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Mendelian Randomization Methods for Causal Inference: Estimands, Identification and Inference

孟德尔随机化因果推断方法:估计对象、识别与推断

Mendelian randomization (MR) has become an essential tool for causal inference in biomedical and public health research. By using genetic variants as instrumental variables, MR helps address unmeasured confounding and reverse causation, offering a quasi-experimental framework to evaluate causal effects of modifiable exposures on health outcomes. Despite its promise, MR faces substantial methodological challenges, including invalid instruments, weak instrument bias, and…

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Cross-Validated Causal Inference: a Modern Method to Combine Experimental and Observational Data

交叉验证因果推断:结合实验与观察数据的方法

We develop new methods to integrate experimental and observational data in causal inference. While randomized controlled trials offer strong internal validity, they are often costly and therefore limited in sample size. Observational data, though cheaper and often with larger sample sizes, are prone to biases due to unmeasured confounders. To harness their complementary strengths, we propose a systematic framework that formulates causal estimation as an empirical risk…

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A Distance Covariance-based Estimator

基于距离协方差的估计量

This paper proposes an estimator that relaxes the conventional relevance condition in instrumental variable (IV) analyses. The method allows endogenous covariates to be weakly correlated, uncorrelated, or even mean-independent -- though not independent -- of the instruments, enabling the use of the maximal set of relevant instruments in a given application. Identification is attainable without exclusion restrictions and without finite-moment assumptions on the disturbance…

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Robust Bayesian Inference of Causal Effects via Randomization Distributions

基于随机化分布的稳健贝叶斯因果效应推断

We present a general framework for Bayesian inference of causal effects that delivers provably robust inferences founded on design-based randomization of treatments. The framework involves fixing the observed potential outcomes and forming a likelihood based on the randomization distribution of a statistic. The method requires specification of a treatment effect model; in many cases, however, it does not require specification of marginal outcome distributions, resulting in…

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Dynamical mean-field analysis of adaptive Langevin diffusions: Propagation-of-chaos and convergence of the linear response

自适应 Langevin 扩散的动力学平均场分析:混沌传播与线性响应收敛

Motivated by an application to empirical Bayes learning in high-dimensional regression, we study a class of Langevin diffusions in a system with random disorder, where the drift coefficient is driven by a parameter that continuously adapts to the empirical distribution of the realized process up to the current time. The resulting dynamics take the form of a stochastic interacting particle system having both a McKean-Vlasov type interaction and a pairwise interaction defined…

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Dynamical mean-field analysis of adaptive Langevin diffusions: Replica-symmetric fixed point and empirical Bayes

自适应 Langevin 扩散的动力学平均场分析:复本对称不动点与经验贝叶斯

In many applications of statistical estimation via sampling, one may wish to sample from a high-dimensional target distribution that is adaptively evolving to the samples already seen. We study an example of such dynamics, given by a Langevin diffusion for posterior sampling in a Bayesian linear regression model with i.i.d. regression design, whose prior continuously adapts to the Langevin trajectory via a maximum marginal-likelihood scheme. Results of dynamical mean-field…

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Penalized Empirical Likelihood for Doubly Robust Causal Inference under Contamination in High Dimensions

污染下高维双重稳健因果推断的惩罚经验似然

We propose a doubly robust estimator for the average treatment effect in high dimensional low sample size observational studies, where contamination and model misspecification pose serious inferential challenges. The estimator combines bounded influence estimating equations for outcome modeling with covariate balancing propensity scores for treatment assignment, embedded within a penalized empirical likelihood framework using nonconvex regularization. It satisfies the oracle…

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Residual Balancing for Non-Linear Outcome Models in High Dimensions

高维非线性结果模型的残差平衡

We extend the approximate residual balancing (ARB) framework to nonlinear models, answering an open problem posed by Athey et al. (2018). Our approach addresses the challenge of estimating average treatment effects in high-dimensional settings where the outcome follows a generalized linear model. We derive a new bias decomposition for nonlinear models that reveals the need for a second-order correction to account for the curvature of the link function. Based on this insight,…

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Agnostic Characterization of Interference in Randomized Experiments

随机实验中干扰效应的弱假设刻画

We give an approach for characterizing interference by lower bounding the number of units whose outcome depends on selected groups of treated individuals, such as depending on the treatment of others, or others who are at least a certain distance away. The approach is applicable to randomized experiments with binary-valued outcomes. Asymptotically conservative point estimates and one-sided confidence intervals may be constructed with no assumptions beyond the known…

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Testing Inequalities Linear in Nuisance Parameters

对干扰参数呈线性的不等式检验

This paper proposes a new test for inequalities that are linear in possibly partially identified nuisance parameters. This type of hypothesis arises in a broad set of problems, including subvector inference for linear unconditional moment (in)equality models, specification testing of such models, and inference for parameters bounded by linear programs. The new test uses a two-step test statistic and a chi-squared critical value with data-dependent degrees of freedom that can…

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Robust Spectral Fuzzy Clustering of Multivariate Time Series with Applications to Electroencephalogram

多元时间序列的稳健谱模糊聚类及其脑电应用

Clustering multivariate time series (MTS) is challenging due to non-stationary cross-dependencies, noise contamination, and gradual or overlapping state boundaries. We introduce a robust fuzzy clustering framework in the spectral domain that leverages Kendall's tau-based canonical coherence to extract frequency-specific monotonic relationships across variables. Our method takes advantage of dominant frequency-based cross-regional connectivity patterns to improve clustering…

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A Unified Framework for Identification and Inference of Local Treatment Effects in Sharp Regression Kink Designs

尖锐回归折点设计中局部处理效应识别与推断的统一框架

This paper develops a unified framework for the identification, estimation, and uniform inference of local treatment effects (LTEs) in sharp regression kink designs (RKDs). These LTEs quantify the effect of a marginal change in the treatment at the kink point on various features of the outcome distribution. The identification strategy applies to Hadamard-differentiable functionals of the outcome distribution -- including means, quantiles, and inequality measures -- and…

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Testing for Peer Effects without Specifying the Network Structure

无需指定网络结构的同伴效应检验

This paper proposes an Anderson-Rubin (AR) test for the presence of peer effects in panel data without the need to specify the network structure. The unrestricted model of our test is a linear panel data model of social interactions with dyad-specific peer effect coefficients for all potential peers. The proposed AR test evaluates if these peer effect coefficients are all zero. As the number of peer effect coefficients increases with the sample size, so does the number of…

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A Unified Theory for Causal Inference: Direct Debiased Machine Learning via Bregman-Riesz Regression

因果推断的统一理论:通过 Bregman-Riesz 回归实现直接去偏机器学习

This note introduces a unified theory for causal inference that integrates Riesz regression, covariate balancing, density-ratio estimation (DRE), targeted maximum likelihood estimation (TMLE), and the matching estimator in average treatment effect (ATE) estimation. In ATE estimation, the balancing weights and the regression functions of the outcome play important roles, where the balancing weights are referred to as the Riesz representer, bias-correction term, and clever…

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Smoothed Quantile Estimation via Interpolation to the Mean

通过向均值插值实现的平滑分位数估计

This paper introduces a unified family of smoothed quantile estimators that continuously interpolate between classical empirical quantiles and the sample mean. The estimators q(z, h) are defined as minimizers of a regularized objective function depending on two parameters: a smoothing parameter h $\ge$ 0 and a location parameter z $\in$ R. When h = 0 and z $\in$ (-1, 1), the estimator reduces to the empirical quantile of order $τ$ = (1z)/2; as h $\rightarrow$ $\infty$, it…

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Predictive Causal Inference via Spatio-Temporal Modeling and Penalized Empirical Likelihood

结合时空建模与惩罚经验似然的预测型因果推断

This study introduces an integrated framework for predictive causal inference designed to overcome limitations inherent in conventional single model approaches. Specifically, we combine a Hidden Markov Model (HMM) for spatial health state estimation with a Multi Task and Multi Graph Convolutional Network (MTGCN) for capturing temporal outcome trajectories. The framework asymmetrically treats temporal and spatial information regarding them as endogenous variables in the…

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Chiseling: Powerful and Valid Subgroup Selection via Interactive Machine Learning

Chiseling:通过交互式机器学习选择子群并保证推断有效性

In regression and causal inference, controlled subgroup selection aims to identify, with inferential guarantees, a subgroup (defined as a subset of the covariate space) on which the average response or treatment effect is above a given threshold. E.g., in a clinical trial, it may be of interest to find a subgroup with a positive average treatment effect. However, existing methods either lack inferential guarantees, heavily restrict the search for the subgroup, or sacrifice…

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Inference on Welfare and Value Functionals under Optimal Treatment Assignment

最优处理分配下福利与价值泛函的推断

We provide theoretical results for the estimation and inference of a class of welfare and value functionals of the nonparametric conditional average treatment effect (CATE) function under optimal treatment assignment, i.e., treatment is assigned to an observed type if and only if its CATE is nonnegative. For the optimal welfare functional defined as the average value of CATE on the subpopulation with nonnegative CATE, we establish the $\sqrt{n}$ asymptotic normality of the…

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Latent Factor Analysis in Short Panels

短面板中的潜在因子分析

We develop a pseudo maximum likelihood method for latent factor analysis in short panels without imposing sphericity nor Gaussianity. We derive an asymptotically uniformly most powerful invariant test for the number of factors. On a large panel of monthly U.S. stock returns, we separate month after month systematic and idiosyncratic risks in short subperiods of bear vs. bull market. We observe an uptrend in the paths of total and idiosyncratic volatilities. The systematic…

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Improving time series estimation and prediction via transfer learning

通过迁移学习改善时间序列估计与预测

There are many time series in the literature with high dimension yet limited sample sizes, such as macroeconomic variables, and it is almost impossible to obtain efficient estimation and accurate prediction by using the corresponding datasets themselves. This paper fills the gap by introducing a novel representation-based transfer learning framework for vector autoregressive models, and information from related source datasets with rich observations can be leveraged to…

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Replicable Bandits for Digital Health Interventions

数字健康干预中的可重复多臂老虎机算法

Adaptive treatment assignment algorithms, such as bandit algorithms, are increasingly used in digital health intervention clinical trials. Frequently, the data collected from these trials is used to conduct causal inference and related data analyses to decide how to refine the intervention, and whether to roll-out the intervention more broadly. This work studies inference for estimands that depend on the adaptive algorithm itself; a simple example is the mean reward under…

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Efficient Adaptive Experimentation with Noncompliance

存在不依从时的高效自适应实验

We study the problem of estimating the average treatment effect (ATE) in adaptive experiments where treatment can only be encouraged -- rather than directly assigned -- via a binary instrumental variable. Building on semiparametric efficiency theory, we derive the efficiency bound for ATE estimation under arbitrary, history-dependent instrument-assignment policies, and show it is minimized by a variance-aware allocation rule that balances outcome noise and compliance…

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Machine-Learning-Assisted Comparison of Regression Functions

机器学习辅助的回归函数比较

We revisit the classical problem of comparing regression functions, a fundamental question in statistical inference with broad relevance to modern applications such as data integration, transfer learning, and causal inference. Existing approaches typically rely on smoothing techniques and are thus hindered by the curse of dimensionality. We propose a generalized notion of kernel-based conditional mean dependence that provides a new characterization of the null hypothesis of…

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GST-UNet: A Neural Framework for Spatiotemporal Causal Inference with Time-Varying Confounding

GST-UNet:处理时变混杂的时空因果推断神经框架

Estimating causal effects from spatiotemporal observational data is essential in public health, environmental science, and policy evaluation, where randomized experiments are often infeasible. Existing approaches, however, either rely on strong structural assumptions or fail to handle key challenges such as interference, spatial confounding, temporal carryover, and time-varying confounding -- where covariates are influenced by past treatments and, in turn, affect future…

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