Estimating time-varying exposure effects through continuous-time modelling in Mendelian randomization
通过连续时间建模估计孟德尔随机化中的时变暴露效应
Mendelian randomization is an instrumental variable method that utilizes genetic information to investigate the causal effect of a modifiable exposure on an outcome. In most cases, the exposure changes over time. Understanding the time-varying causal effect of the exposure can yield detailed insights into mechanistic effects and the potential impact of public health interventions. Recently, a growing number of Mendelian randomization studies have attempted to explore…