Statistical method for pooling categorical biomarkers from multi-center matched/nested case-control studies
多中心匹配/巢式病例对照研究中分类生物标志物的合并统计方法
Pooled analyses that aggregate data from multiple studies are becoming increasingly common in collaborative epidemiologic research in order to increase the size and diversity of the study population. However, biomarker measurements from different studies are subject to systematic measurement errors and directly pooling them for analyses may lead to biased estimates of the regression parameters. Therefore, study-specific calibration processes must be incorporated in the…