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Fast Signal Region Detection with Application to Whole Genome Association Studies

快速信号区域检测及其在全基因组关联研究中的应用

Research on the localization of the genetic basis associated with diseases or traits has been widely conducted in the last a few decades. Scan methods have been developed for region-based analysis in whole-genome association studies, helping us better understand how genetics influences human diseases or traits, especially when the aggregated effects of multiple causal variants are present. In this paper, we propose a fast and effective algorithm coupling with…

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Designing Algorithmic Recommendations to Achieve Human-AI Complementarity

为实现人机互补而设计算法建议

Algorithms frequently assist, rather than replace, human decision-makers. However, the design and analysis of algorithms often focus on predicting outcomes and do not explicitly model their effect on human decisions. This discrepancy between the design and role of algorithmic assistants becomes particularly concerning in light of empirical evidence that suggests that algorithmic assistants again and again fail to improve human decisions. In this article, we formalize the…

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Inference in Partially Linear Models under Dependent Data with Deep Neural Networks

依赖数据下使用深度神经网络的部分线性模型推断

I consider inference in a partially linear regression model under stationary $β$-mixing data after first stage deep neural network (DNN) estimation. Using the DNN results of Brown (2024), I show that the estimator for the finite dimensional parameter, constructed using DNN-estimated nuisance components, achieves $\sqrt{n}$-consistency and asymptotic normality. By avoiding sample splitting, I address one of the key challenges in applying machine learning techniques to…

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On the Computational Complexity of Private High-dimensional Model Selection

隐私约束下高维模型选择的计算复杂性

We consider the problem of model selection in a high-dimensional sparse linear regression model under privacy constraints. We propose a differentially private (DP) best subset selection method with strong statistical utility properties by adopting the well-known exponential mechanism for selecting the best model. To achieve computational expediency, we propose an efficient Metropolis-Hastings algorithm and under certain regularity conditions, we establish that it enjoys…

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FLIPHAT: Joint Differential Privacy for High Dimensional Sparse Linear Bandits

FLIPHAT:高维稀疏线性赌博机的联合差分隐私

High dimensional sparse linear bandits serve as an efficient model for sequential decision-making problems (e.g. personalized medicine), where high dimensional features (e.g. genomic data) on the users are available, but only a small subset of them are relevant. Motivated by data privacy concerns in these applications, we study the joint differentially private high dimensional sparse linear bandits, where both rewards and contexts are considered as private data. First, to…

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On the potential benefits of entropic regularization for smoothing Wasserstein estimators

熵正则化对 Wasserstein 估计量的平滑作用及其潜在收益

This paper is focused on the study of entropic regularization in optimal transport as a smoothing method for Wasserstein estimators, through the prism of the classical tradeoff between approximation and estimation errors in statistics. Wasserstein estimators are defined as solutions of variational problems whose objective function involves the use of an optimal transport cost between probability measures. Such estimators can be regularized by replacing the optimal transport…

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A Fast Coordinate Descent Method for High-Dimensional Non-Negative Least Squares using a Unified Sparse Regression Framework

高维非负最小二乘的快速坐标下降法:统一稀疏回归框架

We develop theoretical results that establish a connection across various regression methods such as the non-negative least squares, bounded variable least squares, simplex constrained least squares, and lasso. In particular, we show in general that a polyhedron constrained least squares problem admits a locally unique sparse solution in high dimensions. We demonstrate the power of our result by concretely quantifying the sparsity level for the aforementioned methods.…

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Statistical Inference in High-dimensional Poisson Regression with Applications to Mediation Analysis

高维泊松回归的统计推断及其在中介分析中的应用

Large-scale datasets with count outcome variables are widely present in various applications, and the Poisson regression model is among the most popular models for handling count outcomes. This paper considers the high-dimensional sparse Poisson regression model and proposes bias-corrected estimators for both linear and quadratic transformations of high-dimensional regression vectors. We establish the asymptotic normality of the estimators, construct asymptotically valid…

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Modular Learning of Deep Causal Generative Models for High-dimensional Causal Inference

面向高维因果推断的深度因果生成模型模块化学习

Sound and complete algorithms have been proposed to compute identifiable causal queries using the causal structure and data. However, most of these algorithms assume accurate estimation of the data distribution, which is impractical for high-dimensional variables such as images. On the other hand, modern deep generative architectures can be trained to sample from high-dimensional distributions. However, training these networks are typically very costly. Thus, it is desirable…

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Nonparametric Density Estimation for Data Scattered on Irregular Spatial Domains: A Likelihood-Based Approach Using Bivariate Penalized Spline Smoothing

不规则空间域散点数据的双变量惩罚样条非参数密度估计

Accurately estimating data density is crucial for making informed decisions and modeling in various fields. This paper presents a novel nonparametric density estimation procedure that utilizes bivariate penalized spline smoothing over triangulation for data scattered over irregular spatial domains. The approach is likelihood-based with a regularization term that addresses the roughness of the logarithm of density based on a second-order differential operator. The proposed…

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Double Debiased Covariate Shift Adaptation Robust to Density-Ratio Estimation

对密度比估计误差稳健的双重去偏协变量漂移适应

Consider a scenario where we have access to train data with both covariates and outcomes while test data only contains covariates. In this scenario, our primary aim is to predict the missing outcomes of the test data. With this objective in mind, we train parametric regression models under a covariate shift, where covariate distributions are different between the train and test data. For this problem, existing studies have proposed covariate shift adaptation via importance…

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Accurate Inference for Penalized Logistic Regression

惩罚逻辑回归的精确推断

Inference for high-dimensional logistic regression models using penalized methods has been a challenging research problem. As an illustration, a major difficulty is the significant bias of the Lasso estimator, which limits its direct application in inference. Although various bias corrected Lasso estimators have been proposed, they often still exhibit substantial biases in finite samples, undermining their inference performance. These finite sample biases become particularly…

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Causal inference and policy evaluation without a control group

没有对照组的因果推断与政策评价

Without a control group, the most widespread methodologies for estimating causal effects cannot be applied. To fill this gap, we propose the Machine Learning Control Method, a new approach for causal panel analysis that estimates causal parameters without relying on untreated units. We formalize identification within the potential outcomes framework and then provide estimation based on machine learning algorithms. To illustrate the practical relevance of our method, we…

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Insights into regression-based cross-temporal forecast reconciliation

基于回归的跨期预测协调方法解析

Cross-temporal forecast reconciliation aims to ensure consistency across forecasts made at different temporal and cross-sectional levels. We explore the relationships between sequential, iterative, and optimal combination approaches, and discuss the conditions under which a sequential reconciliation approach (either first-cross-sectional-then-temporal, or first-temporal-then-cross-sectional) is equivalent to a fully (i.e., cross-temporally) coherent iterative heuristic.…

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Convergence Analysis of regularised Nyström method for Functional Linear Regression

正则化 Nyström 方法在函数型线性回归中的收敛性分析

The functional linear regression model has been widely studied and utilized for dealing with functional predictors. In this paper, we study the Nyström subsampling method, a strategy used to tackle the computational complexities inherent in big data analytics, especially within the domain of functional linear regression model in the framework of reproducing kernel Hilbert space. By adopting a Nyström subsampling strategy, our aim is to mitigate the computational overhead…

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Ablation Studies for Novel Treatment Effect Estimation Models

新型处理效应估计模型的消融研究

Ablation studies are essential for understanding the contribution of individual components within complex models, yet their application in nonparametric treatment effect estimation remains limited. This paper emphasizes the importance of ablation studies by examining the Bayesian Causal Forest (BCF) model, particularly the inclusion of the estimated propensity score $\hatπ(x_i)$ intended to mitigate regularization-induced confounding (RIC). Through a partial ablation study…

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A Neural Phillips Curve and a Deep Output Gap

神经网络菲利普斯曲线与深度产出缺口

Many problems plague empirical Phillips curves (PCs). Among them is the hurdle that the two key components, inflation expectations and the output gap, are both unobserved. Traditional remedies include proxying for the absentees or extracting them via assumptions-heavy filtering procedures. I propose an alternative route: a Hemisphere Neural Network (HNN) whose architecture yields a final layer where components can be interpreted as latent states within a Neural PC. There are…

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A Mean-Field Analysis of Neural Stochastic Gradient Descent-Ascent for Functional Minimax Optimization

函数极小极大优化中神经随机梯度下降上升的平均场分析

This paper studies minimax optimization problems defined over infinite-dimensional function classes of overparameterized two-layer neural networks. In particular, we consider the minimax optimization problem stemming from estimating linear functional equations defined by conditional expectations, where the objective functions are quadratic in the functional spaces. We address (i) the convergence of the stochastic gradient descent-ascent algorithm and (ii) the representation…

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Inferring Latent Graphs from Stationary Signals Using a Graphical Autoregressive Model

用图自回归模型从平稳信号推断潜在图

Graphs are an intuitive way to represent relationships between variables in fields such as finance and neuroscience. However, these graphs often need to be inferred from data. In this paper, we propose a novel framework to infer a latent graph by treating the observed multidimensional data as graph-referenced stationary signals. Specifically, we introduce the graphical autoregressive model (GAR), where the inverse covariance matrix of the observed signals is expressed as a…

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Limit Laws for Gromov-Wasserstein Alignment with Applications to Testing Graph Isomorphisms

Gromov-Wasserstein 对齐的极限定律及其在图同构检验中的应用

The Gromov-Wasserstein (GW) distance enables comparing metric measure spaces based solely on their internal structure, making it invariant to isomorphic transformations. This property is particularly useful for comparing datasets that naturally admit isomorphic representations, such as unlabelled graphs or objects embedded in space. However, apart from the recently derived empirical convergence rates for the quadratic GW problem, a statistical theory for valid estimation and…

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Coefficient Shape Alignment in Multiple Functional Linear Regression

多元函数线性回归中的系数形状对齐

In multivariate functional data analysis, different functional covariates often exhibit homogeneity. The covariates with pronounced homogeneity can be analyzed jointly within the same group, offering a parsimonious approach to modeling multivariate functional data. In this paper, a novel grouped multiple functional regression model with a new regularization approach termed {\it ``coefficient shape alignment"} is developed to tackle functional covariates homogeneity. The…

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Bayes optimal learning in high-dimensional linear regression with network side information

带网络侧信息的高维线性回归贝叶斯最优学习

Supervised learning problems with side information in the form of a network arise frequently in applications in genomics, proteomics and neuroscience. For example, in genetic applications, the network side information can accurately capture background biological information on the intricate relations among the relevant genes. In this paper, we initiate a study of Bayes optimal learning in high-dimensional linear regression with network side information. To this end, we first…

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Causal Fairness under Unobserved Confounding: A Neural Sensitivity Framework

未观测混杂下的因果公平性:神经网络敏感性框架

Fairness for machine learning predictions is widely required in practice for legal, ethical, and societal reasons. Existing work typically focuses on settings without unobserved confounding, even though unobserved confounding can lead to severe violations of causal fairness and, thus, unfair predictions. In this work, we analyze the sensitivity of causal fairness to unobserved confounding. Our contributions are three-fold. First, we derive bounds for causal fairness metrics…

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Enhanced power enhancements for testing many moment equalities: Beyond the $2$- and $\infty$-norm

多重矩等式检验的功效增强:超越二范数与无穷范数

Contemporary testing problems in statistics are increasingly complex, i.e., high-dimensional. Tests based on the $2$- and $\infty$-norm have received considerable attention in such settings, as they are powerful against dense and sparse alternatives, respectively. The power enhancement principle of Fan et al. (2015) combines these two norms to construct improved tests that are powerful against both types of alternatives. In the context of testing whether a candidate…

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