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Granger Causality for Mixed Time Series Generalized Linear Models: A Case Study on Multimodal Brain Connectivity

混合类型时间序列广义线性模型的 Granger 因果性:多模态脑连接案例

This paper is motivated by studies in neuroscience experiments to understand interactions between nodes in a brain network using different types of data modalities that capture different distinct facets of brain activity. To assess Granger-causality, we introduce a flexible framework through a general class of models that accommodates mixed types of data (binary, count, continuous, and positive components) formulated in a generalized linear model (GLM) fashion. Statistical…

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Stationarity of Manifold Time Series

流形时间序列的平稳性

In modern interdisciplinary research, manifold time series data have been garnering more attention. A critical question in analyzing such data is ``stationarity'', which reflects the underlying dynamic behavior and is crucial across various fields like cell biology, neuroscience and empirical finance. Yet, there has been an absence of a formal definition of stationarity that is tailored to manifold time series. This work bridges this gap by proposing the first definitions of…

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A Diagnostic Tool for Functional Causal Discovery

函数型因果发现的诊断工具

Causal discovery methods aim to determine the causal direction between variables using observational data. Functional causal discovery methods, such as those based on the Linear Non-Gaussian Acyclic Model (LiNGAM), rely on structural and distributional assumptions to infer the causal direction. However, approaches for assessing causal discovery methods' performance as a function of sample size or the impact of assumption violations, inevitable in real-world scenarios, are…

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Model Averaging and Double Machine Learning

模型平均与双重机器学习

This paper discusses pairing double/debiased machine learning (DDML) with stacking, a model averaging method for combining multiple candidate learners, to estimate structural parameters. In addition to conventional stacking, we consider two stacking variants available for DDML: short-stacking exploits the cross-fitting step of DDML to substantially reduce the computational burden and pooled stacking enforces common stacking weights over cross-fitting folds. Using calibrated…

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Gaussian Processes for Observational Dose-Response Inference

用于观察性剂量—反应推断的高斯过程

We adapt Gaussian processes for estimating the average dose-response function in observational settings, introducing a powerful complement to treatment effect estimation for understanding heterogeneous effects. We incorporate samples from a Gaussian process posterior for the propensity score into a Gaussian process response model using Girard's approach to integrating over uncertainty in training data. We show Girard's method admits a positive-definite kernel, and provide…

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Bayesian inference for group-level cortical surface image-on-scalar-regression with Gaussian process priors

组水平皮层表面图像-标量回归的高斯过程贝叶斯推断

In regression-based analyses of group-level neuroimage data researchers typically fit a series of marginal general linear models to image outcomes at each spatially-referenced pixel. Spatial regularization of effects of interest is usually induced indirectly by applying spatial smoothing to the data during preprocessing. While this procedure often works well, resulting inference can be poorly calibrated. Spatial modeling of effects of interest leads to more powerful…

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Asymptotic considerations in a Bayesian linear model with nonparametrically modelled time series innovations

创新项时间序列非参数建模下贝叶斯线性模型的渐近分析

This paper considers a semiparametric approach within the general Bayesian linear model where the innovations consist of a stationary, mean zero Gaussian time series. While a parametric prior is specified for the linear model coefficients, the autocovariance structure of the time series is modeled nonparametrically using a Bernstein-Gamma process prior for the spectral density function, the Fourier transform of the autocovariance function. When updating this joint prior with…

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A penalized online sequential test of heterogeneous treatment effects for generalized linear models

广义线性模型中异质性处理效应的惩罚在线序贯检验

Identification of heterogeneous treatment effects (HTEs) has been increasingly popular and critical in various penalized strategy decisions using the A/B testing approach, especially in the scenario of a consecutive online collection of samples. However, in high-dimensional settings, such an identification remains challenging in the sense of lack of detection power of HTEs with insufficient sample instances for each batch sequentially collected online. In this article, a…

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Linear Contextual Bandits with Interference

存在干扰的线性情境老虎机

Interference, a key concept in causal inference, extends the reward modeling process by accounting for the impact of one unit's actions on the rewards of others. In contextual bandit (CB) settings, where multiple units are present in the same round, potential interference can significantly affect the estimation of expected rewards for different arms, thereby influencing the decision-making process. Although some prior work has explored multi-agent and adversarial bandits in…

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Fighting Noise with Noise: Causal Inference with Many Candidate Instruments

以噪声对抗噪声:大量候选工具变量下的因果推断

Instrumental variable methods provide useful tools for inferring causal effects in the presence of unmeasured confounding. To apply these methods with large-scale data sets, a major challenge is to find valid instruments from a possibly large candidate set. In practice, most of the candidate instruments are often not relevant for studying a particular exposure of interest. Moreover, not all relevant candidate instruments are valid as they may directly influence the outcome…

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An Autoregressive Model for Time Series of Random Objects

随机对象时间序列的自回归模型

Random variables in metric spaces indexed by time and observed at equally spaced time points are receiving increased attention due to their broad applicability. The absence of inherent structure in metric spaces has resulted in a literature that is predominantly non-parametric and model-free. To address this gap in models for time series of random objects, we introduce an adaptation of the classical linear autoregressive model tailored for data lying in a Hadamard space. The…

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Counterfactual Slopes and Their Applications in Social Stratification

反事实斜率及其在社会分层研究中的应用

This paper addresses two prominent theses in social stratification research, the great equalizer thesis and Mare's (1980) school transition thesis. Both theses describe the role of an intermediate educational transition in the association between socioeconomic status and an outcome variable. However, the descriptive regularities of the two theses may be driven by differential selection into the intermediate transition, which prevents the two theses from having substantive…

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Batches Stabilize the Minimum Norm Risk in High Dimensional Overparameterized Linear Regression

批处理稳定高维过参数化线性回归中的最小范数风险

Learning algorithms that divide the data into batches are prevalent in many machine-learning applications, typically offering useful trade-offs between computational efficiency and performance. In this paper, we examine the benefits of batch-partitioning through the lens of a minimum-norm overparametrized linear regression model with isotropic Gaussian features. We suggest a natural small-batch version of the minimum-norm estimator and derive bounds on its quadratic risk. We…

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A simple but powerful tail index regression

一种简单而有力的尾指数回归

This paper introduces a flexible framework for the estimation of the conditional tail index of heavy tailed distributions. In this framework, the tail index is computed from an auxiliary linear regression model that facilitates estimation and inference based on established econometric methods, such as ordinary least squares (OLS), least absolute deviations, or M-estimation. We show theoretically and via simulations that OLS provides interesting results. Our Monte Carlo…

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A Two-stage Inference Procedure for Sample Local Average Treatment Effects in Randomized Experiments

随机实验中样本局部平均处理效应的两阶段推断

In a given randomized experiment, individuals are often volunteers and can differ in important ways from a population of interest. It is thus of interest to focus on the sample at hand. This paper focuses on inference about the sample local average treatment effect (LATE) in randomized experiments with non-compliance. We present a two-stage procedure that provides asymptotically correct coverage rate of the sample LATE in randomized experiments. The procedure uses a…

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Prediction of causal genes at GWAS loci with pleiotropic gene regulatory effects using sets of correlated instrumental variables

利用相关工具变量集合预测具有多效性调控作用的 GWAS 位点因果基因

Multivariate Mendelian randomization (MVMR) is a statistical technique that uses sets of genetic instruments to estimate the direct causal effects of multiple exposures on an outcome of interest. At genomic loci with pleiotropic gene regulatory effects, that is, loci where the same genetic variants are associated to multiple nearby genes, MVMR can potentially be used to predict candidate causal genes. However, consensus in the field dictates that the genetic instruments in…

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Non-parametric Replication of Instrumental Variable Estimates Across Studies

跨研究工具变量估计的非参数复现

Replicating causal estimates across different cohorts is crucial for increasing the integrity of epidemiological studies. However, strong assumptions regarding unmeasured confounding and effect modification often hinder this goal. By employing an instrumental variable (IV) approach and targeting the local average treatment effect (LATE), these assumptions can be relaxed to some degree; however, little work has addressed the replicability of IV estimates. In this paper, we…

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Stable and Robust Hyper-Parameter Selection Via Robust Information Sharing Cross-Validation

通过稳健信息共享交叉验证进行稳定且稳健的超参数选择

Robust estimators for linear regression require non-convex objective functions to shield against adverse affects of outliers. This non-convexity brings challenges, particularly when combined with penalization in high-dimensional settings. Selecting hyper-parameters for the penalty based on a finite sample is a critical task. In practice, cross-validation (CV) is the prevalent strategy with good performance for convex estimators. Applied with robust estimators, however, CV…

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Randomization Inference When N Equals One

样本量为一时的随机化推断

N-of-1 experiments, where a unit serves as its own control and treatment in different time windows, have been used in certain medical contexts for decades. However, due to effects that accumulate over long time windows and interventions that have complex evolution, a lack of robust inference tools has limited the widespread applicability of such N-of-1 designs. This work combines techniques from experiment design in causal inference and system identification from control…

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Bridging the Gap Between Design and Analysis: Randomization Inference and Sensitivity Analysis for Matched Observational Studies with Treatment Doses

衔接设计与分析:处理剂量匹配观察研究的随机化推断与敏感性分析

Matching is a commonly used causal inference study design in observational studies. Through matching on measured confounders between different treatment groups, valid randomization inferences can be conducted under the no unmeasured confounding assumption, and sensitivity analysis can be further performed to assess sensitivity of randomization inference results to potential unmeasured confounding. However, for many common matching designs, there is still a lack of valid…

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Testing for equal predictive accuracy with strong dependence

强依赖下的等预测准确度检验

We analyse the properties of the Diebold and Mariano (1995) test in the presence of autocorrelation in the loss differential. We show that the power of the Diebold and Mariano (1995) test decreases as the dependence increases, making it more difficult to obtain statistically significant evidence of superior predictive ability against less accurate benchmarks. We also find that, after a certain threshold, the test has no power and the correct null hypothesis is spuriously…

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Parameters on the boundary in predictive regression

预测回归中的边界参数

We consider bootstrap inference in predictive (or Granger-causality) regressions when the parameter of interest may lie on the boundary of the parameter space, here defined by means of a smooth inequality constraint. For instance, this situation occurs when the definition of the parameter space allows for the cases of either no predictability or sign-restricted predictability. We show that in this context constrained estimation gives rise to bootstrap statistics whose limit…

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Robust Bond Risk Premia Predictability Test in the Quantiles

债券风险溢价可预测性的稳健分位数检验

Different from existing literature on testing the macro-spanning hypothesis of bond risk premia, which only considers mean regressions, this paper investigates whether the yield curve represented by CP factor (Cochrane and Piazzesi, 2005) contains all available information about future bond returns in a predictive quantile regression with many other macroeconomic variables. In this study, we introduce the Trend in Debt Holding (TDH) as a novel predictor, testing it alongside…

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Selecting Subpopulations for Causal Inference in Regression Discontinuity Designs

断点回归设计中因果推断子总体的选择

The Brazil Bolsa Familia (BF) program is a conditional cash transfer program aimed to reduce short-term poverty by direct cash transfers and to fight long-term poverty by increasing human capital among poor Brazilian people. Eligibility for Bolsa Familia benefits depends on a cutoff rule, which classifies the BF study as a regression discontinuity (RD) design. Extracting causal information from RD studies is challenging. Following Li et al (2015) and Branson and Mealli…

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