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利用混合人群试验评估生物标志物亚组疗效的贝叶斯元分析AI 解读

During drug development, evidence can emerge to suggest a treatment is more effective in a specific patient subgroup. Whilst early trials may be conducted in biomarker-mixed populations, later trials are more likely to enrol biomarker-positive patients alone, thus leading to trials of the same treatment investigated in different populations. When conducting a meta-analysis, a conservative approach would be to combine only trials conducted in the biomarker-positive subgroup.…

COVID-19期间美国股票指数表现预测：随机森林与LSTMAI 解读

The US stock market experienced instability following the recession (2007-2009). COVID-19 poses a significant challenge to US stock traders and investors. Traders and investors should keep up with the stock market. This is to mitigate risks and improve profits by using forecasting models that account for the effects of the pandemic. With consideration of the COVID-19 pandemic after the recession, two machine learning models, including Random Forest and LSTM are used to…

理解异质性处理效应估计中的模型选择困境AI 解读

Personalized treatment effect estimates are often of interest in high-stakes applications -- thus, before deploying a model estimating such effects in practice, one needs to be sure that the best candidate from the ever-growing machine learning toolbox for this task was chosen. Unfortunately, due to the absence of counterfactual information in practice, it is usually not possible to rely on standard validation metrics for doing so, leading to a well-known model selection…

基于Cornish–Fisher展开的条件方差、偏度与峰度分位数估计AI 解读

The conditional variance, skewness, and kurtosis play a central role in time series analysis. These three conditional moments (CMs) are often studied by some parametric models but with two big issues: the risk of model mis-specification and the instability of model estimation. To avoid the above two issues, this paper proposes a novel method to estimate these three CMs by the so-called quantiled CMs (QCMs). The QCM method first adopts the idea of Cornish-Fisher expansion to…

实验中利用机器学习推断处理效应方差的稳健方法AI 解读

Experimenters often collect baseline data to study heterogeneity. I propose the first valid confidence intervals for the VCATE, the treatment effect variance explained by observables. Conventional approaches yield incorrect coverage when the VCATE is zero. As a result, practitioners could be prone to detect heterogeneity even when none exists. The reason why coverage worsens at the boundary is that all efficient estimators have a locally-degenerate influence function and may…

条件分布局部线性回归估计的一致收敛结果AI 解读

This paper examines the local linear regression (LLR) estimate of the conditional distribution function $F(y|x)$. We derive three uniform convergence results: the uniform bias expansion, the uniform convergence rate, and the uniform asymptotic linear representation. The uniformity in the above results is with respect to both $x$ and $y$ and therefore has not previously been addressed in the literature on local polynomial regression. Such uniform convergence results are…

异质性处理效应的因果保序校准AI 解读

We propose causal isotonic calibration, a novel nonparametric method for calibrating predictors of heterogeneous treatment effects. Furthermore, we introduce cross-calibration, a data-efficient variant of calibration that eliminates the need for hold-out calibration sets. Cross-calibration leverages cross-fitted predictors and generates a single calibrated predictor using all available data. Under weak conditions that do not assume monotonicity, we establish that both causal…

基于迭代Huber回归的大维矩阵时间序列稳健统计推断AI 解读

Matrix factor model is drawing growing attention for simultaneous two-way dimension reduction of well-structured matrix-valued observations. This paper focuses on robust statistical inference for matrix factor model in the ``diverging dimension" regime. We derive the convergence rates of the robust estimators for loadings, factors and common components under finite second moment assumption of the idiosyncratic errors. In addition, the asymptotic distributions of the…

个体处理效应估计的迁移学习AI 解读

This work considers the problem of transferring causal knowledge between tasks for Individual Treatment Effect (ITE) estimation. To this end, we theoretically assess the feasibility of transferring ITE knowledge and present a practical framework for efficient transfer. A lower bound is introduced on the ITE error of the target task to demonstrate that ITE knowledge transfer is challenging due to the absence of counterfactual information. Nevertheless, we establish…

竞争风险观察研究中平均处理效应重抽样过程的渐近性质AI 解读

In observational studies with time-to-event outcomes, the g-formula can be used to estimate a treatment effect in the presence of confounding factors. However, the asymptotic distribution of the corresponding stochastic process is complicated and thus not suitable for deriving confidence intervals or time-simultaneous confidence bands for the average treatment effect. A common remedy are resampling-based approximations, with Efron's nonparametric bootstrap being the standard…

利用直方图与三次 B 样条估计车辆时间序列的概率密度AI 解读

Random processes play a crucial role in scientific research, often characterized by distribution functions or probability density functions (PDFs). These PDFs serve as essential approximations of the actual and frequently undisclosed distribution governing the random process under examination. Diverse methodologies exist for estimating PDFs, each offering distinct advantages in specific contexts. This publication presents a novel approach that centers on estimating…

没有显著星号是好消息：基于协变量平衡检验 p 值的再随机化AI 解读

Modern social and biomedical scientific publications require the reporting of covariate balance tables with not only covariate means by treatment group but also the associated $p$-values from significance tests of their differences. The practical need to avoid small $p$-values renders balance check and rerandomization by hypothesis testing standards an attractive tool for improving covariate balance in randomized experiments. Despite the intuitiveness of such practice and…

利用多结果面板数据进行个体因果推断AI 解读

Policy evaluation in empirical microeconomics has been focusing on estimating the average treatment effect and more recently the heterogeneous treatment effects, often relying on the unconfoundedness assumption. We propose a method based on the interactive fixed effects model to estimate treatment effects at the individual level, which allows both the treatment assignment and the potential outcomes to be correlated with the unobserved individual characteristics. This method…

非线性结果下的合成控制：2019年香港修例抗议的经济影响AI 解读

The synthetic control estimator (Abadie et al., 2010) is asymptotically unbiased assuming that the outcome is a linear function of the underlying predictors and that the treated unit can be well approximated by the synthetic control before the treatment. When the outcome is nonlinear, the bias of the synthetic control estimator can be severe. In this paper, we provide conditions for the synthetic control estimator to be asymptotically unbiased when the outcome is nonlinear,…

面板正态有限混合回归模型的成分数量检验AI 解读

This paper develops the likelihood ratio-based test of the null hypothesis of a M0-component model against an alternative of (M0 + 1)-component model in the normal mixture panel regression by extending the Expectation-Maximization (EM) test of Chen and Li (2009a) and Kasahara and Shimotsu (2015) to the case of panel data. We show that, unlike the cross-sectional normal mixture, the first-order derivative of the density function for the variance parameter in the panel normal…

用于工具变量回归的深度偏最小二乘法AI 解读

In this paper, we propose deep partial least squares for the estimation of high-dimensional nonlinear instrumental variable regression. As a precursor to a flexible deep neural network architecture, our methodology uses partial least squares for dimension reduction and feature selection from the set of instruments and covariates. A central theoretical result, due to Brillinger (2012) shows that the feature selection provided by partial least squares is consistent and the…

通过倾向得分加权幂先验将外部资料纳入治疗组AI 解读

The incorporation of "real-world data" to supplement the analysis of trials and improve decision-making has spurred the development of statistical techniques to account for introduced confounding. Recently, "hybrid" methods have been developed through which measured confounding is first attenuated via propensity scores and unmeasured confounding is addressed through (Bayesian) dynamic borrowing. Most efforts to date have focused on augmenting control arms with historical…

粗糙 Volterra 随机波动率模型的稳健性与敏感性分析AI 解读

In this paper, we analyze the robustness and sensitivity of various continuous-time rough Volterra stochastic volatility models in relation to the process of market calibration. Model robustness is examined from two perspectives: the sensitivity of option price estimates and the sensitivity of parameter estimates to changes in the option data structure. The following sensitivity analysis consists of statistical tests to determine whether a given studied model is sensitive to…

分治动态规划：高维变点检测的近线性时间方法AI 解读

We develop a novel, general and computationally efficient framework, called Divide and Conquer Dynamic Programming (DCDP), for localizing change points in time series data with high-dimensional features. DCDP deploys a class of greedy algorithms that are applicable to a broad variety of high-dimensional statistical models and can enjoy almost linear computational complexity. We investigate the performance of DCDP in three commonly studied change point settings in high…

状态空间模型的高效变分近似AI 解读

Variational Bayes methods are a potential scalable estimation approach for state space models. However, existing methods are inaccurate or computationally infeasible for many state space models. This paper proposes a variational approximation that is accurate and fast for any model with a closed-form measurement density function and a state transition distribution within the exponential family of distributions. We show that our method can accurately and quickly estimate a…

学校选择中的排序异质性偏好模型AI 解读

School choice mechanism designers use discrete choice models to understand and predict families' preferences. The most widely-used choice model, the multinomial logit (MNL), is linear in school and/or household attributes. While the model is simple and interpretable, it assumes the ranked preference lists arise from a choice process that is uniform throughout the ranking, from top to bottom. In this work, we introduce two strategies for rank-heterogeneous choice modeling…

部分嵌套试验设计中的可推广性分析：坏死性小肠结肠炎外科试验AI 解读

We discuss generalizability analyses under a partially nested trial design, where part of the trial is nested within a cohort of trial-eligible individuals, while the rest of the trial is not nested. This design arises, for example, when only some centers participating in a trial are able to collect data on non-randomized individuals, or when data on non-randomized individuals cannot be collected for the full duration of the trial. Our work is motivated by the Necrotizing…

个性化系统中用户学习效应的因果估计AI 解读

In online platforms, the impact of a treatment on an observed outcome may change over time as 1) users learn about the intervention, and 2) the system personalization, such as individualized recommendations, change over time. We introduce a non-parametric causal model of user actions in a personalized system. We show that the Cookie-Cookie-Day (CCD) experiment, designed for the measurement of the user learning effect, is biased when there is personalization. We derive new…

面板数据模型中的深度神经网络估计AI 解读

In this paper we study neural networks and their approximating power in panel data models. We provide asymptotic guarantees on deep feed-forward neural network estimation of the conditional mean, building on the work of Farrell et al. (2021), and explore latent patterns in the cross-section. We use the proposed estimators to forecast the progression of new COVID-19 cases across the G7 countries during the pandemic. We find significant forecasting gains over both linear panel…