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Inferring Change Points in High-Dimensional Regression via Approximate Message Passing

高维回归中变点的近似消息传递推断

We consider the problem of localizing change points in a generalized linear model (GLM), a model that covers many widely studied problems in statistical learning including linear, logistic, and rectified linear regression. We propose a novel and computationally efficient Approximate Message Passing (AMP) algorithm for estimating both the signals and the change point locations, and rigorously characterize its performance in the high-dimensional limit where the number of…

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Treatment Effects of Multi-Valued Treatments in Hyper-Rectangle Model

超矩形模型中多值处理的处理效应

This study investigates the identification of marginal treatment responses within multi-valued treatment models. Extending the hyper-rectangle model introduced by Lee and Salanie (2018), this paper relaxes restrictive assumptions, including the requirement of known treatment selection thresholds and the dependence of treatments on all unobserved heterogeneity. By incorporating an additional ranked treatment assumption, this study demonstrates that the marginal treatment…

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Tail-robust factor modelling of vector and tensor time series in high dimensions

高维向量与张量时间序列的重尾稳健因子建模

We study the problem of factor modelling vector- and tensor-valued time series in the presence of heavy tails in the data, which produce extreme observations with non-negligible probability. We propose to combine a two-step procedure for tensor decomposition with data truncation, which is easy to implement and does not require an iterative search for a numerical solution. Departing away from the light-tail assumptions often adopted in the time series factor modelling…

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Semi-supervised inference for treatment heterogeneity

处理效应异质性的半监督推断

In causal inference, measuring treatment heterogeneity is crucial as it provides scientific insights into how treatments influence outcomes and guides personalized decision-making. In this work, we study semi-supervised settings where a labeled dataset is accompanied by a large unlabeled dataset, and develop semi-supervised estimators for two measures of treatment heterogeneity: the total treatment heterogeneity (TTH) and the explained treatment heterogeneity (ETH) of a…

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Optimal Estimation for General Gaussian Processes

一般高斯过程的最优估计

This paper proposes a novel exact maximum likelihood (ML) estimation method for general Gaussian processes, where all parameters are estimated jointly. The exact ML estimator (MLE) is consistent and asymptotically normally distributed. We prove the local asymptotic normality (LAN) property of the sequence of statistical experiments for general Gaussian processes in the sense of Le Cam, thereby enabling optimal estimation and facilitating statistical inference. The results…

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A Latent Class Bayesian Model for Multivariate Longitudinal Outcomes with Excess Zeros

含超额零值的多变量纵向结果的潜类别贝叶斯模型

Latent class models have been successfully used to handle complex datasets in different disciplines. For longitudinal outcomes, we often get a trajectory of the outcome for each individual, and on that basis, we cluster them for a powerful statistical inference. Latent class models have been used to handle multivariate longitudinal outcomes coming from biology, health sciences, and economics. In this paper, we propose a Bayesian latent class model for multivariate outcomes…

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Strong Consistency of the SIMEX Estimator in Linear Regression with a Conditionally Poisson Covariate

条件泊松协变量线性回归中 SIMEX 估计量的强相合性

This paper considers estimation for linear regression analysis with covariate measurement error arising from Poisson surrogates. We consider cases where covariates follow a conditional Poisson distribution, capturing non-Gaussian and heteroscedastic error structures. To address this, we extend the simulation extrapolation (SIMEX) algorithm to the conditional Poisson setting (POI-SIMEX), enabling robust adjustment in the absence of internal validation data. Theoretical…

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Precision Mental Health: Predicting Heterogeneous Treatment Effects for Depression through Data Integration

精准精神健康:通过数据整合预测抑郁症的异质性处理效应

When treating depression, clinicians are interested in determining the optimal treatment for a given patient, which is challenging given the amount of treatments available. To advance individualized treatment allocation, integrating data across multiple randomized controlled trials (RCTs) can enhance our understanding of treatment effect heterogeneity by increasing available information. However, extending these inferences to individuals outside of the original RCTs remains…

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An Interpretable Ensemble Framework for Multi-Omics Dementia Biomarker Discovery Under HDLSS Conditions

HDLSS条件下多组学痴呆生物标志物发现的可解释集成框架

Biomarker discovery in neurodegenerative diseases requires robust, interpretable frameworks capable of integrating high-dimensional multi-omics data under low-sample conditions. We propose a novel ensemble approach combining Graph Attention Networks (GAT), MultiOmics Variational AutoEncoder (MOVE), Elastic-net sparse regression, and Storey's False Discovery Rate (FDR). This framework is benchmarked against state-of-the-art methods including DIABLO, MOCAT, AMOGEL, and MOMLIN.…

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Reduce-Rank Matrix Integer-Valued Autoregressive Model

降秩矩阵整数值自回归模型

Integer-valued time series are widely present in many fields, such as finance, economics, disease transmission, and traffic flow. With data dimensions surging, the traditional multivariate generalized integer autoregressive (MGINAR) model faces parameter overload, poor interpretability, and structural information loss. Matrix integer-valued autoregression (MINAR) model captures row-column cross-correlations and reduces the number of parameters to be estimated. However,…

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Estimation of High-Dimensional Markov-Switching VAR Models with an Approximate EM Algorithm

利用近似EM算法估计高维马尔可夫切换VAR模型

Regime shifts in high-dimensional time series arise naturally in many applications, from neuroimaging to finance. This problem has received considerable attention in low-dimensional settings, with both Bayesian and frequentist methods used extensively for parameter estimation. The EM algorithm is a particularly popular strategy for parameter estimation in low-dimensional settings, although the statistical properties of the resulting estimates have not been well understood.…

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Sharp Bounds on the Variance of General Regression Adjustment in Randomized Experiments

随机实验中一般回归调整的方差锐界

A growing statistical literature focuses on causal inference in the context of experiments where the target of inference is the average treatment effect in a finite population and random assignment determines which subjects are allocated to one of the experimental conditions. In this framework, variances of average treatment effect estimators remain unidentified because they depend on the covariance between treated and untreated potential outcomes, which are never jointly…

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An integrated method for clustering and association network inference

聚类与关联网络推断的整合方法

High dimensional Gaussian graphical models provide a rigorous framework to describe a network of statistical dependencies between entities, such as genes in genomic regulation studies or species in ecology. Penalized methods, including the standard Graphical-Lasso, are well-known approaches to infer the parameters of these models. As the number of variables in the model (of entities in the network) grow, the network inference and interpretation become more complex. The…

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Evaluation of Stress Detection as Time Series Events -- A Novel Window-Based F1-Metric

将压力检测视为时间序列事件:一种窗口式F1指标

Accurate evaluation of event detection in time series is essential for applications such as stress monitoring with wearable devices, where ground truth is typically annotated as single-point events, even though the underlying phenomena are gradual and temporally diffused. Standard metrics like F1 and point-adjusted F1 (F1$_{pa}$) often misrepresent model performance in such real-world, imbalanced datasets. We introduce a window-based F1 metric (F1$_w$) that incorporates…

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Bayesian Network Propensity Score to Evaluate Treatment Effects in Observational Studies

用于观察性研究处理效应评估的贝叶斯网络倾向得分

This paper focuses on the Bayesian Network Propensity Score (BNPS), a novel approach for estimating treatment effects in observational studies characterized by unknown (and likely unbalanced) designs and complex dependency structures among covariates. Traditional methods, such as logistic regression, often impose rigid parametric assumptions that may lead to misspecification errors, compromising causal inference. Recent classical and machine learning alternatives, such as…

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Distal Causal Excursion Effects: Modeling Long-Term Effects of Time-Varying Treatments in Micro-Randomized Trials

远期因果偏离效应:微随机试验中时变处理的长期效应建模

Micro-randomized trials (MRTs) play a crucial role in optimizing digital interventions. In an MRT, each participant is sequentially randomized among treatment options hundreds of times. While the interventions tested in MRTs target short-term behavioral responses (proximal outcomes), their ultimate goal is to drive long-term behavior change (distal outcomes). However, existing causal inference methods, such as the causal excursion effect, are limited to proximal outcomes,…

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Calibrated sensitivity models

校准敏感性模型

In causal inference, sensitivity models assess how unmeasured confounders could alter causal analyses, but the sensitivity parameter -- which quantifies the degree of unmeasured confounding -- is often difficult to interpret. For this reason, researchers sometimes compare the sensitivity parameter to an estimate of measured confounding. This is known as calibration, or benchmarking. However, calibrated estimates are not always interpreted correctly, and uncertainty in the…

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Statistical Inference for Heterogeneous Treatment Effect with Right-censored Data from Synthesizing Randomized Clinical Trials and Real-world Data

融合随机试验与真实世界右删失数据的异质处理效应推断

The heterogeneous treatment effect plays a crucial role in precision medicine.There is evidence that real-world data, even subject to biases, can be employed as supplementary evidence for randomized clinical trials to improve the statistical efficiency of the heterogeneous treatment effect estimation. In this paper, for survival data with right censoring, we consider estimating the heterogeneous treatment effect, defined as the difference of the treatment-specific…

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Causal Spatial Quantile Regression

因果空间分位数回归

Treatment effects in a wide range of economic, environmental, and epidemiological applications often vary across space, and understanding the heterogeneity of causal effects across space and outcome quantiles is a critical challenge in spatial causal inference. To effectively capture spatial heterogeneity in distributional treatment effects, we propose a novel semiparametric neural network-based causal framework leveraging deep spatial quantile regression and then construct…

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Bayesian Estimation and Regularization Techniques in Categorical Data Analysis

分类数据分析中的贝叶斯估计与正则化方法

This paper explores Bayesian estimation for categorical data, focusing on simple yet effective models that provide a foundation for applying more advanced methods accurately and reliably in real-world applications. We begin by revisiting Bayesian estimators for the binomial distribution and investigating their properties. Next, we develop hypothesis tests for categorical data (sign test, homogeneity test, symmetry test) based on regularized maximum likelihood estimates of…

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Interpretational errors with instrumental variables

工具变量研究中的解释错误

Instrumental variables (IV) are often used to identify causal effects in observational settings and experiments subject to non-compliance. Under canonical assumptions, IVs allow us to identify a so-called local average treatment effect (LATE). The use of IVs is often accompanied by a pragmatic decision to abandon the identification of the causal parameter that corresponds to the original research question and target the LATE instead. This pragmatic decision presents a…

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Semi-supervised linear regression: enhancing efficiency and robustness in high dimensions

半监督线性回归:高维下提升效率与稳健性

In semi-supervised learning, the prevailing understanding suggests that observing additional unlabeled samples improves estimation accuracy for linear parameters only in the case of model misspecification. In this work, we challenge such a claim and show that additional unlabeled samples are beneficial in high-dimensional settings. Initially focusing on a dense scenario, we introduce robust semi-supervised estimators for the regression coefficient without relying on sparse…

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Monitoring Time Series for Relevant Changes

时间序列中具有实质意义变化的在线监测

We consider the problem of sequentially testing for changes in the mean parameter of a time series, compared to a benchmark period. Most tests in the literature focus on the null hypothesis of a constant mean versus the alternative of a single change at an unknown time. Yet in many applications it is unrealistic that no change occurs at all, or that after one change the time series remains stationary forever. We introduce a new setup, modeling the sequence of means as a…

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On the Estimation of Multinomial Logit and Nested Logit Models: A Conic Optimization Approach

多项 Logit 与嵌套 Logit 估计的锥优化方法

In this paper, we revisit parameter estimation for multinomial logit (MNL), nested logit (NL), and tree-nested logit (TNL) models through the framework of convex conic optimization. Traditional approaches typically solve the maximum likelihood estimation (MLE) problem using gradient-based methods, which are sensitive to step-size selection and initialization, and may therefore suffer from slow or unstable convergence. In contrast, we propose a novel estimation strategy that…

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