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Distributional Matrix Completion via Nearest Neighbors in the Wasserstein Space

通过 Wasserstein 空间近邻进行分布矩阵补全

We study the problem of distributional matrix completion: Given a sparsely observed matrix of empirical distributions, we seek to impute the true distributions associated with both observed and unobserved matrix entries. This is a generalization of traditional matrix completion, where the observations per matrix entry are scalar-valued. To do so, we utilize tools from optimal transport to generalize the nearest neighbors method to the distributional setting. Under a suitable…

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Causal inference in network experiments: regression-based analysis and design-based properties

网络实验中的因果推断:回归分析与设计性质

Network experiments are powerful tools for studying spillover effects, which avoid endogeneity by randomly assigning treatments to units over networks. However, it is non-trivial to analyze network experiments properly without imposing strong modeling assumptions. We show that regression-based point estimators and standard errors can have strong theoretical guarantees if the regression functions and robust standard errors are carefully specified to accommodate the…

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Finite sample expansions and risk bounds in high-dimensional SLS models

高维SLS模型的有限样本展开与风险界

This note extends the results of classical parametric statistics like Fisher and Wilks theorem to modern setups with a high or infinite parameter dimension, limited sample size, and possible model misspecification. We consider a special class of stochastically linear smooth (SLS) models satisfying three major conditions: the stochastic component of the log-likelihood is linear in the model parameter and the expected log-likelihood is a smooth and concave function. For the…

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At the edge of Donsker's Theorem: Asymptotics of multiscale scan statistics

Donsker 定理的边界:多尺度扫描统计量的渐近理论

For nonparametric inference about a function, multiscale testing procedures resolve the need for bandwidth selection and achieve asymptotically optimal detection performance against a broad range of alternatives. However, critical values strongly depend on the noise distribution, and we argue that existing methods are either statistically infeasible, or asymptotically sub-optimal. To address this methodological challenge, we show how to develop a feasible multiscale test via…

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Distributed lag non-linear models with Laplacian-P-splines for analysis of spatially structured time series

用于空间结构时间序列的拉普拉斯 P 样条分布滞后非线性模型

Distributed lag non-linear models (DLNM) have gained popularity for modeling nonlinear lagged relationships between exposures and outcomes. When applied to spatially referenced data, these models must account for spatial dependence, a challenge that has yet to be thoroughly explored within the penalized DLNM framework. This gap is mainly due to the complex model structure and high computational demands, particularly when dealing with large spatio-temporal datasets. To…

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Proximal indirect comparison

近端间接比较

We consider the problem of indirect comparison, where a treatment arm of interest is absent by design in one randomized controlled trial but available in the other. The former is the target trial, and the latter is the source trial. The identifiability of the target population average treatment effect often relies on conditional transportability assumptions. However, it is a common concern whether all relevant effect modifiers are measured and controlled for. We give a new…

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Recover Experimental Data with Selection Bias using Counterfactual Logic

用反事实逻辑恢复存在选择偏差的实验数据

Selection bias, arising from the systematic inclusion or exclusion of certain samples, poses a significant challenge to the validity of causal inference. While Bareinboim et al. introduced methods for recovering unbiased observational and interventional distributions from biased data using partial external information, the complexity of the backdoor adjustment and the method's strong reliance on observational data limit its applicability in many practical settings. In this…

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Leveraging External Data for Testing Experimental Therapies with Biomarker Interactions in Randomized Clinical Trials

利用外部数据检验随机临床试验中的生物标志物交互效应

In oncology the efficacy of novel therapeutics often differs across patient subgroups, and these variations are difficult to predict during the initial phases of the drug development process. The relation between the power of randomized clinical trials and heterogeneous treatment effects has been discussed by several authors. In particular, false negative results are likely to occur when the treatment effects concentrate in a subpopulation but the study design did not…

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Robust and Agnostic Learning of Conditional Distributional Treatment Effects

条件分布处理效应的稳健与模型无关学习

The conditional average treatment effect (CATE) is the best measure of individual causal effects given baseline covariates. However, the CATE only captures the (conditional) average, and can overlook risks and tail events, which are important to treatment choice. In aggregate analyses, this is usually addressed by measuring the distributional treatment effect (DTE), such as differences in quantiles or tail expectations between treatment groups. Hypothetically, one can…

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Conventional and Fuzzy Data Envelopment Analysis with deaR

使用 deaR 进行常规与模糊数据包络分析

deaR is a recently developed R package for data envelopment analysis (DEA) that implements a large number of conventional and fuzzy models, along with super-efficiency models, cross-efficiency analysis, Malmquist index, bootstrapping, and metafrontier analysis. It should be noted that deaR is the only package to date that incorporates Kao-Liu, Guo-Tanaka and possibilistic fuzzy models. The versatility of the package allows the user to work with different returns to scale and…

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Mosaic inference on panel data

面板数据的马赛克推断

Analysis of panel data via linear regression is widespread across disciplines. To perform statistical inference, such analyses typically assume that clusters of observations are jointly independent. For example, one might assume that observations in New York are independent of observations in New Jersey. Are such assumptions plausible? Might there be hidden dependencies between nearby clusters? This paper introduces a mosaic permutation test that can (i) test the…

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Jointly modeling multiple endpoints for efficient treatment effect estimation in randomized controlled trials

联合建模多个终点以提高随机试验处理效应估计效率

Randomized controlled trials are the gold standard for evaluating the efficacy of an intervention. However, there is often a trade-off between selecting the most scientifically relevant primary endpoint versus a less relevant, but more powerful, endpoint. For example, in the context of tobacco regulatory science many trials evaluate cigarettes per day as the primary endpoint instead of abstinence from smoking due to limited power. Additionally, it is often of interest to…

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How to build your latent Markov model -- the role of time and space

如何构建潜在马尔可夫模型:时间与空间的作用

Statistical models that involve latent Markovian state processes have become immensely popular tools for analysing time series and other sequential data. However, the plethora of model formulations, the inconsistent use of terminology, and the various inferential approaches and software packages can be overwhelming to practitioners, especially when they are new to this area. With this review-like paper, we thus aim to provide guidance for both statisticians and practitioners…

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Kernel-based estimators for functional causal effects

函数型因果效应的核估计方法

We propose causal effect estimators based on empirical Fréchet means and operator-valued kernels, tailored to functional data spaces. These methods address the challenges of high-dimensionality, sequential ordering, and model complexity while preserving robustness to treatment misspecification. Using structural assumptions, we obtain compact representations of potential outcomes, enabling scalable estimation of causal effects over time and across covariates. We provide both…

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Deep Learning Enhanced Multivariate GARCH

深度学习增强的多变量 GARCH

This paper introduces a novel multivariate volatility modeling framework, named Long Short-Term Memory enhanced BEKK (LSTM-BEKK), that integrates deep learning into multivariate GARCH processes. By combining the flexibility of recurrent neural networks with the econometric structure of BEKK models, our approach is designed to better capture nonlinear, dynamic, and high-dimensional dependence structures in financial return data. The proposed model addresses key limitations of…

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On the Selection Stability of Stability Selection and Its Applications

稳定性选择的稳定性及其应用

Stability selection is a widely adopted resampling-based framework for high-dimensional variable selection. This paper seeks to broaden the use of an established stability estimator to evaluate the overall stability of the stability selection results, moving beyond single-variable analysis. We suggest that the stability estimator offers two advantages: it can serve as a reference to reflect the robustness of the results obtained, and it can help identify a Pareto optimal…

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Function-on-function Differential Regression

函数对函数微分回归

Function-on-function regression has been a topic of substantial interest due to its broad applicability, where the relation between functional predictor and response is concerned. In this article, we propose a new framework for modeling the regression mapping that extends beyond integral type, motivated by the prevalence of physical phenomena governed by differential relations, which is referred to as function-on-function differential regression. However, a key challenge…

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The High-Dimensional Asymptotics of Principal Component Regression

主成分回归的高维渐近理论

We study principal components regression (PCR) in an asymptotic high-dimensional regression setting, where the number of data points is proportional to the dimension. We derive exact limiting formulas for the estimation and prediction risks, which depend in a complicated manner on the eigenvalues of the population covariance, the alignment between the population PCs and the true signal, and the number of selected PCs. A key challenge in the high-dimensional setting stems…

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Ergodic Network Stochastic Differential Equations

遍历网络随机微分方程

We propose a novel framework for Network Stochastic Differential Equations (N-SDE), where each node in a network is governed by an SDE influenced by interactions with its neighbors. The evolution of each node is driven by the interplay of three key components: the node's intrinsic dynamics (\emph{momentum effect}), feedback from neighboring nodes (\emph{network effect}), and a \emph{stochastic volatility} term modeled by Brownian motion. Our primary objective is to estimate…

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Inference on Extreme Quantiles of Unobserved Individual Heterogeneity

不可观测个体异质性极端分位数的统计推断

We develop a methodology for conducting inference on extreme quantiles of unobserved individual heterogeneity (e.g., heterogeneous coefficients, treatment effects) in panel data and meta-analysis settings. Inference is challenging in such settings: only noisy estimates of heterogeneity are available, and central limit approximations perform poorly in the tails. We derive a necessary and sufficient condition under which noisy estimates are informative about extreme quantiles,…

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Falsification of Unconfoundedness by Testing Independence of Causal Mechanisms

通过检验因果机制独立性证伪无混杂假设

A major challenge in estimating treatment effects in observational studies is the reliance on untestable conditions such as the assumption of no unmeasured confounding. In this work, we propose an algorithm that can falsify the assumption of no unmeasured confounding in a setting with observational data from multiple heterogeneous sources, which we refer to as environments. Our proposed falsification strategy leverages a key observation that unmeasured confounding can cause…

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Uncovering Bias Mechanisms in Observational Studies

揭示观测研究中的偏差机制

Observational studies are a key resource for causal inference but are often affected by systematic biases. Prior work has focused mainly on detecting these biases, via sensitivity analyses and comparisons with randomized controlled trials, or mitigating them through debiasing techniques. However, there remains a lack of methodology for uncovering the underlying mechanisms driving these biases, e.g., whether due to hidden confounding or selection of participants. In this…

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Semiparametric Weighted Spline Regression (SWSR) in Confirmatory Clinical Trials with Time-Varying Placebo Effects

时变安慰剂效应确证性临床试验中的半参数加权样条回归

In confirmatory Phase 3 clinical trials with recruitment over the years, the underlying placebo effect may follow an unknown temporal trend. Taking a clinical trial on Hidradenitis Suppurativa (HS) as an example, fluctuations or variabilities are common in HS-related endpoints, mainly due to the natural disease characteristics, variations of evaluation from different physicians, and standard of care evolvement. The adjustment of time-varying placebo effects receives some…

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Projection Pursuit Density Ratio Estimation

投影寻踪密度比估计

Density ratio estimation (DRE) is a paramount task in machine learning, for its broad applications across multiple domains, such as covariate shift adaptation, causal inference, independence tests and beyond. Parametric methods for estimating the density ratio possibly lead to biased results if models are misspecified, while conventional non-parametric methods suffer from the curse of dimensionality when the dimension of data is large. To address these challenges, in this…

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