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结局均值函数一般半参数约束下的有效估计与数据融合AI 解读

We provide a novel characterization of semiparametric efficiency in a generic supervised learning setting where the outcome mean function -- defined as the conditional expectation of the outcome of interest given the other observed variables -- is restricted to lie in some known semiparametric function class. The primary motivation is causal inference where a researcher running a randomized controlled trial often has access to an auxiliary observational dataset that is…

采用分层复合结局的自适应试验设计与规划：实践示例AI 解读

Hierarchical composite endpoints, such as those analyzed using the Finkelstein-Schoenfeld (FS) statistic, are increasingly used in clinical trials for their ability to incorporate clinically prioritized outcomes. However, adaptive design methods for these endpoints remain underdeveloped. This paper presents a practical framework for implementing sample size re-estimation (SSR) in trials using hierarchical composites, motivated by a cardiovascular trial with mortality,…

将推断推广至目标总体时应对正值性违背AI 解读

Enhancing the external validity of trial results is essential for their applicability to real-world populations. However, violations of the positivity assumption can limit both the generalizability and transportability of findings. To address positivity violations in estimating the average treatment effect for a target population, we propose a framework that integrates characterizing the underrepresented group and performing sensitivity analysis for inference in the original…

治疗副作用的早期检测：一种序贯方法AI 解读

With the emergence and spread of infectious diseases with pandemic potential, such as COVID- 19, the urgency for vaccine development have led to unprecedented compressed and accelerated schedules that shortened the standard development timeline. In a relatively short time, the leading pharmaceutical companies1, received an Emergency Use Authorization (EUA) for vaccine\prime s en-mass deployment To monitor the potential side effect(s) of the vaccine during the (initial)…

利用市场份额数据估计市场层级参数的非参数混合 Logit 模型AI 解读

We propose a nonparametric mixed logit model that is estimated using market-level choice share data. The model treats each market as an agent and represents taste heterogeneity through market-specific parameters by solving a multiagent inverse utility maximization problem, addressing the limitations of existing market-level choice models with parametric estimation. A simulation study is conducted to evaluate the performance of our model in terms of estimation time,…

基于 HP 与 l₁ 滤波的随机游走时间序列多变点检测AI 解读

We propose new methods for detecting multiple change points in time series, specifically designed for random walk processes, where stationarity and variance changes present challenges. Our approach combines two trend estimation methods: the Hodrick Prescott (HP) filter and the l1 filter. A major challenge in these methods is selecting the tuning parameter lambda, which we address by introducing two selection techniques. For the HP based change point detection, we propose a…

利用改进安慰剂检验进行合成控制推断AI 解读

The synthetic control method is often applied to problems with one treated unit and a small number of control units. A common inferential task in this setting is to test null hypotheses regarding the average treatment effect on the treated. Inference procedures that are justified asymptotically are often unsatisfactory due to (1) small sample sizes that render large-sample approximation fragile and (2) simplification of the estimation procedure that is implemented in…

多干预阶梯楔形整群随机试验中的时变处理效应模型AI 解读

The traditional model specification of stepped-wedge cluster-randomized trials assumes a homogeneous treatment effect across time while adjusting for fixed-time effects. However, when treatment effects vary over time, the constant effect estimator may be biased. In the general setting of stepped-wedge cluster-randomized trials with multiple interventions, we derive the expected value of the constant effect estimator when the true treatment effects depend on exposure time…

融合 LASSO 与非交叉分位数回归AI 解读

Growth-at-Risk is vital for empirical macroeconomics but is often suspect to quantile crossing due to data limitations. While existing literature addresses this through post-processing of the fitted quantiles, these methods do not correct the estimated coefficients. We advocate for imposing non-crossing constraints during estimation and demonstrate their equivalence to fused LASSO with quantile-specific shrinkage parameters. By re-examining Growth-at-Risk through an…

整群随机试验中多重中介与溢出效应的贝叶斯非参数方法AI 解读

Cluster randomized trials (CRTs) with multiple unstructured mediators present significant methodological challenges for causal inference due to within-cluster correlation, interference among units, and the complexity introduced by multiple mediators. Existing causal mediation methods often fall short in simultaneously addressing these complexities, particularly in disentangling mediator-specific effects under interference that are central to studying complex mechanisms. To…

连续处理因果导数效应的双重稳健推断AI 解读

Statistical methods for causal inference with continuous treatments mainly focus on estimating the mean potential outcome function, commonly known as the dose-response curve. However, it is often not the dose-response curve but its derivative function that signals the treatment effect. In this paper, we investigate nonparametric inference on the derivative of the dose-response curve with and without the positivity condition. Under the positivity and other regularity…

迈向连续处理的 R-learnerAI 解读

The R-learner is widely used in causal inference due to its flexibility and efficiency in estimating the conditional average treatment effect. However, extending the R-learner framework from binary to continuous treatments introduces a non-identifiability issue, as the functional zero constraint inherent to the conditional average treatment effect cannot be directly imposed in the R-loss under continuous treatments. To address this, we propose a two-step identification…

分组固定效应模型的简便低计算成本估计量AI 解读

This paper introduces a new fixed effects estimator for linear panel data models with clustered time patterns of unobserved heterogeneity. The method avoids non-convex and combinatorial optimization by combining a preliminary consistent estimator of the slope coefficient, an agglomerative pairwise-differencing clustering of cross-sectional units, and a pooled ordinary least squares regression. Asymptotic guarantees are established in a framework where $T$ can grow at any…

利用多个结果变量校正空间相关标准误AI 解读

Empirical research in economics often examines the behavior of agents located in a geographic space. In such cases, statistical inference is complicated by the interdependence of economic outcomes across locations. A common approach to account for this dependence is to cluster standard errors based on a predefined geographic partition. A second strategy is to model dependence in terms of the distance between units. Dependence, however, does not necessarily stop at borders…

基于仅解码器潜在空间模型的动态图变点检测AI 解读

This manuscript studies the unsupervised change point detection problem in time series of graphs using a decoder-only latent space model. The proposed framework consists of learnable prior distributions for low-dimensional graph representations and of a decoder that bridges the observed graphs and latent representations. The prior distributions of the latent spaces are learned from the observed data as empirical Bayes to assist change point detection. Specifically, the model…

面向函数数据的多元偏斜分布聚类加权模型AI 解读

We propose a clustering method, funWeightClustSkew, based on mixtures of functional linear regression models and three skewed multivariate distributions: the variance-gamma distribution, the skew-t distribution, and the normal-inverse Gaussian distribution. Our approach follows the framework of the functional high dimensional data clustering (funHDDC) method, and we extend to functional data the cluster weighted models based on skewed distributions used for finite…

基于统计决策理论的预测算法全面样本外评价AI 解读

We argue that comprehensive out-of-sample (OOS) evaluation using statistical decision theory (SDT) should replace the current practice of K-fold and Common Task Framework validation in machine learning (ML) research on prediction. SDT provides a formal frequentist framework for performing comprehensive OOS evaluation across all possible (1) training samples, (2) populations that may generate training data, and (3) populations of prediction interest. Regarding feature (3), we…

多元时间序列的均值独立成分分析AI 解读

In this article, we introduce the mean independent component analysis for multivariate time series to reduce the parameter space. In particular, we seek for a contemporaneous linear transformation that detects univariate mean independent components so that each component can be modeled separately. The mean independent component analysis is flexible in the sense that no parametric model or distributional assumptions are made. We propose a unified framework to estimate the…

E-TRIALS：支持计算机学习平台数据驱动决策的实验工具AI 解读

Computer-based learning platforms (CBLPs) have become a common medium in schools, transforming how students learn and interact with educational content. However, researchers still lack adequate tools to address the diverse set of challenges that students face in these environments. In this paper, we introduce \textbf{Ed-Tech Research Infrastructure to Advance Learning Sciences (E-TRIALS)}, a free tool developed by ASSISTments to help researchers conduct randomized controlled…

容许无效工具变量的半参数因果发现与推断AI 解读

Learning causal relationships among a set of variables, as encoded by a directed acyclic graph, from observational data is complicated by the presence of unobserved confounders. Instrumental variables (IVs) are a popular remedy for this issue, but most existing methods either assume the validity of all IVs or postulate a specific form of relationship, such as a linear model, between the primary variables and the IVs. To overcome these limitations, we introduce a partially…

断点回归设计的统一诊断检验AI 解读

Diagnostic tests for regression discontinuity design face a size-control problem. We document a massive over-rejection of the diagnostic restriction among empirical studies in the top five economics journals. At least one diagnostic test was rejected for 19 out of 59 studies, whereas less than 5% of the collected 787 tests rejected the null hypotheses. In other words, one-third of the studies rejected at least one of their diagnostic tests, whereas their underlying…

基于谱匹配的乱序线性回归AI 解读

Shuffled linear regression (SLR) seeks to estimate latent features through a linear transformation, complicated by unknown permutations in the measurement dimensions. This problem extends traditional least-squares (LS) and Least Absolute Shrinkage and Selection Operator (LASSO) approaches by jointly estimating the permutation, resulting in shuffled LS and shuffled LASSO formulations. Existing methods, constrained by the combinatorial complexity of permutation recovery, often…

分组检测数据回归模型中的选择后推断AI 解读

We develop methodology for valid inference after variable selection in logistic regression when the responses are partially observed, that is, when one observes a set of error-prone testing outcomes instead of the true values of the responses. Aiming at selecting important covariates while accounting for missing information in the response data, we apply the expectation-maximization algorithm to compute maximum likelihood estimators subject to LASSO penalization. Subsequent…

因果推断中 Plasmode 模拟研究的注意事项AI 解读

Plasmode simulation has become an important tool for evaluating the operating characteristics of different statistical methods in complex settings, such as pharmacoepidemiological studies of treatment effectiveness using electronic health records (EHR) data. These studies provide insight into how estimator performance is impacted by challenges including rare events, small sample size, etc., that can indicate which among a set of methods performs best in a real-world dataset.…