to the complex acyclicity constraint. In this study, we propose a scalable Bayesian approach to effectively learn the posterior distribution over causal graphs given observational data…

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Enabling Causal Discovery in Post-Nonlinear Models with Normalizing Flows

用归一化流实现后非线性模型的因果发现

Post-nonlinear (PNL) causal models stand out as a versatile and adaptable framework for modeling intricate causal relationships. However, accurately capturing the invertibility constraint required in PNL models remains challenging in existing studies. To address this problem, we introduce CAF-PoNo (Causal discovery via Normalizing Flows for Post-Nonlinear models), harnessing the power of the normalizing flows architecture to enforce the crucial invertibility constraint in…

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Intervention effects based on potential benefit

基于潜在获益的干预效应

Optimal treatment rules are mappings from individual patient characteristics to tailored treatment assignments that maximize mean outcomes. In this work, we introduce a conditional potential benefit (CPB) metric that measures the expected improvement under an optimally chosen treatment compared to the status quo, within covariate strata. The potential benefit combines (i) the magnitude of the treatment effect, and (ii) the propensity for subjects to naturally select a…

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Implicit Regularization Paths of Weighted Neural Representations

加权神经表示中的隐式正则化路径

We study the implicit regularization effects induced by (observation) weighting of pretrained features. For weight and feature matrices of bounded operator norms that are infinitesimally free with respect to (normalized) trace functionals, we derive equivalence paths connecting different weighting matrices and ridge regularization levels. Specifically, we show that ridge estimators trained on weighted features along the same path are asymptotically equivalent when evaluated…

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Adaptive Weighted Random Isolation (AWRI): a simple design to estimate causal effects under network interference

自适应加权随机隔离:网络干扰下因果效应的实验设计

Recently, causal inference under interference has gained increasing attention in the literature. In this paper, we focus on randomized designs for estimating the total treatment effect (TTE), defined as the average difference in potential outcomes between fully treated and fully controlled groups. We propose a simple design called weighted random isolation (WRI) along with a restricted difference-in-means estimator (RDIM) for TTE estimation. Additionally, we derive a novel…

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Challenges in Statistically Rejecting the Perfect Competition Hypothesis Using Imperfect Competition Data

用不完全竞争数据拒绝完全竞争假设的统计困难

We theoretically prove why statistically rejecting the null hypothesis of perfect competition is challenging, known as a common problem in the literature. We also assess the finite sample performance of the conduct parameter test in homogeneous goods markets, showing that statistical power increases with the number of markets, a larger conduct parameter, and a stronger demand rotation instrument. However, even with a moderate number of markets and five firms, rejecting the…

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