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一致的贝叶斯局部空间特征选择及其在空间多模态组学中的应用AI 解读

Motivated by a high-dimensional regression problem in spatial multimodal omics (SMO), we propose a Bayesian framework for local spatial feature selection, where a random domain partition prior is introduced to divide the spatial domain into several contiguous clusters with flexible shapes and an unknown number of clusters, conditional on which a local feature selection prior is imposed within each cluster. The notion of "feature" is general and may include both covariates…

基于多元混合效应模型的动态共表达网络估计AI 解读

High-throughput sequencing technologies have enabled the collection of large-scale longitudinal -omics data, providing new opportunities for studying co-expression networks among molecular nodes such as genes and proteins. However, the high dimensionality and temporal dependence inherent in such data require specialized statistical methods. We propose a novel approach to infer dynamic co-expression networks among features over time (DCENt), where each node (feature) is…

面向复杂计算机模型的收缩约束函数标定AI 解读

We propose a new Bayesian model calibration formalism as an alternative to the Kennedy O'Hagan (KOH) framework which we term integrated bias with full uncertainty (IBFU). In KOH, calibration parameters are modeled as fixed, but unknown distributions with relatively weak prior constraints, and their posteriors are inferred jointly with an additive discrepancy Gaussian Process (GP). This formulation often provides limited regularization and leads to confounding pathologies…

高维数据中的测量误差：惩罚回归方法综述与比较AI 解读

In many important statistical analyses, the number of covariates $p$ often exceeds the data size $n$, a regime commonly referred to as high-dimensional. While considerable progress has been made in high-dimensional regression under the assumption of error-free covariates, real-world data frequently involve noisy or corrupted measurements. When left unaddressed, measurement errors can silently distort the analysis and mislead the conclusions. This paper reviews and evaluates…

函数型结局因果效应的半参数推断AI 解读

Difference-in-differences (DiD) is a cornerstone of causal inference, yet extending it to functional outcomes is not a routine scalar generalization; rather, it entails three fundamental challenges in identification, inference, and observation. This paper develops a comprehensive semiparametric inference framework for functional DiD with discretely observed data. First, we define the functional average treatment effect under parallel trends and derive its efficient influence…

rd2d：边界断点设计中的因果推断软件AI 解读

Boundary Discontinuity (BD) designs are used in empirical research to learn about causal treatment effects along a continuous assignment boundary defined by a bivariate score. These designs are also known as multi-score regression discontinuity (RD) designs, and include geographic RD designs as a prominent example. This article introduces \pkg{rd2d}, a statistical software package for \proglang{R}, \proglang{Python}, and \proglang{Stata} that implements local polynomial…

层级预测中信息的作用AI 解读

In hierarchical forecasting, the process of forecast reconciliation transforms a set of "base" or "raw" forecasts, which do not satisfy the hierarchical aggregation constraints in the real data, into a set of "coherent" forecasts, which do satisfy those constraints. The academic literature provides ample simulation evidence and real-world examples demonstrating the value of forecast reconciliation in improving forecasts of hierarchical time series. This improvement is…

连接最大似然与最优传输：随机块模型的高效推断与模型选择AI 解读

We study inference in stochastic block models (SBMs) through the lens of optimal transport (OT). We first establish that maximum likelihood variational inference (MLVI) can be interpreted as a semi-relaxed Gromov-Wasserstein (srGW) projection with entropic regularization. While this formulation yields accurate clustering, the entropic regularization prevents transport plans to be sparse, hindering intrinsic model selection. Consequently, we investigate unregularized srGW…

利用两阶段核岭回归估计连续处理效应AI 解读

We study the problem of estimating the effect function for a continuous treatment, which maps each treatment value to a population-averaged outcome. A central challenge in this setting is confounding: treatment assignment often depends on covariates, creating selection bias that makes direct regression of the response on treatment unreliable. To address this issue, we propose a two-stage kernel ridge regression method. In the first stage, we learn a model for the response as…

网络混杂下基于图神经网络的广义 Mundlak 估计量AI 解读

This paper proposes a generalized Mundlak estimator based on graph neural networks (GME-GNN). The estimator is designed to mitigate bias arising from group-level heterogeneity and to accommodate within-group dependence among individuals. Traditional fixed-effects models handle group heterogeneity via group-specific intercepts, but require overly strict linear additivity and intra-group independence assumptions, and are confined to within-group comparisons. Rather than…

超越准确率：时间序列基础模型是否校准良好？AI 解读

The recent development of foundation models for time series data has generated considerable interest in using such models across a variety of applications. Although foundation models achieve state-of-the-art predictive performance, their calibration properties remain relatively underexplored, despite the fact that calibration can be critical for many practical applications. In this paper, we investigate the calibration-related properties of five recent time series foundation…

含未观测混杂因素的贝叶斯结构化中介分析AI 解读

We explore methods to reduce the impact of unobserved confounders on the causal mediation analysis of high-dimensional mediators with spatially smooth structures, such as brain imaging data. The key approach is to incorporate the latent individual effects, which influence the structured mediators, as unobserved confounders in the outcome model, thereby potentially debiasing the mediation effects. We develop BAyesian Structured Mediation analysis with Unobserved confounders…

黎曼环境流：从受损数据中同时学习流形与生成模型AI 解读

Modern generative modeling methods have demonstrated strong performance in learning complex data distributions from clean samples. In many scientific and imaging applications, however, clean samples are unavailable, and only noisy or linearly corrupted measurements can be observed. Moreover, latent structures, such as manifold geometries, present in the data are important to extract for further downstream scientific analysis. In this work, we introduce Riemannian…

通过数据驱动协变量调整实现随机临床试验的自动化高效无模型推断AI 解读

In 2023, the U.S. Food and Drug Administration issued guidance for adjustment of covariates in randomized clinical trials, emphasizing its role in enhancing precision and power through prognostic baseline variables. Despite its potential, many trials underutilize this method partly due to challenges in pre-specifying optimal baseline covariates and their functional forms. We explore the potential of automated, data-adaptive methods-including stepwise regression, Lasso and…

可解释二元剖面的贝叶斯潜在类别回归AI 解读

High-dimensional categorical data arise in diverse scientific domains and are often accompanied by covariates. Latent class regression models are routinely used in such settings, reducing dimensionality by assuming conditional independence of the categorical variables given a single latent class that depends on covariates through a logistic regression model. However, such methods become unreliable as the dimensionality increases. To address this, we propose Bayesian latent…

基于谱梯度重加权的稳健矩估计AI 解读

Moment-based estimation is a theoretically attractive approach to parametric inference, especially when likelihood-based estimation is unavailable, misspecified, or computationally inconvenient. However, the moment equations involve sample averages, which makes moment-based estimation sensitive to outliers. We propose the SGR-GMM algorithm, a robust generalized method of moments (GMM) procedure that uses a spectral gradient reweighting (SGR) primitive to soft-reweight the…

因果机器学习：综述与开放问题AI 解读

Causal Machine Learning (CausalML) is an umbrella term for machine learning methods that formalize the data-generation process as a structural causal model (SCM). This perspective enables us to reason about the effects of changes to this process (interventions) and what would have happened in hindsight (counterfactuals). We categorize work in CausalML into five groups according to the problems they address: (1) causal supervised learning, (2) causal generative modeling, (3)…

协变量分布偏移下外部有效性的简明稳健性度量AI 解读

This paper studies the robustness of estimated policy effects to changes in the distribution of covariates, a key determinant of the external validity of (quasi)-experimental results. I propose a novel robustness metric $δ^*$ which measures the smallest covariate shift needed to invalidate an empirical claim about the policy effect (e.g., $ATE > 0$). I estimate $δ^*$ via de-biased GMM, achieving a parametric rate of convergence while accommodating machine-learning estimators…

从不完整含噪数据学习未知单调链接的非线性因子模型AI 解读

We study a nonlinear factor model in which observed responses depend on low-rank latent factors through an unknown monotone link function. This setting is challenging and largely underexplored due to severe nonconvexity and identifiability issues. The link function is assumed to lie in a reproducing kernel Hilbert space (RKHS), enabling flexible nonparametric modeling while preserving identifiability. We formulate the problem as the joint recovery of the low-rank factors,…

在生活方式暴露的分子特征构建中考虑因果关系AI 解读

Molecular signatures derived from omics data are increasingly used in epidemiological studies to characterize lifestyle exposures, either as proxies of exposure or to provide insight into disease mechanisms. These signatures are typically constructed by regressing the exposure on high-dimensional omics features. In the literature, an initial univariate screening step has sometimes been applied prior to multivariate modelling, but the causal implications of this choice have…

集合滤波方法中的线性不变量保持AI 解读

Data assimilation combines dynamical models with observations to improve state estimates. Ensemble filters sequentially assimilate observations by updating a set of samples over time, alternating between a forecast and an analysis step. Accurate and robust predictions often require preserving critical invariants such as mass, stoichiometric balance of chemical species, and electrical charge. While modern numerical solvers maintain these invariants, existing…

非线性函数型自回归模型的指数混合性质AI 解读

The importance of functional data analysis has increased substantially in recent years. In machine learning, nonlinear function regression based on deep neural networks is referred to as operator learning, and many of its applications involve functional time series data. However, the theoretical understanding of nonlinear models in functional time series analysis remains limited, as most existing works focus on linear models. In this paper, we derive basic properties for…

高维时间序列因子模型的权重校准估计AI 解读

The factor modeling for high-dimensional time series is powerful in discovering latent common components for dimension reduction and information extraction. Most available estimation methods can be divided into two categories: the covariance-based under asymptotically-identifiable assumption and the autocovariance-based with white idiosyncratic noise. This paper follows the autocovariance-based framework and develops a novel weight-calibrated method to improve the estimation…

依赖处理自然历史的修正处理政策AI 解读

Longitudinal modified treatment policies (LMTP) are a class of interventions that allow the definition, identification, and estimation of causal effects in general settings, such as with continuous or multivariate exposures, treatment regimens that require grace periods. Targeted machine learning estimators (i.e., double/debiased) have been formulated for LMTPs that assign the exposure at time $t$ as a function of the natural value of treatment at time $t$. However,…