Valid Instrumental Variables Selection Methods using Negative Control Outcomes and Constructing Efficient Estimator
利用负对照结局筛选有效工具变量并构造高效估计量
In observational studies, instrumental variable (IV) methods are commonly applied when there exists some unmeasured covariates. In Mendelian Randomization (MR), constructing an allele score by using many single nucleotide polymorphisms (SNPs) is often implemented; however, there are risks estimating biased causal effects by including some invalid IVs. Invalid IVs are candidates of IVs associated with some unobserved variables. To solve this problem, we propose a novel…