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利用相关工具变量集合预测具有多效性调控作用的 GWAS 位点因果基因AI 解读

Multivariate Mendelian randomization (MVMR) is a statistical technique that uses sets of genetic instruments to estimate the direct causal effects of multiple exposures on an outcome of interest. At genomic loci with pleiotropic gene regulatory effects, that is, loci where the same genetic variants are associated to multiple nearby genes, MVMR can potentially be used to predict candidate causal genes. However, consensus in the field dictates that the genetic instruments in…

跨研究工具变量估计的非参数复现AI 解读

Replicating causal estimates across different cohorts is crucial for increasing the integrity of epidemiological studies. However, strong assumptions regarding unmeasured confounding and effect modification often hinder this goal. By employing an instrumental variable (IV) approach and targeting the local average treatment effect (LATE), these assumptions can be relaxed to some degree; however, little work has addressed the replicability of IV estimates. In this paper, we…

通过稳健信息共享交叉验证进行稳定且稳健的超参数选择AI 解读

Robust estimators for linear regression require non-convex objective functions to shield against adverse affects of outliers. This non-convexity brings challenges, particularly when combined with penalization in high-dimensional settings. Selecting hyper-parameters for the penalty based on a finite sample is a critical task. In practice, cross-validation (CV) is the prevalent strategy with good performance for convex estimators. Applied with robust estimators, however, CV…

样本量为一时的随机化推断AI 解读

N-of-1 experiments, where a unit serves as its own control and treatment in different time windows, have been used in certain medical contexts for decades. However, due to effects that accumulate over long time windows and interventions that have complex evolution, a lack of robust inference tools has limited the widespread applicability of such N-of-1 designs. This work combines techniques from experiment design in causal inference and system identification from control…

预测回归中的边界参数AI 解读

We consider bootstrap inference in predictive (or Granger-causality) regressions when the parameter of interest may lie on the boundary of the parameter space, here defined by means of a smooth inequality constraint. For instance, this situation occurs when the definition of the parameter space allows for the cases of either no predictability or sign-restricted predictability. We show that in this context constrained estimation gives rise to bootstrap statistics whose limit…

债券风险溢价可预测性的稳健分位数检验AI 解读

Different from existing literature on testing the macro-spanning hypothesis of bond risk premia, which only considers mean regressions, this paper investigates whether the yield curve represented by CP factor (Cochrane and Piazzesi, 2005) contains all available information about future bond returns in a predictive quantile regression with many other macroeconomic variables. In this study, we introduce the Trend in Debt Holding (TDH) as a novel predictor, testing it alongside…

采用污染正态分布的 Heckman 选择模型AI 解读

The Heckman selection model is one of the most well-renounced econometric models in the analysis of data with sample selection. This model is designed to rectify sample selection biases based on the assumption of bivariate normal error terms. However, real data diverge from this assumption in the presence of heavy tails and/or atypical observations. Recently, this assumption has been relaxed via a more flexible Student's t-distribution, which has appealing statistical…

断点回归设计中因果推断子总体的选择AI 解读

The Brazil Bolsa Familia (BF) program is a conditional cash transfer program aimed to reduce short-term poverty by direct cash transfers and to fight long-term poverty by increasing human capital among poor Brazilian people. Eligibility for Bolsa Familia benefits depends on a cutoff rule, which classifies the BF study as a regression discontinuity (RD) design. Extracting causal information from RD studies is challenging. Following Li et al (2015) and Branson and Mealli…

半连续高维数据的正则化MANOVA检验AI 解读

We propose a MANOVA test for semicontinuous data that is applicable also when the dimensionality exceeds the sample size. The test statistic is obtained as a likelihood ratio, where numerator and denominator are computed at the maxima of penalized likelihood functions under each hypothesis. Closed form solutions for the regularized estimators allow us to avoid computational overheads. We derive the null distribution using a permutation scheme. The power and level of the…

时空点过程的复合似然推断AI 解读

The dynamics of a rain forest is extremely complex involving births, deaths and growth of trees with complex interactions between trees, animals, climate, and environment. We consider the patterns of recruits (new trees) and dead trees between rain forest censuses. For a current census we specify regression models for the conditional intensity of recruits and the conditional probabilities of death given the current trees and spatial covariates. We estimate regression…

高维随机过程模型的 Dantzig 选择器两步估计AI 解读

We consider the sparse estimation for stochastic processes with possibly infinite-dimensional nuisance parameters, by using the Dantzig selector which is a sparse estimation method similar to $Z$-estimation. When a consistent estimator for a nuisance parameter is obtained, it is possible to construct an asymptotically normal estimator for the parameter of interest under appropriate conditions. Motivated by this fact, we establish the asymptotic behavior of the Dantzig…

交叉验证目标最大似然估计的表现AI 解读

Background: Advanced methods for causal inference, such as targeted maximum likelihood estimation (TMLE), require certain conditions for statistical inference. However, in situations where there is not differentiability due to data sparsity or near-positivity violations, the Donsker class condition is violated. In such situations, TMLE variance can suffer from inflation of the type I error and poor coverage, leading to conservative confidence intervals. Cross-validation of…

通过 α 变换预测生命表死亡人数的年龄分布AI 解读

We introduce a compositional power transformation, known as an α-transformation, to model and forecast a time series of life-table death counts, possibly with zero counts observed at older ages. As a generalisation of the isometric log-ratio transformation (i.e., α = 0), the α transformation relies on the tuning parameter α, which can be determined in a data-driven manner. Using the Australian age-specific period life-table death counts from 1921 to 2020, the α…

具有网络结构与非对称性的时空整数值数据波动建模AI 解读

This paper proposes a spatial threshold GARCH-type model for dynamic spatio-temporal integer-valued data with network structure. The proposed model can simplify the parameterization by using network structure in data, and can capture the asymmetric property in dynamic volatility by adopting a threshold structure. The proposed model assumes the conditional distribution is Poisson distribution. Asymptotic theory of maximum likelihood estimation (MLE) for the spatial model is…

基于非概率数据编制商业统计的方法实证比较AI 解读

There is a growing trend among statistical agencies to explore non-probability data sources for producing more timely and detailed statistics, while reducing costs and respondent burden. Coverage and measurement error are two issues that may be present in such data. The imperfections may be corrected using available information relating to the population of interest, such as a census or a reference probability sample. In this paper, we compare a wide range of existing…

支持可推广推断的整群随机试验设计AI 解读

Background: When planning a cluster randomized trial, evaluators often have access to an enumerated cohort representing the target population of clusters. Practicalities of conducting the trial, such as the need to oversample clusters with certain characteristics to improve trial economy or to support inference about subgroups of clusters, may preclude simple random sampling from the cohort into the trial, and thus interfere with the goal of producing generalizable…

生存试验中治疗交叉分析的统一三状态模型框架AI 解读

We present a unified three-state model (TSM) framework for evaluating treatment effects in clinical trials in the presence of treatment crossover. Researchers have proposed diverse methodologies to estimate the treatment effect that would have hypothetically been observed if treatment crossover had not occurred. However, there is little work on understanding the connections between these different approaches from a statistical point of view. The proposed TSM framework…

为何估计尾部指数时也应使用最小二乘法AI 解读

Even though practitioners often estimate Pareto exponents running OLS rank-size regressions, the usual recommendation is to use the Hill MLE with a small-sample correction instead, due to its unbiasedness and efficiency. In this paper, we advocate that you should also apply OLS in empirical applications. On the one hand, we demonstrate that, with a small-sample correction, the OLS estimator is also unbiased. On the other hand, we show that the MLE assigns significantly…

协整矩阵自回归模型AI 解读

We propose a novel cointegrated autoregressive model for matrix-valued time series, with bi-linear cointegrating vectors corresponding to the rows and columns of the matrix data. Compared to the traditional cointegration analysis, our proposed matrix cointegration model better preserves the inherent structure of the data and enables corresponding interpretations. To estimate the cointegrating vectors as well as other coefficients, we introduce two types of estimators based…

广义脉冲响应与多期因果关系的简便稳健两阶段估计与推断AI 解读

This paper introduces a novel two-stage estimation and inference procedure for generalized impulse responses (GIRs). GIRs encompass all coefficients in a multi-horizon linear projection model of future outcomes of y on lagged values (Dufour and Renault, 1998), which include the Sims' impulse response. The conventional use of Least Squares (LS) with heteroskedasticity- and autocorrelation-consistent covariance estimation is less precise and often results in unreliable finite…

大规模资产组合中的冲击自适应稳健最小方差投资组合AI 解读

This paper proposes a robust, shocks-adaptive portfolio in a large-dimensional assets universe where the number of assets could be comparable to or even larger than the sample size. It is well documented that portfolios based on optimizations are sensitive to outliers in return data. We deal with outliers by proposing a robust factor model, contributing methodologically through the development of a robust principal component analysis (PCA) for factor model estimation and a…

广义矩阵因子模型AI 解读

This article introduces a nonlinear generalized matrix factor model (GMFM) that allows for mixed-type variables, extending the scope of linear matrix factor models (LMFM) that are so far limited to handling continuous variables. We introduce a novel augmented Lagrange multiplier method, equivalent to the constraint maximum likelihood estimation, and carefully tailored to be locally concave around the true factor and loading parameters. This statistically guarantees the local…

数据组合下平均处理效应估计的比较分析AI 解读

There is growing interest in exploring causal effects in target populations via data combination. However, most approaches are tailored to specific settings and lack comprehensive comparative analyses. In this article, we focus on a typical scenario involving a source dataset and a target dataset. We first design six settings under covariate shift and conduct a comparative analysis by deriving the semiparametric efficiency bounds for the ATE in the target population. We then…

非平稳与误设造成的低频污染：对异方差与自相关稳健推断的影响AI 解读

We establish theoretical results about the low frequency contamination (i.e., long memory effects) induced by general nonstationarity for estimates such as the sample autocovariance and the periodogram, and deduce consequences for heteroskedasticity and autocorrelation robust (HAR) inference. We present explicit expressions for the asymptotic bias of these estimates. We distinguish cases where this contamination only occurs as a small-sample problem and cases where the…