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估计纵向替代结局治疗效应的半参数联合模型：慢性肾病试验应用AI 解读

In clinical trials where long follow-up is required to measure the primary outcome of interest, there is substantial interest in using an accepted surrogate outcome that can be measured earlier in time or with less cost to estimate a treatment effect. For example, in clinical trials of chronic kidney disease (CKD), the effect of a treatment is often demonstrated on a surrogate outcome, the longitudinal trajectory of glomerular filtration rate (GFR). However, estimating the…

半监督学习中的最优精确恢复：谱方法与图卷积网络研究AI 解读

We delve into the challenge of semi-supervised node classification on the Contextual Stochastic Block Model (CSBM) dataset. Here, nodes from the two-cluster Stochastic Block Model (SBM) are coupled with feature vectors, which are derived from a Gaussian Mixture Model (GMM) that corresponds to their respective node labels. With only a subset of the CSBM node labels accessible for training, our primary objective becomes the accurate classification of the remaining nodes.…

部分线性单指标变系数模型的变量选择AI 解读

This paper focuses on variable selection for a partially linear single-index varying-coefficient model. A regularized variable selection procedure by combining basis function approximations with SCAD penalty is proposed. It can simultaneously select significant variables in the parametric and nonparametric components and estimate the nonzero regression coefficients and coefficient functions. The consistency of the variable selection procedure and the oracle property of the…

机器学习预测的对偶解释AI 解读

Machine learning predictions are typically interpreted as the sum of contributions of predictors. Yet, each out-of-sample prediction can also be expressed as a linear combination of in-sample values of the predicted variable, with weights corresponding to pairwise proximity scores between current and past economic events. While this dual route leads nowhere in some contexts (e.g., large cross-sectional datasets), it provides sparser interpretations in settings with many…

放松随机效应正态假设的Meta分析模型：系统综述与模拟AI 解读

Random effects meta-analysis is widely used for synthesizing studies under the assumption that underlying effects come from a normal distribution. However, under certain conditions the use of alternative distributions might be more appropriate. We conducted a systematic review to identify articles introducing alternative meta-analysis models assuming non-normal between-study distributions. We identified 27 eligible articles suggesting 24 alternative meta-analysis models…

用于多变量二值数据建模的Ising相似度回归模型AI 解读

Understanding the dependence structure between response variables is an important component in the analysis of correlated multivariate data. This article focuses on modeling dependence structures in multivariate binary data, motivated by a study aiming to understand how patterns in different U.S. senators' votes are determined by similarities (or lack thereof) in their attributes, e.g., political parties and social network profiles. To address such a research question, we…

目标估计量框架与因果推断：相互补充的范式AI 解读

The creation of the ICH E9 (R1) estimands framework has led to more precise specification of the treatment effects of interest in the design and statistical analysis of clinical trials. However, it is unclear how the new framework relates to causal inference, as both approaches appear to define what is being estimated and have a quantity labelled an estimand. Using illustrative examples, we show that both approaches can be used to define a population-based summary of an…

生存结局下异质性处理效应的变量重要性度量AI 解读

Treatment effect heterogeneity plays an important role in many areas of causal inference and within recent years, estimation of the conditional average treatment effect (CATE) has received much attention in the statistical community. While accurate estimation of the CATE-function through flexible machine learning procedures provides a tool for prediction of the individual treatment effect, it does not provide further insight into the driving features of potential treatment…

高维稀疏可加模型的谱去混杂AI 解读

Many high-dimensional data sets suffer from hidden confounding which affects both the predictors and the response of interest. In such situations, standard regression methods or algorithms lead to biased estimates. This paper substantially extends previous work on spectral deconfounding for high-dimensional linear models to the nonlinear setting and with this, establishes a proof of concept that spectral deconfounding is valid for general nonlinear models. Concretely, we…

缺失数据下的函数型条件波动率建模及能源商品应用AI 解读

This paper explores the nonparametric estimation of the volatility component in a heteroscedastic scalar-on-function regression model, where the underlying discrete-time process is ergodic and subject to a missing-at-random mechanism. We first propose a simplified estimator for the regression and volatility operators, constructed solely from the observed data. The asymptotic properties of these estimators, including the almost sure uniform consistency rate and asymptotic…

结合模型平均与匹配估计异方差下的条件平均处理效应AI 解读

We propose a model averaging approach, combined with a partition and matching method to estimate the conditional average treatment effects under heteroskedastic error settings. The proposed approach has asymptotic optimality and consistency of weights and estimator. Numerical studies show that our method has good finite-sample performances.

因果中介分析中Bootstrap推断的校准问题AI 解读

Mediation analysis is a form of causal inference that investigates indirect effects and causal mechanisms. Confidence intervals for indirect effects play a central role in conducting inference. The problem is non-standard leading to coverage rates that deviate considerably from their nominal level. The default inference method in the mediation model is the paired bootstrap, which resamples directly from the observed data. However, a residual bootstrap that explicitly…

ABC3：基于Cohn准则的随机实验贝叶斯主动因果推断AI 解读

In causal inference, randomized experiment is a de facto method to overcome various theoretical issues in observational study. However, the experimental design requires expensive costs, so an efficient experimental design is necessary. We propose ABC3, a Bayesian active learning policy for causal inference. We show a policy minimizing an estimation error on conditional average treatment effect is equivalent to minimizing an integrated posterior variance, similar to Cohn…

群体差距的非参数因果分解AI 解读

We introduce a new nonparametric causal decomposition approach that identifies the mechanisms by which a treatment variable contributes to a group-based outcome disparity. Our approach distinguishes three mechanisms: group differences in 1) treatment prevalence, 2) average treatment effects, and 3) selection into treatment based on individual-level treatment effects. Our approach reformulates classic Kitagawa-Blinder-Oaxaca decompositions in causal and nonparametric terms,…

工具变量模型中对识别与维度稳健的检验AI 解读

Using modifications of Lindeberg's interpolation technique, I propose a new identification-robust test for the structural parameter in a heteroskedastic instrumental variables model. While my analysis allows the number of instruments to be much larger than the sample size, it does not require many instruments, making my test applicable in settings that have not been well studied. Instead, the proposed test statistic has a limiting chi-squared distribution so long as an…

基于自适应检测时间尺度的多尺度自回归AI 解读

We propose a multiscale approach to time series autoregression, in which linear regressors for the process in question include features of its own path that live on multiple timescales. We take these multiscale features to be the recent averages of the process over multiple timescales, whose number or spans are not known to the analyst and are estimated from the data via a change-point detection technique. The resulting construction, termed Adaptive Multiscale AutoRegression…

面向高维协变量空间观测的双重正则化广义线性模型AI 解读

A discrete spatial lattice can be cast as a network structure over which spatially-correlated outcomes are observed. A second network structure may also capture similarities among measured features, when such information is available. Incorporating the network structures when analyzing such doubly-structured data can improve predictive power, and lead to better identification of important features in the data-generating process. Motivated by applications in spatial disease…

基于催化先验分布的Cox回归模型贝叶斯推断AI 解读

The Cox proportional hazards model (Cox model) is a popular model for survival data analysis. When the sample size is small relative to the dimension of the model, the standard maximum partial likelihood inference is often problematic. In this work, we propose the Cox catalytic prior distributions for Bayesian inference on Cox models, which is an extension of a general class of prior distributions originally designed for stabilizing complex parametric models. The Cox…

用于COVID-19相关临床测量的反馈切换多过程状态空间模型AI 解读

Clinical measurements, such as body temperature, are often collected over time to monitor an individual's underlying health condition. These measurements exhibit complex temporal dynamics, necessitating sophisticated statistical models to capture patterns and detect deviations. We propose a novel multiprocess state space model with feedback and switching mechanisms to analyze the dynamics of clinical measurements. This model captures the evolution of time series through…

平台试验中利用非同期对照识别与估计因果效应AI 解读

Platform trials are multi-arm designs that simultaneously evaluate multiple treatments for a single disease within the same overall trial structure. Unlike traditional randomized controlled trials, they allow treatment arms to enter and exit the trial at distinct times while maintaining a control arm throughout. This control arm comprises both concurrent controls, where participants are randomized concurrently to either the treatment or control arm, and non-concurrent…

暴露缺失情形下因果建模的模型选择AI 解读

In causal inference, properly selecting the propensity score (PS) model is an important topic and has been widely investigated in observational studies. There is also a large literature focusing on the missing data problem. However, there are very few studies investigating the model selection issue for causal inference when the exposure is missing at random (MAR). In this paper, we discuss how to select both imputation and PS models, which can result in the smallest root…

存在受试者协变量时受控实验的协同设计AI 解读

We consider the optimal experimental design problem of allocating subjects to treatment or control when subjects participate in multiple, separate controlled experiments within a short time-frame and subject covariate information is available. Here, in addition to subject covariates, we consider the dependence among the responses coming from the subject's random effect across experiments. In this setting, the goal of the allocation is to provide precise estimates of…

高维向量自回归模型中的序贯变点检测AI 解读

Sequential (online) change-point detection involves continuously monitoring time-series data and triggering an alarm when shifts in the data distribution are detected. We propose an algorithm for real-time identification of alterations in the transition matrices of high-dimensional vector autoregressive models. The algorithm estimates transition matrices and error term variances using regularization techniques applied to training data, then computes a specific test statistic…

用于多尺度函数聚类的灵活贝叶斯非参数乘积混合模型AI 解读

There is a rich literature on clustering functional data with applications to time-series modeling, trajectory data, and even spatio-temporal applications. However, existing methods routinely perform global clustering that enforces identical atom values within the same cluster. Such grouping may be inadequate for high-dimensional functions, where the clustering patterns may change between the more dominant high-level features and the finer resolution local features. While…