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A Unified Theory for Causal Inference: Direct Debiased Machine Learning via Bregman-Riesz Regression

因果推断的统一理论:通过 Bregman-Riesz 回归实现直接去偏机器学习

This note introduces a unified theory for causal inference that integrates Riesz regression, covariate balancing, density-ratio estimation (DRE), targeted maximum likelihood estimation (TMLE), and the matching estimator in average treatment effect (ATE) estimation. In ATE estimation, the balancing weights and the regression functions of the outcome play important roles, where the balancing weights are referred to as the Riesz representer, bias-correction term, and clever…

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Direct Debiased Machine Learning via Bregman Divergence Minimization

通过最小化 Bregman 散度实现直接去偏机器学习

We develop a direct debiased machine learning framework comprising Neyman targeted estimation and generalized Riesz regression. Our framework unifies Riesz regression for automatic debiased machine learning, covariate balancing, targeted maximum likelihood estimation (TMLE), and density-ratio estimation. In many problems involving causal effects or structural models, the parameters of interest depend on regression functions. Plugging regression functions estimated by machine…

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Smoothed Quantile Estimation via Interpolation to the Mean

通过向均值插值实现的平滑分位数估计

This paper introduces a unified family of smoothed quantile estimators that continuously interpolate between classical empirical quantiles and the sample mean. The estimators q(z, h) are defined as minimizers of a regularized objective function depending on two parameters: a smoothing parameter h $\ge$ 0 and a location parameter z $\in$ R. When h = 0 and z $\in$ (-1, 1), the estimator reduces to the empirical quantile of order $τ$ = (1z)/2; as h $\rightarrow$ $\infty$, it…

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Predictive Causal Inference via Spatio-Temporal Modeling and Penalized Empirical Likelihood

结合时空建模与惩罚经验似然的预测型因果推断

This study introduces an integrated framework for predictive causal inference designed to overcome limitations inherent in conventional single model approaches. Specifically, we combine a Hidden Markov Model (HMM) for spatial health state estimation with a Multi Task and Multi Graph Convolutional Network (MTGCN) for capturing temporal outcome trajectories. The framework asymmetrically treats temporal and spatial information regarding them as endogenous variables in the…

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Structured Lasso for convex nonparametric least squares: An application to Swedish electricity distribution networks

凸非参数最小二乘的结构化 Lasso:瑞典配电网络应用

We study the problem of variable selection in convex nonparametric least squares (CNLS). Whereas the least absolute shrinkage and selection operator (Lasso) is a popular technique for least squares, its variable selection performance is unknown in CNLS problems. In this work, we investigate the performance of the Lasso estimator and find out it is usually unable to select variables efficiently. Exploiting the unique structure of the subgradients in CNLS, we develop a…

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Designing a quasi-experiment to study the clinical impact of adaptive risk prediction models

评估自适应风险预测模型临床影响的准实验设计

Clinical risk prediction is a valuable tool for guiding healthcare interventions toward those most likely to benefit. Yet, evaluating the pairing of a risk prediction model with an intervention using randomized controlled trials presents substantial challenges, making quasi-experimental designs an attractive alternatives. Existing designs, however, assume that both the model and the decision rules used to trigger interventions (typically a risk threshold) remain fixed. This…

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Chiseling: Powerful and Valid Subgroup Selection via Interactive Machine Learning

Chiseling:通过交互式机器学习选择子群并保证推断有效性

In regression and causal inference, controlled subgroup selection aims to identify, with inferential guarantees, a subgroup (defined as a subset of the covariate space) on which the average response or treatment effect is above a given threshold. E.g., in a clinical trial, it may be of interest to find a subgroup with a positive average treatment effect. However, existing methods either lack inferential guarantees, heavily restrict the search for the subgroup, or sacrifice…

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Inference on Welfare and Value Functionals under Optimal Treatment Assignment

最优处理分配下福利与价值泛函的推断

We provide theoretical results for the estimation and inference of a class of welfare and value functionals of the nonparametric conditional average treatment effect (CATE) function under optimal treatment assignment, i.e., treatment is assigned to an observed type if and only if its CATE is nonnegative. For the optimal welfare functional defined as the average value of CATE on the subpopulation with nonnegative CATE, we establish the $\sqrt{n}$ asymptotic normality of the…

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Improving time series estimation and prediction via transfer learning

通过迁移学习改善时间序列估计与预测

There are many time series in the literature with high dimension yet limited sample sizes, such as macroeconomic variables, and it is almost impossible to obtain efficient estimation and accurate prediction by using the corresponding datasets themselves. This paper fills the gap by introducing a novel representation-based transfer learning framework for vector autoregressive models, and information from related source datasets with rich observations can be leveraged to…

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Transfer Learning for Kernel-based Regression

基于核回归的迁移学习

In recent years, transfer learning has garnered significant attention. Its ability to leverage knowledge from related studies to improve generalization performance in a target study has made it highly appealing. This paper focuses on investigating the transfer learning problem within the context of nonparametric regression over a reproducing kernel Hilbert space. The aim is to bridge the gap between practical effectiveness and theoretical guarantees. We specifically consider…

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Replicable Bandits for Digital Health Interventions

数字健康干预中的可重复多臂老虎机算法

Adaptive treatment assignment algorithms, such as bandit algorithms, are increasingly used in digital health intervention clinical trials. Frequently, the data collected from these trials is used to conduct causal inference and related data analyses to decide how to refine the intervention, and whether to roll-out the intervention more broadly. This work studies inference for estimands that depend on the adaptive algorithm itself; a simple example is the mean reward under…

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Efficient Adaptive Experimentation with Noncompliance

存在不依从时的高效自适应实验

We study the problem of estimating the average treatment effect (ATE) in adaptive experiments where treatment can only be encouraged -- rather than directly assigned -- via a binary instrumental variable. Building on semiparametric efficiency theory, we derive the efficiency bound for ATE estimation under arbitrary, history-dependent instrument-assignment policies, and show it is minimized by a variance-aware allocation rule that balances outcome noise and compliance…

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Machine-Learning-Assisted Comparison of Regression Functions

机器学习辅助的回归函数比较

We revisit the classical problem of comparing regression functions, a fundamental question in statistical inference with broad relevance to modern applications such as data integration, transfer learning, and causal inference. Existing approaches typically rely on smoothing techniques and are thus hindered by the curse of dimensionality. We propose a generalized notion of kernel-based conditional mean dependence that provides a new characterization of the null hypothesis of…

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GST-UNet: A Neural Framework for Spatiotemporal Causal Inference with Time-Varying Confounding

GST-UNet:处理时变混杂的时空因果推断神经框架

Estimating causal effects from spatiotemporal observational data is essential in public health, environmental science, and policy evaluation, where randomized experiments are often infeasible. Existing approaches, however, either rely on strong structural assumptions or fail to handle key challenges such as interference, spatial confounding, temporal carryover, and time-varying confounding -- where covariates are influenced by past treatments and, in turn, affect future…

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Panel data models with randomly generated groups

具有随机生成群组的面板数据模型

We develop a structural framework for modeling and inferring unobserved heterogeneity in dynamic panel-data models. Unlike methods treating clustering as a descriptive device, we model heterogeneity as arising from a latent clustering mechanism, where the number of clusters is unknown and estimated. Building on the mixture of finite mixtures (MFM) approach, our method avoids the clustering inconsistency issues of Dirichlet process mixtures and provides an interpretable…

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Regularisation of CART trees by summation of $p$-values

基于 p 值求和的 CART 树正则化

The standard procedure to decide on the complexity of a CART regression tree is to use cross-validation with the aim of obtaining a predictor that generalises well to unseen data. The randomness in the selection of folds implies that the selected CART regression tree is not a deterministic function of the data. Moreover, the cross-validation procedure may become time consuming and result in inefficient use of training data. We propose a simple deterministic in-sample method…

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Nearest Neighbor Matching as Least Squares Density Ratio Estimation and Riesz Regression

最近邻匹配的最小二乘密度比估计与 Riesz 回归解释

This study proves that Nearest Neighbor (NN) matching can be interpreted as an instance of Riesz regression for automatic debiased machine learning. Lin et al. (2023) shows that NN matching is an instance of density-ratio estimation with their new density-ratio estimator. Chernozhukov et al. (2024) develops Riesz regression for automatic debiased machine learning, which directly estimates the Riesz representer (or equivalently, the bias-correction term) by minimizing the…

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Quantifying inconsistency in one-stage individual participant data meta-analyses of treatment-covariate interactions: a simulation study

单阶段个体参与者数据元分析中治疗与协变量交互作用的不一致性度量

It is recommended that measures of between-study effect heterogeneity be reported when conducting individual-participant data meta-analyses (IPD-MA). Methods exist to quantify inconsistency between trials via I^2 (the percentage of variation in the treatment effect due to between-study heterogeneity) when conducting two-stage IPD-MA, and when conducting one-stage IPD-MA with approximately equal numbers of treatment and control group participants. We extend formulae to…

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Lee Bounds with a Continuous Treatment in Sample Selection

样本选择下连续处理的 Lee 界限

We study causal inference in sample selection models where a continuous or multivalued treatment affects both outcome and their observability (eg., employment or survey response). We generalized the widely used Lee (2009)'s bounds for binary treatment effects. Our key innovation is a sufficient treatment value assumption that imposes weak restrictions on selection heterogeneity and is implicit in separable threshold-crossing models, including monotone effects on selection.…

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Illustrating implications of misaligned causal questions and statistics in settings with competing events and interest in treatment mechanisms

竞争事件下因果问题与统计方法错位的影响:以治疗机制为关注点

In the presence of competing events, many investigators are interested in a direct treatment effect on the event of interest that does not capture treatment effects on competing events. Classical survival analysis methods that treat competing events like censoring events, at best, target a controlled direct effect: the effect of the treatment under a difficult to imagine and typically clinically irrelevant scenario where competing events are somehow eliminated. A separable…

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Fast Bayesian Basis Selection for Functional Data Representation with Correlated Errors

相关误差下函数数据表示的快速贝叶斯基选择

Functional data analysis finds widespread application across various fields. While functional data are intrinsically infinite-dimensional, in practice, they are observed only at a finite set of points, typically over a dense grid. As a result, smoothing techniques are often used to approximate the observed data as functions. In this work, we propose a novel Bayesian approach for selecting basis functions for smoothing one or multiple curves simultaneously. Our method…

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MECfda: An R Package for Bias Correction Due to Measurement Error in Functional and Scalar Covariates in Scalar-on-Function Regression Models

MECfda:标量对函数回归中函数与标量协变量测量误差偏差校正的R包

Functional data analysis (FDA) deals with high-resolution data recorded over a continuum, such as time, space or frequency. Device-based assessments of physical activity or sleep are objective yet still prone to measurement error. We present MECfda, an R package that (i) fits scalar-on-function, generalized scalar-on-function, and functional quantile regression models, and (ii) provides bias-corrected estimation when functional covariates are measured with error. By unifying…

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Control VAR: a counterfactual based approach to inference in macroeconomics

Control VAR:基于反事实的宏观经济推断方法

This paper addresses the challenges of giving a causal interpretation to vector autoregressions (VARs). I show that under independence assumptions VARs can identify average treatment effects, average causal responses, or a mix of the two, depending on the distribution of the policy. But what about situations in which the economist cannot rely on independence assumptions? I propose an alternative method, defined as control-VAR, which uses control variables to estimate causal…

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Stratification-based Instrumental Variable Analysis Framework for Nonlinear Effect Analysis

基于分层的非线性效应工具变量分析框架

Nonlinear causal effects are prevalent in many research scenarios involving continuous exposures, and instrumental variables (IVs) can be employed to investigate such effects, particularly in the presence of unmeasured confounders. However, common IV methods for nonlinear effect analysis, such as IV regression or the control-function method, have inherent limitations, leading to either low statistical power or potentially misleading conclusions. In this work, we propose an…

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