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随机设计下线性与核回归模型的渐近乐观度AI 解读

We derived the closed-form asymptotic optimism of linear regression models under random designs, and generalizes it to kernel ridge regression. Using scaled asymptotic optimism as a generic predictive model complexity measure, we studied the fundamental different behaviors of linear regression model, tangent kernel (NTK) regression model and three-layer fully connected neural networks (NN). Our contribution is two-fold: we provided theoretical ground for using scaled…

治疗不依从下因果生存分析的多重稳健估计AI 解读

Comparative effectiveness research frequently addresses a time-to-event outcome and can require unique considerations in the presence of treatment noncompliance. Motivated by the challenges in addressing noncompliance in the ADAPTABLE pragmatic clinical trial, we develop a multiply robust estimator to estimate the principal survival causal effects under the principal ignorability and monotonicity. The multiply robust estimator is consistent even if one, and sometimes two, of…

纵向因果推断中治疗模型的自适应稀疏化与平滑AI 解读

Causal variable selection in time-varying treatment settings is challenging due to evolving confounding effects. Existing methods mainly focus on time-fixed exposures and are not directly applicable to time-varying scenarios. We propose a novel two-step procedure for variable selection when modeling the treatment probability at each time point. We first introduce a novel approach to longitudinal confounder selection using a Longitudinal Outcome Adaptive LASSO (LOAL) that…

具有 S-vine Copula 结构的近似因子模型AI 解读

We propose a novel framework for approximate factor models that integrates an S-vine copula structure to capture complex dependencies among common factors. Our estimation procedure proceeds in two steps: first, we apply principal component analysis (PCA) to extract the factors; second, we employ maximum likelihood estimation that combines kernel density estimation for the margins with an S-vine copula to model the dependence structure. Jointly fitting the S-vine copula with…

化学反应网络中部分观测扩散过程的基于分裂格式的模拟推断AI 解读

We address the problem of simulation and parameter inference for chemical reaction networks described by the chemical Langevin equation, a stochastic differential equation (SDE) representation of the dynamics of the chemical species. This is challenging for two main reasons. First, the (multi-dimensional) SDEs cannot be explicitly solved and are driven by multiplicative and non-commutative noise, requiring the development of advanced numerical schemes for their approximation…

足球主场优势有多重要：英超联赛的因果推断分析AI 解读

In many sports, it is commonly believed that the home team has an advantage over the visiting team, known as the home field advantage. Yet its causal effect on team performance is largely unknown. In this paper, we propose a novel causal inference approach to study the causal effect of home field advantage in English Premier League. We develop a hierarchical causal model and show that both league level and team level causal effects are identifiable and can be conveniently…

特征与自回归滞后的贝叶斯联合选择：环境与金融预测应用AI 解读

We develop a Bayesian framework for variable selection in linear regression with autocorrelated errors, accommodating lagged covariates and autoregressive structures. This setting occurs in time series applications where responses depend on contemporaneous or past explanatory variables and persistent stochastic shocks, including financial modeling, hydrological forecasting, and meteorological applications requiring temporal dependency capture. Our methodology uses…

关联研究中的函数型方差分析AI 解读

While progress has been made in identifying common genetic variants associated with human diseases, for most of common complex diseases, the identified genetic variants only account for a small proportion of heritability. Challenges remain in finding additional unknown genetic variants predisposing to complex diseases. With the advance in next-generation sequencing technologies, sequencing studies have become commonplace in genetic research. The ongoing exome-sequencing and…

自相关数据下 Mann–Kendall tau 的高斯分布问题AI 解读

Non-parametric Mann-Kendall tests for autocorrelated data rely on the assumption that the distribution of the normalized Mann-Kendall tau is Gaussian. While this assumption holds asymptotically for stationary autoregressive processes of order 1 (AR(1)) and simple moving average (SMA) processes when sampling over an increasingly long period, it often fails for finite-length time series. In such cases, the empirical distribution of the Mann-Kendall tau deviates significantly…

早期临床试验中零膨胀生物标志物的两步检验AI 解读

In early-phase clinical trials, a predictive biomarker may identify subgroups that benefit from an experimental therapy, even when the overall average treatment effect is negligible. Recently proposed nonparametric interaction tests such as the Average Kolmogorov-Smirnov Approach (AKSA) avoid prespecified biomarker cutting points and model assumptions, but their power degrades when the biomarker distribution is zero-inflated. We propose a two-step test that partitions the…

基于条件线性规划的部分识别：估计与政策学习AI 解读

Many important quantities of interest are only partially identified from observable data: the data can limit them to a set of plausible values, but not uniquely determine them. This paper develops a unified framework for covariate-assisted estimation, inference, and decision making in partial identification problems where the parameter of interest satisfies a series of linear constraints, conditional on covariates. In such settings, bounds on the parameter can be written as…

固定时间维度下异质性面板模型的双向均值组估计AI 解读

We consider a correlated random coefficient panel data model with two-way fixed effects and interactive fixed effects in a fixed T framework. We propose a two-way mean group (TW-MG) estimator for the expected value of the slope coefficient and propose a leave-one-out jackknife method for valid inference. We also consider a pooled estimator and provide a Hausman-type test for poolability. Simulations demonstrate the excellent performance of our estimators and inference…

复杂函数型纵向研究的因果识别AI 解读

Real-time monitoring in modern medical research introduces functional longitudinal data, characterized by continuous-time measurements of outcomes, treatments, and confounders. This complexity leads to uncountably infinite treatment-confounder feedbacks, which traditional causal inference methodologies cannot handle. Inspired by the coarsened data framework, we adopt stochastic process theory, measure theory, and net convergence to propose a nonparametric causal…

治疗启动时间的增量因果效应AI 解读

We consider time to treatment initialization. This can commonly occur in preventive medicine, such as disease screening and vaccination; it can also occur with non-fatal health conditions such as HIV infection without the onset of AIDS; or in tech industry where items wait to be reviewed manually as abusive or not, etc. While traditional causal inference focused on `when to treat' and its effects, including their possible dependence on subject characteristics, we consider…

交错实施下的推断：以《平价医疗法案》为例AI 解读

Panel data consists of a collection of $N$ units that are observed over $T$ units of time. A policy or treatment is subject to staggered adoption if different units take on treatment at different times and remains treated (or never at all). Assessing the effectiveness of such a policy requires estimating the treatment effect, corresponding to the difference between outcomes for treated versus untreated units. We develop inference procedures that build upon a computationally…

协变量缺失时协变量自适应随机试验的回归调整AI 解读

Covariate-adaptive randomization is widely used in clinical trials to balance prognostic factors, and regression adjustments are often adopted to further enhance the estimation and inference efficiency. In practice, the covariates may contain missing values. Various methods have been proposed to handle the covariate missing problem under simple randomization. However, the statistical properties of the resulting average treatment effect estimators under stratified…

随机效应模型下多区域临床试验的一致性评估与样本量计算AI 解读

Multi-regional clinical trials (MRCTs) have become common practice for drug development and global registration. Once overall significance is established, demonstrating regional consistency is critical for local health authorities. Methods for evaluating such consistency and calculating regional sample sizes have been proposed based on the fixed effects model using various criteria. To better account for the heterogeneity of treatment effects across regions, the random…

M-learner：中介模型中异质处理效应的学习框架AI 解读

We propose a novel method, termed the M-learner, for estimating heterogeneous indirect and total treatment effects and identifying relevant subgroups within a mediation framework. The procedure comprises four key steps. First, we compute individual-level conditional average indirect/total treatment effect Second, we construct a distance matrix based on pairwise differences. Third, we apply tSNE to project this matrix into a low-dimensional Euclidean space, followed by…

配对簇随机试验中的推断AI 解读

This paper studies inference in cluster randomized trials where treatment status is determined according to a "matched pairs" design. Here, by a cluster randomized experiment, we mean one in which treatment is assigned at the level of the cluster; by a "matched pairs" design, we mean that a sample of clusters is paired according to baseline, cluster-level covariates and, within each pair, one cluster is selected at random for treatment. We study the large-sample behavior of…

图神经网络的过度压缩与重连策略的因果评估AI 解读

Graph neural networks (GNNs) have exhibited state-of-the-art performance across wide-range of domains such as recommender systems, material design, and drug repurposing. Yet message-passing GNNs suffer from over-squashing -- exponential compression of long-range information from distant nodes -- which limits expressivity. Rewiring techniques can ease this bottleneck; but their practical impacts are unclear due to the lack of a direct empirical over-squashing metric. We…

高维纵向数据下基于去稀疏化 Dantzig 选择器的统计推断AI 解读

In this paper, we consider statistical inference with generalized linear models in high dimensions under a longitudinal clustered data framework. Specifically, we propose a de-sparsified version of an initial Dantzig-type regularized estimator in regression settings and provide theoretical justification for both linear and generalized linear models. We present extensive numerical simulations demonstrating the effectiveness of our method for continuous and binary data. For…

观点：因果机器学习的广泛应用需要严格的合成实验AI 解读

Causal machine learning has the potential to revolutionize decision-making by combining the predictive power of machine learning algorithms with the theory of causal inference. However, these methods remain underutilized by the broader machine learning community, in part because current empirical evaluations do not permit assessment of their reliability and robustness, undermining their practical utility. Specifically, one of the principal criticisms made by the community is…

推动平均处理效应AI 解读

The instrumental variable method is a prominent approach to recover under certain conditions, valid inference about a treatment causal effect even when unmeasured confounding might be present. In a groundbreaking paper, Imbens and Angrist (1994) established that a valid instrument nonparametrically identifies the average causal effect among compliers, also known as the local average treatment effect under a certain monotonicity assumption which rules out the existence of…

基于 Copula 标准化流的未观测混杂敏感性分析AI 解读

We propose a novel method for sensitivity analysis to unobserved confounding in causal inference. The method builds on a copula-based causal graphical normalizing flow that we term $ρ$-GNF, where $ρ\in [-1,+1]$ is the sensitivity parameter. The parameter represents the non-causal association between exposure and outcome due to unobserved confounding, which is modeled as a Gaussian copula. In other words, the $ρ$-GNF enables scholars to estimate the average causal effect…