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Leveraging Local Distributions in Mendelian Randomization: Uncertain Opinions are Invalid

利用局部分布开展孟德尔随机化:不确定的意见无效

Mendelian randomization (MR) considers using genetic variants as instrumental variables (IVs) to infer causal effects in observational studies. However, the validity of causal inference in MR can be compromised when the IVs are potentially invalid. In this work, we propose a new method, MR-Local, to infer the causal effect in the existence of possibly invalid IVs. By leveraging the distribution of ratio estimates around the true causal effect, MR-Local selects the cluster of…

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Change Point Detection with Copula Entropy based Two-Sample Test

基于 Copula 熵双样本检验的变点检测

Change point detection is a typical task that aim to find changes in time series and can be tackled with two-sample test. Copula Entropy is a mathematical concept for measuring statistical independence and a two-sample test based on it was introduced recently. In this paper we propose a nonparametric multivariate method for multiple change point detection with the copula entropy-based two-sample test. The single change point detection is first proposed as a group of…

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Prediction modelling with many correlated and zero-inflated predictors: assessing a nonnegative garrote approach

含大量相关与零膨胀预测变量的预测建模:非负绞刑估计评估

Building prediction models from mass-spectrometry data is challenging due to the abundance of correlated features with varying degrees of zero-inflation, leading to a common interest in reducing the features to a concise predictor set with good predictive performance. In this study, we formally established and examined regularized regression approaches, designed to address zero-inflated and correlated predictors. In particular, we describe a novel two-stage regularized…

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Predicting Batting Averages in Specific Matchups Using Generalized Linked Matrix Factorization

用广义连接矩阵分解预测特定对阵中的打击率

Predicting batting averages for specific batters against specific pitchers is a challenging problem in baseball. Previous methods for estimating batting averages in these matchups have used regression models that can incorporate the pitcher's and batter's individual batting averages. However, these methods are limited in their flexibility to include many additional parameters because of the challenges of high-dimensional data in regression. Dimension reduction methods can be…

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The Connection Between R-Learning and Inverse-Variance Weighting for Estimation of Heterogeneous Treatment Effects

异质性处理效应估计中 R-Learning 与逆方差加权的联系

Many methods for estimating conditional average treatment effects (CATEs) can be expressed as weighted pseudo-outcome regressions (PORs). Previous comparisons of POR techniques have paid careful attention to the choice of pseudo-outcome transformation. However, we argue that the dominant driver of performance is actually the choice of weights. For example, we point out that R-Learning implicitly performs a POR with inverse-variance weights (IVWs). In the CATE setting, IVWs…

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Semiparametric Mixed-effects Model for Longitudinal Data with Non-normal Errors

非正态误差纵向数据的半参数混合效应模型

Difficulties may arise when analyzing longitudinal data using mixed-effects models if there are nonparametric functions present in the linear predictor component. This study extends the use of semiparametric mixed-effects modeling in cases when the response variable does not always follow a normal distribution and the nonparametric component is structured as an additive model. A novel approach is proposed to identify significant linear and non-linear components using a…

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Data-driven model selection within the matrix completion method for causal panel data models

因果面板模型矩阵补全方法中的数据驱动模型选择

Matrix completion estimators are employed in causal panel data models to regulate the rank of the underlying factor model using nuclear norm minimization. This convex optimization problem enables concurrent regularization of a potentially high-dimensional set of covariates to shrink the model size. For valid finite sample inference, we adopt a permutation-based approach and prove its validity for any treatment assignment mechanism. Simulations illustrate the consistency of…

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DoubleMLDeep: Estimation of Causal Effects with Multimodal Data

DoubleMLDeep:利用多模态数据估计因果效应

This paper explores the use of unstructured, multimodal data, namely text and images, in causal inference and treatment effect estimation. We propose a neural network architecture that is adapted to the double machine learning (DML) framework, specifically the partially linear model. An additional contribution of our paper is a new method to generate a semi-synthetic dataset which can be used to evaluate the performance of causal effect estimation in the presence of text and…

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Overlap, matching, or entropy weights: what are we weighting for?

重叠权重、匹配权重与熵权重:究竟在估计什么?

There has been a recent surge in statistical methods for handling the lack of adequate positivity when using inverse probability weights (IPW). However, these nascent developments have raised a number of questions. Thus, we demonstrate the ability of equipoise estimators (overlap, matching, and entropy weights) to handle the lack of positivity. Compared to IPW, the equipoise estimators have been shown to be flexible and easy to interpret. However, promoting their wide use…

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Bayesian Causal Inference with Gaussian Process Networks

基于高斯过程网络的贝叶斯因果推断

Causal discovery and inference from observational data is an essential problem in statistics posing both modeling and computational challenges. These are typically addressed by imposing strict assumptions on the joint distribution such as linearity. We consider the problem of the Bayesian estimation of the effects of hypothetical interventions in the Gaussian Process Network (GPN) model, a flexible causal framework which allows describing the causal relationships…

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Multivariate ordinal regression for multiple repeated measurements

多重重复测量的多变量有序回归

In this paper we propose a multivariate ordinal regression model which allows the joint modeling of three-dimensional panel data containing both repeated and multiple measurements for a collection of subjects. This is achieved by a multivariate autoregressive structure on the errors of the latent variables underlying the ordinal responses, where we distinguish between the correlations at a single point in time and the persistence over time. The error distribution is assumed…

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Stochastic convergence in per capita CO$_2$ emissions. An approach from nonlinear stationarity analysis

人均二氧化碳排放的随机收敛:非线性平稳性分析

This paper studies stochastic convergence of per capita CO$_2$ emissions in 28 OECD countries for the 1901-2009 period. The analysis is carried out at two aggregation levels, first for the whole set of countries (joint analysis) and then separately for developed and developing states (group analysis). A powerful time series methodology, adapted to a nonlinear framework that allows for quadratic trends with possibly smooth transitions between regimes, is applied. This…

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On the design-dependent suboptimality of the Lasso

Lasso 的设计依赖次优性

This paper investigates the effect of the design matrix on the ability (or inability) to estimate a sparse parameter in linear regression. More specifically, we characterize the optimal rate of estimation when the smallest singular value of the design matrix is bounded away from zero. In addition to this information-theoretic result, we provide and analyze a procedure which is simultaneously statistically optimal and computationally efficient, based on soft thresholding the…

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Finite- and Large-Sample Inference for Ranks using Multinomial Data with an Application to Ranking Political Parties

多项分布数据下排名的有限样本与大样本推断:政党排名应用

It is common to rank different categories by means of preferences that are revealed through data on choices. A prominent example is the ranking of political candidates or parties using the estimated share of support each one receives in surveys or polls about political attitudes. Since these rankings are computed using estimates of the share of support rather than the true share of support, there may be considerable uncertainty concerning the true ranking of the political…

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The Fourier-Malliavin Volatility (FMVol) MATLAB library

Fourier–Malliavin 波动率估计 MATLAB 库 FMVol

This paper presents the Fourier-Malliavin Volatility (FMVol) estimation library for MATLAB. This library includes functions that implement Fourier- Malliavin estimators (see Malliavin and Mancino (2002, 2009)) of the volatility and co-volatility of continuous stochastic volatility processes and second-order quantities, like the quarticity (the squared volatility), the volatility of volatility and the leverage (the covariance between changes in the process and changes in its…

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Bayesian regularization for flexible baseline hazard functions in Cox survival models

Cox生存模型中灵活基线风险函数的贝叶斯正则化

Fully Bayesian methods for Cox models specify a model for the baseline hazard function. Parametric approaches generally provide monotone estimations. Semi-parametric choices allow for more flexible patterns but they can suffer from overfitting and instability. Regularization methods through prior distributions with correlated structures usually give reasonable answers to these types of situations. We discuss Bayesian regularization for Cox survival models defined via…

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RCT Rejection Sampling for Causal Estimation Evaluation

用于因果估计评估的随机对照试验拒绝采样

Confounding is a significant obstacle to unbiased estimation of causal effects from observational data. For settings with high-dimensional covariates -- such as text data, genomics, or the behavioral social sciences -- researchers have proposed methods to adjust for confounding by adapting machine learning methods to the goal of causal estimation. However, empirical evaluation of these adjustment methods has been challenging and limited. In this work, we build on a promising…

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Hierarchical Bias-Driven Stratification for Interpretable Causal Effect Estimation

用于可解释因果效应估计的分层偏差驱动分层方法

Interpretability and transparency are essential for incorporating causal effect models from observational data into policy decision-making. They can provide trust for the model in the absence of ground truth labels to evaluate the accuracy of such models. To date, attempts at transparent causal effect estimation consist of applying post hoc explanation methods to black-box models, which are not interpretable. Here, we present BICauseTree: an interpretable balancing method…

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River flow modelling using nonparametric functional data analysis

利用非参数函数型数据分析建模河流流量

Time series and extreme value analyses are two statistical approaches usually applied to study hydrological data. Classical techniques, such as ARIMA models (in the case of mean flow predictions), and parametric generalised extreme value (GEV) fits and nonparametric extreme value methods (in the case of extreme value theory) have been usually employed in this context. In this paper, nonparametric functional data methods are used to perform mean monthly flow predictions and…

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On the partial autocorrelation function for locally stationary time series: characterization, estimation and inference

局部平稳时间序列的偏自相关函数:刻画、估计与推断

For stationary time series, it is common to use the plots of partial autocorrelation function (PACF) or PACF-based tests to explore the temporal dependence structure of such processes. To our best knowledge, such analogs for non-stationary time series have not been fully established yet. In this paper, we fill this gap for locally stationary time series with short-range dependence. First, we characterize the PACF locally in the time domain and show that the $j$th PACF,…

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Doubly-robust and heteroscedasticity-aware sample trimming for causal inference

因果推断中兼顾双重稳健与异方差的样本修剪

A popular method for variance reduction in observational causal inference is propensity-based trimming, the practice of removing units with extreme propensities from the sample. This practice has theoretical grounding when the data are homoscedastic and the propensity model is parametric (Yang and Ding, 2018; Crump et al. 2009), but in modern settings where heteroscedastic data are analyzed with non-parametric models, existing theory fails to support current practice. In…

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Graph Neural Networks: Theory for Estimation with Application on Network Heterogeneity

图神经网络估计理论及其网络异质性应用

This paper presents a novel application of graph neural networks for modeling and estimating network heterogeneity. Network heterogeneity is characterized by variations in unit's decisions or outcomes that depend not only on its own attributes but also on the conditions of its surrounding neighborhood. We delineate the convergence rate of the graph neural networks estimator, as well as its applicability in semiparametric causal inference with heterogeneous treatment effects.…

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Notes on Causation, Comparison, and Regression

关于因果、比较与回归的札记

Comparison and contrast are the basic means to unveil causation and learn which treatments work. To build good comparison groups, randomized experimentation is key, yet often infeasible. In such non-experimental settings, we illustrate and discuss diagnostics to assess how well the common linear regression approach to causal inference approximates desirable features of randomized experiments, such as covariate balance, study representativeness, interpolated estimation, and…

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GT-PCA: Effective and Interpretable Dimensionality Reduction with General Transform-Invariant Principal Component Analysis

GT-PCA:基于一般变换不变主成分分析的有效且可解释降维

Data analysis often requires methods that are invariant with respect to specific transformations, such as rotations in case of images or shifts in case of images and time series. While principal component analysis (PCA) is a widely-used dimension reduction technique, it lacks robustness with respect to these transformations. Modern alternatives, such as autoencoders, can be invariant with respect to specific transformations but are generally not interpretable. We introduce…

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