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临床试验设计阶段的胜率比AI 解读

The win ratio offers a flexible approach to incorporate the hierarchy of clinical outcomes into the analysis of a composite endpoint, enabling simultaneous consideration of multiple outcome types, unlike traditional time-to-first-event (TTFE) analysis or focus on a single outcome. We examined the statistical power of the win ratio compared to single-endpoint analyses and TTFE analysis through a case study and simulation studies. Furthermore, we provide a novel formula to…

自然中介效应与随机干预类比量差异的检测与理解AI 解读

In causal mediation analysis, the natural direct and indirect effects (natural effects) are nonparametrically unidentifiable in the presence of treatment-induced confounding, which motivated the development of randomized interventional analogues (RIAs) of the natural effects. Being easier to identify, the RIAs are becoming widely used in practice. However, applied researchers often interpret RIA estimates as if they were the natural effects, even though the RIAs can be poor…

近似消息传递的留一法AI 解读

Approximate message passing (AMP) has emerged both as a popular class of iterative algorithms and as a powerful analytic tool in a wide range of statistical estimation problems and statistical physics models. A well established line of AMP theory proves Gaussian approximations for the empirical distributions of the AMP iterate in the high dimensional limit, under the GOE random matrix model and its variants. This paper provides a non-asymptotic, leave-one-out representation…

面板数据估计与推断：同质性与异质性AI 解读

In this paper, we define an underlying data generating process that allows for different magnitudes of cross-sectional dependence, along with time series autocorrelation. This is achieved via high-dimensional moving average processes of infinite order (HDMA($\infty$)). Our setup and investigation integrates and enhances homogenous and heterogeneous panel data estimation and testing in a unified way. To study HDMA($\infty$), we extend the Beveridge-Nelson decomposition to a…

协变量分布与正值性违反对加权间接比较的影响：模拟研究AI 解读

Population-Adjusted Indirect Comparisons (PAICs) are used to estimate treatment effects when direct comparisons are infeasible and individual patient data (IPD) are only available for one trial. Among PAIC methods, Matching-Adjusted Indirect Comparison (MAIC) is the most widely used. However, little is known about how MAIC performs under challenging conditions such as limited covariate overlap or markedly non-normal covariate distributions. We conducted a Monte Carlo…

分层抽样下聚类失效时间的半参数加速失效时间模型变量选择AI 解读

In large-scale epidemiological studies, statistical inference is often complicated by high-dimensional covariates under stratified sampling designs for failure times. Variable selection methods developed for full cohort data do not extend naturally to stratified sampling designs, and appropriate adjustments for the sampling scheme are necessary. Further challenges arise when the failure times are clustered and exhibit within-cluster dependence. As an alternative of Cox…

用于双变量非高斯时间序列预测的广义自回归模型AI 解读

This paper introduces a novel approach, the bivariate generalized autoregressive (BGAR) model, for modeling and forecasting bivariate time series data. The BGAR model generalizes the bivariate vector autoregressive (VAR) models by allowing data that does not necessarily follow a normal distribution. We consider a random vector of two time series and assume each belongs to the canonical exponential family, similarly to the univariate generalized autoregressive moving average…

更好地理解三重差分估计量AI 解读

Triple Differences (DDD) designs are widely used in empirical work to relax parallel trends assumptions in Difference-in-Differences (DiD) settings. This paper highlights that common DDD implementations -- such as taking the difference between two DiDs or applying three-way fixed effects regressions -- are generally invalid when identification requires conditioning on covariates. In staggered adoption settings, the common DiD practice of pooling all not-yet-treated units as…

用立方体方法重新审视实验随机化AI 解读

We introduce a new randomization procedure for experiments based on the cube method, which achieves near-exact covariate balance. This ensures compliance with standard balance tests and allows for balancing on many covariates, enabling more precise estimation of treatment effects using pre-experimental information. We derive theoretical bounds on imbalance as functions of sample size and covariate dimension, and establish consistency and asymptotic normality of the resulting…

未观测混杂下双向近端因果推断的回归方法AI 解读

Proxy variables are commonly used in causal inference when unmeasured confounding exists. While most existing proximal methods assume a unidirectional causal relationship between two primary variables, many social and biological systems exhibit complex feedback mechanisms that imply bidirectional causality. In this paper, using regression-based models, we extend the proximal framework to identify bidirectional causal effects in the presence of unmeasured confounding. We…

半参数时间序列模型的伪方差准极大似然估计AI 解读

We propose a novel estimation approach for a general class of semi-parametric time series models where the conditional expectation is modeled through a parametric function. The proposed class of estimators is based on a Gaussian quasi-likelihood function and it relies on the specification of a parametric pseudo-variance that can contain parametric restrictions with respect to the conditional expectation. The specification of the pseudo-variance and the parametric…

多元非负观测驱动模型的两阶段加权最小二乘估计AI 解读

A novel estimation approach for a general class of semi-parametric multivariate time series models is introduced where the conditional mean is modeled through parametric functions. The focus of the estimation is the conditional mean parameter vector for non-negative time series. Quasi-Maximum Likelihood Estimators (QMLEs) based on the linear exponential family are typically employed for such estimation problems when the true multivariate conditional probability distribution…

半参数单指标模型下异质性处理效应的统计推断AI 解读

In recent years, with the rapid development of science and technology, heterogeneous treatment effects have emerged as a focal research topic in statistics, econometrics, and sociology. This paper investigates HTE through semiparametric single-index models based on doubly robust estimation. Departing from conventional approaches, we neither impose boundedness constraints on the link function in single-index models nor restrict its support range. By employing the sieve method…

重访伯克利录取数据：因果假设的统计检验AI 解读

Reasoning about fairness through correlation-based notions is rife with pitfalls. The 1973 University of California, Berkeley graduate school admissions case from Bickel et. al. (1975) is a classic example of one such pitfall, namely Simpson's paradox. The discrepancy in admission rates among males and female applicants, in the aggregate data over all departments, vanishes when admission rates per department are examined. We reason about the Berkeley graduate school…

将因果推断形式化为目标总体上的预测AI 解读

The standard approach to causal modelling especially in social and health sciences is the potential outcomes framework due to Neyman and Rubin. In this framework, observations are thought to be drawn from a distribution over variables of interest, and the goal is to identify parameters of this distribution. Even though the stated goal is often to inform decision making on some target population, there is no straightforward way to include these target populations in the…

因果—非因果VAR模型的非线性预测、回溯预测与创新过滤AI 解读

We show that the mixed causal-noncausal Vector Autoregressive (VAR) processes satisfy the Markov property in both calendar and reverse time. Based on that property, we introduce closed-form formulas of forward and backward predictive densities for point and interval forecasting and backcasting out-of-sample. The backcasting formula is used for adjusting the forecast interval to obtain a desired coverage level when the tail quantiles are difficult to estimate. A confidence…

元回归方法评估：地点与时间异质性的模拟研究AI 解读

In this paper, we conduct a simulation study with subject-level data to evaluate conventional meta-regression approaches (study-level random, fixed, and mixed effects) against seven methodology specifications new to meta-regressions that control joint heterogeneity in location and time (including a new one that we introduce). We systematically vary heterogeneity levels to assess statistical power, estimator bias and model robustness for each methodology specification. This…

For data segmentation in high-dimensional linear regression settings, the regression parameters are often assumed to be sparse segment-wise, which enables many existing methods to estimate the parameters locally via $\ell_1$-regularised maximum likelihood-type estimation and then contrast them for change point detection. Contrary to this common practice, we show that the exact sparsity of neither regression parameters nor their differences, a.k.a.\ differential parameters,…

高频金融数据的同步化AI 解读

Asynchronous trading in high-frequency financial markets introduces significant biases into econometric analysis, distorting risk estimates and leading to suboptimal portfolio decisions. Existing synchronization methods, such as the previous-tick approach, suffer from information loss and create artificial price staleness. We introduce a novel framework that recasts the data synchronization challenge as a constrained matrix completion problem. Our approach recovers the…

生命表死亡人数年龄分布的自助预测区间AI 解读

We introduce a nonparametric bootstrap procedure based on a dynamic factor model to construct pointwise prediction intervals for period life-table death counts. The age distribution of death counts is an example of constrained data, which are nonnegative and have a constrained integral. A centered log-ratio transformation is used to remove the constraints. With a time series of unconstrained data, we introduce our bootstrap method to construct prediction intervals, thereby…

事件时间结局自适应临床试验设计的一般贝叶斯方法AI 解读

Clinical trials are an integral component of medical research. Trials require careful design to, for example, maintain the safety of participants, use resources efficiently and allow clinically meaningful conclusions to be drawn. Adaptive clinical trials (i.e. trials that can be altered based on evidence that has accrued) are often more efficient, informative and ethical than standard or non-adaptive trials because they require fewer participants, target more promising…

保险数据惩罚回归模型的系数区间估计AI 解读

The Tweedie exponential dispersion family is a popular choice among many to model insurance losses that consist of zero-inflated semicontinuous data. In such data, it is often important to obtain credibility (inference) of the most important features that describe the endogenous variables. Post-selection inference is the standard procedure in statistics to obtain confidence intervals of model parameters after performing a feature extraction procedure. For a linear model, the…

构造目标最小损失／最大似然估计量：建立直觉的简单示例AI 解读

Use of machine learning to estimate nuisance functions (e.g. outcomes models, propensity score models) in estimators used in causal inference is increasingly common, as it can mitigate bias due to model misspecification. However, it can be challenging to achieve valid inference (e.g., estimate valid confidence intervals). The efficient influence function (EIF) provides a recipe to go from a statistical estimand relevant to our causal question, to an estimator that can…

INAR模型系数与创新分布的联合半参数自助推断AI 解读

For modeling the serial dependence in time series of counts, various approaches have been proposed in the literature. In particular, models based on a recursive, autoregressive-type structure such as the well-known integer-valued autoregressive (INAR) models are very popular in practice. The distribution of such INAR models is fully determined by a vector of autoregressive binomial thinning coefficients and the discrete innovation distribution. While fully parametric…