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Multiply robust estimators in longitudinal studies with missing data under control-based imputation

基于对照组插补的纵向缺失数据多重稳健估计

Longitudinal studies are often subject to missing data. The ICH E9(R1) addendum addresses the importance of defining a treatment effect estimand with the consideration of intercurrent events. Jump-to-reference (J2R) is one classically envisioned control-based scenario for the treatment effect evaluation using the hypothetical strategy, where the participants in the treatment group after intercurrent events are assumed to have the same disease progress as those with identical…

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Fourier Methods for Sufficient Dimension Reduction in Time Series

时间序列充分降维的傅里叶方法

Dimensionality reduction has always been one of the most significant and challenging problems in the analysis of high-dimensional data. In the context of time series analysis, our focus is on the estimation and inference of conditional mean and variance functions. By using central mean and variance dimension reduction subspaces that preserve sufficient information about the response, one can effectively estimate the unknown mean and variance functions of the time series.…

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A Class of Directed Acyclic Graphs with Mixed Data Types in Mediation Analysis

中介分析中适用于混合数据类型的一类有向无环图

We propose a unified class of generalized structural equation models (GSEMs) with data of mixed types in mediation analysis, including continuous, categorical, and count variables. Such models extend substantially the classical linear structural equation model to accommodate many data types arising from the application of mediation analysis. Invoking the hierarchical modeling approach, we specify GSEMs by a copula joint distribution of outcome variable, mediator and exposure…

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Bayesian Nonlinear Regression using Sums of Simple Functions

基于简单函数之和的贝叶斯非线性回归

This paper proposes a new Bayesian machine learning model that can be applied to large datasets arising in macroeconomics. Our framework sums over many simple two-component location mixtures. The transition between components is determined by a logistic function that depends on a single threshold variable and two hyperparameters. Each of these individual models only accounts for a minor portion of the variation in the endogenous variables. But many of them are capable of…

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Dimension-agnostic Change Point Detection

不依赖维度选择的变点检测

Change point testing for high-dimensional data has attracted a lot of attention in statistics and machine learning owing to the emergence of high-dimensional data with structural breaks from many fields. In practice, when the dimension is less than the sample size but is not small, it is often unclear whether a method that is tailored to high-dimensional data or simply a classical method that is developed and justified for low-dimensional data is preferred. In addition, the…

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Policy Evaluation for Temporal and/or Spatial Dependent Experiments

时间或空间依赖实验中的策略评估

The aim of this paper is to establish a causal link between the policies implemented by technology companies and the outcomes they yield within intricate temporal and/or spatial dependent experiments. We propose a novel temporal/spatio-temporal Varying Coefficient Decision Process (VCDP) model, capable of effectively capturing the evolving treatment effects in situations characterized by temporal and/or spatial dependence. Our methodology encompasses the decomposition of the…

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Marginal Density Ratio for Off-Policy Evaluation in Contextual Bandits

情境老虎机离线策略评估中的边际密度比

Off-Policy Evaluation (OPE) in contextual bandits is crucial for assessing new policies using existing data without costly experimentation. However, current OPE methods, such as Inverse Probability Weighting (IPW) and Doubly Robust (DR) estimators, suffer from high variance, particularly in cases of low overlap between target and behavior policies or large action and context spaces. In this paper, we introduce a new OPE estimator for contextual bandits, the Marginal Ratio…

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A unified framework for covariate adjustment under stratified randomization

分层随机化下协变量调整的统一框架

Randomization, as a key technique in clinical trials, can eliminate sources of bias and produce comparable treatment groups. In randomized experiments, the treatment effect is a parameter of general interest. Researchers have explored the validity of using linear models to estimate the treatment effect and perform covariate adjustment and thus improve the estimation efficiency. However, the relationship between covariates and outcomes is not necessarily linear, and is often…

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Identification and Inference for Synthetic Controls with Confounding

存在混杂时合成控制的识别与推断

This paper studies inference on treatment effects in panel data settings with unobserved confounding. We model outcome variables through a factor model with random factors and loadings. Such factors and loadings may act as unobserved confounders: when the treatment is implemented depends on time-varying factors, and who receives the treatment depends on unit-level confounders. We study the identification of treatment effects and illustrate the presence of a trade-off between…

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Bandwidth Selection for Gaussian Kernel Ridge Regression via Jacobian Control

基于雅可比控制的高斯核岭回归带宽选择

Most machine learning methods require tuning of hyper-parameters. For kernel ridge regression with the Gaussian kernel, the hyper-parameter is the bandwidth. The bandwidth specifies the length scale of the kernel and has to be carefully selected to obtain a model with good generalization. The default methods for bandwidth selection, cross-validation and marginal likelihood maximization, often yield good results, albeit at high computational costs. Inspired by Jacobian…

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Applying the estimands framework to non-inferiority trials: guidance on choice of hypothetical estimands for non-adherence and comparison of estimation methods

非劣效试验中的估计目标框架:不依从的假想目标与估计方法比较

A common concern in non-inferiority (NI) trials is that non adherence due, for example, to poor study conduct can make treatment arms artificially similar. Because intention to treat analyses can be anti-conservative in this situation, per protocol analyses are sometimes recommended. However, such advice does not consider the estimands framework, nor the risk of bias from per protocol analyses. We therefore sought to update the above guidance using the estimands framework,…

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Supervised Factor Modeling for High-Dimensional Linear Time Series

高维线性时间序列的监督因子建模

Motivated by Tucker tensor decomposition, this paper imposes low-rank structures to the column and row spaces of coefficient matrices in a multivariate infinite-order vector autoregression (VAR), which leads to a supervised factor model with two factor modelings being conducted to responses and predictors simultaneously. Interestingly, the stationarity condition implies an intrinsic weak group sparsity mechanism of infinite-order VAR, and hence a rank-constrained group Lasso…

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A Policy Gradient Method for Confounded POMDPs

混杂部分可观测马尔可夫决策过程的策略梯度方法

In this paper, we propose a policy gradient method for confounded partially observable Markov decision processes (POMDPs) with continuous state and observation spaces in the offline setting. We first establish a novel identification result to non-parametrically estimate any history-dependent policy gradient under POMDPs using the offline data. The identification enables us to solve a sequence of conditional moment restrictions and adopt the min-max learning procedure with…

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The Functional Average Treatment Effect

泛函平均处理效应

This paper establishes the functional average as an important estimand for causal inference. The significance of the estimand lies in its robustness against traditional issues of confounding. We prove that this robustness holds even when the probability distribution of the outcome, conditional on treatment or some other vector of adjusting variables, differs almost arbitrarily from its counterfactual analogue. This paper also examines possible estimators of the functional…

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Bootstrap Inference on Partially Linear Binary Choice Model

部分线性二元选择模型的 Bootstrap 推断

The partially linear binary choice model can be used for estimating structural equations where nonlinearity may appear due to diminishing marginal returns, different life cycle regimes, or hectic physical phenomena. The inference procedure for this model based on the analytic asymptotic approximation could be unreliable in finite samples if the sample size is not sufficiently large. This paper proposes a bootstrap inference approach for the model. Monte Carlo simulations…

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First-order multivariate integer-valued autoregressive model with multivariate mixture distributions

采用多元混合分布的一阶多元整数值自回归模型

The univariate integer-valued time series has been extensively studied, but literature on multivariate integer-valued time series models is quite limited and the complex correlation structure among the multivariate integer-valued time series is barely discussed. In this study, we proposed a first-order multivariate integer-valued autoregressive model to characterize the correlation among multivariate integer-valued time series with higher flexibility. Under the general…

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Identification in Endogenous Sequential Treatment Regimes

内生序贯处理方案中的识别

This paper develops a novel nonparametric identification method for treatment effects in settings where individuals self-select into treatment sequences. I propose an identification strategy which relies on a dynamic version of standard Instrumental Variables (IV) assumptions and builds on a dynamic version of the Marginal Treatment Effects (MTE) as the fundamental building block for treatment effects. The main contribution of the paper is to relax assumptions on the support…

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Local causal effects with continuous exposures: A matching estimator for the average causal derivative effect

连续暴露的局部因果效应:平均因果导数效应的匹配估计

The estimation of causal effects is a fundamental goal in the field of causal inference. However, it is challenging for various reasons. One reason is that the exposure (or treatment) is naturally continuous in many real-world scenarios. When dealing with continuous exposure, dichotomizing the exposure variable based on a pre-defined threshold may result in a biased understanding of causal relationships. In this paper, we propose a novel causal inference framework that can…

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Extrapolating Away from the Cutoff in Regression Discontinuity Designs

回归不连续设计中远离阈值的效应外推

Canonical RD designs yield credible local estimates of the treatment effect at the cutoff under mild continuity assumptions, but they fail to identify treatment effects away from the cutoff without additional assumptions. The fundamental challenge of identifying treatment effects away from the cutoff is that the counterfactual outcome under the alternative treatment status is never observed. This paper aims to provide a methodological blueprint to identify treatment effects…

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On the Limits of Regression Adjustment

回归调整的收益上限

Regression adjustment, sometimes known as Controlled-experiment Using Pre-Experiment Data (CUPED), is an important technique in internet experimentation. It decreases the variance of effect size estimates, often cutting confidence interval widths in half or more while never making them worse. It does so by carefully regressing the goal metric against pre-experiment features to reduce the variance. The tremendous gains of regression adjustment begs the question: How much…

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Risk-based decision making: estimands for sequential prediction under interventions

基于风险的决策:干预下序贯预测的估计目标

Prediction models are used amongst others to inform medical decisions on interventions. Typically, individuals with high risks of adverse outcomes are advised to undergo an intervention while those at low risk are advised to refrain from it. Standard prediction models do not always provide risks that are relevant to inform such decisions: e.g., an individual may be estimated to be at low risk because similar individuals in the past received an intervention which lowered…

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Inference of Sample Complier Average Causal Effects in Completely Randomized Experiments

完全随机实验中样本依从者平均因果效应的推断

In randomized experiments with non-compliance scholars have argued that the complier average causal effect (CACE) ought to be the main causal estimand. The literature on inference of the complier average treatment effect (CACE) has focused on inference about the population CACE. However, in general individuals in the experiments are volunteers. This means that there is a risk that individuals partaking in a given experiment differ in important ways from a population of…

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Strong consistency of an estimator by the truncated singular value decomposition for an errors-in-variables regression model with collinearity

共线性变量误差回归中截断奇异值分解估计的强相合性

In this paper, we prove strong consistency of an estimator by the truncated singular value decomposition for a multivariate errors-in-variables linear regression model with collinearity. This result is an extension of Gleser's proof of the strong consistency of total least squares solutions to the case with modern rank constraints. While the usual discussion of consistency in the absence of solution uniqueness deals with the minimal norm solution, the contribution of this…

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A Primer on Deep Learning for Causal Inference

因果推断中的深度学习入门

This review systematizes the emerging literature for causal inference using deep neural networks under the potential outcomes framework. It provides an intuitive introduction on how deep learning can be used to estimate/predict heterogeneous treatment effects and extend causal inference to settings where confounding is non-linear, time varying, or encoded in text, networks, and images. To maximize accessibility, we also introduce prerequisite concepts from causal inference…

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