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关联研究中的函数型方差分析AI 解读

While progress has been made in identifying common genetic variants associated with human diseases, for most of common complex diseases, the identified genetic variants only account for a small proportion of heritability. Challenges remain in finding additional unknown genetic variants predisposing to complex diseases. With the advance in next-generation sequencing technologies, sequencing studies have become commonplace in genetic research. The ongoing exome-sequencing and…

早期临床试验中零膨胀生物标志物的两步检验AI 解读

In early-phase clinical trials, a predictive biomarker may identify subgroups that benefit from an experimental therapy, even when the overall average treatment effect is negligible. Recently proposed nonparametric interaction tests such as the Average Kolmogorov-Smirnov Approach (AKSA) avoid prespecified biomarker cutting points and model assumptions, but their power degrades when the biomarker distribution is zero-inflated. We propose a two-step test that partitions the…

基于条件线性规划的部分识别：估计与政策学习AI 解读

Many important quantities of interest are only partially identified from observable data: the data can limit them to a set of plausible values, but not uniquely determine them. This paper develops a unified framework for covariate-assisted estimation, inference, and decision making in partial identification problems where the parameter of interest satisfies a series of linear constraints, conditional on covariates. In such settings, bounds on the parameter can be written as…

时间 Wasserstein 插补：一种灵活的时间序列缺失值方法AI 解读

Missing data can significantly hamper standard time series analysis, yet they occur frequently in applications. In this paper, we introduce temporal Wasserstein imputation, a novel method for imputing missing data in time series. Unlike most existing techniques, our approach is fully nonparametric, circumventing the need for model specification prior to imputation, making it suitable for empirical applications even with nonlinear dynamics. Its principled algorithmic…

复杂函数型纵向研究的因果识别AI 解读

Real-time monitoring in modern medical research introduces functional longitudinal data, characterized by continuous-time measurements of outcomes, treatments, and confounders. This complexity leads to uncountably infinite treatment-confounder feedbacks, which traditional causal inference methodologies cannot handle. Inspired by the coarsened data framework, we adopt stochastic process theory, measure theory, and net convergence to propose a nonparametric causal…

治疗启动时间的增量因果效应AI 解读

We consider time to treatment initialization. This can commonly occur in preventive medicine, such as disease screening and vaccination; it can also occur with non-fatal health conditions such as HIV infection without the onset of AIDS; or in tech industry where items wait to be reviewed manually as abusive or not, etc. While traditional causal inference focused on `when to treat' and its effects, including their possible dependence on subject characteristics, we consider…

推动平均处理效应AI 解读

The instrumental variable method is a prominent approach to recover under certain conditions, valid inference about a treatment causal effect even when unmeasured confounding might be present. In a groundbreaking paper, Imbens and Angrist (1994) established that a valid instrument nonparametrically identifies the average causal effect among compliers, also known as the local average treatment effect under a certain monotonicity assumption which rules out the existence of…

未观测混杂的多元回归分析AI 解读

Whereas confidence intervals are used to assess uncertainty due to unmeasured individuals, confounding intervals can be used to assess uncertainty due to unmeasured attributes. Previously, we have introduced a methodology for computing confounding intervals in a simple regression setting in a paper titled ``Regression Analysis of Unmeasured Confounding." Here we extend that methodology for more general application in the context of multiple regression. Our multiple…

结构周期向量自回归AI 解读

While seasonality inherent to raw macroeconomic data is commonly removed by seasonal adjustment techniques before it is used for structural inference, this may distort valuable information in the data. As an alternative method to commonly used structural vector autoregressions (SVARs) for seasonally adjusted data, we propose to model potential periodicity in seasonally unadjusted (raw) data directly by structural periodic vector autoregressions (SPVARs). This approach does…

连续工具变量下局部处理效应的非参数估计AI 解读

Instrumental variable methods are widely used to address unmeasured confounding, yet much of the existing literature has focused on the binary instrument setting. Extensions to continuous instruments often impose strong parametric assumptions for identification and estimation, which can be difficult to justify and may limit their applicability in complex real-world settings. In this work, we develop theory and methods for nonparametric estimation of treatment effects with a…

用于因果推断中自动混杂发现与子群分析的大语言模型智能体AI 解读

Estimating individualized treatment effects from observational data presents a persistent challenge due to unmeasured confounding and structural bias. Causal Machine Learning (causal ML) methods, such as causal trees and doubly robust estimators, provide tools for estimating conditional average treatment effects. These methods have limited effectiveness in complex real-world environments due to the presence of latent confounders or those described in unstructured formats.…

跨反事实世界的倾向得分加权：正值性违背下的纵向效应AI 解读

When examining a contrast between two interventions, longitudinal causal inference studies frequently encounter positivity violations when one or both regimes are impossible to observe for some subjects. Existing weighting methods either assume positivity holds or produce effects that conflate interventions' impacts on ultimate outcomes with their effects on intermediate treatments and covariates. We propose a novel class of estimands -- cumulative cross-world weighted…

函数型因子回归及其在电价曲线建模中的应用AI 解读

We propose a function-on-function linear regression model for time-dependent curve data that is consistently estimated by imposing factor structures on the regressors. An integral operator based on cross-covariances identifies two components for each functional regressor: a predictive low-dimensional component, along with associated factors that are guaranteed to be correlated with the dependent variable, and an infinite-dimensional component that has no predictive power. In…

积分方程解的线性泛函置信集合的渐近有效性AI 解读

This paper examines the construction of confidence sets for parameters defined as linear functionals of a function of W and X whose conditional mean given Z and X equals the conditional mean of another variable Y given Z and X. Many estimands of interest in causal inference can be expressed in this form, including the average treatment effect in proximal causal inference and treatment effect contrasts in instrumental variable models. We derive a necessary condition for a…

误差方差弱递增下最小迹有向无环图的可识别性与爬山搜索AI 解读

We prove that the true underlying directed acyclic graph (DAG) in Gaussian linear structural equation models is identifiable as the minimum-trace DAG when the error variances are weakly increasing with respect to the true causal ordering. This result bridges two existing frameworks as it extends the identifiable cases within the minimum-trace DAG method and provides a principled interpretation of the algorithmic ordering search approach, revealing that its objective is…

基于邻域选择的矩阵变量数据图估计AI 解读

Undirected graphical models are powerful tools for uncovering complex relationships among high-dimensional variables. This paper aims to fully recover the structure of an undirected graphical model when the data naturally take matrix form, such as temporal multivariate data. As conventional vector-variate analyses have clear limitations in handling such matrix-structured data, several approaches have been proposed, mostly relying on the likelihood of the Gaussian…

同伴效应估计中的弱识别AI 解读

It is commonly accepted that some phenomena are social: for example, individuals' smoking habits often correlate with those of their peers. Such correlations can have a variety of explanations, such as direct contagion or shared socioeconomic circumstances. The network linear-in-means model is a workhorse statistical model which incorporates these peer effects by including average neighborhood characteristics as regressors. Although the model's parameters are identifiable…

以剂量为工具变量、利用暴露数据稳健估计因果剂量响应关系AI 解读

An accurate estimation of the dose-response relationship is important to determine the optimal dose. For this purpose, a dose finding trial in which subjects are randomized to a few fixed dose levels is the most commonly used design. Often, the estimation uses response data only, although drug exposure data are often obtained during the trial. The use of exposure data to improve this estimation is difficult, as exposure-response relationships are typically subject to…

剂量—暴露—响应建模对剂量响应估计与优化的收益AI 解读

In randomized dose-finding trials, although drug exposure data form a part of key information for dose selection, the evaluation of the dose-response (DR) relationship often mainly uses DR data. We examine the benefit of dose-exposure-response (DER) modeling by sequentially modeling the dose-exposure (DE) and exposure-response (ER) relationships in parameter estimation and prediction, compared with direct DR modeling without PK data. We consider ER modeling approaches with…

评估处理效应异质性AI 解读

Heterogeneous treatment effects are of major interest in economics. For example, a poverty reduction measure would be best evaluated by its effects on those who would be poor in the absence of the treatment, or by the share among the poor who would increase their earnings because of the treatment. While these quantities are not identified, we derive nonparametrically sharp bounds using only the marginal distributions of the control and treated outcomes. Applications to…

存在不依从的2^K析因实验中因果效应的界限AI 解读

Factorial experiments are ubiquitous in the social and biomedical sciences, but when units fail to comply with each assigned factors, identification and estimation of the average treatment effects become impossible without strong assumptions. Leveraging an instrumental variables approach, previous studies have shown how to identify and estimate the causal effect of treatment uptake among respondents who comply with treatment. A major caveat is that these identification…

利用辅助总体工具变量识别因果效应与多重稳健估计AI 解读

Estimating causal effects in a target population with unmeasured confounders is challenging, especially when instrumental variables (IVs) are unavailable. However, IVs from auxiliary populations with similar problems can help infer causal effects in the target population. While the homogeneous conditional average treatment effect assumption has been widely used for effect transportability, it has not been explored in IV-based data fusion. We include it as a basic approach,…

同时反馈与未观测混杂下的同伴效应估计AI 解读

Estimating peer causal effects within complex real-world networks such as social networks is challenging, primarily due to simultaneous feedback between peers and unobserved confounders. Existing methods either address unobserved confounders while ignoring the simultaneous feedback, or account for feedback but under restrictive linear assumptions, thus failing to obtain accurate peer effect estimation. In this paper, we propose DIG2RSI, a novel Deep learning framework which…

断点回归设计中的结构外推：学校支出公投应用AI 解读

We propose a structural approach to extrapolate average partial effects away from the cutoff in regression discontinuity designs (RDDs). Our focus is on applications that exploit closely contested school district referenda to estimate the effects of changes in education spending on local economic outcomes. We embed these outcomes in a spatial equilibrium model of local jurisdictions in which fiscal policy is determined by majority rule voting. This integration provides a…