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Semiparametric Estimation of Treatment Effects in Randomized Experiments

随机实验中处理效应的半参数估计

We develop new semiparametric methods for estimating treatment effects. We focus on settings where the outcome distributions may be thick tailed, where treatment effects may be small, where sample sizes are large and where assignment is completely random. This setting is of particular interest in recent online experimentation. We propose using parametric models for the treatment effects, leading to semiparametric models for the outcome distributions. We derive the…

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Evaluating hybrid controls methodology in early-phase oncology trials: a simulation study based on the MORPHEUS-UC trial

早期肿瘤试验混合对照方法评估:基于MORPHEUS-UC的模拟研究

Phase Ib/II oncology trials, despite their small sample sizes, aim to provide information for optimal internal company decision-making concerning novel drug development. Hybrid controls (a combination of the current control arm and controls from one or more sources of historical trial data [HTD]) can be used to increase the statistical precision. Here we assess combining two sources of Roche HTD to construct a hybrid control in targeted therapy for decision-making via an…

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Modelling Structural Breaks In Stock Price Time Series Using Stochastic Differential Equations

利用随机微分方程刻画股票价格时间序列的结构突变

This paper studies the effect of quarterly earnings reports on the stock price. The profitability of the stock is modelled by geometric Brownian diffusion and the Constant Elasticity of Variance model. We fit several variations of stochastic differential equations to the pre-and after-report period using the Maximum Likelihood Estimation and Grid Search of parameters method. By examining the change in the model parameters after reports' publication, the study reveals that…

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Quantile Time Series Regression Models Revisited

分位数时间序列回归模型再探

This article discusses recent developments in the literature of quantile time series models in the cases of stationary and nonstationary underline stochastic processes.

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Forecasting inflation using disaggregates and machine learning

利用细分数据与机器学习预测通胀

This paper examines the effectiveness of several forecasting methods for predicting inflation, focusing on aggregating disaggregated forecasts - also known in the literature as the bottom-up approach. Taking the Brazilian case as an application, we consider different disaggregation levels for inflation and employ a range of traditional time series techniques as well as linear and nonlinear machine learning (ML) models to deal with a larger number of predictors. For many…

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Fast Two-Stage Variational Bayesian Approach to Estimating Panel Spatial Autoregressive Models with Unrestricted Spatial Weights Matrices

无预设空间权重限制的面板空间自回归模型快速两阶段变分贝叶斯估计

This paper proposes a fast two-stage variational Bayesian (VB) algorithm to estimate unrestricted panel spatial autoregressive models. Using Dirichlet-Laplace priors, we are able to uncover the spatial relationships between cross-sectional units without imposing any a priori restrictions. Monte Carlo experiments show that our approach works well for both long and short panels. We are also the first in the literature to develop VB methods to estimate large covariance matrices…

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Econometrics of Machine Learning Methods in Economic Forecasting

经济预测中机器学习方法的计量经济学综述

This paper surveys the recent advances in machine learning method for economic forecasting. The survey covers the following topics: nowcasting, textual data, panel and tensor data, high-dimensional Granger causality tests, time series cross-validation, classification with economic losses.

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Simulation Experiments as a Causal Problem

将模拟实验视为因果问题

Simulation methods are among the most ubiquitous methodological tools in statistical science. In particular, statisticians often is simulation to explore properties of statistical functionals in models for which developed statistical theory is insufficient or to assess finite sample properties of theoretical results. We show that the design of simulation experiments can be viewed from the perspective of causal intervention on a data generating mechanism. We then demonstrate…

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A Comprehensive Framework for the Evaluation of Individual Treatment Rules From Observational Data

基于观察数据评估个体化治疗规则的综合框架

Individualized treatment rules (ITRs) are deterministic decision rules that recommend treatments to individuals based on their characteristics. Though ubiquitous in medicine, ITRs are hardly ever evaluated in randomized controlled trials. To evaluate ITRs from observational data, we introduce a new probabilistic model and distinguish two situations: i) the situation of a newly developed ITR, where data are from a population where no patient implements the ITR, and ii) the…

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Asymptotic Theory for Unit Root Moderate Deviations in Quantile Autoregressions and Predictive Regressions

分位数自回归与预测回归中单位根中等偏离的渐近理论

We establish the asymptotic theory in quantile autoregression when the model parameter is specified with respect to moderate deviations from the unit boundary of the form (1 + c / k) with a convergence sequence that diverges at a rate slower than the sample size n. Then, extending the framework proposed by Phillips and Magdalinos (2007), we consider the limit theory for the near-stationary and the near-explosive cases when the model is estimated with a conditional quantile…

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Proximal Causal Inference for Synthetic Control with Surrogates

利用替代指标的合成控制近端因果推断

The synthetic control method (SCM) has become a popular tool for estimating causal effects in policy evaluation, where a single treated unit is observed, and a heterogeneous set of untreated units with pre- and post-policy change data are also observed. However, the synthetic control method faces challenges in accurately predicting post-intervention potential outcome had, contrary to fact, the treatment been withheld, when the pre-intervention period is short or the…

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Universal Difference-in-Differences for Causal Inference in Epidemiology

流行病学因果推断中的通用双重差分

Difference-in-differences is undoubtedly one of the most widely used methods for evaluating the causal effect of an intervention in observational (i.e., nonrandomized) settings. The approach is typically used when pre- and post-exposure outcome measurements are available, and one can reasonably assume that the association of the unobserved confounder with the outcome has the same absolute magnitude in the two exposure arms, and is constant over time; a so-called parallel…

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Semiparametric Estimation of Long-Term Treatment Effects

长期处理效应的半参数估计

Long-term outcomes of experimental evaluations are necessarily observed after long delays. We develop semiparametric methods for combining the short-term outcomes of experiments with observational measurements of short-term and long-term outcomes, in order to estimate long-term treatment effects. We characterize semiparametric efficiency bounds for various instances of this problem. These calculations facilitate the construction of several estimators. We analyze the…

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Modeling Interference Using Experiment Roll-out

利用实验分阶段推出建模干扰效应

Experiments on online marketplaces and social networks suffer from interference, where the outcome of a unit is impacted by the treatment status of other units. We propose a framework for modeling interference using a ubiquitous deployment mechanism for experiments, staggered roll-out designs, which slowly increase the fraction of units exposed to the treatment to mitigate any unanticipated adverse side effects. Our main idea is to leverage the temporal variations in…

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AI-Assisted Discovery of Quantitative and Formal Models in Social Science

社会科学中定量与形式模型的 AI 辅助发现

In social science, formal and quantitative models, such as ones describing economic growth and collective action, are used to formulate mechanistic explanations, provide predictions, and uncover questions about observed phenomena. Here, we demonstrate the use of a machine learning system to aid the discovery of symbolic models that capture nonlinear and dynamical relationships in social science datasets. By extending neuro-symbolic methods to find compact functions and…

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Computer vision-enriched discrete choice models, with an application to residential location choice

计算机视觉增强的离散选择模型:居住区位选择应用

Visual imagery is indispensable to many multi-attribute decision situations. Examples of such decision situations in travel behaviour research include residential location choices, vehicle choices, tourist destination choices, and various safety-related choices. However, current discrete choice models cannot handle image data and thus cannot incorporate information embedded in images into their representations of choice behaviour. This gap between discrete choice models'…

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CUTS+: High-dimensional Causal Discovery from Irregular Time-series

CUTS+:不规则时间序列中的高维因果发现

Causal discovery in time-series is a fundamental problem in the machine learning community, enabling causal reasoning and decision-making in complex scenarios. Recently, researchers successfully discover causality by combining neural networks with Granger causality, but their performances degrade largely when encountering high-dimensional data because of the highly redundant network design and huge causal graphs. Moreover, the missing entries in the observations further…

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Just what the doctor ordered: An evaluation of provider preference-based Instrumental Variable methods in observational studies, with application for comparative effectiveness of type 2 diabetes therapy

医生处方偏好工具变量方法的评估:以二型糖尿病治疗为例

Instrumental Variables provide a way of addressing bias due to unmeasured confounding when estimating treatment effects using observational data. As instrument prescription preference of individual healthcare providers has been proposed. Because prescription preference is hard to measure and often unobserved, a surrogate measure constructed from available data is often required for the analysis. Different construction methods for this surrogate measure are possible, such as…

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Optimizing B2B Product Offers with Machine Learning, Mixed Logit, and Nonlinear Programming

结合机器学习、混合 Logit 与非线性规划优化 B2B 产品报价

In B2B markets, value-based pricing and selling has become an important alternative to discounting. This study outlines a modeling method that uses customer data (product offers made to each current or potential customer, features, discounts, and customer purchase decisions) to estimate a mixed logit choice model. The model is estimated via hierarchical Bayes and machine learning, delivering customer-level parameter estimates. Customer-level estimates are input into a…

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Non-Asymptotic Pointwise and Worst-Case Bounds for Classical Spectrum Estimators

经典谱估计量的非渐近逐点与最坏情形误差界

Spectrum estimation is a fundamental methodology in the analysis of time-series data, with applications including medicine, speech analysis, and control design. The asymptotic theory of spectrum estimation is well-understood, but the theory is limited when the number of samples is fixed and finite. This paper gives non-asymptotic error bounds for a broad class of spectral estimators, both pointwise (at specific frequencies) and in the worst case over all frequencies. The…

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The Yule-Frisch-Waugh-Lovell Theorem for Linear Instrumental Variables Estimation

线性工具变量估计中的 Yule–Frisch–Waugh–Lovell 定理

In this paper, I discuss three aspects of the Frisch-Waugh-Lovell theorem. First, I show that the theorem holds for linear instrumental variables estimation of a multiple regression model that is either exactly or overidentified. I show that with linear instrumental variables estimation: (a) coefficients on endogenous variables are identical in full and partial (or residualized) regressions; (b) residual vectors are identical for full and partial regressions; and (c)…

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Quantile regression outcome-adaptive lasso: variable selection for causal quantile treatment effect estimation

分位数回归结局自适应 lasso:因果分位数处理效应的变量选择

Quantile treatment effects (QTEs) can characterize the potentially heterogeneous causal effect of a treatment on different points of the entire outcome distribution. Propensity score (PS) methods are commonly employed for estimating QTEs in non-randomized studies. Empirical and theoretical studies have shown that insufficient and unnecessary adjustment for covariates in PS models can lead to bias and efficiency loss in estimating treatment effects. Striking a balance between…

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Adaptive Robust Large Volatility Matrix Estimation Based on High-Frequency Financial Data

基于高频金融数据的大维波动率矩阵自适应稳健估计

Several novel statistical methods have been developed to estimate large integrated volatility matrices based on high-frequency financial data. To investigate their asymptotic behaviors, they require a sub-Gaussian or finite high-order moment assumption for observed log-returns, which cannot account for the heavy-tail phenomenon of stock-returns. Recently, a robust estimator was developed to handle heavy-tailed distributions with some bounded fourth-moment assumption.…

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A new method for clustered survival data]{A new method for clustered survival data: Estimation of treatment effect heterogeneity and variable selection

集群生存数据的新方法:处理效应异质性估计与变量选择

We recently developed a new method riAFT-BART to draw causal inferences about population treatment effect on patient survival from clustered and censored survival data while accounting for the multilevel data structure. The practical utility of this method goes beyond the estimation of population average treatment effect. In this work, we exposit how riAFT-BART can be used to solve two important statistical questions with clustered survival data: estimating the treatment…

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