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Statistical method for pooling categorical biomarkers from multi-center matched/nested case-control studies

多中心匹配/巢式病例对照研究中分类生物标志物的合并统计方法

Pooled analyses that aggregate data from multiple studies are becoming increasingly common in collaborative epidemiologic research in order to increase the size and diversity of the study population. However, biomarker measurements from different studies are subject to systematic measurement errors and directly pooling them for analyses may lead to biased estimates of the regression parameters. Therefore, study-specific calibration processes must be incorporated in the…

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Latent Variable Estimation in Bayesian Black-Litterman Models

贝叶斯 Black-Litterman 模型中的潜变量估计

We revisit the Bayesian Black-Litterman (BL) portfolio model and remove its reliance on subjective investor views. Classical BL requires an investor "view": a forecast vector $q$ and its uncertainty matrix $Ω$ that describe how much a chosen portfolio should outperform the market. Our key idea is to treat $(q,Ω)$ as latent variables and learn them from market data within a single Bayesian network. Consequently, the resulting posterior estimation admits closed-form…

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Enhancing Data Completeness in Time Series: Imputation Strategies for Missing Data Using Significant Periodically Correlated Components

利用显著周期相关成分改进时间序列缺失数据插补

Missing data is a pervasive issue in statistical analyses, affecting the reliability and validity of research across diverse scientific disciplines. Failure to adequately address missing data can lead to biased estimates and consequently flawed conclusions. In this study, we present a novel imputation method that leverages significant annual components identified through the Variable Bandpass Periodic Block Bootstrap (VBPBB) technique to improve the accuracy and integrity of…

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Extended Fiducial Inference for Individual Treatment Effects via Deep Neural Networks

通过深度神经网络开展个体治疗效应的扩展信赖推断

Individual treatment effect estimation has gained significant attention in recent data science literature. This work introduces the Double Neural Network (Double-NN) method to address this problem within the framework of extended fiducial inference (EFI). In the proposed method, deep neural networks are used to model the treatment and control effect functions, while an additional neural network is employed to estimate their parameters. The universal approximation capability…

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Granger Causality in High-Dimensional Networks of Time Series

高维时间序列网络中的 Granger 因果关系

A novel approach is developed for discovering directed connectivity between specified pairs of nodes in a high-dimensional network (HDN) of brain signals. To accurately identify causal connectivity for such specified objectives, it is necessary to properly address the influence of all other nodes within the network. The proposed procedure herein starts with the estimation of a low-dimensional representation of the other nodes in the network utilizing (frequency-domain-based)…

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Unemployment Dynamics Forecasting with Machine Learning Regression Models

使用机器学习回归模型预测失业动态

In this paper, I explored how a range of regression and machine learning techniques can be applied to monthly U.S. unemployment data to produce timely forecasts. I compared seven models: Linear Regression, SGDRegressor, Random Forest, XGBoost, CatBoost, Support Vector Regression, and an LSTM network, training each on a historical span of data and then evaluating on a later hold-out period. Input features include macro indicators (GDP growth, CPI), labor market measures (job…

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Social Interactions in Endogenous Groups

内生群组中的社会互动

This paper investigates social interactions in endogenous groups. We specify a two-sided many-to-one matching model, where individuals select groups based on preferences, while groups admit individuals based on qualifications until reaching capacities. Endogenous formation of groups leads to selection bias in peer effect estimation, which is complicated by equilibrium effects and alternative groups. We propose novel methods to simplify selection bias and develop a sieve OLS…

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Predicting the Price of Gold in the Financial Markets Using Hybrid Models

使用混合模型预测金融市场黄金价格

Predicting the price that has the least error and can provide the best and highest accuracy has been one of the most challenging issues and one of the most critical concerns among capital market activists and researchers. Therefore, a model that can solve problems and provide results with high accuracy is one of the topics of interest among researchers. In this project, using time series prediction models such as ARIMA to estimate the price, variables, and indicators related…

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Overview and practical recommendations on using Shapley Values for identifying predictive biomarkers via CATE modeling

通过 CATE 建模与 Shapley 值识别预测性生物标志物:概述与实践建议

In recent years, two parallel research trends have emerged in machine learning, yet their intersections remain largely unexplored. On one hand, there has been a significant increase in literature focused on Individual Treatment Effect (ITE) modeling, particularly targeting the Conditional Average Treatment Effect (CATE) using meta-learner techniques. These approaches often aim to identify causal effects from observational data. On the other hand, the field of Explainable…

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Cluster-robust jackknife and bootstrap inference for logistic regression models

Logistic 回归模型的聚类稳健刀切法与自助法推断

We study cluster-robust inference for logistic regression (logit) models. Inference based on the most commonly-used cluster-robust variance matrix estimator (CRVE) can be very unreliable. We study several alternatives. Conceptually the simplest of these, but also the most computationally demanding, involves jackknifing at the cluster level. We also propose a linearized version of the cluster-jackknife variance matrix estimator as well as linearized versions of the wild…

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Demystifying and avoiding the OLS "weighting problem": Unmodeled heterogeneity and straightforward solutions

理解并避免 OLS 的“加权问题”:未建模的异质性与直接解决方案

Researchers frequently estimate treatment effects by regressing outcomes (Y) on treatment (D) and covariates (X). Even without unobserved confounding, the coefficient on D yields a conditional-variance-weighted average of strata-wise effects, not the average treatment effect. Scholars have proposed characterizing the severity of these weights, evaluating resulting biases, or changing investigators' target estimand to the conditional-variance-weighted effect. We aim to…

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What is estimated in cluster randomized crossover trials with informative sizes? -- A survey of estimands and common estimators

信息性规模下的整群随机交叉试验究竟估计什么:目标量与常用估计量综述

In the analysis of cluster randomized trials (CRTs), previous work has defined two meaningful estimands: the individual-average treatment effect (iATE) and cluster-average treatment effect (cATE) estimand, to address individual and cluster-level hypotheses. In multi-period CRT designs, such as the cluster randomized crossover (CRXO) trial, additional weighted average treatment effect estimands help fully reflect the longitudinal nature of these trial designs, namely the…

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Reinforcement Learning with Continuous Actions Under Unmeasured Confounding

未测混杂下连续动作空间的强化学习

This paper addresses the challenge of offline policy learning in reinforcement learning with continuous action spaces when unmeasured confounders are present. While most existing research focuses on policy evaluation within partially observable Markov decision processes (POMDPs) and assumes discrete action spaces, we advance this field by establishing a novel identification result to enable the nonparametric estimation of policy value for a given target policy under an…

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Inference for max-linear Bayesian networks with noise

带噪声最大线性贝叶斯网络的推断

Max-Linear Bayesian Networks (MLBNs) provide a powerful framework for causal inference in extreme-value settings; we consider MLBNs with noise parameters with a given topology in terms of the max-plus algebra by taking its logarithm. Then, we show that an estimator of a parameter for each edge in a directed acyclic graph (DAG) is distributed normally. We end this paper with computational experiments with the expectation and maximization (EM) algorithm and quadratic…

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Identification and Inference on Treatment Effects under Covariate-Adaptive Randomization and Imperfect Compliance

协变量自适应随机化与不完全依从下处理效应的识别和推断

Randomized controlled trials (RCTs) frequently utilize covariate-adaptive randomization (CAR) (e.g., stratified block randomization) and commonly suffer from imperfect compliance. This paper studies the identification and inference for the average treatment effect (ATE) and the average treatment effect on the treated (ATT) in such RCTs with a binary treatment. We first develop characterizations of the identified sets for both estimands. Since data are generally not i.i.d.…

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Orthogonal Causal Calibration

正交因果校准

Estimates of heterogeneous treatment effects such as conditional average treatment effects (CATEs) and conditional quantile treatment effects (CQTEs) play an important role in real-world decision making. Given this importance, one should ensure these estimates are calibrated. While there is a rich literature on calibrating estimators of non-causal parameters, very few methods have been derived for calibrating estimators of causal parameters, or more generally estimators of…

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Nonlinear Causal Discovery with Confounders

存在混杂时的非线性因果发现

This article introduces a causal discovery method to learn nonlinear relationships in a directed acyclic graph with correlated Gaussian errors due to confounding. First, we derive model identifiability under the sublinear growth assumption. Then, we propose a novel method, named the Deconfounded Functional Structure Estimation (DeFuSE), consisting of a deconfounding adjustment to remove the confounding effects and a sequential procedure to estimate the causal order of…

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On the Robustness of Mixture Models in the Presence of Hidden Markov Regimes with Covariate-Dependent Transition Probabilities

协变量依赖转移概率下隐马尔可夫状态的混合模型稳健性

This paper studies the robustness of quasi-maximum-likelihood (QML) estimation in hidden Markov models (HMMs) when the regime-switching structure is misspecified. Specifically, we examine the case where the true data-generating process features a hidden Markov regime sequence with covariate-dependent transition probabilities, but estimation proceeds under a simplified mixture model that assumes regimes are independent and identically distributed. We show that the parameters…

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Convergence rate for Nearest Neighbour matching: geometry of the domain and higher-order regularity

最近邻匹配的收敛率:支持域几何与高阶正则性

Estimating some mathematical expectations from partially observed data and in particular missing outcomes is a central problem encountered in numerous fields such as transfer learning, counterfactual analysis or causal inference. Matching estimators, estimators based on k-nearest neighbours, are widely used in this context. It is known that the variance of such estimators can converge to zero at a parametric rate, but their bias can have a slower rate when the dimension of…

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Inference for Regression with Variables Generated by AI or Machine Learning

使用人工智能或机器学习生成变量的回归推断

Researchers now routinely use AI or other machine learning methods to estimate latent variables of economic interest, then plug-in the estimates as covariates in a regression. We show both theoretically and empirically that naively treating AI/ML-generated variables as "data" leads to biased estimates and invalid inference. To restore valid inference, we propose two methods: (1) an explicit bias correction with bias-corrected confidence intervals, and (2) joint estimation of…

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Real-time Program Evaluation using Anytime-valid Rank Tests

利用随时有效秩检验开展实时项目评估

Counterfactual mean estimators such as difference-in-differences and synthetic control have grown into workhorse tools for program evaluation. Inference for these estimators is well-developed in settings where all post-treatment data is available at the time of analysis. However, in settings where data arrives sequentially, these tests do not permit real-time inference, as they require a pre-specified sample size T. We introduce real-time inference for program evaluation…

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An Efficient Dual ADMM for Huber Regression with Fused Lasso Penalty

融合Lasso惩罚下Huber回归的高效对偶ADMM算法

The ordinary least squares estimate in linear regression is sensitive to the influence of errors with large variance, which reduces its robustness, especially when dealing with heavy-tailed errors or outliers frequently encountered in real-world scenarios. To address this issue and accommodate the sparsity of coefficients along with their sequential disparities, we combine the adaptive robust Huber loss function with a fused lasso penalty. This combination yields a robust…

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Hurdle Network Model With Latent Dynamic Shrinkage For Enhanced Edge Prediction in Zero-Inflated Directed Network Time Series

潜在动态收缩障碍网络模型:零膨胀有向网络时间序列的边预测

This article aims to model international trade relationships among 29 countries in the apparel industry between 1994 and 2013. Bilateral trade flows can be represented as a directed network, where nodes correspond to countries and directed edges indicate trade flows (i.e., whether one country exported to another in a given year). Additionally, node (e.g., GDP) and edge-specific (e.g., labor provision) covariates are also available. The study focuses on two key challenges:…

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SARMA: Scalable Low-Rank High-Dimensional Autoregressive Moving Averages via Tensor Decomposition

SARMA:基于张量分解的可扩展低秩高维自回归移动平均模型

Existing models for high-dimensional time series are overwhelmingly developed within the finite-order vector autoregressive (VAR) framework. However, the more flexible vector autoregressive moving averages (VARMA) have been much less considered. This paper introduces a Tucker-low-rank framework to efficiently capture VARMA-type dynamics for high-dimensional time series, named the Scalable ARMA (SARMA) model. It generalizes the Tucker-low-rank finite-order VAR model to the…

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