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评估临床治疗规则效用的非参数界限AI 解读

Evaluating the value of new clinical treatment rules based on patient characteristics is important but often complicated by hidden confounding factors in observational studies. Standard methods for estimating the average patient outcome if a new rule were universally adopted typically rely on strong, untestable assumptions about these hidden factors. This paper tackles this challenge by developing nonparametric bounds - a range of plausible values - for the expected outcome…

联合分位数收缩：面向非交叉贝叶斯分位数模型的状态空间方法AI 解读

Crossing of fitted conditional quantiles is a prevalent problem for quantile regression models. We propose a new Bayesian modelling framework that penalises multiple quantile regression functions toward the desired non-crossing space. We achieve this by estimating multiple quantiles jointly with a prior on variation across quantiles, a fused shrinkage prior with quantile adaptivity. The posterior is derived from a decision-theoretic general Bayes perspective, whose form…

疾病筛查与严重程度预测的联合建模：多任务与稀疏正则化方法AI 解读

Identifying clinically relevant biomarkers and developing predictive models are central challenges in biomedical research. Biomarkers are commonly used for disease screening, and some provide information not only on the presence or absence of a disease but also on its severity. Such biomarkers can contribute to treatment prioritization and support clinical decision-making. To address both disease screening and severity prediction, this paper focuses on regression modeling…

采用累积收缩先验的离散自回归切换过程与时间序列图建模AI 解读

We propose a flexible Bayesian approach for sparse Gaussian graphical modeling of multivariate time series. We account for temporal correlation in the data by assuming that observations are characterized by an underlying and unobserved hidden discrete autoregressive process. We assume multivariate Gaussian emission distributions and capture spatial dependencies by modeling the state-specific precision matrices via graphical horseshoe priors. We characterize the mixing…

内生连续处理因果效应的部分识别AI 解读

No unmeasured confounding is a common assumption when reasoning about counterfactual outcomes, but such an assumption may not be plausible in observational studies. Sensitivity analysis is often employed to assess the robustness of causal conclusions to unmeasured confounding, but existing methods are predominantly designed for binary treatments. In this paper, we provide natural extensions of two extensively used sensitivity frameworks -- the Rosenbaum and Marginal…

因果效应与反事实的界限估计AI 解读

Causal inference often hinges on strong assumptions - such as no unmeasured confounding or perfect compliance - that are rarely satisfied in practice. Partial identification offers a principled alternative: instead of relying on unverifiable assumptions to estimate causal effects precisely, it derives bounds that reflect the uncertainty inherent in the data. Despite its theoretical appeal, partial identification remains underutilized in applied work, in part due to the…

重建哥伦比亚地方劳动指标：机器学习与深度学习的整合方法AI 解读

This study proposes a unified multi-stage framework to reconstruct consistent monthly and annual labor indicators for all 33 Colombian departments from 1993 to 2025. The approach integrates temporal disaggregation, time-series splicing and interpolation, statistical learning, and institutional covariates to estimate seven key variables: employment, unemployment, labor force participation (PEA), inactivity, working-age population (PET), total population, and informality rate,…

复杂时间动态下单调平滑时变函数的同时推断AI 解读

We propose a new framework for the simultaneous inference of monotone and smoothly time-varying functions under complex temporal dynamics. This will be done utilizing the monotone rearrangement and the nonparametric estimation. We capitalize the Gaussian approximation for the nonparametric monotone estimator and construct the asymptotically correct simultaneous confidence bands (SCBs) using designed bootstrap methods. We investigate two general and practical scenarios. The…

去偏且具有半参数效率的变化中变化估计量AI 解读

We present a novel extension of the influential changes-in-changes (CiC) framework of Athey and Imbens (2006) for estimating the average treatment effect on the treated (ATT) and distributional causal effects in panel data with unmeasured confounding. While CiC relaxes the parallel trends assumption in difference-in-differences (DiD), existing methods typically assume a scalar unobserved confounder and monotonic outcome relationships, and lack inference tools that…

基于多方向正则化的并行网络重构AI 解读

Reconstructing large-scale latent networks from observed dynamics is crucial for understanding complex systems. However, the existing methods based on compressive sensing are often rendered infeasible in practice by prohibitive computational and memory costs. To address this challenge, we introduce a new distributed computing framework for efficient large-scale network reconstruction with parallel computing, namely PALMS (Parallel Adaptive Lasso with Multi-directional…

正则化改进的两正态均值问题解AI 解读

The many-normal-means problem is a classic example that motivates the development of many important inferential procedures in the history of statistics. In this short note, we consider a further special case of the problem, which involves only two normally distributed data points with a constraint that the pair of means are not too far apart from one another. Starting with a regularized ML estimator, we construct a novel possibilistic IM for marginal inference on one of the…

二元分布回归：理论、估计及代际流动应用AI 解读

We employ distribution regression (DR) to estimate the joint distribution of two outcome variables conditional on chosen covariates. While Bivariate Distribution Regression (BDR) is useful in a variety of settings, it is particularly valuable when some dependence between the outcomes persists after accounting for the impact of the covariates. Our analysis relies on a result from Chernozhukov et al. (2018) which shows that any conditional joint distribution has a local…

用于因果推断的贝叶斯双重机器学习AI 解读

This paper proposes a simple, novel, and fully-Bayesian approach for causal inference in partially linear models with high-dimensional control variables. Off-the-shelf machine learning methods can introduce biases in the causal parameter known as regularization-induced confounding. To address this, we propose a Bayesian Double Machine Learning (BDML) method, which modifies a standard Bayesian multivariate regression model and recovers the causal effect of interest from the…

多变量孟德尔随机化的一种更稳健方法AI 解读

Multivariable Mendelian randomization (MVMR) uses genetic variants as instrumental variables to infer the direct effects of multiple exposures on an outcome. However, unlike univariable Mendelian randomization, MVMR often faces greater challenges with many weak instruments, which can lead to bias not necessarily toward zero and inflation of type I errors. In this work, we introduce a new asymptotic regime that allows exposures to have varying degrees of instrument strength,…

工具变量回归中弱工具稳健推断的统计学指南及 Python 示例AI 解读

We provide an overview of results relating to estimation and weak-instrument-robust inference in instrumental variables regression. Methods are implemented in the ivmodels software package for Python, which we use to illustrate results.

序贯自适应实验的有效统计估计及其对自适应设计的启示AI 解读

Adaptive experimental designs have gained popularity in clinical trials and online experiments. Unlike traditional, fixed experimental designs, adaptive designs can dynamically adjust treatment randomization probabilities and other design features in response to data accumulated sequentially during the experiment. These adaptations are useful to achieve diverse objectives, including reducing uncertainty in the estimation of causal estimands or increasing participants'…

差分隐私下的协变量平衡因果推断AI 解读

Differential privacy is the leading mathematical framework for privacy protection, providing a probabilistic guarantee that safeguards individuals' private information when publishing statistics from a dataset. This guarantee is achieved by applying a randomized algorithm to the original data, which introduces unique challenges in data analysis by distorting inherent patterns. In particular, causal inference using observational data in privacy-sensitive contexts is…

治疗不依从下因果生存分析的多重稳健估计AI 解读

Comparative effectiveness research frequently addresses a time-to-event outcome and can require unique considerations in the presence of treatment noncompliance. Motivated by the challenges in addressing noncompliance in the ADAPTABLE pragmatic clinical trial, we develop a multiply robust estimator to estimate the principal survival causal effects under the principal ignorability and monotonicity. The multiply robust estimator is consistent even if one, and sometimes two, of…

纵向因果推断中治疗模型的自适应稀疏化与平滑AI 解读

Causal variable selection in time-varying treatment settings is challenging due to evolving confounding effects. Existing methods mainly focus on time-fixed exposures and are not directly applicable to time-varying scenarios. We propose a novel two-step procedure for variable selection when modeling the treatment probability at each time point. We first introduce a novel approach to longitudinal confounder selection using a Longitudinal Outcome Adaptive LASSO (LOAL) that…

含噪声、非光滑与非凸矩条件模型的估计AI 解读

A practical challenge for structural estimation is the requirement to accurately minimize a sample objective function which is often non-smooth, non-convex, or both. This paper proposes a simple algorithm designed to find accurate solutions without performing an exhaustive search. It augments each iteration from a new Gauss-Newton algorithm with a grid search step. A finite sample analysis derives its optimization and statistical properties simultaneously using only…

具有 S-vine Copula 结构的近似因子模型AI 解读

We propose a novel framework for approximate factor models that integrates an S-vine copula structure to capture complex dependencies among common factors. Our estimation procedure proceeds in two steps: first, we apply principal component analysis (PCA) to extract the factors; second, we employ maximum likelihood estimation that combines kernel density estimation for the margins with an S-vine copula to model the dependence structure. Jointly fitting the S-vine copula with…

足球主场优势有多重要：英超联赛的因果推断分析AI 解读

In many sports, it is commonly believed that the home team has an advantage over the visiting team, known as the home field advantage. Yet its causal effect on team performance is largely unknown. In this paper, we propose a novel causal inference approach to study the causal effect of home field advantage in English Premier League. We develop a hierarchical causal model and show that both league level and team level causal effects are identifiable and can be conveniently…

早期临床试验中零膨胀生物标志物的两步检验AI 解读

In early-phase clinical trials, a predictive biomarker may identify subgroups that benefit from an experimental therapy, even when the overall average treatment effect is negligible. Recently proposed nonparametric interaction tests such as the Average Kolmogorov-Smirnov Approach (AKSA) avoid prespecified biomarker cutting points and model assumptions, but their power degrades when the biomarker distribution is zero-inflated. We propose a two-step test that partitions the…

基于条件线性规划的部分识别：估计与政策学习AI 解读

Many important quantities of interest are only partially identified from observable data: the data can limit them to a set of plausible values, but not uniquely determine them. This paper develops a unified framework for covariate-assisted estimation, inference, and decision making in partial identification problems where the parameter of interest satisfies a series of linear constraints, conditional on covariates. In such settings, bounds on the parameter can be written as…