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Statistical Validation of Computer Models: Global and Subdomain Hypothesis Testing

计算机模型的统计验证:全局与子域假设检验

Computer simulations play an important role in scientific discovery and engineering innovation. Reliable computer models enable virtual experimentation that reduces the need for costly and time-consuming physical testing. However, the credibility of such models hinges on rigorous statistical validation against real-world data. This paper develops a formal frequentist framework for both global and subdomain validation of computer models. We propose the Fourier Maximum Modulus…

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Profit-Aligned CATE Estimation: Reconciling Policy Learning and Inference

与利润目标一致的条件平均处理效应估计:协调政策学习与推断

We propose a framework that aligns Conditional Average Treatment Effect (CATE) estimation with profit maximization. Our method recognizes that, for customers with extreme treatment effects, additional estimation accuracy is unlikely to change the recommended actions. In contrast, accuracy is critical near the decision boundary, where treatment effects are close to treatment costs. Our approach optimizes a novel objective function that concentrates learning capacity along…

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A Sensitivity Approach to Causal Inference Under Limited Overlap

有限重叠下因果推断的敏感性方法

Limited overlap between treated and control groups is a key challenge in observational analysis. Standard approaches like trimming importance weights can reduce variance but introduce a fundamental bias. We propose a sensitivity framework for contextualizing findings under limited overlap, where we assess how irregular the outcome function has to be in order for the main finding to be invalidated. Our approach is based on worst-case confidence bounds on the bias introduced…

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Mixture Matrix-valued Autoregressive Model

混合矩阵值自回归模型

Time series of matrix-valued data are increasingly available in various areas including economics, finance, social science, among others. These data may shed light on the inter-dynamical relationships between two sets of attributes, for instance, countries and economic indices. The matrix autoregressive (MAR) model provides a parsimonious approach for analyzing such data. However, the MAR model, being a linear model with parametric constraints, cannot capture the nonlinear…

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Integrating Diagnostic Checks into Estimation

将诊断检验融入估计

Empirical researchers often use diagnostic checks to assess the plausibility of their modeling assumptions, such as testing for covariate balance in RCTs, pre-trends in event studies, or instrument validity in IV designs. While these checks are traditionally treated as external hurdles to estimation, we argue they should be integrated into the estimation process itself. In particular, we propose residualizing one's baseline estimator against the vector of diagnostic check…

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Multi-Experiment Analysis

多实验联合分析

Online controlled experiments face growing challenges from overlapping tests on shared traffic, where interactions between concurrent experiments obscure insights into feature combinations and produce effect estimates that do not correspond to any actionable launch scenario. While traffic splitting, layering, and sequential execution (non-concurrent) mitigate some of these issues, they require coordination overhead and can reduce experimentation velocity. We propose…

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Horseshoe Predictive Inference

马蹄先验下的预测推断

Predictive inference in the sparse Gaussian sequence model has received considerably less attention than its non-sparse, finite-sample counterpart. Existing work has largely been confined to discrete mixture priors. In this paper, we study predictive inference under a widely used continuous mixture prior, the Horseshoe. We provide new theoretical results establishing exact asymptotic minimax optimality of the predictive Bayes estimator when the sparsity level is known.…

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Network Meta-analysis and Diffusion

网络荟萃分析与扩散

We show that the covariance matrix of the treatment effect estimates in a network meta-analysis can be obtained without matrix inversion using a geometric series of diffusion matrices. This property extends to the hat matrix and provides a connection between parameter estimation in regression analysis and random walks on the network graph. We also provide a number of visualization tools implemented in R.

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Simultaneous Inference for Covariance and Precision Matrices of Long-Range Dependent Time Series

长程依赖时间序列协方差矩阵与精度矩阵的同时推断

For time series with long-range temporal dependence, inference for covariance and precision matrices is non-trivial. We propose a Berry-Esseen type Gaussian approximation result that gives a finite-sample bound for the Kolmogorov distance between the infinity norms of the estimation error of sample covariance matrix and the corresponding Gaussian approximation. The method utilizes martingale and m-dependent approximation and relies on constructing triadic blocks. We also…

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Extreme Value Analysis based on Blockwise Top-Two Order Statistics

基于分块前两大次序统计量的极值分析

Extreme value analysis for time series is often based on the block maxima method, in particular for environmental applications. In the classical univariate case, the latter is based on fitting an extreme-value distribution to the sample of (annual) block maxima. Mathematically, the target parameters of the extreme-value distribution also show up in limit results for other high order statistics, which suggests estimation based on blockwise large order statistics. It is shown…

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Taxonomy and Estimation of Multiple Breakpoints in High-Dimensional Factor Models

高维因子模型中多重断点的分类与估计

This paper proposes a quasi-maximum likelihood (QML) estimator for break points in high-dimensional factor models, specifically accounting for multiple structural breaks. We begin by establishing a necessary and sufficient condition to categorize two distinct types of breaks in factor loadings: singular changes and rotational changes. The analysis of the nearly singular subsample covariance matrices of the pseudo-factors plays a key role in our approach. It allows us to…

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Causal inference for censored data with continuous marks

带连续标记的删失数据因果推断

This paper presents a framework for causal inference in the presence of censored data,where the failure time is marked by a continuous variable referred to as a mark.The mark is observed after treatment and is not meaningful when the failure time is censored. In addition, due to the continuous nature of the marks, observations at each given mark are sparse. These facts make the identification and estimation of causality a challenging task. To address these issues, we define…

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Informativeness under Model Uncertainty: Shadow Prices and Ridge Penalties

模型不确定性下的信息量:影子价格与岭惩罚

We develop inference under model uncertainty due to weak, noisy, multiple candidate restrictions and theories, and nuisance control covariates. A unified framework is given with degrees of misspecification and corresponding shadow prices, based on a Lagrangian constrained optimization approach, and a data$-$driven tolerance parameter selected via a Stein$-$type (shrinkage) risk criterion. A debiasing step is based on Karush$-$Kuhn$-$Tucker conditions. We introduce individual…

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True and Pseudo-True Parameters

真实参数与伪真实参数

Parameter estimates in misspecified models converge to pseudo-true parameter values, which minimize a population objective function. Pseudo-true values often differ from quantities of economic interest, raising questions of how, if at all, they are relevant for decision-making. To study this question we consider Bayesian decision-makers facing a linear population minimum distance problem. Within a class of priors motivated by the minimum distance objective, we characterize…

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Inference on covariance structure in high-dimensional multi-view data

高维多视图数据协方差结构的推断

This article focuses on covariance estimation for multi-view data. Popular approaches rely on factor-analytic decompositions that have shared and view-specific latent factors. Posterior computation is conducted via expensive and brittle Markov chain Monte Carlo (MCMC) sampling or variational approximations that underestimate uncertainty and lack theoretical guarantees. Our proposed methodology employs spectral decompositions to estimate and align latent factors that are…

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Generalization of Pearl's Front-Door Criterion

Pearl 前门准则的推广

Pearl's front-door criterion provides a set of sufficient conditions for estimating the total causal effect from observational data in the presence of latent confounding, using the functional P(y | do(x := x*)) = \sum_z P(z | x*) \sum_x P(y | x, z) P(x). An open question is whether these conditions can be generalized to be both necessary and sufficient for the validity of this functional, similar to the generalization achieved for the back-door adjustment criterion by…

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On the Conservativeness of Robust Variance Estimators in Propensity Score Weighted Cox Models

倾向得分加权 Cox 模型中稳健方差估计的保守性

In propensity score weighted analysis, robust variance that does not account for weight estimation is commonly used. In propensity score weighted Cox models (CoxPSW), the robust variance is known to be conservative when weights for the average treatment effect (ATE) are used, but it remains unclear whether this conservativeness also holds for other weighting schemes. This study evaluated the performance of the robust variance in CoxPSW when weights other than ATE are…

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Adaptive Multi-Prior Lasso for High-Dimensional Generalized Linear Models

高维广义线性模型的自适应多先验 Lasso

Incorporation of external information into high-dimensional modeling for gene expression data has been shown, both theoretically and empirically, to substantially enhance performance. Such external information, sometimes referred to as prior information or priors, has become increasingly accessible from multiple sources, yet its reliability may vary considerably. Existing approaches often integrate these priors without sufficiently accounting for their quality, which may…

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Causal Decomposition Analysis with Synergistic Interventions: A Triply-Robust Machine Learning Approach to Addressing Multiple Dimensions of Social Disparities

协同干预的因果分解分析:处理多维社会差距的三重稳健机器学习方法

Educational disparities are rooted in and perpetuate social inequalities across multiple dimensions such as race, socioeconomic status, and geography. To reduce disparities, most intervention strategies focus on a single domain and frequently evaluate their effectiveness by using causal decomposition analysis. However, a growing body of research suggests that single-domain interventions may be insufficient for individuals marginalized on multiple fronts. While interventions…

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Estimating the roughness exponent of stochastic volatility from discrete observations of the integrated variance

从积分方差的离散观测估计随机波动率的粗糙指数

We consider the problem of estimating the roughness of the volatility process in a stochastic volatility model that arises as a nonlinear function of fractional Brownian motion with drift. To this end, we introduce a new estimator that measures the so-called roughness exponent of a continuous trajectory, based on discrete observations of its antiderivative. The estimator has a very simple form and can be computed with great efficiency on large data sets. It is not derived…

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The Promises of Multiple Experiments: Identifying Joint Distribution of Potential Outcomes

多个实验的潜力:识别潜在结果的联合分布

Typical causal effects are defined based on the marginal distribution of potential outcomes. However, many real-world applications require causal estimands involving the joint distribution of potential outcomes to enable more nuanced treatment evaluation and selection. In this article, we propose a novel framework for identifying and estimating the joint distribution of potential outcomes using multiple experimental datasets. We introduce the assumption of transportability…

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Who Saw It Coming? Historical Experience and the 2021 Inflation Forecast Failure

谁预见了通胀?历史经验与 2021 年通胀预测失误

This paper studies the 2021 U.S. inflation forecasting failure. I show that the failure was primarily driven by sample composition rather than functional-form misspecification: estimation samples dominated by the Great Moderation underweight supply-shock regimes, and expectations anchored to that regime were slow to recognize the shift. Three historically informed adjustments, an intercept correction, a similarity re-estimation on 1970s data, and a kernel-weighted estimator,…

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Doubly Robust Estimators with Weak Overlap

弱重叠条件下的双重稳健估计量

Doubly robust (DR) estimators guard against model misspecification but remain sensitive to weak covariate overlap. We show that trimming propensity scores reduces variance but eliminates double robustness. We introduce DR estimators that retain double robustness after trimming through bias correction, preserving the original causal targets across unconfoundedness, instrumental variables, and difference-in-differences designs. In four applications, the proposed estimator…

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Combining Bayesian and Frequentist Inference for Laboratory-Specific Performance Guarantees in Copy Number Variation Detection

结合贝叶斯与频率派推断:拷贝数变异检测中的实验室特异性性能保证

Targeted amplicon panels are widely used in oncology diagnostics, but providing per-gene performance guarantees for copy number variant (CNV) detection remains challenging due to amplification artifacts, process-mismatch heterogeneity, and limited validation sample sizes. While Bayesian CNV callers naturally quantify per-sample uncertainty, translating this into the frequentist population-level guarantees required for clinical validation, coverage rates, false-positive…

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