A New Causal Approach to Account for Treatment Switching in Randomized Experiments under a Structural Cumulative Survival Model
结构累积生存模型下处理随机试验治疗转换的因果方法
Treatment switching in a randomized controlled trial is said to occur when a patient randomized to one treatment arm switches to another treatment arm during follow-up. This can occur at the point of disease progression, whereby patients in the control arm may be offered the experimental treatment. It is widely known that failure to account for treatment switching can seriously dilute the estimated effect of treatment on overall survival. In this paper, we aim to account for…