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Causal inference of post-transcriptional regulation timelines from long-read sequencing in Arabidopsis thaliana

利用拟南芥长读长测序推断转录后调控时间线

We propose a novel framework for reconstructing the chronology of genetic regulation using causal inference based on Pearl's theory. The approach proceeds in three main stages: causal discovery, causal inference, and chronology construction. We apply it to the ndhB and ndhD genes of the chloroplast in Arabidopsis thaliana, generating four alternative maturation timeline models per gene, each derived from a different causal discovery algorithm (HC, PC, LiNGAM, or NOTEARS).…

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Finite-Sample Distortion in Kernel Specification Tests: A Perturbation Analysis of Empirical Directional Components

核设定检验的有限样本失真:经验方向分量的扰动分析

This paper provides a new theoretical lens for understanding the finite-sample performance of kernel-based specification tests, such as the Kernel Conditional Moment (KCM) test. Rather than introducing a fundamentally new test, we isolate and rigorously analyze the finite-sample distortion arising from the discrepancy between the empirical and population eigenspaces of the kernel operator. Using perturbation theory for compact operators, we demonstrate that the estimation…

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Almost Dominance: Inference and Application

近似占优关系:统计推断与应用

This paper proposes a general framework for inference on three types of almost dominances: almost Lorenz dominance, almost inverse stochastic dominance, and almost stochastic dominance. We first generalize almost Lorenz dominance to almost upward and downward Lorenz dominances. We then provide a bootstrap inference procedure for the Lorenz dominance coefficients, which measure the degrees of almost Lorenz dominance. Furthermore, we propose almost upward and downward inverse…

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Optimal break tests for large linear time series models

大型线性时间序列模型中的最优结构突变检验

We develop a class of optimal tests for a structural break occurring at an unknown date in infinite and growing-order time series regression models, such as AR($\infty$), linear regression with increasingly many covariates, and nonparametric regression. Under an auxiliary i.i.d. Gaussian error assumption, we derive an average power optimal test, establishing a growing-dimensional analog of the exponential tests of Andrews and Ploberger (1994) to handle identification failure…

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Interactive, Grouped and Non-separable Fixed Effects: A Practitioner's Guide to the New Panel Data Econometrics

交互、分组与非可分固定效应:新面板计量方法的实践指南

The past 20 years have brought fundamental advances in modeling unobserved heterogeneity in panel data. Interactive Fixed Effects (IFE) proved to be a foundational framework, generalizing the standard one-way and two-way fixed effects models by allowing the unit-specific unobserved heterogeneity to be interacted with unobserved time-varying common factors, allowing for more general forms of omitted variables. The IFE framework laid the theoretical foundations for other forms…

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L2-relaxation for Economic Prediction

经济预测中的L2松弛方法

We leverage an ensemble of many regressors, the number of which can exceed the sample size, for economic prediction. An underlying latent factor structure implies a dense regression model with highly correlated covariates. We propose the L2-relaxation method for estimating the regression coefficients and extrapolating the out-of-sample (OOS) outcomes. This framework can be applied to policy evaluation using the panel data approach (PDA), where we further establish inference…

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Constrained Identifiability of Causal Effects

约束条件下因果效应的可识别性

We study the identification of causal effects in the presence of different types of constraints (e.g., logical constraints) in addition to the causal graph. These constraints impose restrictions on the models (parameterizations) induced by the causal graph, reducing the set of models considered by the identifiability problem. We formalize the notion of constrained identifiability, which takes a set of constraints as another input to the classical definition of…

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Gaussian Approximation for High-Dimensional $U$-statistics with Size-Dependent Kernels

样本量依赖核的高维U统计量高斯近似

Motivated by small bandwidth asymptotics for kernel-based semiparametric estimators in econometrics, this paper establishes Gaussian approximation results for high-dimensional fixed-order $U$-statistics whose kernels depend on the sample size. Our results allow for a situation where the dominant component of the Hoeffding decomposition is absent or unknown, including cases with known degrees of degeneracy as special forms. The obtained error bounds for Gaussian…

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Disentangling network dependence among multiple variables

分离多个变量之间的共同网络依赖

When two variables depend on the same or similar underlying network, their shared network dependence structure can lead to spurious associations. While statistical associations between two variables sampled from interconnected subjects are a common inferential goal across various fields, little research has focused on how to disentangle shared dependence for valid statistical inference. We revisit two different approaches from distinct fields that may address shared network…

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The Power of Prognosis: Improving Covariate Balance Tests with Outcome Information

预后信息的力量:利用结局信息改进协变量平衡检验

Scholars frequently use covariate balance tests to test the validity of natural experiments and related designs. Unfortunately, when measured covariates are unrelated to potential outcomes, balance is uninformative about key identification conditions. We show that balance tests can then lead to erroneous conclusions. To build stronger tests, researchers should identify covariates that are jointly predictive of potential outcomes; formally measure and report covariate…

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Developing an information criterion for spatial data analysis through Bayesian generalized fused lasso

面向空间数据分析的贝叶斯广义融合套索信息准则

In the field of spatial data analysis, spatially varying coefficients (SVC) models, which allow regression coefficients to vary by region and flexibly capture spatial heterogeneity, have continued to be developed in various directions. Moreover, the Bayesian generalized fused lasso is often used as a method that efficiently provides estimation under the natural assumption that regression coefficients of adjacent regions tend to take the same value. In most Bayesian methods,…

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Discovering and Reasoning of Causality in the Hidden World with Large Language Models

借助大语言模型发现隐含变量并开展因果发现与推理

Revealing hidden causal variables alongside the underlying causal mechanisms is essential to the development of science. Despite the progress in the past decades, existing practice in causal discovery (CD) heavily relies on high-quality measured variables, which are usually given by human experts. In fact, the lack of well-defined high-level variables behind unstructured data has been a longstanding roadblock to a broader real-world application of CD. This procedure can…

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Dimension Reduction for Conditional Density Estimation with Applications to High-Dimensional Causal Inference

条件密度估计的降维及其在高维因果推断中的应用

We propose a novel and computationally efficient approach for nonparametric conditional density estimation in high-dimensional settings that achieves dimension reduction without imposing restrictive distributional or functional form assumptions. To uncover the underlying sparsity structure of the data, we develop an innovative conditional dependence measure and a modified cross-validation procedure that enables data-driven variable selection, thereby circumventing the need…

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Identification and Estimation of Heterogeneous Interference Effects under Unknown Network

未知网络下异质性干扰效应的识别与估计

Interference--in which a unit's outcome is affected by the treatment of other units--poses significant challenges for the identification and estimation of causal effects. Most existing methods for estimating interference effects assume that the interference networks are known. In many practical settings, this assumption is unrealistic as such networks are typically latent. To address this challenge, we propose a novel framework for identifying and estimating heterogeneous…

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Density-valued time series: Nonparametric density-on-density regression

密度值时间序列:非参数密度对密度回归

This paper is concerned with forecasting probability density functions. Density functions are nonnegative and have a constrained integral; thus, they do not constitute a vector space. Implementing unconstrained functional time-series forecasting methods is problematic for such nonlinear and constrained data. A novel forecasting method is developed based on a nonparametric function-on-function regression, where both the response and the predictor are probability density…

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Applying non-negative matrix factorization with covariates to label matrix for classification

带协变量的非负矩阵分解用于标签矩阵分类

Non-negative matrix factorization (NMF) is widely used for dimensionality reduction and interpretable analysis, but standard formulations are unsupervised and cannot directly exploit class labels. Existing supervised or semi-supervised extensions usually incorporate labels only via penalties or graph constraints, still requiring an external classifier. We propose \textit{NMF-LAB} (Non-negative Matrix Factorization for Label Matrix), which redefines classification as the…

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A burn-in(g) question: How long should an initial equal randomization stage be before Bayesian response-adaptive randomization?

贝叶斯响应自适应随机化之前的等概率随机分配阶段应多长?

Response-adaptive randomization (RAR) can increase participant benefit in clinical trials, but also complicates statistical analysis. The burn-in period (a non-adaptive initial stage) is commonly used to mitigate this disadvantage, yet guidance on its optimal duration is scarce. To address this critical gap, this paper introduces an exact evaluation approach to investigate how the burn-in length impacts statistical operating characteristics of two-arm binary Bayesian RAR…

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Predictive posteriors under hidden confounding

隐藏混杂下的预测后验

Predicting outcomes in external domains is challenging due to hidden confounders that potentially influence both predictors and outcomes. Well-established methods frequently rely on stringent assumptions, explicit knowledge about the distribution shift across domains, or bias-inducing regularization schemes to enhance generalization. While recent developments in point prediction under hidden confounding attempt to mitigate these shortcomings, they generally do not provide…

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A Unified Framework for Spatial and Temporal Treatment Effect Boundaries: Theory and Identification

空间与时间处理效应边界的统一框架:理论与识别

This paper develops a unified theoretical framework for detecting and estimating boundaries in treatment effects across both spatial and temporal dimensions. We formalize the concept of treatment effect boundaries as structural parameters characterizing regime transitions where causal effects cease to operate. Building on reaction-diffusion models of information propagation, we establish conditions under which spatial and temporal boundaries share common dynamics governed by…

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Estimating Continuous Treatment Effects in Panel Data using Machine Learning with a Climate Application

利用机器学习估计面板数据连续处理效应:气候应用

Economists often estimate continuous treatment effects in panel data using linear two-way fixed effects models (TWFE). When the treatment-outcome relationship is nonlinear, TWFE is misspecifed and potentially biased for the average partial derivative (APD). We develop an automatic double/de-biased machine learning (ADML) estimator that is consistent for the population APD while allowing additive unit fixed effects, nonlinearities, and high dimensional heterogeneity. We prove…

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Hypothesis testing on invariant subspaces of non-diagonalizable matrices with applications to network statistics

不可对角化矩阵不变子空间的假设检验及网络统计应用

We generalise the inference procedure for eigenvectors of symmetrizable matrices of Tyler (1981) to that of invariant and singular subspaces of non-diagonalizable matrices. Wald tests for invariant vectors and $t$-tests for their individual coefficients perform well in simulations, despite the matrix being not symmetric. Using these results, it is now possible to perform inference on network statistics that depend on eigenvectors of non-symmetric adjacency matrices as they…

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Statistical methods: Basic concepts, interpretations, and cautions

统计方法:基本概念、解释与注意事项

The study of associations and their causal explanations is a central research activity whose methodology varies tremendously across fields. Even within specialized subfields, comparisons across textbooks and journals reveals that the basics are subject to considerable variation and controversy. This variation is often obscured by the singular viewpoints presented within textbooks and journal guidelines, which may be deceptively written as if the norms they adopt are…

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PrivATE: Differentially Private Confidence Intervals for Average Treatment Effects

PrivATE:平均处理效应的差分隐私置信区间

The average treatment effect (ATE) is widely used to evaluate the effectiveness of drugs and other medical interventions. In safety-critical applications like medicine, reliable inferences about the ATE typically require valid uncertainty quantification, such as through confidence intervals (CIs). However, estimating treatment effects in these settings often involves sensitive data that must be kept private. In this work, we present PrivATE, a novel machine learning…

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Team Networks with Partially Observed Links

链接部分可观测的团队网络

This paper studies a linear production model in team networks with missing links. In the model, heterogeneous workers, represented as nodes, produce jointly and repeatedly within teams, represented as links. Links are omitted when their associated outcome variables fall below a threshold, resulting in partial observability of the network. To address this, I propose a Generalized Method of Moments estimator under normally distributed errors and develop a distribution-free…

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