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Causal Mediation and Sensitivity Analysis for Mixed-Scale Data

混合尺度数据的因果中介与敏感性分析

The goal of causal mediation analysis, often described within the potential outcomes framework, is to decompose the effect of an exposure on an outcome of interest along different causal pathways. Using the assumption of sequential ignorability to attain non-parametric identification, Imai et al. (2010) proposed a flexible approach to measuring mediation effects, focusing on parametric and semiparametric normal/Bernoulli models for the outcome and mediator. Less attention…

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Towards Principled Causal Effect Estimation by Deep Identifiable Models

利用深度可识别模型开展有原则的因果效应估计

As an important problem in causal inference, we discuss the estimation of treatment effects (TEs). Representing the confounder as a latent variable, we propose Intact-VAE, a new variant of variational autoencoder (VAE), motivated by the prognostic score that is sufficient for identifying TEs. Our VAE also naturally gives representations balanced for treatment groups, using its prior. Experiments on (semi-)synthetic datasets show state-of-the-art performance under diverse…

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Partially Intervenable Causal Models

仅允许部分变量干预的因果模型

Graphical causal models led to the development of complete non-parametric identification theory in arbitrary structured systems, and general approaches to efficient inference. Nevertheless, graphical approaches to causal inference have not been embraced by the statistics and public health communities. In those communities causal assumptions are instead expressed in terms of potential outcomes, or responses to hypothetical interventions. Such interventions are generally…

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Efficient Online Estimation of Causal Effects by Deciding What to Observe

通过选择观测内容高效在线估计因果效应

Researchers often face data fusion problems, where multiple data sources are available, each capturing a distinct subset of variables. While problem formulations typically take the data as given, in practice, data acquisition can be an ongoing process. In this paper, we aim to estimate any functional of a probabilistic model (e.g., a causal effect) as efficiently as possible, by deciding, at each time, which data source to query. We propose online moment selection (OMS), a…

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Cause-effect inference through spectral independence in linear dynamical systems: theoretical foundations

线性动态系统中谱独立性因果推断的理论基础

Distinguishing between cause and effect using time series observational data is a major challenge in many scientific fields. A new perspective has been provided based on the principle of Independence of Causal Mechanisms (ICM), leading to the Spectral Independence Criterion (SIC), postulating that the power spectral density (PSD) of the cause time series is uncorrelated with the squared modulus of the frequency response of the filter generating the effect. Since SIC rests on…

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Individualized Decision-Making Under Partial Identification: Three Perspectives, Two Optimality Results, and One Paradox

部分识别下的个体化决策:三种视角、两个最优性结果与一个悖论

Unmeasured confounding is a threat to causal inference and gives rise to biased estimates. In this article, we consider the problem of individualized decision-making under partial identification. Firstly, we argue that when faced with unmeasured confounding, one should pursue individualized decision-making using partial identification in a comprehensive manner. We establish a formal link between individualized decision-making under partial identification and classical…

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Difference-in-Differences with Geocoded Microdata

使用地理编码微观数据的双重差分

This paper formalizes a common approach for estimating effects of treatment at a specific location using geocoded microdata. This estimator compares units immediately next to treatment (an inner-ring) to units just slightly further away (an outer-ring). I introduce intuitive assumptions needed to identify the average treatment effect among the affected units and illustrates pitfalls that occur when these assumptions fail. Since one of these assumptions requires knowledge of…

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Revisiting identification concepts in Bayesian analysis

重新审视贝叶斯分析中的识别概念

This paper studies the role played by identification in the Bayesian analysis of statistical and econometric models. First, for unidentified models we demonstrate that there are situations where the introduction of a non-degenerate prior distribution can make a parameter that is nonidentified in frequentist theory identified in Bayesian theory. In other situations, it is preferable to work with the unidentified model and construct a Markov Chain Monte Carlo (MCMC) algorithms…

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Robust Generalized Method of Moments: A Finite Sample Viewpoint

稳健广义矩估计:有限样本视角

For many inference problems in statistics and econometrics, the unknown parameter is identified by a set of moment conditions. A generic method of solving moment conditions is the Generalized Method of Moments (GMM). However, classical GMM estimation is potentially very sensitive to outliers. Robustified GMM estimators have been developed in the past, but suffer from several drawbacks: computational intractability, poor dimension-dependence, and no quantitative recovery…

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$β$-Intact-VAE: Identifying and Estimating Causal Effects under Limited Overlap

β-Intact-VAE:有限重叠下因果效应的识别与估计

As an important problem in causal inference, we discuss the identification and estimation of treatment effects (TEs) under limited overlap; that is, when subjects with certain features belong to a single treatment group. We use a latent variable to model a prognostic score which is widely used in biostatistics and sufficient for TEs; i.e., we build a generative prognostic model. We prove that the latent variable recovers a prognostic score, and the model identifies…

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Two-stage least squares with a randomly right censored outcome

结果变量随机右删失时的两阶段最小二乘估计

This note develops a simple two-stage least squares (2SLS) procedure to estimate the causal effect of some endogenous regressors on a randomly right censored outcome in the linear model. The proposal replaces the usual ordinary least squares regressions of the standard 2SLS by weighted least squares regressions. The weights correspond to the inverse probability of censoring. We show consistency and asymptotic normality of the estimator. The estimator exhibits good finite…

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Many Proxy Controls

大量代理控制变量

A recent literature considers causal inference using noisy proxies for unobserved confounding factors. The proxies are divided into two sets that are independent conditional on the confounders. One set of proxies are `negative control treatments' and the other are `negative control outcomes'. Existing work applies to low-dimensional settings with a fixed number of proxies and confounders. In this work we consider linear models with many proxy controls and possibly many…

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Causal inference in survival analysis using longitudinal observational data: Sequential trials and marginal structural models

纵向观察数据中的生存因果推断:序贯试验与边际结构模型

Longitudinal observational patient data can be used to investigate the causal effects of time-varying treatments on time-to-event outcomes. Several methods have been developed for controlling for the time-dependent confounding that typically occurs. The most commonly used is inverse probability weighted estimation of marginal structural models (MSM-IPTW). An alternative, the sequential trials approach, is increasingly popular, in particular in combination with the target…

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Inference with Many Weak Instruments

大量弱工具变量下的统计推断

We develop a concept of weak identification in linear IV models in which the number of instruments can grow at the same rate or slower than the sample size. We propose a jackknifed version of the classical weak identification-robust Anderson-Rubin (AR) test statistic. Large-sample inference based on the jackknifed AR is valid under heteroscedasticity and weak identification. The feasible version of this statistic uses a novel variance estimator. The test has uniformly…

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Disentangling the effects of traits with shared clustered genetic predictors using multivariable Mendelian randomization

利用多变量孟德尔随机化分离共享聚集遗传预测因子的性状效应

When genetic variants in a gene cluster are associated with a disease outcome, the causal pathway from the variants to the outcome can be difficult to disentangle. For example, the chemokine receptor gene cluster contains genetic variants associated with various cytokines. Associations between variants in this cluster and stroke risk may be driven by any of these cytokines. Multivariable Mendelian randomization is an extension of standard univariable Mendelian randomization…

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Causal Matrix Completion

因果矩阵补全

Matrix completion is the study of recovering an underlying matrix from a sparse subset of noisy observations. Traditionally, it is assumed that the entries of the matrix are "missing completely at random" (MCAR), i.e., each entry is revealed at random, independent of everything else, with uniform probability. This is likely unrealistic due to the presence of "latent confounders", i.e., unobserved factors that determine both the entries of the underlying matrix and the…

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Nonparametric Bounds on Treatment Effects with Imperfect Instruments

不完美工具变量下处理效应的非参数界

This paper extends the identification results in Nevo and Rosen (2012) to nonparametric models. We derive nonparametric bounds on the average treatment effect when an imperfect instrument is available. As in Nevo and Rosen (2012), we assume that the correlation between the imperfect instrument and the unobserved latent variables has the same sign as the correlation between the endogenous variable and the latent variables. We show that the monotone treatment selection and…

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An Automated Approach to Causal Inference in Discrete Settings

离散情形下因果推断的自动化方法

When causal quantities cannot be point identified, researchers often pursue partial identification to quantify the range of possible values. However, the peculiarities of applied research conditions can make this analytically intractable. We present a general and automated approach to causal inference in discrete settings. We show causal questions with discrete data reduce to polynomial programming problems, and we present an algorithm to automatically bound causal effects…

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Nonparametric identification is not enough, but randomized controlled trials are

非参数识别还不够:随机对照试验的特殊作用

We argue that randomized controlled trials (RCTs) are special even among settings where average treatment effects are identified by a nonparametric unconfoundedness assumption. This claim follows from two results of Robins and Ritov (1997): (1) with at least one continuous covariate control, no estimator of the average treatment effect exists which is uniformly consistent without further assumptions, (2) knowledge of the propensity score yields a uniformly consistent…

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Geographic Difference-in-Discontinuities

地理断点差分方法

A recent econometric literature has critiqued the use of regression discontinuities where administrative borders serves as the 'cutoff'. Identification in this context is difficult since multiple treatments can change at the cutoff and individuals can easily sort on either side of the border. This note extends the difference-in-discontinuities framework discussed in Grembi et. al. (2016) to a geographic setting. The paper formalizes the identifying assumptions in this…

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A Control Function Approach to Estimate Panel Data Binary Response Model

面板二元响应模型估计的控制函数方法

We propose a new control function (CF) method to estimate a binary response model in a triangular system with multiple unobserved heterogeneities The CFs are the expected values of the heterogeneity terms in the reduced form equations conditional on the histories of the endogenous and the exogenous variables. The method requires weaker restrictions compared to CF methods with similar imposed structures. If the support of endogenous regressors is large, average partial…

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Nested Counterfactual Identification from Arbitrary Surrogate Experiments

利用任意替代实验识别嵌套反事实

The Ladder of Causation describes three qualitatively different types of activities an agent may be interested in engaging in, namely, seeing (observational), doing (interventional), and imagining (counterfactual) (Pearl and Mackenzie, 2018). The inferential challenge imposed by the causal hierarchy is that data is collected by an agent observing or intervening in a system (layers 1 and 2), while its goal may be to understand what would have happened had it taken a different…

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Propensity Score Adapted Covariate Selection for Causal Inference

面向因果推断的倾向得分适配协变量选择

In this paper, we propose a propensity score adapted variable selection procedure to select covariates for inclusion in propensity score models, in order to eliminate confounding bias and improve statistical efficiency in observational studies. Our variable selection approach is specially designed for causal inference, it only requires the propensity scores to be $\sqrt{n}$-consistently estimated through a parametric model and need not correct specification of potential…

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Variance Reduction for Causal Inference

因果推断中的方差降低

Propensity score methods have been shown to be powerful in obtaining efficient estimators of average treatment effect (ATE) from observational data, especially under the existence of confounding factors. When estimating, deciding which type of covariates need to be included in the propensity score function is important, since incorporating some unnecessary covariates may amplify both bias and variance of estimators of ATE. In this paper, we show that including additional…

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