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Causal Inference on Networks under Misspecified Exposure Mappings: A Partial Identification Framework

暴露映射误设下网络因果推断的部分识别框架

Estimating treatment effects in networks is challenging, as each potential outcome depends on the treatments of all other nodes in the network. To overcome this difficulty, existing methods typically impose an exposure mapping that compresses the treatment assignments in the network into a low-dimensional summary. However, if this mapping is misspecified, standard estimators for direct and spillover effects can be severely biased. We propose a novel partial identification…

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Causal inference for calibrated scaling interventions on time-to-event processes

事件时间过程中校准缩放干预的因果推断

This work develops a flexible inferential framework for nonparametric causal inference in time-to-event settings, based on stochastic interventions defined through multiplicative scaling of the intensity governing an intermediate event process. These interventions induce a family of estimands indexed by a scalar parameter α, representing effects of modifying event rates while preserving the temporal and covariate-dependent structure of the observed data generating mechanism.…

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Blinded sample size re-estimation accounting for uncertainty in mid-trial estimation

考虑试验中期估计不确定性的盲态样本量重估

For randomized controlled trials to be conclusive, it is important to set the target sample size accurately at the design stage. Comparing two normal populations, the sample size calculation requires specification of the variance other than the treatment effect and misspecification can lead to underpowered studies. Blinded sample size re-estimation is an approach to minimize the risk of inconclusive studies. Existing methods proposed to use the total (one-sample) variance…

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Factorial Difference-in-Differences

析因双重差分

We formulate factorial difference-in-differences (FDID), a research design that extends canonical difference-in-differences (DID) to settings in which an event affects all units. In many panel data applications, researchers exploit cross-sectional variation in a baseline factor alongside temporal variation in the event, but the corresponding estimand is often implicit and the justification for applying the DID estimator remains unclear. We frame FDID as a factorial design…

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Neural Entropic Optimal Transport and Gromov-Wasserstein Alignment

神经熵正则最优传输与 Gromov-Wasserstein 对齐

Optimal transport (OT) and Gromov-Wasserstein (GW) alignment are powerful frameworks for geometrically driven matching of probability distributions, yet their large-scale usage is hampered by high statistical and computational costs. Entropic regularization has emerged as a promising solution, allowing parametric convergence rates via the plug-in estimator, which can be computed using the Sinkhorn algorithm (or its iterations in the GW case). However, Sinkhorn's $O(n^2)$ time…

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Decision-Focused Optimal Transport

决策导向的最优传输

We propose a fundamental metric for measuring the distance between two distributions. This metric, referred to as the decision-focused (DF) divergence, is tailored to stochastic linear optimization problems in which the objective coefficients are random and may follow two distinct distributions. Traditional metrics such as KL divergence and Wasserstein distance are not well-suited for quantifying the resulting cost discrepancy, because changes in the coefficient distribution…

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Disentangling spatial interference and spatial confounding biases in causal inference

区分因果推断中的空间干扰与空间混杂偏差

Spatial interference and spatial confounding are two major issues inhibiting precise causal estimates when dealing with observational spatial data. Moreover, the definition and interpretation of spatial confounding remain arguable in the literature. In this paper, our goal is to provide clarity in a novel way on misconception and issues around spatial confounding from Directed Acyclic Graph (DAG) perspective and to disentangle both direct, indirect spatial confounding and…

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Selective Information Borrowing for Region-Specific Treatment Effect Inference under Covariate Mismatch in Multi-Regional Clinical Trials

多区域临床试验中协变量不匹配下的区域治疗效应推断

Multi-regional clinical trials (MRCTs) are central to global drug development, enabling evaluation of treatment effects across diverse populations. A key challenge is valid and efficient inference for a region-specific estimand when the target region is small and differs from auxiliary regions in baseline covariates or unmeasured factors. We adopt an estimand-based framework and focus on the region-specific average treatment effect (RSATE) in a prespecified target region,…

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Nonparametric Inference with an Instrumental Variable under a Separable Binary Treatment Choice Model

可分二元治疗选择模型下的工具变量非参数推断

Instrumental variable (IV) methods are widely used to infer treatment effects in the presence of unmeasured confounding. In this paper, we study nonparametric inference with an IV under a separable binary treatment choice model, which posits that the odds of the probability of taking the treatment, conditional on the instrument and the treatment-free potential outcome, factor into separable components for each variable. While nonparametric identification of smooth…

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Causal Inference for Preprocessed Outcomes with an Application to Functional Connectivity

预处理结局的因果推断及其在功能连接中的应用

In biomedical research, repeated measurements within each subject are often processed to remove artifacts and unwanted sources of variation. The resulting data are used to construct derived outcomes that act as proxies for scientific outcomes that are not directly observable. Although intra-subject processing is widely used, its impact on inter-subject statistical inference has not been systematically studied, and a principled framework for causal analysis in this setting is…

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Posterior Uncertainty for Targeted Parameters in Bayesian Bootstrap Procedures

贝叶斯自助法中目标参数的后验不确定性

We propose a general method to carry out a valid Bayesian analysis of a finite-dimensional `targeted' parameter in the presence of a finite-dimensional nuisance parameter. We apply our methods to causal inference based on estimating equations. While much of the literature in Bayesian causal inference has relied on the conventional 'likelihood times prior' framework, a recently proposed method, the 'Linked Bayesian Bootstrap', deviated from this classical setting to obtain…

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Neural Network Machine Regression (NNMR): A Deep Learning Framework for Uncovering High-order Synergistic Effects

神经网络机器回归:揭示高阶协同效应的深度学习框架

We propose a new neural network framework, termed Neural Network Machine Regression (NNMR), which integrates trainable input gating and adaptive depth regularization to jointly perform feature selection and function estimation in an end-to-end manner. By penalizing both gating parameters and redundant layers, NNMR yields sparse and interpretable architectures while capturing complex nonlinear relationships driven by high-order synergistic effects. We further develop a…

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Forecasting Oil Consumption: The Statistical Review of World Energy Meets Machine Learning

预测石油消费:世界能源统计与机器学习的结合

This paper studies whether a small set of dominant countries can account for most of the dynamics of regional oil demand and improve forecasting performance. We focus on dominant drivers within the OECD and a broad GVAR sample covering over 90\% of world GDP. Our approach identifies dominant drivers from a high-dimensional concentration matrix estimated row by row using two complementary variable-selection methods, LASSO and the one-covariate-at-a-time multiple testing…

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Performance of prior event rate ratio method in the presence of differential mortality or dropout

差异性死亡或退出下既往事件率比方法的表现

Purpose: Prior event rate ratio (PERR) method was proposed to control for measured or unmeasured confounders in real-world evaluation of effectiveness and safety of medical treatments using electronic medical records data. A widely cited simulation study showed that PERR estimate of treatment effect was biased in the presence of differential morality/dropout. However, the study only considered one specific PERR estimator of treatment effect and one specific scenario of…

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Designing Time Series Experiments in A/B Testing with Transformer Reinforcement Learning

利用 Transformer 强化学习设计时间序列 A/B 实验

A/B testing has become a gold standard for modern technological companies to conduct policy evaluation. Yet, its application to time series experiments, where policies are sequentially assigned over time, remains challenging. Existing designs suffer from two limitations: (i) they do not fully leverage the entire history for treatment allocation; (ii) they rely on strong assumptions to approximate the objective function (e.g., the mean squared error of the estimated treatment…

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The Innovation Tax: Generative AI Adoption, Productivity Paradox, and Systemic Risk in the U.S. Banking Sector

创新税:生成式人工智能采用、生产率悖论与美国银行业系统性风险

This paper evaluates the causal impact of Generative Artificial Intelligence (GenAI) adoption on productivity and systemic risk in the U.S. banking sector. Using a novel dataset linking SEC 10-Q filings to Federal Reserve regulatory data for 809 financial institutions over 2018--2025, we employ two complementary identification strategies: Dynamic Spatial Durbin Models (DSDM) to capture network spillovers and Synthetic Difference-in-Differences (SDID) for causal inference…

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Counterfactual Forecasting for Panel Data

面板数据的反事实预测

We address the challenge of forecasting counterfactual outcomes in a panel data with missing entries and temporally dependent latent factors -- a common scenario in causal inference, where estimating unobserved potential outcomes ahead of time is essential. We propose Forecasting Counterfactuals under Stochastic Dynamics (FOCUS), a method that extends traditional matrix completion methods by leveraging time series dynamics of the factors, thereby enhancing the prediction…

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Demystify Doubly-Robust Estimation: The Role of Overlap

理解双重稳健估计:协变量重叠的作用

The doubly-robust (DR) estimator is popular for evaluating causal effects in observational studies and is often perceived as more desirable than inverse probability weighting (IPW) or outcome modeling alone because it provides extra protection against model misspecification. However, double robustness is an asymptotic property that may not hold in finite samples. We investigate how the finite sample performance of the DR estimator depends on the degree of covariate overlap…

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Difference-in-Differences under Local Dependence on Networks

网络局部依赖下的双重差分

Estimating causal effects under interference, where the stable unit treatment value assumption is violated, is critical in fields such as regional and public economics. Much of the existing research on causal inference under interference relies on a pre-specified "exposure mapping". This paper focuses on difference-in-difference and proposes a nonparametric identification strategy for direct and indirect average treatment effects under local interference on an observed…

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Identification and Estimation in Fuzzy Regression Discontinuity Designs with Covariates

含协变量的模糊断点回归设计:识别与估计

We study fuzzy regression discontinuity designs with covariates and characterize the weighted averages of conditional local average treatment effects (WLATEs) that are point identified. Any identified WLATE equals a Wald ratio of conditional reduced-form and first-stage discontinuities. We highlight the Compliance-Weighted LATE (CWLATE), which weights cells by squared first-stage discontinuities and maximizes first-stage strength. For discrete covariates, we provide simple…

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To Adopt or Not to Adopt: Heterogeneous Trade Effects of the Euro

是否采用欧元:欧元对贸易影响的异质性

Two decades of research on the euro's trade effects have produced estimates ranging from 4% to 30%, with no consensus on the magnitude. We find evidence that this divergence may reflect genuine heterogeneity in the euro's trade effect across country pairs rather than methodological differences alone. Using Eurostat data on 15 EU countries (12 eurozone members plus Denmark, Sweden, and the UK as controls) from 1995-2015, we estimate that euro adoption increased bilateral…

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Dynamic causal inference with time series data

时间序列数据中的动态因果推断

We generalize the potential outcome framework to time series with an intervention by defining causal effects on stochastic processes. Interventions in dynamic systems alter not only outcome levels but also evolutionary dynamics -- changing persistence and transition laws. Our framework treats potential outcomes as entire trajectories, enabling causal estimands, identification conditions, and estimators to be formulated directly on path space. The resulting Dynamic Average…

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Synthetic Regressing Control

合成回归控制法

Estimating weights in the synthetic control method, typically resulting in sparse weights where only a few control units have non-zero weights, involves an optimization procedure that selects and combines control units to closely match the treated unit. However, it is not uncommon for the linear combination of pre-treatment period outcomes for the control units, using nonnegative weights with the constraint that their sum equals one, to inadequately approximate the…

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Hybrid Meta-learners for Estimating Heterogeneous Treatment Effects

估计异质性处理效应的混合元学习器

Estimating conditional average treatment effects (CATE) from observational data involves modeling decisions that differ from supervised learning, particularly concerning how to regularize model complexity. Previous approaches can be grouped into two primary "meta-learner" paradigms that impose distinct inductive biases. Indirect meta-learners first fit and regularize separate potential outcome (PO) models and then estimate CATE by taking their difference, whereas direct…

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