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Mixing Samples to Address Weak Overlap in Causal Inference

通过混合样本应对因果推断中的弱重叠

In observational studies, the assumption of sufficient overlap (positivity) is fundamental for the identification and estimation of causal effects. Failing to account for this assumption yields inaccurate and potentially infeasible estimators. To address this issue, we introduce a simple yet novel approach, \textit{mixing}, which mitigates overlap violations by constructing a synthetic treated group that combines treated and control units. Our strategy offers three key…

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Estimation of the complier causal hazard ratio under dependent censoring

依赖删失下服从者因果风险比的估计

In this work, we are interested in studying the causal effect of an endogenous binary treatment on a dependently censored duration outcome. By dependent censoring, it is meant that the duration time ($T$) and right censoring time ($C$) are not statistically independent of each other, even after conditioning on the measured covariates. The endogeneity issue is handled by making use of a binary instrumental variable for the treatment. To deal with the dependent censoring…

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A Causal Inference Framework for Data Rich Environments

数据丰富环境下的因果推断框架

We propose a formal model for counterfactual estimation with unobserved confounding in "data-rich" settings, i.e., where there are a large number of units and a large number of measurements per unit. Our model provides a bridge between the structural causal model view of causal inference common in the graphical models literature with that of the latent factor model view common in the potential outcomes literature. We show how classic models for potential outcomes and…

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Unsupervised domain adaptation under hidden confounding

隐藏混杂下的无监督领域适应

We introduce a new predictive mechanism that operates in the presence of hidden confounding across distributionally diverse data sources while ensuring consistent estimation of causal parameters-despite their recognized suboptimality for prediction in the literature. Our method is based on a novel estimand that captures the dependence structure between response noise and covariates, incorporating causal parameters into a generative model that adaptively replicates the…

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Noise-Induced Randomization in Regression Discontinuity Designs

断点回归设计中的噪声诱导随机化

Regression discontinuity designs assess causal effects in settings where treatment is determined by whether an observed running variable crosses a pre-specified threshold. Here we propose a new approach to identification, estimation, and inference in regression discontinuity designs that uses knowledge about exogenous noise (e.g., measurement error) in the running variable. In our strategy, we weight treated and control units to balance a latent variable of which the running…

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A Unified Approach for Estimating Various Treatment Effects in Causal Inference

因果推断中多类处理效应的统一估计方法

In this paper, we introduce a unified estimator to analyze various treatment effects in causal inference, including but not limited to the average treatment effect (ATE) and the quantile treatment effect (QTE). The proposed estimator is developed under the statistical functional and cumulative distribution function structure, which leads to a flexible and robust estimator and covers some frequent treatment effects. In addition, our approach also takes variable selection into…

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Identification and estimation of treatment effects in a linear factor model with fixed number of time periods

固定时期数线性因子模型中处理效应的识别与估计

This paper provides a new approach for identifying and estimating the Average Treatment Effect on the Treated under a linear factor model that allows for multiple time-varying unobservables. Unlike the majority of the literature on treatment effects in linear factor models, our approach does not require the number of pre-treatment periods to go to infinity to obtain a valid estimator. Our identification approach employs a certain nonlinear transformations of the time…

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Dynamic Regression Discontinuity: An Event-Study Approach

动态断点回归:事件研究方法

I propose a novel argument to identify economically interpretable intertemporal treatment effects in dynamic regression discontinuity designs (RDDs). Specifically, I develop a dynamic potential outcomes model and reformulate two assumptions from the difference-in-differences literature, no anticipation and common trends, to attain point identification of cutoff-specific impulse responses. The estimand of each target parameter can be expressed as the sum of two static RDD…

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Copula-based Sensitivity Analysis for Multi-Treatment Causal Inference with Unobserved Confounding

未观测混杂下多处理因果推断的copula敏感性分析

Recent work has focused on the potential and pitfalls of causal identification in observational studies with multiple simultaneous treatments. Building on previous work, we show that even if the conditional distribution of unmeasured confounders given treatments were known exactly, the causal effects would not in general be identifiable, although they may be partially identified. Given these results, we propose a sensitivity analysis method for characterizing the effects of…

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Large Structural VARs with Multiple Sign and Ranking Restrictions

具有多重符号与排序限制的大型结构VAR

Large VARs are increasingly used in structural analysis as a unified framework to study the impacts of multiple structural shocks simultaneously. However, the concurrent identification of multiple shocks using sign and ranking restrictions poses significant practical challenges to the point where existing algorithms cannot be used with such large VARs. To address this, we introduce a new numerically efficient algorithm that facilitates the estimation of impulse responses and…

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Bounds on the Distribution of a Sum of Two Random Variables: Revisiting a problem of Kolmogorov with application to Individual Treatment Effects

两个随机变量之和的分布界:重访Kolmogorov问题及个体处理效应应用

We revisit the following problem, proposed by Kolmogorov: given prescribed marginal distributions $F$ and $G$ for random variables $X,Y$ respectively, characterize the set of compatible distribution functions for the sum $Z=X+Y$. Bounds on the distribution function for $Z$ were first given by Markarov (1982) and Rüschendorf (1982) independently. Frank et al. (1987) provided a solution to the same problem using copula theory. However, though these authors obtain the same…

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Identification of Average Treatment Effects in Nonparametric Panel Models

非参数面板模型中平均处理效应的识别

This paper studies identification of average treatment effects in a panel data setting. It introduces a novel nonparametric factor model and proves identification of average treatment effects. The identification proof is based on the introduction of a consistent estimator. Underlying the proof is a result that there is a consistent estimator for the expected outcome in the absence of the treatment for each unit and time period; this result can be applied more broadly, for…

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Adding covariates to bounds: What is the question?

给识别界加入协变量:究竟要回答什么问题?

Symbolic nonparametric bounds for partial identification of causal effects now have a long history in the causal literature. Sharp bounds, bounds that use all available information to make the range of values as narrow as possible, are often the goal. For this reason, many publications have focused on deriving sharp bounds, but the concept of sharp bounds is nuanced and can be misleading. In settings with ancillary covariates, the situation becomes more complex. We provide…

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Local Interference: Removing Interference Bias in Semi-Parametric Causal Models

局部干扰:半参数因果模型中干扰偏差的消除

Interference bias is a major impediment to identifying causal effects in real-world settings. For example, vaccination reduces the transmission of a virus in a population such that everyone benefits -- even those who are not treated. This is a source of bias that must be accounted for if one wants to learn the true effect of a vaccine on an individual's immune system. Previous approaches addressing interference bias require strong domain knowledge in the form of a graphical…

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Score matching through the roof: linear, nonlinear, and latent variables causal discovery

基于得分匹配的线性、非线性与潜变量因果发现

Causal discovery from observational data holds great promise, but existing methods rely on strong assumptions about the underlying causal structure, often requiring full observability of all relevant variables. We tackle these challenges by leveraging the score function $\nabla \log p(X)$ of observed variables for causal discovery and propose the following contributions. First, we fine-tune the existing identifiability results with the score on additive noise models, showing…

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Nonparametric Factor Analysis and Beyond

非参数因子分析及其拓展

Nearly all identifiability results in unsupervised representation learning inspired by, e.g., independent component analysis, factor analysis, and causal representation learning, rely on assumptions of additive independent noise or noiseless regimes. In contrast, we study the more general case where noise can take arbitrary forms, depend on latent variables, and be non-invertibly entangled within a nonlinear function. We propose a general framework for identifying latent…

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Multi-View Orthogonal Projection Regression with Application in Multi-omics integration

多视图正交投影回归及其在多组学整合中的应用

Multi-omics integration offers novel insights into complex biological mechanisms by utlizing the fused information from various omics datasets. However, the inherent within- and inter-modality correlations in multi-omics data present significant challenges for traditional variable selection methods, such as Lasso regression. These correlations can lead to multicollinearity, compromising the stability and interpretability of selected variables. To address these problems, we…

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Integrative Analysis of High-dimensional RCT and RWD Subject to Censoring and Hidden Confounding

删失与隐藏混杂下高维随机试验和真实世界数据的整合分析

In this study, we focus on estimating the heterogeneous treatment effect (HTE) for survival outcome. The outcome is subject to censoring and the number of covariates is high-dimensional. We utilize data from both the randomized controlled trial (RCT), considered as the gold standard, and real-world data (RWD), possibly affected by hidden confounding factors. To achieve a more efficient HTE estimate, such integrative analysis requires great insight into the data generation…

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Robust Identification in Randomized Experiments with Noncompliance

存在不依从的随机实验中的稳健识别

Instrument variable (IV) methods are widely used in empirical research to identify causal effects of a policy. In the local average treatment effect (LATE) framework, the IV estimand identifies the LATE under three main assumptions: random assignment, exclusion restriction, and monotonicity. However, these assumptions are often questionable in many applications, leading some researchers to doubt the causal interpretation of the IV estimand. This paper considers a robust…

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A Shrinkage Likelihood Ratio Test for High-Dimensional Subgroup Analysis with a Logistic-Normal Mixture Model

逻辑斯蒂—正态混合模型下高维亚组分析的收缩似然比检验

In subgroup analysis, testing the existence of a subgroup with a differential treatment effect serves as protection against spurious subgroup discovery. Despite its importance, this hypothesis testing possesses a complicated nature: parameter characterizing subgroup classification is not identified under the null hypothesis of no subgroup. Due to this irregularity, the existing methods have the following two limitations. First, the asymptotic null distribution of test…

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Linear programming approach to partially identified econometric models

部分识别计量模型的线性规划方法

Sharp bounds on partially identified parameters are often given by the values of linear programs (LPs). This paper introduces a novel estimator of the LP value. Unlike existing procedures, our estimator is root-n-consistent, pointwise in the probability measure, whenever the population LP is feasible and finite. Our estimator is valid under point-identification, over-identifying constraints, and solution multiplicity. Turning to uniformity properties, we prove that the LP…

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Counterfactual Generative Modeling with Variational Causal Inference

基于变分因果推断的反事实生成建模

Estimating an individual's counterfactual outcomes under interventions is a challenging task for traditional causal inference and supervised learning approaches when the outcome is high-dimensional (e.g. gene expressions, facial images) and covariates are relatively limited. In this case, to predict one's outcomes under counterfactual treatments, it is crucial to leverage individual information contained in the observed outcome in addition to the covariates. Prior works…

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A flexible control function approach for survival data subject to different types of censoring

适用于多种删失机制的生存数据灵活控制函数方法

This paper addresses the problem of identifying and estimating the causal effect of a treatment in the presence of unmeasured confounding and various types of right-censoring. Examples of these censoring mechanisms are administrative censoring, competing risks and dependent censoring (e.g. loss to follow-up). Different parametric transformations are applied to each event time, resulting in a regression model with a more additive structure and error terms that are…

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Regularized Parameter Estimation in Mixed Model Trace Regression

混合模型迹回归中的正则化参数估计

We introduce mixed model trace regression (MMTR), a mixed model linear regression extension for scalar responses and high-dimensional matrix-valued covariates. MMTR's fixed effects component is equivalent to trace regression, with an element-wise lasso penalty imposed on the regression coefficients matrix to facilitate the estimation of a sparse mean parameter. MMTR's key innovation lies in modeling the covariance structure of matrix-variate random effects as a Kronecker…

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