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Pulling back the curtain: the road from statistical estimand to machine-learning based estimator for epidemiologists (no wizard required)

从统计目标量到机器学习估计量:面向流行病学研究者的推导指南

Epidemiologists increasingly use causal inference methods that rely on machine learning, as these approaches can relax unnecessary model specification assumptions. While deriving and studying asymptotic properties of such estimators is a task usually associated with statisticians, it is useful for epidemiologists to understand the steps involved, as epidemiologists are often at the forefront of defining important new research questions and translating them into new…

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Order selection in GARMA models for count time series: a Bayesian perspective

计数时间序列 GARMA 模型的贝叶斯阶数选择

Estimation in GARMA models has traditionally been carried out under the frequentist approach. To date, Bayesian approaches for such estimation have been relatively limited. In the context of GARMA models for count time series, Bayesian estimation achieves satisfactory results in terms of point estimation. Model selection in this context often relies on the use of information criteria. Despite its prominence in the literature, the use of information criteria for model…

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Estimating Parameters of Structural Models Using Neural Networks

利用神经网络估计结构模型参数

We study an alternative use of machine learning. We train neural nets to provide the parameter estimate of a given (structural) econometric model, for example, discrete choice or consumer search. Training examples consist of datasets generated by the econometric model under a range of parameter values. The neural net takes the moments of a dataset as input and tries to recognize the parameter value underlying that dataset. Besides the point estimate, the neural net can also…

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Optimistic Algorithms for Adaptive Estimation of the Average Treatment Effect

平均处理效应自适应估计的乐观算法

Estimation and inference for the Average Treatment Effect (ATE) is a cornerstone of causal inference and often serves as the foundation for developing procedures for more complicated settings. Although traditionally analyzed in a batch setting, recent advances in martingale theory have paved the way for adaptive methods that can enhance the power of downstream inference. Despite these advances, progress in understanding and developing adaptive algorithms remains in its early…

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A Beta Cauchy-Cauchy (BECCA) shrinkage prior for Bayesian variable selection

用于贝叶斯变量选择的 Beta Cauchy-Cauchy 收缩先验

This paper introduces a novel Bayesian approach for variable selection in high-dimensional and potentially sparse regression settings. Our method replaces the indicator variables in the traditional spike and slab prior with continuous, Beta-distributed random variables and places half Cauchy priors over the parameters of the Beta distribution, which significantly improves the predictive and inferential performance of the technique. Similar to shrinkage methods, our…

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Identification and Inference in General Bunching Designs

一般聚束设计中的识别与推断

This paper develops an econometric framework and tools for the identification and inference of a structural parameter in general bunching designs. We present point and partial identification results, which generalize previous approaches in the literature. The key assumption for point identification is the analyticity of the counterfactual density, which defines a broader class of distributions than many commonly used parametric families. In the partial identification…

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The ARR2 prior: flexible predictive prior definition for Bayesian auto-regressions

ARR2 先验:贝叶斯自回归模型的灵活预测先验

We present the ARR2 prior, a joint prior over the auto-regressive components in Bayesian time-series models and their induced $R^2$. Compared to other priors designed for times-series models, the ARR2 prior allows for flexible and intuitive shrinkage. We derive the prior for pure auto-regressive models, and extend it to auto-regressive models with exogenous inputs, and state-space models. Through both simulations and real-world modelling exercises, we demonstrate the…

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Observable asymptotics of regularized Cox regression models with standard Gaussian designs: a statistical mechanics approach

标准高斯设计下正则化Cox回归的可观测渐近性质:统计力学方法

We study the asymptotic behaviour of the Regularized Maximum Partial Likelihood Estimator (RMPLE) in the proportional limit, considering an arbitrary convex regularizer and assuming that the covariates $\mathbf{X}_i\in\mathbb{R}^{p}$ follow a multivariate Gaussian law with covariance $\mathbf{I}_p/p$ for each $i=1, \dots, n$. In order to efficiently compute the estimator under investigation, we propose a modified Approximate Message Passing (AMP) algorithm, that we name…

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Combining Clusters for the Approximate Randomization Test

近似随机化检验中的聚类合并方法

This paper develops procedures to combine clusters for the approximate randomization test proposed by Canay, Romano, and Shaikh (2017). Their test can be used to conduct inference with a small number of clusters and imposes weak requirements on the correlation structure. However, their test requires the target parameter to be identified within each cluster. A leading example where this requirement fails to hold is when a variable has no variation within clusters. For…

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MXMap: A Multivariate Cross Mapping Framework for Causal Discovery in Dynamical Systems

MXMap:动力系统因果发现的多变量交叉映射框架

Convergent Cross Mapping (CCM) is a powerful method for detecting causality in coupled nonlinear dynamical systems, providing a model-free approach to capture dynamic causal interactions. Partial Cross Mapping (PCM) was introduced as an extension of CCM to address indirect causality in three-variable systems by comparing cross-mapping quality between direct cause-effect mapping and indirect mapping through an intermediate conditioning variable. However, PCM remains limited…

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Scale-Insensitive Neural Network Significance Tests

尺度不敏感的神经网络显著性检验

This paper develops a scale-insensitive framework for neural network significance testing, substantially generalizing existing approaches through three key innovations. First, we replace metric entropy calculations with Rademacher complexity bounds, enabling the analysis of neural networks without requiring bounded weights or specific architectural constraints. Second, we weaken the regularity conditions on the target function to require only Sobolev space membership $H^s([-1,1]^d)$…

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Distribution learning via neural differential equations: minimal energy regularization and approximation theory

神经微分方程分布学习:最小能量正则化与逼近理论

Neural ordinary differential equations (ODEs) provide expressive representations of invertible transport maps that can be used to approximate complex probability distributions, e.g., for generative modeling, density estimation, and Bayesian inference. We show that for a large class of transport maps $T$, there exists a time-dependent ODE velocity field realizing a straight-line interpolation $(1-t)x + tT(x)$, $t \in [0,1]$, of the displacement induced by the map. Moreover,…

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A novel longitudinal rank-sum test for multiple primary endpoints in clinical trials: Applications to neurodegenerative disorders

临床试验多主要终点的纵向秩和检验:神经退行性疾病应用

Neurodegenerative disorders such as Alzheimer's disease (AD) present a significant global health challenge, characterized by cognitive decline, functional impairment, and other debilitating effects. Current AD clinical trials often assess multiple longitudinal primary endpoints to comprehensively evaluate treatment efficacy. Traditional methods, however, may fail to capture global treatment effects, require larger sample sizes due to multiplicity adjustments, and may not…

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Causal survival analysis under competing risks using longitudinal modified treatment policies

利用纵向修正治疗策略开展竞争风险下的因果生存分析

Longitudinal modified treatment policies (LMTP) have been recently developed as a novel method to define and estimate causal parameters that depend on the natural value of treatment. LMTPs represent an important advancement in causal inference for longitudinal studies as they allow the non-parametric definition and estimation of the joint effect of multiple categorical, numerical, or continuous exposures measured at several time points. We extend the LMTP methodology to…

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Ordinal Patterns Based Change Points Detection

基于序模式的变点检测

The ordinal patterns of a fixed number of consecutive values in a time series is the spatial ordering of these values. Counting how often a specific ordinal pattern occurs in a time series provides important insights into the properties of the time series. In this work, we prove the asymptotic normality of the relative frequency of ordinal patterns for time series with linear increments. Moreover, we apply ordinal patterns to detect changes in the distribution of a time…

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RieszBoost: Gradient Boosting for Riesz Regression

RieszBoost:用于 Riesz 回归的梯度提升

Answering causal questions often involves estimating linear functionals of conditional expectations, such as the average treatment effect or the effect of a longitudinal modified treatment policy. By the Riesz representation theorem, these functionals can be expressed as the expected product of the conditional expectation of the outcome and the Riesz representer, a key component in doubly robust estimation methods. Traditionally, the Riesz representer is estimated indirectly…

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Data-adaptive exposure thresholds for the Horvitz-Thompson estimator of the Average Treatment Effect in experiments with network interference

网络干扰实验中平均处理效应 Horvitz–Thompson 估计的自适应暴露阈值

Randomized controlled trials often suffer from interference, a violation of the Stable Unit Treatment Values Assumption (SUTVA) in which a unit's treatment assignment affects the outcomes of its neighbors. This interference causes bias in naive estimators of the average treatment effect (ATE). A popular method to achieve unbiasedness is to pair the Horvitz-Thompson estimator of the ATE with a known exposure mapping: a function that identifies which units in a given…

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Practically Effective Adjustment Variable Selection in Causal Inference

因果推断中具有实际效果的调整变量选择

In the estimation of causal effects, one common method for removing the influence of confounders is to adjust the variables that satisfy the back-door criterion. However, it is not always possible to uniquely determine sets of such variables. Moreover, real-world data is almost always limited, which means it may be insufficient for statistical estimation. Therefore, we propose criteria for selecting variables from a list of candidate adjustment variables along with an…

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Randomization Inference: Theory and Applications

随机化推断:理论与应用

We review approaches to statistical inference based on randomization. Permutation tests are treated as an important special case. Under a certain group invariance property, referred to as the ``randomization hypothesis,'' randomization tests achieve exact control of the Type I error rate in finite samples. Although this unequivocal precision is very appealing, the range of problems that satisfy the randomization hypothesis is somewhat limited. We show that randomization…

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Synthetic Random Environmental Time Series Generation with Similarity Control, Preserving Original Signal's Statistical Characteristics

相似度可控且保留原信号统计特征的随机环境时间序列生成

Synthetic datasets are widely used in many applications, such as missing data imputation, examining non-stationary scenarios, in simulations, training data-driven models, and analyzing system robustness. Typically, synthetic data are based on historical data obtained from the observed system. The data needs to represent a specific behavior of the system, yet be new and diverse enough so that the system is challenged with a broad range of inputs. This paper presents a method,…

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Heteroscedastic Double Bayesian Elastic Net

异方差双重贝叶斯弹性网

In many practical applications, regression models are employed to uncover relationships between predictors and a response variable, yet the common assumption of constant error variance is frequently violated. This issue is further compounded in high-dimensional settings where the number of predictors exceeds the sample size, necessitating regularization for effective estimation and variable selection. To address this problem, we propose the Heteroscedastic Double Bayesian…

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Inference for multiple treatment effects using confounder importance learning

利用混杂变量重要性学习推断多个处理效应

We address modelling and computational issues for multiple treatment effect inference under many potential confounders. Our main contribution is providing a trade-off between preventing the omission of relevant confounders, while not running into an over-selection of instruments that significantly inflates variance. We propose a novel empirical Bayes framework for Bayesian model averaging that learns from data the prior inclusion probabilities of key covariates. Our…

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Regressions under Adverse Conditions

不利条件下的回归

We introduce a new regression method that relates the mean of an outcome variable to covariates, under the "adverse condition" that a distress variable falls in its tail. This allows to tailor classical mean regressions to adverse scenarios, which receive increasing interest in economics and finance, among many others. In the terminology of the systemic risk literature, our method can be interpreted as a regression for the Marginal Expected Shortfall. We propose a two-step…

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Statistical inference for high-dimensional spectral density matrix

高维谱密度矩阵的统计推断

The spectral density matrix is a fundamental object of interest in time series analysis, and it encodes both contemporary and dynamic linear relationships between component processes of the multivariate system. In this paper we develop novel inference procedures for the spectral density matrix in the high-dimensional setting. Specifically, we introduce a new global testing procedure to test the nullity of the cross-spectral density for a given set of frequencies and across…

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