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观察性研究中的因果效应估计框架：混杂调整与工具变量比较AI 解读

To estimate causal effects, analysts performing observational studies in health settings utilize several strategies to mitigate bias due to confounding by indication. There are two broad classes of approaches for these purposes: use of confounders and instrumental variables (IVs). Because such approaches are largely characterized by untestable assumptions, analysts must operate under an indefinite paradigm that these methods will work imperfectly. In this tutorial, we…

允许条件依赖的潜在类别模型AI 解读

Latent Class Models (LCMs) are used to cluster multivariate categorical data (e.g. group participants based on survey responses). Traditional LCMs assume a property called conditional independence. This assumption can be restrictive, leading to model misspecification and overparameterization. To combat this problem, we developed a novel Bayesian model called a Dependent Latent Class Model (DLCM), which permits conditional dependence. We verify identifiability of DLCMs. We…

微生物组数据中组成型中介效应选择的贝叶斯联合模型AI 解读

Analyzing multivariate count data generated by high-throughput sequencing technology in microbiome research studies is challenging due to the high-dimensional and compositional structure of the data and overdispersion. In practice, researchers are often interested in investigating how the microbiome may mediate the relation between an assigned treatment and an observed phenotypic response. Existing approaches designed for compositional mediation analysis are unable to…

存在中间混杂时用于因果中介分析的非行动主体干预AI 解读

Recent approaches to causal inference have focused on causal effects defined as contrasts between the distribution of counterfactual outcomes under hypothetical interventions on the nodes of a graphical model. In this article we develop theory for causal effects defined with respect to a different type of intervention, one which alters the information propagated through the edges of the graph. These information transfer interventions may be more useful than node…

选择无效工具变量以改进双样本汇总数据的孟德尔随机化AI 解读

Mendelian randomization (MR) is a widely-used method to estimate the causal relationship between a risk factor and disease. A fundamental part of any MR analysis is to choose appropriate genetic variants as instrumental variables. Genome-wide association studies often reveal that hundreds of genetic variants may be robustly associated with a risk factor, but in some situations investigators may have greater confidence in the instrument validity of only a smaller subset of…

条件增量效应的非参数估计AI 解读

Conditional effect estimation has great scientific and policy importance because interventions may impact subjects differently depending on their characteristics. Most research has focused on estimating the conditional average treatment effect (CATE). However, identification of the CATE requires all subjects have a non-zero probability of receiving treatment, or positivity, which may be unrealistic in practice. Instead, we propose conditional effects based on incremental…

结合变分自编码器与前门准则的因果效应估计AI 解读

An essential problem in causal inference is estimating causal effects from observational data. The problem becomes more challenging with the presence of unobserved confounders. When there are unobserved confounders, the commonly used back-door adjustment is not applicable. Although the instrumental variable (IV) methods can deal with unobserved confounders, they all assume that the treatment directly affects the outcome, and there is no mediator between the treatment and the…

利用次序统计量识别拍卖模型AI 解读

Auction data often contain information on only the most competitive bids as opposed to all bids. The usual measurement error approaches to unobserved heterogeneity are inapplicable due to dependence among order statistics. We bridge this gap by providing a set of positive identification results. First, we show that symmetric auctions with discrete unobserved heterogeneity are identifiable using two consecutive order statistics and an instrument. Second, we extend the results…

有偏样本选择下的政策学习AI 解读

Practitioners often use data from a randomized controlled trial to learn a treatment assignment policy that can be deployed on a target population. A recurring concern in doing so is that, even if the randomized trial was well-executed (i.e., internal validity holds), the study participants may not represent a random sample of the target population (i.e., external validity fails)--and this may lead to policies that perform suboptimally on the target population. We consider a…

大量弱工具变量下的条件线性组合检验AI 解读

We consider a linear combination of jackknife Anderson-Rubin (AR), jackknife Lagrangian multiplier (LM), and orthogonalized jackknife LM tests for inference in IV regressions with many weak instruments and heteroskedasticity. Following I.Andrews (2016), we choose the weights in the linear combination based on a decision-theoretic rule that is adaptive to the identification strength. Under both weak and strong identifications, the proposed test controls asymptotic size and is…

无效工具变量下的因果推断：选择后问题与搜索、抽样解法AI 解读

Instrumental variable methods are among the most commonly used causal inference approaches to deal with unmeasured confounders in observational studies. The presence of invalid instruments is the primary concern for practical applications, and a fast-growing area of research is inference for the causal effect with possibly invalid instruments. This paper illustrates that the existing confidence intervals may undercover when the valid and invalid instruments are hard to…

线性与非参数工具变量模型中的处理效应同质性检验AI 解读

The hypothesis of homogeneous treatment effects is central to the instrumental variables literature. This assumption signifies that treatment effects are constant across all subjects. It allows to interpret instrumental variable estimates as average treatment effects over the whole population of the study. When this assumption does not hold, the bias of instrumental variable estimators can be larger than that of naive estimators ignoring endogeneity. This paper develops two…

载荷状态切换的高维因子模型：估计与推断AI 解读

This paper proposes maximum (quasi)likelihood estimation for high dimensional factor models with regime switching in the loadings. The model parameters are estimated jointly by the EM (expectation maximization) algorithm, which in the current context only requires iteratively calculating regime probabilities and principal components of the weighted sample covariance matrix. When regime dynamics are taken into account, smoothed regime probabilities are calculated using a…

将预测模型与因果效应估计相连接AI 解读

A predictive model makes outcome predictions based on some given features, i.e., it estimates the conditional probability of the outcome given a feature vector. In general, a predictive model cannot estimate the causal effect of a feature on the outcome, i.e., how the outcome will change if the feature is changed while keeping the values of other features unchanged. This is because causal effect estimation requires interventional probabilities. However, many real world…

任意噪声加性模型中基于分数匹配的因果发现AI 解读

Causal discovery methods are intrinsically constrained by the set of assumptions needed to ensure structure identifiability. Moreover additional restrictions are often imposed in order to simplify the inference task: this is the case for the Gaussian noise assumption on additive non-linear models, which is common to many causal discovery approaches. In this paper we show the shortcomings of inference under this hypothesis, analyzing the risk of edge inversion under violation…

PStrata：用于主分层分析的 R 软件包AI 解读

Post-treatment confounding is a common problem in causal inference, including special cases of noncompliance, truncation by death, surrogate endpoint, etc. Principal stratification (Frangakis and Rubin 2002) is a general framework for defining and estimating causal effects in the presence of post-treatment confounding. A prominent special case is the instrumental variable approach to noncompliance in randomized experiments (Angrist, Imbens, and Rubin 1996). Despite its…

存在干扰、不依从和结果缺失的两阶段随机实验贝叶斯分析AI 解读

Three critical issues for causal inference that often occur in modern, complicated experiments are interference, treatment nonadherence, and missing outcomes. A great deal of research efforts has been dedicated to developing causal inferential methodologies that address these issues separately. However, methodologies that can address these issues simultaneously are lacking. We propose a Bayesian causal inference methodology to address this gap. Our methodology extends…

csa2sls：面向多工具变量的 Stata 完全子集平均方法AI 解读

We develop a Stata command $\texttt{csa2sls}$ that implements the complete subset averaging two-stage least squares (CSA2SLS) estimator in Lee and Shin (2021). The CSA2SLS estimator is an alternative to the two-stage least squares estimator that remedies the bias issue caused by many correlated instruments. We conduct Monte Carlo simulations and confirm that the CSA2SLS estimator reduces both the mean squared error and the estimation bias substantially when instruments are…

纠缠缺失的图模型AI 解读

Despite the growing interest in causal and statistical inference for settings with data dependence, few methods currently exist to account for missing data in dependent data settings; most classical missing data methods in statistics and causal inference treat data units as independent and identically distributed (i.i.d.). We develop a graphical modeling based framework for causal inference in the presence of entangled missingness, defined as missingness with data…

通过因果边际问题界定致因概率AI 解读

Probabilities of Causation play a fundamental role in decision making in law, health care and public policy. Nevertheless, their point identification is challenging, requiring strong assumptions such as monotonicity. In the absence of such assumptions, existing work requires multiple observations of datasets that contain the same treatment and outcome variables, in order to establish bounds on these probabilities. However, in many clinical trials and public policy evaluation…

替代与互补关系模式的检验和识别AI 解读

This paper studies semiparametric identification of substitution and complementarity patterns between two goods using a panel multinomial choice model with bundles. The model allows the two goods to be either substitutes or complements and admits heterogeneous complementarity through observed characteristics. I first provide testable implications for the complementarity relationship between goods. I then characterize the sharp identified set for the model parameters and…

TSCI：利用无效工具变量进行因果推断的两阶段曲率识别AI 解读

TSCI implements treatment effect estimation from observational data under invalid instruments in the R statistical computing environment. Existing instrumental variable approaches rely on arguably strong and untestable identification assumptions, which limits their practical application. TSCI does not require the classical instrumental variable identification conditions and is effective even if all instruments are invalid. TSCI implements a two-stage algorithm. In the first…

离散工具变量与处理误报下边际处理效应的部分识别AI 解读

This paper provides partial identification results for the marginal treatment effect ($MTE$) when the binary treatment variable is potentially misreported and the instrumental variable is discrete. Identification results are derived under different sets of nonparametric assumptions. The identification results are illustrated in identifying the marginal treatment effects of food stamps on health.

实时监测经济：实际活动与价格的趋势和缺口AI 解读

We propose two specifications of a real-time mixed-frequency semi-structural time series model for evaluating the output potential, output gap, Phillips curve, and Okun's law for the US. The baseline model uses minimal theory-based multivariate identification restrictions to inform trend-cycle decomposition, while the alternative model adds the CBO's output gap measure as an observed variable. The latter model results in a smoother output potential and lower cyclical…