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Leveraging specificity for causal inference in observational studies

利用特异性进行观察研究中的因果推断

Hill's specificity criterion has been highly influential in biomedical and epidemiological research. However, it remains controversial and its application often relies on subjective and qualitative analysis without a comprehensive and rigorous causal theory. Focusing on unmeasured confounding adjustment with multiple treatments and multiple outcomes, this paper develops a formal and quantitative framework for leveraging specificity for causal inference in observational…

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Improving precision of cumulative incidence estimates in randomized controlled trials with external controls

利用外部对照提高随机试验累积发生率估计的精度

Augmenting the control arm in clinical trials with external data can improve statistical power for demonstrating treatment effects. In many time-to-event outcome trials, participants are subject to truncation by death. Direct application of methods for competing risks analysis on the joint data may introduce bias, for example, due to covariate shifts between the populations. In this work, we consider transportability of the conditional cause-specific hazard of the event of…

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The Persistent Effects of Peru's Mining MITA: Double Machine Learning Approach

秘鲁矿业米塔制度的持久影响:双重机器学习方法

This study examines the long-term economic impact of the colonial Mita system in Peru, building on Melissa Dell's foundational work on the enduring effects of forced labor institutions. The Mita, imposed by the Spanish colonial authorities from 1573 to 1812, required indigenous communities within a designated boundary to supply labor to mines, primarily near Potosi. Dell's original regression discontinuity design (RDD) analysis, leveraging the Mita boundary to estimate the…

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Minimax rates for learning kernels in operators

算子中核学习的极小极大收敛速率

Learning kernels in operators from data lies at the intersection of inverse problems and statistical learning, providing a powerful framework for capturing non-local dependencies in function spaces and high-dimensional settings. In contrast to classical nonparametric regression, where the inverse problem is well-posed, kernel estimation involves a compact normal operator and an ill-posed deconvolution. To address these challenges, we introduce adaptive spectral Sobolev…

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GRASP: Grouped Regression with Adaptive Shrinkage Priors

GRASP:带自适应收缩先验的分组回归

We introduce GRASP, a simple Bayesian framework for regression with grouped predictors, built on the normal beta prime (NBP) prior. The NBP prior is an adaptive generalization of the horseshoe prior with tunable hyperparameters that control tail behavior, enabling a flexible range of sparsity, from strong shrinkage to ridge-like regularization. Unlike prior work that introduced the group inverse-gamma gamma (GIGG) prior by decomposing the NBP prior into structured…

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Bayesian Inference for Left-Truncated Log-Logistic Distributions for Time-to-event Data Analysis

左截断对数逻辑斯蒂分布的贝叶斯推断:面向时间事件数据

Parameter estimation is a foundational step in statistical modeling, enabling us to extract knowledge from data and apply it effectively. Bayesian estimation of parameters incorporates prior beliefs with observed data to infer distribution parameters probabilistically and robustly. Moreover, it provides full posterior distributions, allowing uncertainty quantification and regularization, especially useful in small or truncated samples. Utilizing the left-truncated…

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Structural restrictions in local causal discovery: identifying direct causes of a target variable

局部因果发现中的结构限制:识别目标变量的直接原因

We consider the problem of learning a set of direct causes of a target variable from an observational joint distribution. Learning directed acyclic graphs (DAGs) that represent the causal structure is a fundamental problem in science. Several results are known when the full DAG is identifiable from the distribution, such as assuming a nonlinear Gaussian data-generating process. Here, we are only interested in identifying the direct causes of one target variable (local causal…

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Efficient Difference-in-Differences and Event Study Estimators

高效的双重差分与事件研究估计量

This paper investigates efficient Difference-in-Differences (DiD) and Event Study (ES) estimation using short panel data sets within the heterogeneous treatment effect framework, free from parametric functional form assumptions and allowing for variation in treatment timing. We provide an equivalent characterization of the DiD potential outcome model using sequential conditional moment restrictions on observables, which shows that the DiD identification assumptions typically…

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Asymptotic theory for the likelihood-based block maxima method in time series

时间序列中基于似然的分块最大值方法的渐近理论

This paper develops a rigorous asymptotic framework for likelihood-based inference in the Block Maxima (BM) method for stationary time series. While Bayesian inference under the BM approach has been widely studied in the independence setting, no asymptotic theory currently exists for time series. Further results are needed to establish that BM method can be applied with the kind of dependent time series models relevant to applied fields. To address this gap we first…

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Decision Theory for Treatment Choice Problems with Partial Identification

部分识别下处理选择问题的决策理论

We apply classical statistical decision theory to a large class of treatment choice problems with partial identification. We show that, in a general class of problems with Gaussian likelihood, all decision rules are admissible; it is maximin-welfare optimal to ignore all data; and, for severe enough partial identification, there are infinitely many minimax-regret optimal decision rules, all of which sometimes randomize the policy recommendation. We uniquely characterize the…

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Regularized Targeted Maximum Likelihood Estimation in Highly Adaptive Lasso Implied Working Models

高适应Lasso隐含工作模型中的正则化目标最大似然估计

We address the challenge of performing Targeted Maximum Likelihood Estimation (TMLE) after an initial Highly Adaptive Lasso (HAL) fit. Existing approaches that utilize the data-adaptive working model selected by HAL-such as the relaxed HAL update-can be simple and versatile but may become computationally unstable when the HAL basis expansions introduce collinearity. Undersmoothed HAL may fail to solve the efficient influence curve (EIC) at the desired level without…

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Autoregressive Hypergraph

自回归超图模型

Traditional graph representations are insufficient for modelling real-world phenomena involving multi-entity interactions, such as collaborative projects or protein complexes, necessitating the use of hypergraphs. While hypergraphs preserve the intrinsic nature of such complex relationships, existing models often overlook temporal evolution in relational data. To address this, we introduce a first-order autoregressive (i.e. AR(1)) model for dynamic non-uniform hypergraphs.…

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When Can We Use Two-Way Fixed-Effects (TWFE): A Comparison of TWFE and Novel Dynamic Difference-in-Differences Estimators

何时可以使用双向固定效应:与新型动态双重差分估计量的比较

The conventional Two-Way Fixed-Effects (TWFE) estimator has come under scrutiny lately. Recent literature has revealed potential shortcomings of TWFE when the treatment effects are heterogeneous. Scholars have developed new advanced dynamic Difference-in-Differences (DiD) estimators to tackle these potential shortcomings. However, confusion remains in applied research as to when the conventional TWFE is biased and what issues the novel estimators can and cannot address. In…

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Dimension free ridge regression

无维度限制的岭回归

Random matrix theory has become a widely useful tool in high-dimensional statistics and theoretical machine learning. However, random matrix theory is largely focused on the proportional asymptotics in which the number of columns grows proportionally to the number of rows of the data matrix. This is not always the most natural setting in statistics where columns correspond to covariates and rows to samples. With the objective to move beyond the proportional asymptotics, we…

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Adaptive Experimental Design for Policy Learning

用于政策学习的自适应实验设计

This study investigates the contextual best arm identification (BAI) problem, aiming to design an adaptive experiment to identify the best treatment arm conditioned on contextual information (covariates). We consider a decision-maker who assigns treatment arms to experimental units during an experiment and recommends the estimated best treatment arm based on the contexts at the end of the experiment. The decision-maker uses a policy for recommendations, which is a function…

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A Unified Principal Components Analysis for Stationary Functional Time Series

平稳函数型时间序列的统一主成分分析

Functional time series (FTS) data have become increasingly available in real-world applications. Research on such data typically focuses on two objectives: curve reconstruction and forecasting, both of which require efficient dimension reduction. While functional principal component analysis (FPCA) serves as a standard tool, existing methods often fail to achieve simultaneous parsimony and optimality in dimension reduction, thereby restricting their practical implementation.…

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Regularized Learning for Fractional Brownian Motion via Path Signatures

基于路径签名的分数布朗运动正则化学习

Fractional Brownian motion (fBm) extends classical Brownian motion by introducing dependence between increments, governed by the Hurst parameter $H\in (0,1)$. Unlike traditional Brownian motion, the increments of an fBm are not independent. Paths generated by fractional Brownian motions can exhibit significant irregularity, particularly when the Hurst parameter is small. As a result, classical regression methods may not perform effectively. Signatures, defined as iterated…

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Estimating Multiple Weighted Networks with Node-Sparse Differences and Shared Low-Rank Structure

估计具有节点稀疏差异与共享低秩结构的多个加权网络

We study the problem of modeling multiple symmetric, weighted networks defined on a common set of nodes, where networks arise from different groups or conditions. We propose a model in which each network is expressed as the sum of a shared low-rank structure and a node-sparse matrix that captures the differences between conditions. This formulation is motivated by practical scenarios, such as in connectomics, where most nodes share a global connectivity structure while only…

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Sequential Synthetic Difference in Differences

序贯合成双重差分

We propose the Sequential Synthetic Difference-in-Differences (Sequential SDiD) estimator for event studies with staggered treatment adoption, particularly when the parallel trends assumption fails. The method uses an iterative imputation procedure on aggregated data, where estimates for early-adopting cohorts are used to construct counterfactuals for later ones. We prove the estimator is asymptotically equivalent to an infeasible oracle OLS estimator within a linear model…

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Statistical Learning for Heterogeneous Treatment Effects: Pretraining, Prognosis, and Prediction

异质性处理效应的统计学习:预训练、预后与预测

Robust estimation of heterogeneous treatment effects is a fundamental challenge for optimal decision-making in domains ranging from personalized medicine to educational policy. In recent years, predictive machine learning has emerged as a valuable toolbox for causal estimation, enabling more flexible effect estimation. However, accurately estimating conditional average treatment effects (CATE) remains a major challenge, particularly in the presence of many covariates. In…

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Impulse Response Analysis of Structural Nonlinear Time Series Models

结构非线性时间序列模型的脉冲响应分析

This paper proposes a semiparametric sieve approach to estimate impulse response functions of nonlinear time series within a general class of structural autoregressive models. We prove that a two-step procedure can flexibly accommodate nonlinear specifications while avoiding the need to choose fixed parametric forms. Sieve impulse responses are proven to be consistent by deriving uniform estimation guarantees, and an iterative algorithm makes it straightforward to compute…

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KANITE: Kolmogorov-Arnold Networks for ITE estimation

KANITE:用于个体处理效应估计的 Kolmogorov–Arnold 网络

We introduce KANITE, a framework leveraging Kolmogorov-Arnold Networks (KANs) for Individual Treatment Effect (ITE) estimation under multiple treatments setting in causal inference. By utilizing KAN's unique abilities to learn univariate activation functions as opposed to learning linear weights by Multi-Layer Perceptrons (MLPs), we improve the estimates of ITEs. The KANITE framework comprises two key architectures: 1.Integral Probability Metric (IPM) architecture: This…

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Identifiable and interpretable nonparametric factor analysis

可识别且可解释的非参数因子分析

Factor models are widely used to reduce dimensionality in modeling high-dimensional data. However, there remains a need for models that can be reliably fit in modest sample sizes and are identifiable, interpretable, and flexible. To address this gap, we propose a NIFTY model that uses a linear factor structure with Gaussian residuals, but with a novel latent variable modeling structure. In particular, we model each latent variable as a one-dimensional nonlinear mapping of a…

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Causal inference amid missingness-specific independencies and mechanism shifts

缺失特定独立性与机制变化下的因果推断

The recovery of causal effects in structural models with missing data often relies on $m$-graphs, which assume that missingness mechanisms do not directly influence substantive variables. Yet, in many real-world settings, missing data can alter decision-making processes, as the absence of key information may affect downstream actions and states. To overcome this limitation, we introduce $lm$-SCMs and $lm$-graphs, which extend $m$-graphs by integrating a label set that…

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