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对数凹反事实密度的双重稳健估计与推断AI 解读

We consider the problem of causal inference based on observational data (or the related missing data problem) with a binary or discrete treatment variable. In that context, we study inference for the counterfactual density functions and contrasts thereof, which can provide more nuanced information than counterfactual means and the average treatment effect. We impose the shape-constraint of log-concavity, a type of unimodality constraint, on the counterfactual densities, and…

组合商品选择的半参数离散选择模型AI 解读

We propose two approaches to estimate semiparametric discrete choice models for bundles. Our first approach is a kernel-weighted rank estimator based on a matching-based identification strategy. We establish its complete asymptotic properties and prove the validity of the nonparametric bootstrap for inference. We then introduce a new multi-index least absolute deviations (LAD) estimator as an alternative, of which the main advantage is its capacity to estimate preference…

检测阴性设计下评估新冠疫苗有效性的双重机器学习方法AI 解读

The test-negative design (TND), which is routinely used for monitoring seasonal flu vaccine effectiveness (VE), has recently become integral to COVID-19 vaccine surveillance, notably in Québec, Canada. Some studies have addressed the identifiability and estimation of causal parameters under the TND, but efficiency bounds for nonparametric estimators of the target parameter under the unconfoundedness assumption have not yet been investigated. Motivated by the goal of…

平均处理效应的厚尾稳健估计与推断AI 解读

We study the probability tail properties of Inverse Probability Weighting (IPW) estimators of the Average Treatment Effect (ATE) when there is limited overlap between the covariate distributions of the treatment and control groups. Under unconfoundedness of treatment assignment conditional on covariates, such limited overlap is manifested in the propensity score for certain units being very close (but not equal) to 0 or 1. This renders IPW estimators possibly heavy tailed,…

内生接受情形下的处理交互作用AI 解读

We study causal inference in randomized experiments (or quasi-experiments) following a $2\times 2$ factorial design. There are two treatments, denoted $A$ and $B$, and units are randomly assigned to one of four categories: treatment $A$ alone, treatment $B$ alone, joint treatment, or none. Allowing for endogenous non-compliance with the two binary instruments representing the intended assignment, as well as unrestricted interference across the two treatments, we derive the…

利用基展开快速进行 Sobol 敏感度图的 pick-freeze 估计AI 解读

Global sensitivity analysis (GSA) aims at quantifying the contribution of input variables over the variability of model outputs. In the frame of functional outputs, a common goal is to compute sensitivity maps (SM), i.e sensitivity indices at each output dimension (e.g. time step for time series, or pixels for spatial outputs). In specific settings, some works have shown that the computation of Sobol' SM can be speeded up by using basis expansions employed for dimension…

后验均值的稳健性AI 解读

Consider a normal location model $X \mid θ\sim N(θ, σ^2)$ with known $σ^2$. Suppose $θ\sim G_0$, where the prior $G_0$ has zero mean and variance bounded by $V$. Let $G_1$ be a possibly misspecified prior with zero mean and variance bounded by $V$. We show that the squared error Bayes risk of the posterior mean under $G_1$ is bounded, subjected to an additional tail condition on $G_1$, uniformly over $G_0, G_1, σ^2 > 0$.

通过随机位移干预与交叉验证靶向学习自适应识别效应修饰因素AI 解读

In epidemiology, identifying subpopulations that are particularly vulnerable to exposures and those who may benefit differently from exposure-reducing interventions is essential. Factors such as age, gender-specific vulnerabilities, and physiological states such as pregnancy are critical for policymakers when setting regulatory guidelines. However, current semi-parametric methods for estimating heterogeneous treatment effects are often limited to binary exposures and can…

利用全局-局部先验改进数据整合下的小区域推断AI 解读

We present and apply methodology to improve inference for small area parameters by using data from several sources. This work extends Cahoy and Sedransk (2023) who showed how to integrate summary statistics from several sources. Our methodology uses hierarchical global-local prior distributions to make inferences for the proportion of individuals in Florida's counties who do not have health insurance. Results from an extensive simulation study show that this methodology will…

非可忽略协变量缺失下优化动态治疗方案的加权 Q-learningAI 解读

Dynamic treatment regimes (DTRs) formalize medical decision-making as a sequence of rules for different stages, mapping patient-level information to recommended treatments. In practice, estimating an optimal DTR using observational data from electronic medical record (EMR) databases can be complicated by nonignorable missing covariates resulting from informative monitoring of patients. Since complete case analysis can provide consistent estimation of outcome model parameters…

Lipschitz 损失正则化经验风险最小化中稀疏深度 ReLU 网络的近最优学习AI 解读

We propose a sparse deep ReLU network (SDRN) estimator of the regression function obtained from regularized empirical risk minimization with a Lipschitz loss function. Our framework can be applied to a variety of regression and classification problems. We establish novel non-asymptotic excess risk bounds for our SDRN estimator when the regression function belongs to a Sobolev space with mixed derivatives. We obtain a new nearly optimal risk rate in the sense that the SDRN…

比例风险下限制平均生存时间检验与对数秩检验的效率比较AI 解读

Background: For RCTs with time-to-event endpoints, proportional hazard (PH) models are typically used to estimate treatment effects and logrank tests are commonly used for hypothesis testing. There is growing support for replacing this approach with a model-free estimand and assumption-lean analysis method. One alternative is to base the analysis on the difference in restricted mean survival time (RMST) at a specific time, a single-number summary measure that can be defined…

比较高维时间序列的变量选择AI 解读

Given a pair of multivariate time-series data of the same length and dimensions, an approach is proposed to select variables and time intervals where the two series are significantly different. In applications where one time series is an output from a computationally expensive simulator, the approach may be used for validating the simulator against real data, for comparing the outputs of two simulators, and for validating a machine learning-based emulator against the…

一类非正则计量模型中的最小切片距离估计AI 解读

This paper proposes minimum sliced distance estimation in structural econometric models with possibly parameter-dependent supports. In contrast to likelihood-based estimation, we show that under mild regularity conditions, the minimum sliced distance estimator is asymptotically normally distributed leading to simple inference regardless of the presence/absence of parameter dependent supports. We illustrate the performance of our estimator on an auction model.

用算法替代人类决策者的统计检验AI 解读

This paper proposes a statistical framework of using artificial intelligence to improve human decision making. The performance of each human decision maker is benchmarked against that of machine predictions. We replace the diagnoses made by a subset of the decision makers with the recommendation from the machine learning algorithm. We apply both a heuristic frequentist approach and a Bayesian posterior loss function approach to abnormal birth detection using a nationwide…

实验项目收益的优化AI 解读

Experimentation in online digital platforms is used to inform decision making. Specifically, the goal of many experiments is to optimize a metric of interest. Null hypothesis statistical testing can be ill-suited to this task, as it is indifferent to the magnitude of effect sizes and opportunity costs. Given access to a pool of related past experiments, we discuss how experimentation practice should change when the goal is optimization. We survey the literature on empirical…

存在不稳定性时的分位数格兰杰因果检验AI 解读

We propose a new framework for assessing Granger causality in quantiles in unstable environments, for a fixed quantile or over a continuum of quantile levels. Our proposed test statistics are consistent against fixed alternatives, they have nontrivial power against local alternatives, and they are pivotal in certain important special cases. In addition, we show the validity of a bootstrap procedure when asymptotic distributions depend on nuisance parameters. Monte Carlo…

高维相依数据中多解释变量与弱信号下的建模AI 解读

This article considers a novel and widely applicable approach to modeling high-dimensional dependent data when a large number of explanatory variables are available and the signal-to-noise ratio is low. We postulate that a $p$-dimensional response series is the sum of a linear regression with many observable explanatory variables and an error term driven by some latent common factors and an idiosyncratic noise. The common factors have dynamic dependence whereas the…

广义弹性网惩罚稀疏线性回归的迭代重加权算法框架AI 解读

The elastic net penalty is frequently employed in high-dimensional statistics for parameter regression and variable selection. It is particularly beneficial compared to lasso when the number of predictors greatly surpasses the number of observations. However, empirical evidence has shown that the $\ell_q$-norm penalty (where $0 < q < 1$) often provides better regression compared to the $\ell_1$-norm penalty, demonstrating enhanced robustness in various scenarios. In this…

用于验证与推断的边际因果流模型AI 解读

Investigating the marginal causal effect of an intervention on an outcome from complex data remains challenging due to the inflexibility of employed models and the lack of complexity in causal benchmark datasets, which often fail to reproduce intricate real-world data patterns. In this paper we introduce Frugal Flows, a novel likelihood-based machine learning model that uses normalising flows to flexibly learn the data-generating process, while also directly inferring the…

结合 Huber M 估计的矩方法随机效应元分析AI 解读

Meta-analyses are commonly used to provide solid evidence across numerous studies. Traditional moment methods, such as the DerSimonian-Laird method, remain popular in spite of the availability of more accurate alternatives. While moment estimators are simple and intuitive, they are known to underestimate the variance of the overall treatment effect, particularly when the number of studies is small. This underestimation can lead to excessively narrow confidence intervals that…

R.O.A.D.：通向临床试验模拟的框架AI 解读

Observational studies provide the only evidence on the effectiveness of interventions when randomized controlled trials (RCTs) are impractical due to cost, ethical concerns, or time constraints. While many methodologies aim to draw causal inferences from observational data, there is a growing trend to model observational study designs after RCTs, a strategy known as "target trial emulation." Despite its potential, causal inference through target trial emulation cannot fully…

纵向协变量与部分区间删失数据的联合建模：惩罚似然方法及其在Anti-PD1脑协作试验中的应用AI 解读

This article considers the joint modeling of longitudinal covariates and partly-interval censored time-to-event data. Longitudinal time-varying covariates play a crucial role in obtaining accurate clinically relevant predictions using a survival regression model. However, these covariates are often measured at limited time points and may be subject to measurement error. Further methodological challenges arise from the fact that, in many clinical studies, the event times of…

消除神经网络解释中的伪相关AI 解读

The existing algorithms for identification of neurons responsible for undesired and harmful behaviors do not consider the effects of confounders such as topic of the conversation. In this work, we show that confounders can create spurious correlations and propose a new causal mediation approach that controls the impact of the topic. In experiments with two large language models, we study the localization hypothesis and show that adjusting for the effect of conversation…