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Improving Mendelian Randomization Analysis by Instrument Borrowing from Auxiliary Outcome Traits

Mendelian randomization (MR) infers causal effects of exposures on outcomes using genetic variants as instrumental variables, but existing methods remain vulnerable to bias and loss of power when instruments are invalid. We hypothesize that closely related outcome traits share a large overlap in their valid instruments for a given exposure, so that borrowing instruments across such traits can yield more robust MR inference. To operationalize this, we introduce a novel…

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Heterogeneous Policy Effects in Comparative Case Studies with Treated-Unit Microdata

This article develops an identification framework for heterogeneous policy effects when individual-level data are available only in the treated jurisdiction. The framework combines outcome changes from repeated cross-sections within that jurisdiction with a population-average effect identified from aggregate panel data. Under conditional relative parallel trends and overlap, this information identifies subgroup effects standardized to the treated jurisdiction's overall…

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Two Gaussians, Too Many: A bootstrap-based approach to assess identifiability in non-Gaussian structural vector autoregressions

Normality pre-tests on reduced-form innovations cannot detect whether two or more underlying structural shocks are Gaussian, and hence cannot detect a failure of identification in non-Gaussian SVARs. We propose a bootstrap-based approach that reveals such a failure. Under the null of valid identification and certain regularity conditions, the conditional bootstrap distribution of the maximum likelihood estimator of the impact matrix is asymptotically normal, so the…

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Principal stratification with continuous treatments and continuous post-treatment variables

Principal stratification (PS) is a commonly used approach for understanding the mechanisms through which a treatment affects an outcome. The goal of this work is to extend the PS framework to studies with continuous treatments, which introduces a number of both challenges and opportunities in terms of defining causal effects and performing inference. This manuscript provides multiple key methodological contributions: 1) we introduce principal causal estimands for continuous…

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Random sets from the perspective of metric statistics

度量统计视角下的随机集

Since the seminal work by Beresteanu and Molinari(2008), the random set theory and related inference methods have been widely applied in partially identified econometric models. Meanwhile, there is an emerging field in statistics for studying random objects in metric spaces, called metric statistics. This paper clarifies a relationship between two fundamental concepts in these literatures, the Aumann and Fréchet means, and presents some applications of metric statistics to…

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Generalized Odds for Ordinal Outcomes: A Causal Inference Framework Adjusting for Covariates

Background: Generalized Odds (Gen Odds) provide summaries for ordinal outcomes without requiring the proportional odds assumption. However, conventional Gen Odds compares independently drawn treatment and control outcomes and targets a population-level contrast rather than an individual-level contrast. We developed an individual-level causal formulation of Gen Odds and examined its identification. Methods: We defined the Causal Gen Odds using the joint distribution of…

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Testing Cumulative Treatment Effects in Continuous Time with ODE Dynamics and Noisy Observations

We develop a semiparametric continuous time inferential framework for testing cumulative treatment effects, including both immediate and carryover effects. The latent state process is modeled by an ordinary differential equation (ODE) whose drift depends on state and treatment, while the observed data are noisy measurements of this latent state at irregular, multi resolution time points. We define the average treatment effect (ATE) as the difference of expected cumulative…

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On Local Inference for Functionals of Ill-Posed Inverse Problems

We study inference for continuous linear functionals of solutions to ill-posed inverse problems, including Euclidean parameters arising in nonparametric instrumental variables, proximal causal inference, and shadow-variable models. Although pointwise root-$n$ inference is possible under standard conditions, we show that this need not translate into locally reliable inference. Under a model imposing only minimal regularity conditions, the target is Hellinger discontinuous…

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Inverse Probability Weighting-based Mediation Analysis for Microbiome Data

Motivation: Mediation analysis is an important tool for elucidating causal mechanisms in biomedical research and has recently gained increasing attention in microbiome studies. Motivated by a microbiome study of acute myeloid leukemia (AML) patients, we investigate whether the effect of induction chemotherapy intensity on infection status is mediated through gut microbial taxa. This problem poses substantial methodological challenges due to the high dimensionality, zero…

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Relative Bias Under Imperfect Identification in Observational Causal Inference

观测因果推断中不完全识别下的相对偏差

To conduct causal inference in observational settings, researchers must rely on certain identifying assumptions. In practice, these assumptions are unlikely to hold exactly. This paper considers the bias of selection-on-observables, instrumental variables, and proximal inference estimates under violations of their identifying assumptions. We develop bias expressions for IV and proximal inference that show how violations of their respective assumptions are amplified by any…

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Generalizing Identifiability Results in Causal Discovery from Complete Data to Missing Data Settings

While causal discovery methods have matured for complete data, such algorithms for handling missing values remain limited. We establish general sufficient conditions under which causal graphs remain identifiable (i.e., uniquely determined from the available data distribution) under various missingness categories, including Missing Not At Random, and provide a framework to extend correctness guarantees from causal discovery algorithms for complete data to missing data…

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Identification and Inference in proxy-SVARs with non-Gaussian shocks

Two frequent approaches for identifying structural VARs are external instruments, which carry economic content but are often weak, and non-Gaussianity of the shocks, which provides statistical identification but carries no economic meaning. We combine the two strategies in a single generalized method of moments framework. This hybrid approach point-identifies the target shocks while also identifying the non-target shocks up to sign and ordering. Under suitable rank…

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Multilevel Main Effects Matrix Factor Model

多层主效应矩阵因子模型

We propose a multilevel main effects matrix factor model (MMEFM) to extract meaningful row and column effects from groups of matrix data. As a generalization of a multilevel matrix factor model, we provide rigorous definitions of MMEFM and identifications, together with iterative algorithms for the estimators of all global and local components in the main effects and common component, including global/local main effects and core ranks, with rates of convergence spelt out. An…

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Linear Regression Beyond Covariance: Latent Slope Spectra from Higher-Order Cumulants

超越协方差的线性回归:高阶累积量中的潜在斜率谱

Least squares summarizes the joint distribution of a response and regressor through second-order information. When an observed regressor is composed of latent components carrying different relationships with the response, this summary can average over distinct linear effects. We study the additional linear information contained in higher-order mixed cumulants and formalize it through the latent slope spectrum. Ordinary least squares is a variance-weighted barycenter of this…

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Difference-in-Differences Estimators When No Unit Remains Untreated

We study difference-in-differences designs in which all units are initially untreated and later receive heterogeneous, strictly positive treatment doses. When quasi-untreated units receive doses close to zero, a difference-in-difference estimand using those units as the control group identifies a weighted average treatment effect per unit of treatment, under a parallel-trends assumption. We develop a nonparametric estimator and bias-corrected confidence intervals for this…

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Pseudo-Panel Event Studies: Econometric Foundations for Credible Applications

伪面板事件研究:可信应用的计量经济学基础

Event studies with panel data are widely used to estimate treatment effects. With repeated cross-sections, future treatment dates are unobserved for untreated individuals. Pseudo-panel event studies impute pre-treatment outcomes of the treated using matched untreated individuals. This paper establishes identification in such designs and characterizes bias when identification conditions fail. I show that the pseudo-panel regression is equivalent to weighted least squares with…

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Randomized Experiments with Ambiguous Record Linkage

记录链接存在歧义时的随机实验

Randomized experiments are often linked to administrative data to measure outcomes, but coarse identifiers can leave multiple administrative records consistent with each experimental unit. We show that unbiased estimation of the sample average treatment effect is possible without resolving these ambiguous links or specifying an outcome model. Our key linkage requirement is that the true administrative outcome is contained among the candidate outcomes for each experimental…

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Identification problem and quasi-maximum likelihood estimation for matrix-variate CP-factor models

矩阵值 CP 因子模型的识别问题与准极大似然估计

Matrix-valued time series, arising in diverse fields such as economics, neuroscience, and recommender systems, have become increasingly prominent in modern data analysis. Among various modeling frameworks, the matrix-variate CP-factor model represents an important and widely applicable class for capturing low-rank structures in matrix time series. In this paper, we provide a unified treatment for the identification problem of CP factor models using both analytic and…

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Identification and Estimation of Treatment Effects from Network Data with Confounded Social Links

社会网络数据中处理效应的识别与估计:当社会连接存在混杂时

In observational network data, the adoption of a treatment and the formation of social ties often depend on the same characteristics that affect outcomes. We propose a generalized propensity score for each unit's effective treatment, built from a model for treatment assignment and a dyadic model for network formation, which may include latent node heterogeneity. The score is marginalized over the network given covariates rather than conditioned on the realized network, and…

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Minimax Rates for Learning Smooth Populations of Parameters

学习光滑参数总体的极小极大速率

We study pointwise estimation of a smooth binomial mixing density and characterize its minimax rates. Assuming that the mixing density is $s$-Hölder smooth, we first consider the homogeneous setting with a common number of binomial trials $t$. We derive matching lower and upper bounds that reveal three regimes depending on the relative sizes of the sample size $n$ and the number of trials $t$. When $t$ is small, the finite number of trials creates an identification barrier…

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Principal Component Analysis for High-Dimensional Approximate Factor Models in Time Series: Assumptions, Asymptotic Theory, and Identification

高维近似因子时间序列模型的主成分分析:假设、渐近理论与识别

We consider estimation of large approximate factor models in high-dimensional panels of stationary time series using Principal Component Analysis (PCA). We review the key results establishing the necessary and sufficient conditions for consistency and asymptotic normality of the estimators, which hold when both the cross-sectional dimension $n$ and the sample size $T$ tend to infinity. Special emphasis is placed on identification. First, we show that the common and…

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Intentionally Overidentifying Local Projections

有意过度识别的局部投影

Local projections (LPs) have become a standard tool for estimating dynamic effects in macroeconomics and are typically implemented using ordinary least squares (OLS) for a given lag order. We propose an alternative approach that exploits additional lags as excluded instrumental variables (IVs). Under a finite-order model with martingale-difference shocks, the resulting (optimally weighted) IV estimator is never asymptotically less efficient than OLS and, as we show, can…

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Choosing the Dictionary and Penalty for IV-LASSO

IV-LASSO 的工具变量字典与惩罚选择

Estimating the first stage of an instrumental variables (IV) model with the least absolute shrinkage and selection operator (LASSO) requires choosing a dictionary of technical instruments and a penalty level. First-order asymptotic theory offers no guidance on these choices, as any consistent implementation yields a structural parameter estimator with the same limiting distribution. In finite samples, however, these choices can have a substantial impact on the resulting…

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An efficient stochastic generalized method of moments estimator for nonlinear moment models

非线性矩模型的高效随机广义矩估计

We study the asymptotic properties of the nonlinear stochastic GMM algorithm proposed by Chen, Lee, Liao, Seo, Shin and Song for recursively estimating parameters defined by possibly nonlinear and overidentified moment restrictions $\E[g(X,β^*)]=0$. Each observation updates estimates of the moment Jacobian, inverse covariance matrix and Gauss--Newton preconditioner at a cost independent of sample size. For linear and nonlinear instrumental-variable moments, we derive an…

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