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Simultaneous inference for generalized linear models with unmeasured confounders

含未测混杂因素的广义线性模型同时推断

Tens of thousands of simultaneous hypothesis tests are routinely performed in genomic studies to identify differentially expressed genes. However, due to unmeasured confounders, many standard statistical approaches may be substantially biased. This paper investigates the large-scale hypothesis testing problem for multivariate generalized linear models in the presence of confounding effects. Under arbitrary confounding mechanisms, we propose a unified statistical estimation…

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The Probability of Tiered Benefit: Partial Identification with Robust and Stable Inference

分层获益概率:部分识别与稳健、稳定的推断

We define the Probability of Tiered Benefit in scenarios with a binary exposure and an outcome that is either categorical with $K \geq 2$ ordered tiers or continuous partitioned by $K-1$ fixed thresholds into disjoint intervals. Similarly to other pure counterfactual queries, this parameter is not $g$-identifiable without additional assumptions. We demonstrate that strong monotonicity does not suffice for point identification when $K \geq 3$ and provide sharp bounds both…

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Penalized Principal Component Analysis for Large-dimension Factor Model with Group Pursuit

带群组识别的高维因子模型惩罚主成分分析

This paper investigates the intrinsic group structures within the framework of large-dimensional approximate factor models, which portrays homogeneous effects of the common factors on the individuals that fall into the same group. To this end, we propose a fusion Penalized Principal Component Analysis (PPCA) method and derive a closed-form solution for the $\ell_2$-norm optimization problem. We also show the asymptotic properties of our proposed PPCA estimates. With the PPCA…

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Longitudinal Causal Inference with Selective Eligibility

具有选择性资格的纵向因果推断

Dropout poses a significant challenge to causal inference in longitudinal studies with time-varying treatments. However, existing research does not simultaneously address dropout and time-varying treatments. We examine selective eligibility, an important yet overlooked source of non-ignorable dropout in such settings. This problem arises when a unit's prior treatment history influences its eligibility for subsequent treatments, a common scenario in medical and other…

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Graph Topic Modeling for Documents with Spatial or Covariate Dependencies

面向具有空间或协变量依赖文档的图主题建模

We address the challenge of incorporating document-level metadata into topic modeling to improve topic mixture estimation. To overcome the computational complexity and lack of theoretical guarantees in existing Bayesian methods, we extend probabilistic latent semantic indexing (pLSI), a frequentist framework for topic modeling, by incorporating document-level covariates or known similarities between documents through a graph formalism. Modeling documents as nodes and edges…

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Estimating interaction effects with panel data

面板数据交互效应的估计

This paper analyzes how interaction effects can be consistently estimated under economically plausible assumptions in linear panel models with a fixed $T$-dimension. We advocate for a \emph{correlated interaction term estimator} (CITE) and show that it is consistent under conditions that are not sufficient for consistency of the interaction term estimator that is most common in applied econometric work. Our paper discusses the empirical content of these conditions, shows…

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Causal Quantile Treatment Effects with missing data by double-sampling

通过双重抽样处理缺失数据的因果分位数处理效应

Causal weighted quantile treatment effects (WQTE) are a useful complement to standard causal contrasts that focus on the mean when interest lies at the tails of the counterfactual distribution. To-date, however, methods for estimation and inference regarding causal WQTEs have assumed complete data on all relevant factors. In most practical settings, however, data will be missing or incomplete data, particularly when the data are not collected for research purposes, as is the…

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Modeling complex measurement error in microbiome experiments to estimate relative abundances and detection effects

微生物组实验中复杂测量误差的建模:相对丰度与检测效应估计

Accurate estimates of microbial species abundances are needed to advance our understanding of the role that microbiomes play in human and environmental health. However, artificially constructed microbiomes demonstrate that intuitive estimators of microbial relative abundances are biased. To address this, we propose a semiparametric method to estimate relative abundances, species detection effects, and/or cross-sample contamination in microbiome experiments. We show that…

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On the numerical approximation of minimax regret rules via fictitious play

通过虚拟博弈数值逼近极小极大遗憾规则

Finding numerical approximations to minimax regret treatment rules is of key interest. To do so when potential outcomes are in {0,1} we discretize the action space of nature and apply a variant of Robinson's (1951) algorithm for iterative solutions for finite two-person zero sum games. Our approach avoids the need to evaluate regret of each treatment rule in each iteration. When potential outcomes are in [0,1] we apply the so-called coarsening approach. We consider a…

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Benign Overfitting in Time Series Linear Models with Over-Parameterization

过参数化时间序列线性模型中的良性过拟合

The success of large-scale models in recent years has increased the importance of statistical models with numerous parameters. Several studies have analyzed over-parameterized linear models with high-dimensional data, which may not be sparse; however, existing results rely on the assumption of sample independence. In this study, we analyze a linear regression model with dependent time-series data in an over-parameterized setting. We consider an estimator using interpolation…

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The Breakdown of Gaussian Universality in Classification of High-dimensional Linear Factor Mixtures

高维线性因子混合分类中高斯普适性的失效

The assumption of Gaussian or Gaussian mixture data has been extensively exploited in a long series of precise performance analyses of machine learning (ML) methods, on large datasets having comparably numerous samples and features. To relax this restrictive assumption, subsequent efforts have been devoted to establish "Gaussian equivalent principles" by studying scenarios of Gaussian universality where the asymptotic performance of ML methods on non-Gaussian data remains…

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Designing Graph Convolutional Neural Networks for Discrete Choice with Network Effects

面向具有网络效应的离散选择设计图卷积神经网络

We introduce a novel model architecture that incorporates network effects into discrete choice problems, achieving higher predictive performance than standard discrete choice models while offering greater interpretability than general-purpose flexible model classes. Econometric discrete choice models aid in studying individual decision-making, where agents select the option with the highest reward from a discrete set of alternatives. Intuitively, the utility an individual…

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Non-Asymptotic Analysis of Classical Spectrum Estimators with $L$-mixing Time-series Data

L-mixing 时间序列下经典谱估计量的非渐近分析

Spectral estimation is a fundamental problem for time series analysis, which is widely applied in economics, speech analysis, seismology, and control systems. The asymptotic convergence theory for classical, non-parametric estimators, is well-understood, but the non-asymptotic theory is still rather limited. Our recent work gave the first non-asymptotic error bounds on the well-known Bartlett and Welch methods, but under restrictive assumptions. In this paper, we derive…

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A generalized Bayesian approach for high-dimensional robust regression with serially correlated errors and predictors

高维稳健回归的广义贝叶斯方法:序列相关误差与预测变量

This paper introduces a loss-based generalized Bayesian methodology for high-dimensional robust regression with serially correlated errors and predictors. The proposed framework employs a novel scaled pseudo-Huber (SPH) loss function, which smooths the well-known Huber loss, effectively balancing quadratic ($\ell_2$) and absolute linear ($\ell_1$) loss behaviors. This flexibility enables the framework to accommodate both thin-tailed and heavy-tailed data efficiently. The…

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The Logic of Counterfactuals and the Epistemology of Causal Inference

反事实逻辑与因果推断的认识论

The 2021 Nobel Prize in Economics recognized an epistemology of causal inference based on the Rubin causal model (Rubin 1974), which merits broader attention in philosophy. This model, in fact, presupposes a logical principle of counterfactuals, Conditional Excluded Middle (CEM), the locus of a pivotal debate between Stalnaker (1968) and Lewis (1973) on the semantics of counterfactuals. Proponents of CEM should recognize that this connection points to a new argument for CEM…

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On a new robust method of inference for general time series models

一般时间序列模型的一种稳健推断新方法

In this article, we propose a novel logistic quasi-maximum likelihood estimation (LQMLE) for general parametric time series models. Compared to the classical Gaussian QMLE and existing robust estimations, it enjoys many distinctive advantages, such as robustness in respect of distributional misspecification and heavy-tailedness of the innovation, more resiliency to outliers, smoothness and strict concavity of the log logistic quasi-likelihood function, and boundedness of the…

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A Multi-Omics Framework for Survival Mediation Analysis of High-Dimensional Proteogenomic Data

高维蛋白基因组数据的多组学生存中介分析框架

Survival analysis plays a crucial role in understanding time-to-event (survival) outcomes such as disease progression. Despite recent advancements in causal mediation frameworks for survival analysis, existing methods are typically based on Cox regression and primarily focus on a single exposure or individual omics layers, often overlooking multi-omics interplay. This limitation hinders the full potential of integrated biological insights. In this paper, we propose SMAHP, a…

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Out-of-distribution robustness for multivariate analysis via causal regularisation

通过因果正则化提升多元分析的分布外稳健性

We propose a regularisation strategy of classical machine learning algorithms rooted in causality that ensures robustness against distribution shifts. Building upon the anchor regression framework, we demonstrate how incorporating a straightforward regularisation term into the loss function of classical multivariate analysis algorithms, such as (orthonormalized) partial least squares, reduced-rank regression, and multiple linear regression, enables out-of-distribution…

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Doubly robust omnibus sensitivity analysis of externally controlled trials with intercurrent events

存在试验期间事件的外部对照试验:双重稳健综合敏感性分析

Externally controlled trials are crucial in clinical development when randomized controlled trials are unethical or impractical. These trials consist of a full treatment arm with the experimental treatment and a full external control arm. However, they present significant challenges in learning the treatment effect due to the lack of randomization and a parallel control group. Besides baseline incomparability, outcome mean non-exchangeability, caused by differences in…

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Double Machine Learning Methods for Estimating Average Treatment Effects: A Comparative Study

估计平均处理效应的双重机器学习方法:比较研究

Observational cohort studies are increasingly being used for comparative effectiveness research to assess the safety of therapeutics. Recently, various doubly robust methods have been proposed for average treatment effect estimation by combining the treatment model and the outcome model via different vehicles, such as matching, weighting, and regression. The key advantage of doubly robust estimators is that they require either the treatment model or the outcome model to be…

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How to improve the regression factor score predictor when individuals have different factor loadings

个体因子载荷不同时如何改进回归因子得分预测

Previous research has shown that ignoring individual differences of factor loadings in conventional factor models may reduce the determinacy of factor score predictors. Therefore, the aim of the present study is to propose a heterogeneous regression factor score with larger determinacy than the conventional regression factor score when individuals have different factor loadings. First, a method for the estimation of individual loadings is proposed. The individual loading…

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Bootstrapping Fisher Market Equilibrium and First-Price Pacing Equilibrium

费舍尔市场均衡与一价拍卖预算调节均衡的自助法推断

The linear Fisher market (LFM) is a basic equilibrium model from economics, which also has applications in fair and efficient resource allocation. First-price pacing equilibrium (FPPE) is a model capturing budget-management mechanisms in first-price auctions. In certain practical settings such as advertising auctions, there is an interest in performing statistical inference over these models. A popular methodology for general statistical inference is the bootstrap procedure.…

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Extremes of structural causal models

结构因果模型的极端行为

The behavior of extreme observations is well-understood for time series or spatial data, but little is known if the data generating process is a structural causal model (SCM). We study the behavior of extremes in this model class, both for the observational distribution and under extremal interventions. We show that under suitable regularity conditions on the structure functions, the extremal behavior is described by a multivariate Pareto distribution, which can be…

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Black Box Causal Inference: Effect Estimation via Meta Prediction

黑箱因果推断:通过元预测估计效应

Causal inference and the estimation of causal effects plays a central role in decision-making across many areas, including healthcare and economics. Estimating causal effects typically requires an estimator that is tailored to each problem of interest. But developing estimators can take significant effort for even a single causal inference setting. For example, algorithms for regression-based estimators, propensity score methods, and doubly robust methods were designed…

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