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Functional Clustering for Longitudinal Associations between Social Determinants of Health and Stroke Mortality in the US

美国健康社会决定因素与卒中死亡率纵向关联的功能聚类

Understanding the longitudinally changing associations between Social Determinants of Health (SDOH) and stroke mortality is essential for effective stroke management. Previous studies have uncovered significant regional disparities in the relationships between SDOH and stroke mortality. However, existing studies have not utilized longitudinal associations to develop data-driven methods for regional division in stroke control. To fill this gap, we propose a novel clustering…

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Treatment Effects in Market Equilibrium

市场均衡中的处理效应

Policy-relevant treatment effect estimation in a marketplace setting requires taking into account both the direct benefit of the treatment and any spillovers induced by changes to the market equilibrium. The standard way to address these challenges is to evaluate interventions via cluster-randomized experiments, where each cluster corresponds to an isolated market. This approach, however, cannot be used when we only have access to a single market (or a small number of…

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Optimizing Feature Selection in Causal Inference: A Three-Stage Computational Framework for Unbiased Estimation

因果推断中的特征选择优化:无偏估计的三阶段计算框架

Feature selection is an important but challenging task in causal inference for obtaining unbiased estimates of causal quantities. Properly selected features in causal inference not only significantly reduce the time required to implement a matching algorithm but, more importantly, can also reduce the bias and variance when estimating causal quantities. When feature selection techniques are applied in causal inference, the crucial criterion is to select variables that, when…

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Serial-Dependence and Persistence Robust Inference in Predictive Regressions

预测回归中对序列依赖与持久性稳健的推断

This paper introduces a new method for testing the statistical significance of estimated parameters in predictive regressions. The approach features a new family of test statistics that are robust to the degree of persistence of the predictors. Importantly, the method accounts for serial correlation and conditional heteroskedasticity without requiring any corrections or adjustments. This is achieved through a mechanism embedded within the test statistics that effectively…

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Uncertainty Quantification in Synthetic Controls with Staggered Treatment Adoption

错位处理采用下合成控制的不确定性量化

We propose principled prediction intervals to quantify the uncertainty of a large class of synthetic control predictions (or estimators) in settings with staggered treatment adoption, offering precise non-asymptotic coverage probability guarantees. From a methodological perspective, we provide a detailed discussion of different causal quantities to be predicted, which we call causal predictands, allowing for multiple treated units with treatment adoption at possibly…

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Confidence intervals for intentionally biased estimators

有意引入偏差的估计器的置信区间

We propose and study three confidence intervals (CIs) centered at an estimator that is intentionally biased to reduce mean squared error. The first CI simply uses an unbiased estimator's standard error; compared to centering at the unbiased estimator, this CI has higher coverage probability for confidence levels above 91.7%, even if the biased and unbiased estimators have equal mean squared error. The second CI trades some of this "excess" coverage for shorter length. The…

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Score-Preserving Targeted Maximum Likelihood Estimation

保分数定向最大似然估计

Targeted maximum likelihood estimators (TMLEs) are asymptotically optimal among regular, asymptotically linear estimators. In small samples, however, we may be far from "asymptopia" and not reap the benefits of optimality. Here we propose a variant (score-preserving TMLE; SP-TMLE) that leverages an initial estimator defined as the solution of a large number of possibly data-dependent score equations. Instead of targeting only the efficient influence function in the TMLE…

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Right-censored models on massive data

大规模数据下的右删失模型

This article considers the automatic selection problem of the relevant explanatory variables in a right-censored model on a massive database. We propose and study four aggregated censored adaptive LASSO estimators constructed by dividing the observations in such a way as to keep the consistency of the estimator of the survival curve. We show that these estimators have the same theoretical oracle properties as the one built on the full database. Moreover, by Monte Carlo…

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The Chained Difference-in-Differences

链式双重差分

This paper studies the identification, estimation, and inference of long-term (binary) treatment effect parameters when balanced panel data is not available, or consists of only a subset of the available data. We develop a new estimator: the chained difference-in-differences, which leverages the overlapping structure of many unbalanced panel data sets. This approach consists in aggregating a collection of short-term treatment effects estimated on multiple incomplete panels.…

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Zero-Inflated Bandits

零膨胀多臂老虎机

Many real-world bandit applications are characterized by sparse rewards, which can significantly hinder learning efficiency. Leveraging problem-specific structures for careful distribution modeling is recognized as essential for improving estimation efficiency in statistics. However, this approach remains under-explored in the context of bandits. To address this gap, we initiate the study of zero-inflated bandits, where the reward is modeled using a classic semi-parametric…

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A Bayesian decision-theoretic approach to sparse estimation

稀疏估计的贝叶斯决策论方法

We extend the work of Hahn and Carvalho (2015) and develop a doubly-regularized sparse regression estimator by synthesizing Bayesian regularization with penalized least squares within a decision-theoretic framework. In contrast to existing Bayesian decision-theoretic formulation chiefly reliant upon the symmetric 0-1 loss, the new method -- which we call Bayesian Decoupling -- employs a family of penalized loss functions indexed by a sparsity-tuning parameter. We propose a…

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Causal effect on the number of life years lost due to a specific event: Average treatment effect and variable importance

特定事件导致寿命损失年数的因果效应:平均处理效应与变量重要性

Competing risk is a common phenomenon when dealing with time-to-event outcomes in biostatistical applications. An attractive estimand in this setting is the "number of life-years lost due to a specific cause of death", Andersen et al. (2013). It provides a direct interpretation on the time-scale on which the data is observed. In this paper, we introduce the causal effect on the number of life years lost due to a specific event, and we give assumptions under which the average…

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A Bivariate Transformation Model for Time-to-Event Data Affected by Unobserved Confounding: Revisiting the Illinois Reemployment Bonus Experiment

未观测混杂下事件时间数据的二元变换模型:重访伊利诺伊再就业奖励实验

Motivated by empirical studies investigating treatment effects in survival analysis, we propose a bivariate transformation model to quantify the impact of a binary treatment on a time-to-event outcome. The model equations are connected through a bivariate Gaussian distribution, with the dependence parameter capturing unobserved confounding, and are specified as functions of additive predictors to flexibly account for the impacts of observed confounders. Moreover, the…

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Proportional asymptotics of piecewise exponential proportional hazards models

分段指数比例风险模型的比例渐近理论

We study the flexible piecewise exponential model in a high dimensional setting where the number of covariates $p$ grows proportionally to the number of observations $n$ and under the hypothesis of random uncorrelated Gaussian designs. We prove rigorously that the optimal ridge penalized log-likelihood of the model converges in probability to the saddle point of a surrogate objective function. The technique of proof is the Convex Gaussian Min-Max theorem of Thrampoulidis,…

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Recent advances in doubly-robust weighted ordinary least squares techniques for dynamic treatment regime estimation

动态治疗方案估计中双稳健加权最小二乘技术的最新进展

A dynamic treatment regime (DTR) is an approach to delivering precision medicine that uses patient characteristics to guide treatment decisions for optimal health outcomes. Numerous methods have been proposed for DTR estimation, including dynamic weighted ordinary least squares (dWOLS), a regression-based approach that affords double robustness to model misspecification within an easy to implement analytical framework. Initially, the dWOLS approach was developed under the…

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Efficient Estimation Under Data Fusion

数据融合下的有效估计

We aim to make inferences about a smooth, finite-dimensional parameter by fusing data from multiple sources together. Previous works have studied the estimation of a variety of parameters in similar data fusion settings, including in the estimation of the average treatment effect and average reward under a policy, with the majority of them merging one historical data source with covariates, actions, and rewards and one data source of the same covariates. In this work, we…

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Cross Sectional Regression with Cluster Dependence: Inference based on Averaging

聚类依赖下的横截面回归:基于平均化的推断

We re-investigate the asymptotic properties of the traditional OLS (pooled) estimator, $\hatβ _P$, in the context of cluster dependence. The present study considers various scenarios under various restrictions on the cluster sizes and number of clusters. It is shown that $\hatβ_P$ could be inconsistent in many realistic situations. We propose a simple estimator, $\hatβ_A$ based on data averaging. The asymptotic properties of $\hatβ_A$ are studied. It is shown that $\hatβ_A$ i…

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A spectral clustering-type algorithm for the consistent estimation of the Hurst distribution in moderately high dimensions

中等高维下稳健估计 Hurst 分布的谱聚类型算法

Scale invariance (fractality) is a prominent feature of the large-scale behavior of many stochastic systems. In this work, we construct an algorithm for the statistical identification of the Hurst distribution (in particular, the scaling exponents) undergirding a high-dimensional fractal system. The algorithm is based on wavelet random matrices, modified spectral clustering and a model selection step for picking the value of the clustering precision hyperparameter. In a…

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Interference Among First-Price Pacing Equilibria: A Bias and Variance Analysis

第一价格节奏均衡间的干扰:偏差与方差分析

Online A/B testing is widely used in the internet industry to inform decisions on new feature roll-outs. For online marketplaces (such as advertising markets), standard approaches to A/B testing may lead to biased results when buyers operate under a budget constraint, as budget consumption in one arm of the experiment impacts performance of the other arm. To counteract this interference, one can use a budget-split design where the budget constraint operates on a per-arm…

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Dynamic treatment effects: high-dimensional inference under model misspecification

动态处理效应:模型误设下的高维推断

Estimating dynamic treatment effects is crucial across various disciplines, providing insights into the time-dependent causal impact of interventions. However, this estimation poses challenges due to time-varying confounding, leading to potentially biased estimates. Furthermore, accurately specifying the growing number of treatment assignments and outcome models with multiple exposures appears increasingly challenging to accomplish. Double robustness, which permits model…

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Nonparametric Cointegrating Regression Functions with Endogeneity and Semi-Long Memory

具有内生性与半长记忆的非参数协整回归函数

This article develops nonparametric cointegrating regression models with endogeneity and semi-long memory. We assume that semi-long memory is produced in the regressor process by tempering of random shock coefficients. The fundamental properties of long memory processes are thus retained in the regressor process. Nonparametric nonlinear cointegrating regressions with serially dependent errors and endogenous regressors driven by long memory innovations have been considered in…

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Semiparametric Localized Principal Stratification Analysis with Continuous Strata

连续主分层的半参数局部化分析

Principal stratification is essential for revealing causal mechanisms involving post-treatment intermediate variables, in real-world applications like surrogate marker evaluation. Principal stratification analysis with continuous intermediate variables is increasingly common but challenging due to the infinite principal strata and the nonidentifiability and nonregularity of principal causal effects. Inspired by recent research, we resolve these challenges by first using a…

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Bayesian Variable Selection in Distributed Lag Models: A Focus on Binary Quantile and Count Data Regressions

分布滞后模型的贝叶斯变量选择:二元分位数与计数回归

Distributed Lag Models (DLMs) and similar regression approaches such as MIDAS have been used for many decades in econometrics and more recently to investigate how poor air quality adversely affects human health. In this paper we describe how to expand the utility of these models for Bayesian inference by leveraging latent variables. In particular we explain how to perform binary regression to better handle imbalanced data, how to incorporate negative binomial regression, and…

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Algorithmic syntactic causal identification

算法化的句法因果识别

Causal identification in causal Bayes nets (CBNs) is an important tool in causal inference allowing the derivation of interventional distributions from observational distributions where this is possible in principle. However, most existing formulations of causal identification using techniques such as d-separation and do-calculus are expressed within the mathematical language of classical probability theory on CBNs. However, there are many causal settings where probability…

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