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Cluster-robust jackknife and bootstrap inference for logistic regression models

Logistic 回归模型的聚类稳健刀切法与自助法推断

We study cluster-robust inference for logistic regression (logit) models. Inference based on the most commonly-used cluster-robust variance matrix estimator (CRVE) can be very unreliable. We study several alternatives. Conceptually the simplest of these, but also the most computationally demanding, involves jackknifing at the cluster level. We also propose a linearized version of the cluster-jackknife variance matrix estimator as well as linearized versions of the wild…

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What is estimated in cluster randomized crossover trials with informative sizes? -- A survey of estimands and common estimators

信息性规模下的整群随机交叉试验究竟估计什么:目标量与常用估计量综述

In the analysis of cluster randomized trials (CRTs), previous work has defined two meaningful estimands: the individual-average treatment effect (iATE) and cluster-average treatment effect (cATE) estimand, to address individual and cluster-level hypotheses. In multi-period CRT designs, such as the cluster randomized crossover (CRXO) trial, additional weighted average treatment effect estimands help fully reflect the longitudinal nature of these trial designs, namely the…

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Q-Learning with Clustered-SMART (cSMART) Data: Examining Moderators in the Construction of Clustered Adaptive Interventions

聚类序贯多次随机试验的 Q 学习:自适应干预中的效应调节变量

A clustered adaptive intervention (cAI) is a pre-specified sequence of decision rules that guides practitioners on how best - and based on which measures - to tailor cluster-level intervention to improve outcomes at the level of individuals within the clusters. A clustered sequential multiple assignment randomized trial (cSMART) is a type of trial that is used to inform the empirical development of a cAI. The most common type of secondary aim in a cSMART focuses on assessing…

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Large Volatility Matrix Prediction using Tensor Factor Structure

利用张量因子结构预测大型波动率矩阵

Several approaches for predicting large volatility matrices have been developed based on high-dimensional factor-based Itô processes. These methods often impose restrictions to reduce the model complexity, such as constant eigenvectors or factor loadings over time. However, several studies indicate that eigenvector processes are also time-varying. To address this feature, this paper generalizes the factor structure by representing the integrated volatility matrix process as…

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Inference for max-linear Bayesian networks with noise

带噪声最大线性贝叶斯网络的推断

Max-Linear Bayesian Networks (MLBNs) provide a powerful framework for causal inference in extreme-value settings; we consider MLBNs with noise parameters with a given topology in terms of the max-plus algebra by taking its logarithm. Then, we show that an estimator of a parameter for each edge in a directed acyclic graph (DAG) is distributed normally. We end this paper with computational experiments with the expectation and maximization (EM) algorithm and quadratic…

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Identification and Inference on Treatment Effects under Covariate-Adaptive Randomization and Imperfect Compliance

协变量自适应随机化与不完全依从下处理效应的识别和推断

Randomized controlled trials (RCTs) frequently utilize covariate-adaptive randomization (CAR) (e.g., stratified block randomization) and commonly suffer from imperfect compliance. This paper studies the identification and inference for the average treatment effect (ATE) and the average treatment effect on the treated (ATT) in such RCTs with a binary treatment. We first develop characterizations of the identified sets for both estimands. Since data are generally not i.i.d.…

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On the Robustness of Mixture Models in the Presence of Hidden Markov Regimes with Covariate-Dependent Transition Probabilities

协变量依赖转移概率下隐马尔可夫状态的混合模型稳健性

This paper studies the robustness of quasi-maximum-likelihood (QML) estimation in hidden Markov models (HMMs) when the regime-switching structure is misspecified. Specifically, we examine the case where the true data-generating process features a hidden Markov regime sequence with covariate-dependent transition probabilities, but estimation proceeds under a simplified mixture model that assumes regimes are independent and identically distributed. We show that the parameters…

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Convergence rate for Nearest Neighbour matching: geometry of the domain and higher-order regularity

最近邻匹配的收敛率:支持域几何与高阶正则性

Estimating some mathematical expectations from partially observed data and in particular missing outcomes is a central problem encountered in numerous fields such as transfer learning, counterfactual analysis or causal inference. Matching estimators, estimators based on k-nearest neighbours, are widely used in this context. It is known that the variance of such estimators can converge to zero at a parametric rate, but their bias can have a slower rate when the dimension of…

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Inference for Regression with Variables Generated by AI or Machine Learning

使用人工智能或机器学习生成变量的回归推断

Researchers now routinely use AI or other machine learning methods to estimate latent variables of economic interest, then plug-in the estimates as covariates in a regression. We show both theoretically and empirically that naively treating AI/ML-generated variables as "data" leads to biased estimates and invalid inference. To restore valid inference, we propose two methods: (1) an explicit bias correction with bias-corrected confidence intervals, and (2) joint estimation of…

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Real-time Program Evaluation using Anytime-valid Rank Tests

利用随时有效秩检验开展实时项目评估

Counterfactual mean estimators such as difference-in-differences and synthetic control have grown into workhorse tools for program evaluation. Inference for these estimators is well-developed in settings where all post-treatment data is available at the time of analysis. However, in settings where data arrives sequentially, these tests do not permit real-time inference, as they require a pre-specified sample size T. We introduce real-time inference for program evaluation…

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An Efficient Dual ADMM for Huber Regression with Fused Lasso Penalty

融合Lasso惩罚下Huber回归的高效对偶ADMM算法

The ordinary least squares estimate in linear regression is sensitive to the influence of errors with large variance, which reduces its robustness, especially when dealing with heavy-tailed errors or outliers frequently encountered in real-world scenarios. To address this issue and accommodate the sparsity of coefficients along with their sequential disparities, we combine the adaptive robust Huber loss function with a fused lasso penalty. This combination yields a robust…

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Multi-Domain Causal Discovery in Bijective Causal Models

双射因果模型中的多域因果发现

We consider the problem of causal discovery (a.k.a., causal structure learning) in a multi-domain setting. We assume that the causal functions are invariant across the domains, while the distribution of the exogenous noise may vary. Under causal sufficiency (i.e., no confounders exist), we show that the causal diagram can be discovered under less restrictive functional assumptions compared to previous work. What enables causal discovery in this setting is bijective…

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Assessing the replicability of RCTs in RWE emulations

评估真实世界证据模拟研究对随机试验的可重复性

Background: The standard regulatory approach to assess replication success is the two-trials rule, requiring both the original and the replication study to be significant with effect estimates in the same direction. The sceptical p-value was recently presented as an alternative method for the statistical assessment of the replicability of study results. Methods: We review the statistical properties of the sceptical p-value and compare those to the two-trials rule. We extend…

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Policy Learning with Distributional Welfare

面向分布福利的政策学习

In this paper, we explore optimal treatment allocation policies that target distributional welfare. Most literature on treatment choice has considered utilitarian welfare based on the conditional average treatment effect (ATE). While average welfare is intuitive, it may yield undesirable allocations especially when individuals are heterogeneous (e.g., with outliers) - the very reason individualized treatments were introduced in the first place. This observation motivates us…

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Inference of high-dimensional weak instrumental variable regression models without ridge-regularization

无需岭正则化的高维弱工具变量回归推断

Inference of instrumental variable regression models with many weak instruments attracts many attentions recently. To extend the classical Anderson-Rubin test to high-dimensional setting, many procedures adopt ridge-regularization. However, we show that it is not necessary to consider ridge-regularization. Actually we propose a new quadratic-type test statistic which does not involve tuning parameters. Our quadratic-type test exhibits high power against dense alternatives.…

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Representation Learning Preserving Ignorability and Covariate Matching for Treatment Effects

保持可忽略性并实现协变量匹配的处理效应表示学习

Estimating treatment effects from observational data is challenging due to two main reasons: (a) hidden confounding, and (b) covariate mismatch (control and treatment groups not having identical distributions). Long lines of works exist that address only either of these issues. To address the former, conventional techniques that require detailed knowledge in the form of causal graphs have been proposed. For the latter, covariate matching and importance weighting methods have…

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When Knockoffs fail: diagnosing and fixing non-exchangeability of Knockoffs

当 Knockoffs 失效:诊断并修正 Knockoffs 的不可交换性

Knockoffs are a popular statistical framework that addresses the challenging problem of conditional variable selection in high-dimensional settings with statistical control. Such statistical control is essential for the reliability of inference. However, knockoff guarantees rely on an exchangeability assumption that is difficult to test in practice, and there is little discussion in the literature on how to deal with unfulfilled hypotheses. This assumption is related to the…

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Estimating treatment effects from observational data under truncation by death using survival-incorporated quantiles

死亡截断下利用纳入生存信息的分位数估计观测数据处理效应

The issue of "truncation by death" commonly arises in clinical research: subjects may die before their follow-up assessment, resulting in undefined clinical outcomes. To address this issue, we focus on survival-incorporated quantiles -- quantiles of a composite outcome combining death and clinical outcomes -- to summarize the effect of treatment. Using inverse probability of treatment weighting (IPTW), we propose an estimator for survival-incorporated quantiles from…

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Functional Sieve Bootstrap for the Partial Sum Process with Application to Change-Point Detection

部分和过程的函数型筛自助法及其变化点检测应用

This paper applies the functional sieve bootstrap (FSB) to estimate the distribution of the partial sum process for time series stemming from a weakly stationary functional process. Consistency of the FSB procedure under weak assumptions on the underlying functional process is established. This result allows for the application of the FSB procedure to testing for a change-point in the mean of a functional time series using the CUSUM-statistic. We show that the FSB…

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Semiparametric Conditional Factor Models in Asset Pricing

资产定价中的半参数条件因子模型

We introduce a simple and tractable methodology for estimating semiparametric conditional latent factor models. Our approach disentangles the roles of characteristics in capturing factor betas of asset returns from ``alpha.'' We construct factors by extracting principal components from Fama-MacBeth managed portfolios. Applying this methodology to the cross-section of U.S. individual stock returns, we find compelling evidence of substantial nonzero pricing errors, even though…

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Debiased Estimating Equation Method for Robust and Efficient Mendelian Randomization Using a Large Number of Correlated Weak and Invalid Instruments

使用大量相关弱工具和无效工具的稳健有效孟德尔随机化:去偏估计方程法

Mendelian randomization (MR) is a widely used tool for causal inference in the presence of unmeasured confounders, which uses single nucleotide polymorphisms (SNPs) as instrumental variables to estimate causal effects. However, SNPs often have weak effects on complex traits, leading to bias in existing MR analysis when weak instruments are included. In addition, existing MR methods often restrict analysis to independent SNPs via linkage disequilibrium clumping and result in…

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Selective randomization inference for subgroup effects with continuous biomarkers

连续生物标志物亚组效应的选择性随机化推断

Randomization tests are a popular method for testing causal effects in clinical trials with finite-sample validity. In the presence of heterogeneous treatment effects, it is often of interest to select a subgroup that benefits from the treatment, frequently by choosing a cutoff for a continuous biomarker. However, selecting the cutoff and testing the effect on the same data may fail to control the type I error. To address this, we propose using "self-contained" methods for…

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Negative Control Falsification Tests for Instrumental Variable Designs

工具变量设计的负对照证伪检验

The validity of instrumental variable (IV) designs is typically tested using two types of falsification tests. We characterize these tests as conditional independence tests between negative control variables -- proxies for unobserved variables posing a threat to the identification -- and the IV or the outcome. We describe the conditions that variables must satisfy in order to serve as negative controls. We show that these falsification tests examine not only independence and…

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Causal Q-Aggregation for CATE Model Selection

用于条件平均处理效应模型选择的因果 Q 聚合

Accurate estimation of conditional average treatment effects (CATE) is at the core of personalized decision making. While there is a plethora of models for CATE estimation, model selection is a nontrivial task, due to the fundamental problem of causal inference. Recent empirical work provides evidence in favor of proxy loss metrics with double robust properties and in favor of model ensembling. However, theoretical understanding is lacking. Direct application of prior…

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